PROGRAMME SCIENTIFIQUE
Mise à jour 19/11/2007
Télécharger le programme scientifique (PDF)
Mercredi 21 novembre 2007 |
| 12h00 - 14h00 |
Accueil des participants |
14h00 - 15h00 |
Conférence d'ouverture
Modérateur: Rudi Balling, Helmholtz Centre for Infection Research, Braunschweig, Germany
Discours de bienvenue: Alice Dautry, President of Institut Pasteur, Paris, France
Discours d'ouverture: Anthony Allison, Altavita Pharmaceuticals, Mountain View, USA
Major Genes Conferring Resistance to Malaria in Humans
Philippe Gros, McGill University, Montréal, Canada
Simple and complex genetic control of susceptibility to infectious diseases:
Lessons from the laboratory mouse |
| 15h00 - 18h30 |
| 15h-15h30 |
| 15h30-16h00 |
| 16h00-16h30 |
| 16h30-17h00 |
| 17h00-17h30 |
| 17h30-18h00 |
| 18h00-18h15 |
| 18h15-18h30 |
|
Session 1: Primary Immunodeficiencies
Chairs: James Di Santo, Institut Pasteur, Paris, France
Chris Goodnow, Australian National University, Canberra, Australia |
| Mary-Ellen Conley, St. Jude Children's Research Hospital, Memphis, USA - Defects in B cell development: Different infections at different ages |
| Jean-Laurent Casanova, Hôpital Necker-Enfants Malades, Paris, France - A genetic dissection of immunity to infection in natura |
| Pause-café |
| Alain Fischer, Hôpital Necker-Enfants Malades, Paris, France - Genetic susceptibility to infection by the Epstein-Barr virus and related immunopathology |
| Yoshihiro Kawaoka, University of Wisconsin-Madison, USA/Institute of Medical Science, Tokyo, Japan - Why Influenza Kills and will Kill Again |
| Bruce Beutler, The Scripps Research Institute, La Jolla, USA - ENU mutagenesis in the analysis of immunity in mice |
| Horst Von Bernuth, Hôpital Necker-Enfants Malades, Paris, France-
Human MYD88 deficiency |
| Felix Randow, MRC Laboratory of Molecular Biology, Cambridge, UK -
Somatic cell genetics for the study of Toll-like receptors and NF-KB |
|
18h30-20h30 |
Session posters et Wine and Cheese |
|
Jeudi 22 novembre 2007 |
9h00 - 12h30 |
| 9h00-9h30 |
| 9h30-10h00 |
| 10h00-10h30 |
| 10h30-11h00 |
| 11h00-11h30 |
| 11h30-11h45 |
| 11h45-12h00 |
| 12h00-12h15 |
| 12h15-12h30 |
|
Session 2: Genetics of common infectious diseases
Chairs: Genevieve Milon, Institut Pasteur, Paris, France
|
| Alexandre Alcaïs, Hôpital Necker-Enfants Malades, Paris, France - Anatomy of genetic predisposition to leprosy |
| Laurent Abel, Hôpital Necker-Enfants Malades, Paris, France - Human genetics of tuberculosis: a continuous spectrum of predisposition |
| Alain Dessein, Faculté de Médecine la Timone, Marseille, France - Major genes in the control of parasitic diseases |
| Pause-café |
| Etienne Pays, Université Libre de Bruxelles, Gosselies, Belgium - Mechanisms of human resistance and susceptibility to infection by african trypanosomes |
| Eileen Hoal, Stellenbosch University and MRC, Tygerberg, South Africa - Vitamin D receptor gene polymorphisms and sputum conversion time in pulmonary tuberculosis patients |
| Jacinta Bustamante, Hôpital Necker-Enfants Malades, Paris, France - A germline but macrophage-specific CYBB mutation in patients with X-Linked predisposition to mycobacterial diseases |
| Christophe Chevillard, Faculté de Medicine la Timone, Marseille, France - IL13 and STAT6 gene Polymorphisms are associated with high Infection levels in urinary schistosomiasis |
| Frédéric Lantier, INRA, Nouzilly, France - Genetics of susceptibility to transmissible spongiform encephalopathies in sheep |
|
12h30-14h00 |
Déjeuner |
| 14h00 - 18h30 |
| 14h00-14h30 |
| 14h30-15h00 |
| 15h00-15h30 |
| 15h30-16h00 |
| 16h00-16h30 |
| 16h30-17h00 |
| 17h00-17h30 |
| 17h30-18h00 |
| 18h00-18h15 |
| 18h15-18h30 |
|
Session 3: Genetic and functional studies of resistance to viruses
Chairs: Fernando Arenzana-Seisdedos, Institut Pasteur, Paris, France
Philippe Despres, Institut Pasteur, Paris, France |
| Michael Malim, King's College London , London, UK - APOBEC Proteins, Cytidine Deamination and Intrinsic Resistance to HIV Infection |
| Mary Carrington, SAIC-Frederick, Bethesda, USA - The influence of genetic variation at the HLA and KIR loci on HIV disease |
| Philip Goulder, University of Oxford, Oxford,UK - Control of HIV-1 mediated by HLA class I |
| Gérard Orth, Institut Pasteur, Paris, France - Epidermodysplasia verruciformis and the host defenses against papillomaviruses |
| Pause-café |
| Otto Haller, University of Freiburg, Freiburg, Germany - Interferon- induced MX GTPases in antiviral resistance |
| Lennart Svensson, University of Linköping, Linkoping, Sweden - Mendelian resistance to human norovirus infections: genetic and functional studies |
| Anavaj Sakuntabhai, Institut Pasteur, Paris, France -
Genetics Susceptibility to Dengue viral infection |
| Edward Wright, University College London, London, United Kingdom -
Effect of duffy antigen receptor For chemokine (DARC) polymorphisms on susceptibility to HIV infection and progression to AIDS |
Michel Favre, Institut Pasteur, Paris, France
Possible role of ever proteins in infection with cutaneous oncogenic human papillomaviruses |
|
18h30-20h30 |
Session Poster et Wine and Cheese |
|
Vendredi 23 novembre 2007 |
9h00 - 12h30 |
| 9h00-9h30 |
| 9h30-10h00 |
| 10h00-10h30 |
| 10h30-11h00 |
| 1h00-11h30 |
| 11h30-11h45 |
| 11h45-12h00 |
| 12h00-12h15 |
| 12h15-12h30 |
|
Session 4: Non mammalian models to study host genetics of infections
Chairs: Jonathan Ewbank, Centre d'Immunologie de Marseille-Luminy, Marseille, France
Bruno Lemaitre, Centre de Génétique Moléculaire, Gif-sur-Yvette, France |
| Jean-Luc Imler, IBMC, Strasbourg, France - Antiviral defenses in Drosophila |
| Sara Cherry, University of Pennsylvania, Philadelphia , USA - Identification of antiviral innate immune pathways in Drosophila |
| Jonathan Hodgkin, University of Oxford , Oxford, United Kingdom - Susceptibility to bacterial disease in the nematode C. elegans |
| Coffee Break |
| Paul Schulze-Lefert, Max-Planck-Institut für Züchtungsforschung, Köln, Germany - Receptor functions and execution of immune responses in the plant immune system |
| Dominique Ferrandon, IBMC, Strasbourg, France -
Dual detection of fungal infections in Drosophila through recognition of microbial structures and sensing of virulence factors |
| Petros Ligoxygakis, University of Oxford, Oxford, UK -
The E3 ubiquitin-ligases Hakai and Ari-2 are negative regulators of IMD pathway signalling and act to regulate Drosophila survival and apoptosis |
Nicolas Buchon, Global Health Institute EPFL, Lausanne, Switzerland
Prevalence of the gut immune response and its subversion in a Drosophila/Pseudomonas oral model of infection |
Sophie Cypowyj, Centre d’Immunologie de Marseille-Luminy, Marseille, France
a tribbles-like kinase defines distinct innate immune responses to infection and wounding in the C. elegans epidermis |
|
12h30-14h00 |
Déjeuner |
14h00 - 18h00 |
| 14h00-14h30 |
| 14h30-15h00 |
| 15h00-15h30 |
| 15h30-15h45 |
| 15h45-16h00 |
| 16h00-16h30 |
| 16h30-16h45 |
| 16h45-17h00 |
| 17h00-17h15 |
| 17h15-17h30 |
| 17h30-17h45 |
| 17h45-18h00 |
|
Session 5: Mouse models to study host genetics of infections
Chairs: Jean-Jacques Panthier, Institut Pasteur, Paris, France
Philip Avner, Institut Pasteur, Paris, France |
| Dirk Heinz, Helmholtz Centre for Infection Research, Braunschweig, Germany - Structural basis of bacterial invasion |
| Sylvia Vidal, McGill Center for Host Resistance, Montréal, Canada - Molecular mechanisms of innate resistance to mouse cytomegalovirus infection |
| Simon Foote, Menzies Research Institute, Melburne and Hobart, Australia - The role of platelets in clearance of malarial parasites |
Vanessa Sancho Shimizu, McGill University, Montreal, Canada
Genetic dissection of two loci (Ity2 and Ity3) controlling host response to Salmonella typhimurium infection in wild-derived mice |
Laura Boubbane, Harwell, Oxon, UK
The genetics of susceptibility to systemic pneumococcal infection |
| Pause-café |
| Bastian Pasche, Helmholtz Centre for Infection Research, Braunschweig, Germany - The “infection challenge platform” for mutant mice: a site for standard immune phenotyping |
Eva Medina, Helmholtz Centre for Infection Research, Braunschweig, Germany
Genetic control of susceptibility to Staphylococcus aureus infection in the mouse model |
Gundula Min-Oo, General Hospital Research Institute, Montreal, Canada
The role of pantetheinase and cysteamine in modulating the host response to blood-stage malaria |
Tania Di Pietrantonio, McGill University, Montreal, Canada
The genetic architecture of host responsiveness to low dose infection with different strains of bcg |
Eva Mertens, Institut Pasteur, Paris, France
Escape of West Nile virus variant from Oas1b-mediated antiviral defense in mice |
Jean François Bureau, Institut Pasteur, Paris, France
Role of a cluster of cytokines on Theiler’s virus induced neurological diseases |
|
20h30 |
Dinner de gala |
|
Samedi 24 novembre 2007 |
9h00 - 12h30 |
| 9h00-9h30 |
| 9h30-10h00 |
| 10h00-10h30 |
| 10h30-11h00 |
| 11h00-11h30 |
| 11h30-11h45 |
| 11h45-12h00 |
| 12h00-12h15 |
| 12h15-12h30 |
|
Session 6: Infections, chronic inflammation and autoimmune diseases
Chairs: Jean Pierre Hugot, Hôpital Robert Debré, Paris, France
Philippe Sansonetti, Institut Pasteur, Paris, France |
| Philippe Sansonetti, Institut Pasteur, Paris, France - Rupture, invasion and inflammatory destruction of the intestinal epithelium by Shigella: war and peace at mucosal surface |
| Chris Goodnow, Australian National University, Canberra, Australia - Cellular and geneteic mechanisms of self tolerance and autoimmunity |
| Anthony W. Segal, University College London, London, UK - Crohn’s disease is caused by a failure of the innate immune response |
| Pause-café |
| Silvia Bolland, NIAID, Rockville, USA - Gene dose effect of RNA-sensing receptors in autoimmune inflammation |
Frédérick Barreau, Hôpital Robert Debré, Paris, France
CARD15/NOD2 is required for Peyer’s patches homeostasis in mice |
Yan ching ken Chow, Institut Pasteur, Paris, France
Role of CXCL12-dependent signalling pathways in human papillomavirus (HPV) pathogenesis: insight into the chronic and malignant HPV infections in WHIM syndrome |
Shen-Ying Zhang, Hôpital Necker-Enfants Malades, Paris, France
Impaired ex vivo interferon production in a patient with severe varicella |
Henry Bayele, University College London, London, UK
Regulation of NRAMP1/SLC11A1 expression level polymorphisms by HIF-1α links host genetics and susceptibility to infection |
|
12h30-14h00 |
Déjeuner |
| 14h00 - 18h00 |
| 14h00-14h30 |
| 14h30-15h00 |
| 15h00-15h30 |
| 15h30-15h45 |
| 15h45-16h00 |
| 16h00-16h30 |
| 16h30-16h45 |
| 16h45-17h00 |
| 17h00-17h30 |
|
Session 7 : The impact of pathogens on human evolution and their diseases
Chairs: Simon Wain-Hobson, Institut Pasteur, Paris, France
François Renaud, Centre de Recherche I.R.D., Montpellier, France |
| Dominic Kwiatkowski, University of Oxford, Oxford, UK - Human genome variation and resistance to malaria |
| Lluis Quintana-Murci, Institut Pasteur, Paris, France - Human genome variability, natural selection and infectious diseases |
Michael Bamshad, University of Washington, Seattle, USA
Race, ancestry, and genetic risk factors for infectious disease |
Bryndis Yngvadottir, The Wellcome Trust Sanger Institute, Cambridge, UK
When is less more? Investigating gene loss in recent human evolution |
Luis Barreiro, Institut Pasteur, Paris, France
Searching for the footprints of natural selection in the human genome |
| Pause-café |
Martin Sikora, Universitat Pompeu Fabra, Barcelona, Spain
Searching for signtures of selection in genes of two pathways implicated in placental malaria infection |
Pedro Ferreita, Karolinska Institute, Stockholm, Sweden
Polymorphism of antimalaria drug metabolizing, nuclear receptor and drug transport genes among malaria patients in Zanzibar, East Africa |
Conclusion :
Jean-Louis Guenet, Institut Pasteur, Paris, France |
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