Series at the Institut Pasteur |
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GENETICS AND MECHANISMS OF SUSCEPTIBILITY TO INFECTIOUS DISEASES
November 21-24, 2007 |
SCIENTIFIC PROGRAM
Last update:11/19/07
Download the scientific program (PDF format)
Wednesday November 21st, 2007 |
| 12.00 am-2.00 pm |
Registration |
2.00 pm-3.00 pm |
Opening ceremony
Chairperson: Rudi Balling, Helmholtz Centre for Infection Research, Braunschweig, Germany
Welcome address: Alice Dautry, President, Institut Pasteur, Paris, France
Opening Lecture: Anthony Allison, Altavita Pharmaceuticals, Mountain View, USA
Major Genes Conferring Resistance to Malaria in Humans
Keynote lecture: Philippe Gros, McGill University, Montreal, Canada
Simple and complex genetic control of susceptibility to infectious diseases:
Lessons from the laboratory mouse |
3.00 -6.30 pm |
| 3.00-3.30 pm |
| 3.30-4.00 pm |
| 4.00-4.30 pm |
| 4.30-5.00 pm |
| 5.00-5.30 pm |
| 5.30-6.00 pm |
| 6.00-6.15 pm |
| 6.15-6.30 pm |
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Session 1: Primary Immunodeficiencies
Chairs: James Di Santo, Institut Pasteur, Paris, France
Chris Goodnow, Australian National University, Canberra, Australia |
| Mary Ellen Conley, St. Jude Children's Research Hospital, Memphis, USA - Defects in B cell development: Different infections at different ages |
| Jean-Laurent Casanova, Hôpital Necker-Enfants Malades, Paris, France - A genetic dissection of immunity to infection in natura |
| Coffee Break |
| Alain Fischer, Hôpital Necker-Enfants Malades, Paris, France - Genetic susceptibility to infection by the Epstein-Barr virus and related immunopathology |
| Yoshihiro Kawaoka, University of Wisconsin - Madison, USA/Institute of Medical Science, Tokyo, Japan - Why Influenza Kills and will Kill Again |
| Bruce Beutler, The Scripps Research Institute, La Jolla, USA - ENU mutagenesis in the analysis of immunity in mice |
| Horst von Bernuth, Hôpital Necker-Enfants Malades, Paris, France-
Human MYD88 deficiency |
| Felix Randow, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom -
Somatic cell genetics for the study of Toll-like receptors and NF-KB |
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6.30 pm-8.30 pm |
Poster session and Wine and Cheese |
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Thursday November 22nd, 2007 |
| 9.00 am-12.30 pm |
| 9.00-9.30 am |
| 9.30-10.00 am |
| 10.00-10.30 am |
| 10.30-11.00 am |
| 11.00-11.30 am |
| 11.30-11.45 am |
| 11.45-12.00 am |
| 12.00-12.15 am |
| 12.15-12.30 am |
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Session 2: Genetics of common infectious diseases
Chairs: Genevieve Milon , Institut Pasteur, Paris, France
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| Alexandre Alcaïs, Hôpital Necker-Enfants Malades, Paris, France - Anatomy of genetic predisposition to leprosy |
| Laurent Abel, Hôpital Necker-Enfants Malades, Paris, France - Human genetics of tuberculosis: a continuous spectrum of predisposition |
| Alain Dessein, Faculté de Médecine la Timone, Marseille, France - Major genes in the control of parasitic diseases |
| Coffee break |
| Etienne Pays, Université Libre de Bruxelles, Gosselies, Belgium - Mechanisms of human resistance and susceptibility to infection by african trypanosomes |
| Eileen Hoal, Stellenbosch University and MRC, Tygerberg, South Africa - Vitamin D receptor gene polymorphisms and sputum conversion time in pulmonary tuberculosis patients |
| Jacinta Bustamante, Hôpital Necker-Enfants Malades, Paris, France - A germline but macrophage-specific CYBB mutation in patients with X-Linked predisposition to mycobacterial diseases |
| Christophe Chevillard, Faculté de Medicine la Timone, Marseille, France - IL13 and STAT6 gene Polymorphisms are associated with high Infection levels in urinary Schistosomiasis |
| Frédéric Lantier, INRA, Nouzilly, France - Genetics of susceptibility to transmissible spongiform encephalopathies in sheep |
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| 12.30 pm-2.00 pm |
Lunch |
2.00 pm-6.30 pm |
| 2.00-2.30 pm |
| 2.30-3.00 pm |
| 3.00-3.30 pm |
| 3.30-4.00 pm |
| 4.00-4.30 pm |
| 4.30-5.00 pm |
| 5.00-5.30 pm |
| 5.30-6.00 pm |
| 6.00-6.15 pm |
| 6.15-6.30 pm |
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Session 3: Genetic and functional studies of resistance to viruses
Chairs: Fernando Arenzana-Seisdedos, Institut Pasteur, Paris, France
Philippe Despres, Institut Pasteur, Paris, France |
| Michael Malim, King's College London , London, United Kingdom - APOBEC Proteins, Cytidine Deamination and Intrinsic Resistance to HIV Infection |
| Mary Carrington, SAIC-Frederick, Bethesda, USA - The influence of genetic variation at the HLA and KIR loci on HIV disease |
| Philip Goulder, University of Oxford, Oxford,UK - Control of HIV-1 mediated by HLA class I |
| Gérard Orth, Institut Pasteur, Paris, France -Epidermodysplasia verruciformis and the host defenses against papillomaviruses |
| Coffee Break |
| Otto Haller, University of Freiburg, Freiburg, Germany - Interferon- induced Mx GTPases in antiviral resistance |
| Lennart Svensson, University of Linköping, Linköping, Sweden - Mendelian resistance to human norovirus infections: genetic and functional studies |
| Anavaj Sakuntabhai, Institut Pasteur, Paris, France - Genetics Susceptibility to Dengue viral infection |
Edward Wright, University College London, London, United Kingdom
Effect of duffy antigen receptor for chemokine (DARC) polymorphisms on susceptibility to HIV infection and progression to AIDS |
Michel Favre, Institut Pasteur, Paris, France
Possible role of ever proteins in infection with cutaneous oncogenic human papillomaviruses |
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| 6.30 pm-8.30 pm |
Poster session and Wine and Cheese |
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Friday November 23rd, 2007 |
9.00 am-12.30 am |
| 9.00-9.30 am |
| 9.30-10.00 am |
| 10.00-10.30 am |
| 10.30-11.00 am |
| 11.00-11.30 am |
| 11.30-11.45 am |
| 145.12.00 am |
| 12.00-12.15 am |
| 12.15-12.30 am |
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Session 4: Non mammalian models to study host genetics of infections
Chairs: Jonathan Ewbank, Centre d'Immunologie de Marseille-Luminy, Marseille, France
Bruno Lemaitre, Centre de Génétique Moléculaire, Gif-sur-Yvette, France |
| Jean-Luc Imler, IBMC, Strasbourg, France - Antiviral defenses in Drosophila |
| Sara Cherry, University of Pennsylvania, Philadelphia , USA - Identification of antiviral innate immune pathways in Drosophila |
| Jonathan Hodgkin, University of Oxford , Oxford, UK - Susceptibility to bacterial disease in the nematode C. elegans |
| Coffee Break |
| Paul Schulze-Lefert, Max-Planck-Institut für Züchtungsforschung, Köln, Germany - Receptor functions and execution of immune responses in the plant immune system |
Dominique Ferrandon, IBMC, Strasbourg, France
Dual detection of fungal infections in Drosophila through recognition of microbial structures and sensing of virulence factors |
Petros Ligoxygakis, University of Oxford, Oxford, UK
The E3 ubiquitin-ligases Hakai and Ari-2 are negative regulators of imd pathway signalling and act to regulate Drosophila survival and apoptosis |
Nicolas Buchon, Global Health Institute EPFL, Lausanne, Switzerland
Prevalence of the gut immune response and its subversion in a Drosophila/Pseudomonas oral model of infection |
Sophie Cypowyj, Centre d’Immunologie de Marseille-Luminy, Marseille, France
A tribbles-like kinase defines distinct innate immune responses to infection and wounding in the C. elegans epidermis |
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| 12.30 pm-2.00 pm |
Lunch |
| 2.00 pm-6.00 pm |
| 2.00-2.30 pm |
| 2.30-3.00 pm |
| 3.00-3.30 pm |
| 3.30-3.45 pm |
| 3.45-4.00 pm |
| 4.00-4.30 pm |
| 4.30-4.45 pm |
| 4.45.5.00 pm |
| 5.00-5.15 pm |
| 5.15-5.30 pm |
| 5.30-5.45 pm |
| 5.45-6.00 pm |
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Session 5: Mouse models to study host genetics of infections
Chairs: Jean-Jacques Panthier, Institut Pasteur, Paris, France
Philip Avner, Institut Pasteur, Paris, France |
| Dirk Heinz, Helmholtz Centre for Infection Research, Braunschweig, Germany - Structural basis of bacterial invasion |
| Sylvia Vidal, McGill Center for Host Resistance, Montreal, Canada - Molecular mechanisms of innate resistance to mouse cytomegalovirus infection |
| Simon Foote, Menzies Research Institute, Melburne and Hobart, Australia - The role of platelets in clearance of malarial parasites |
Vanessa Sancho-Shimizu, McGill University, Montreal, Canada
Genetic dissection of two loci (Ity2 and Ity3) controlling host response to Salmonella typhimurium infection in wild-derived mice |
Laura Boubbane, Harwell, Oxon, UK
The genetics of susceptibility to systemic pneumococcal infection |
| Coffee break |
| Bastian Pasche, Helmholtz Centre for Infection Research, Braunschweig, Germany - The “infection challenge platform” for mutant mice: a site for standard immune phenotyping |
Eva Medina, Helmholtz Centre for Infection Research, Braunschweig, Germany
Genetic control of susceptibility to Staphylococcus aureus infection in the mouse model |
Gundula Min-Oo, General Hospital Research Institute, Montreal, Canada
The role of pantetheinase and cysteamine in modulating the host response to blood-stage malaria |
Tania Di Pietrantonio, McGill University, Montreal, Canada
The genetic architecture of host responsiveness to low dose infection with different strains of bcg |
Eva Mertens, Institut Pasteur, Paris, France
Escape of West Nile virus variant from Oas1b-mediated antiviral defense in mice |
Jean-François Bureau, Institut Pasteur, Paris, France
Role of a cluster of cytokines on Theiler’s virus induced neurological diseases |
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8.30 pm |
Gala Dinner |
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Saturday November 24th, 2007 |
| 9.00 am-12.30 pm |
| 9.00-9.30 am |
| 9.30-10.00 am |
| 10.00-10.30 am |
| 10.30-11.00 am |
| 11.00-11.30 am |
| 11.30-11.45 am |
| 11.45-12.00 am |
| 12.00-12.15 am |
| 12.15-12.30 am |
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Session 6: Infections, chronic inflammation and autoimmune diseases
Chairs: Jean Pierre Hugot, Hôpital Robert Debré, Paris, France
Philippe Sansonetti, Institut Pasteur, Paris, France |
| Philippe Sansonetti, Institut Pasteur, Paris, France - Rupture, invasion and inflammatory destruction of the intestinal epithelium by Shigella: war and peace at mucosal surface |
| Chris Goodnow, Australian National University, Canberra, Australia - Cellular and geneteic mechanisms of self tolerance and autoimmunity |
| Anthony W. Segal, University College London, London, UK - Crohn’s disease is caused by a failure of the innate immune response |
| Coffee Break |
| Silvia Bolland, NIAID, Rockville , USA - Gene dose effect of RNA-sensing receptors in autoimmune inflammation |
Frédérick Barreau, Hôpital Robert Debré, Paris, France
CARD15/NOD2 is required for Peyer’s patches homeostasis in mice |
Yan ching ken Chow, Institut Pasteur, Paris, France
Role of CXCl12-dependent signalling pathways in human Papillomavirus (HPV) pathogenesis: insight into the chronic and malignant hpv infections in WHIM syndrome |
Shen-Ying Zhang, Hôpital Necker-Enfants Malades, Paris, France
Impaired ex vivo interferon production in a patient with severe Varicella |
Henry Bayele, University College London, London, UK
Regulation of NRAMP1/SLC11A1 expression level polymorphisms by HIF-1α links host genetics and susceptibility to infection |
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12.30 pm-2.00 pm |
Lunch |
2.00 pm-6.00 pm |
| 2.00-2.30 pm |
| 2.30-3.00 pm |
| 3.00-3.30 pm |
| 3.30-3.45 am |
| 3.45-4.00 pm |
| 4.00-4.30 pm |
| 4.30-4.45 pm |
| 4.45-5.00 pm |
| 5.00-5.30 pm |
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Session 7 : The impact of pathogens on human evolution and their diseases
Chairs: Simon Wain-Hobson, Institut Pasteur, Paris, France
François Renaud, Centre de Recherche I.R.D., Montpellier, France |
| Dominic Kwiatkowski, University of Oxford, Oxford, UK - Human genome variation and resistance to malaria |
| Lluis Quintana-Murci, Institut Pasteur, Paris, France - Human genome variability, natural selection and infectious diseases |
Michael Bamshad, University of Washington, Seattle, USA
Race, ancestry, and genetic risk factors for infectious disease |
Bryndis Yngvadottir, The Wellcome Trust Sanger Institute, Cambridge, UK
When is less more? investigating gene loss in recent human evolution |
Luis Barreiro, Institut Pasteur, Paris, France
Searching for the footprints of natural selection in the human genome |
| Coffee Break |
Martin Sikora, Universitat Pompeu Fabra, Barcelona, Spain
Searching for signtures of selection in genes of two pathways implicated in placental malaria infection |
Pedro Ferreira, Karolinska Institute, Stockholm, Sweden
Polymorphism of antimalaria drug metabolizing, nuclear receptor and drug transport genes among malaria patients in Zanzibar, East Africa |
Concluding remarks:
Jean-Louis Guenet, Institut Pasteur, Paris, France |
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