Study of Chikungunya virus replication and entry into mammalian cells

A postdoctoral position, funded by the Laboratory of Excellence Integrative Biology of Emerging Infectious Diseases (LabEx IBEID:, is available in the "Virus and Immunity" research unit directed by Olivier Schwartz at the Institut Pasteur in Paris.

Study of Chikungunya virus replication and entry into mammalian cells
Chikungunya virus (CHIKV) is a re-emerging mosquito-borne alphavirus responsible for a recent, unexpectedly severe and long-lasting epidemic in the Indian Ocean region. Although many alphaviruses have been well characterized, the biology and pathogenesis of CHIKV are less understood. Very little is known about the cellular and molecular mechanisms of CHIKV entry and replication in mammalian cells. Our laboratory has completed, in collaboration with Institut Pasteur Korea, a genome-wide siRNA screen to identify cellular proteins involved in CHIKV replication.
The project is aimed at characterizing the role of selected proteins identified in this screen. The proteins will be silenced and/or expressed in relevant cells and the impact on viral replication and host/virus interplay will be studied, using state-of-the-art techniques in cellular and molecular biology, real-time imaging, virology and immunology.


Candidate requirements: Strong expertise in cellular biology, virology or immunology


To apply: Applicants should send their CV, a motivation letter and 3 references to Olivier Schwartz ( Unité Virus et Immunité, Institut Pasteur, 28 rue du Dr Roux 75015 Paris

Mis à jour le 08/11/2013