Publications

Bourgeron Laboratory

 

2014

 

Toro R., Poline JB, Huguet G., Loth E, Frouin V, Banaschewski T., Barker GJ, Bokde A, Buchel C., Carvalho FM, Conrod P, Fauth­Buhler M., Flor H, Gallinat J, Garavan H, Gowland P., Heinz A, Ittermann B, Lawrence C, Lemaitre H, Mann K, Nees F, Paus T, Pausova Z, Rietschel M, Robbins T, Smolka MN, Strohle A, Schumann G, and Bourgeron T Genomic architecture of human neuroanatomical diversity Molecular Psychiatry In Press

 

Leblond CS, Nava C, Polge A, Gauthier J, Huguet G, Lumbroso S, Giuliano F, Stordeur C, Depienne C, Mouzat K, Pinto D, Howe J, Lemière N, Durand CM, Guibert J, Ey E, Toro R, Peyre H, Mathieu A, Amsellem F, Rastam M, Gillberg IC, Rappold GA, Holt R, Monaco AP, Maestrini E, Galan P, Heron D, Jacquette A, Afenjar A, Rastetter A, Brice A, Devillard F, Assouline B, Laffargue F, Lespinasse J, Chiesa J, Rivier F, Bonneau D, Regnault B, Zelenika D, Delepine M, Lathrop M, Sanlaville D, Schluth-Bolard C, Edery P, Perrin L, Tabet AC, Schmeisser MJ, Boeckers TM, Coleman M, Sato D, Szatmari P, Scherer SW, Rouleau GA, Betancur C, Leboyer M, Gillberg C, Delorme R, Bourgeron T. Meta-analysis of SHANK mutations in Autism Spectrum Disorders: A gradient of severity in cognitive impairments. PLOS Genetics. 2014 10, e1004580.

 

T. Karayannis, E. Au, J. Patel, I. Kruglikov, S. Mark, R. Delorme, D. Héron, J. Glessner, S. Restituito, A. Gordon, L. Rodriguez-Murillo, N.C. Roy, J. Gogos, B. Rudy, M.E. Rice, M. Karayiorgou, H. Hakonarson, B. Keren, G. Huguet, Bourgeron T, C. Hoeffer, R.W. Tsien, E. Peles, G. Fishell. Cntnap4 Differentially Contributes to GABAergic and Dopaminergic Synaptic Transmission Nature 2014 May 25. doi: 10.1038

 

Pinel P, Lalanne C, Bourgeron T, Fauchereau F, Poupon C, Artiges E, Le Bihan D, Dehaene-Lambertz G, Dehaene S. Genetic and Environmental Influences on the Visual Word Form and Fusiform Face Areas. Cereb Cortex. 2014 May 13.

 

Pinto D, Delaby E, Merico D, Barbosa M, Merikangas A, Klei L, Thiruvahindrapuram B, Xu X, Ziman R, Wang Z, Vorstman JA, Thompson A, Regan R, Pilorge M, Pellecchia G, Pagnamenta AT, Oliveira B, Marshall CR, Magalhaes TR, Lowe JK, Howe JL, Griswold AJ, Gilbert J, Duketis E, Dombroski BA, De Jonge MV, Cuccaro M, Crawford EL, Correia CT, Conroy J, Conceição IC, Chiocchetti AG, Casey JP, Cai G, Cabrol C, Bolshakova N, Bacchelli E, Anney R, Gallinger S, Cotterchio M, Casey G, Zwaigenbaum L, Wittemeyer K, Wing K, Wallace S, van Engeland H, Tryfon A, Thomson S, Soorya L, Rogé B, Roberts W, Poustka F, Mouga S, Minshew N, McInnes LA, McGrew SG, Lord C, Leboyer M, Le Couteur AS, Kolevzon A, Jiménez González P, Jacob S, Holt R, Guter S, Green J, Green A, Gillberg C, Fernandez BA, Duque F, Delorme R, Dawson G, Chaste P, Café C, Brennan S, Bourgeron T, Bolton PF, Bölte S, Bernier R, Baird G, Bailey AJ, Anagnostou E, Almeida J, Wijsman EM, Vieland VJ, Vicente AM, Schellenberg GD, Pericak-Vance M, Paterson AD, Parr JR, Oliveira G, Nurnberger JI, Monaco AP, Maestrini E, Klauck SM, Hakonarson H, Haines JL, Geschwind DH, Freitag CM, Folstein SE, Ennis S, Coon H, Battaglia A, Szatmari P, Sutcliffe JS, Hallmayer J, Gill M, Cook EH, Buxbaum JD, Devlin B, Gallagher L, Betancur C, Scherer SW. Convergence of genes and cellular pathways dysregulated in autism spectrum disorders. Am J Hum Genet. 2014 May 1;94(5):677-94.

 

Huguet G., Nava C., Lemière N, Ey E, Brice A., Leboyer M., Szepetowski P, Gillberg C., Depienne C., Delorme R., Bourgeron T. Heterogeneous pattern of selective pressure for PRRT2 in human populations, but no association with autism spectrum disorders. PLoS One 9 (3); e886000

 

Fernell E, Wilson P, Hadjikhani N, Bourgeron T, Neville B, Taylor D, Minnis H, Gillberg C. Screening, Intervention and Outcome in Autism and Other Developmental Disorders: The Role of Randomized Controlled Trials. J Autism Dev Disord. 2014 Feb 20.

 

Waltes R, Duketis E, Knapp M, Anney RJ, Huguet G, Schlitt S, Jarczok TA, Sachse M, Kämpfer LM, Kleinböck T, Poustka F, Bölte S, Schmötzer G, Voran A, Huy E, Meyer J, Bourgeron T, Klauck SM, Freitag CM, Chiocchetti AG. Common variants in genes of the postsynaptic FMRP signalling pathway are risk factors for autism spectrum disorders. Hum Genet. 2014 Jan 19.

 

Kleijer KT, Schmeisser MJ, Krueger DD, Boeckers TM, Scheiffele P, Bourgeron T, Brose N, Burbach JP. Neurobiology of autism gene products: towards pathogenesis and drug targets. Psychopharmacology (Berl). 2014 Mar;231(6):1037-62.

 

2013

 

Scheid I, Maruani A, Huguet G, Leblond CS, Nygren G, Anckarsäter H, Beggiato A, Rastam M, Amsellem F, Gillberg IC, Elmaleh M, Leboyer M, Gillberg C, Betancur C, Coleman M, Hama H, Cook EH, Bourgeron T, Delorme R. Heterozygous FA2H mutations in autism spectrum disorders. BMC Med Genet. 2013 Dec 3;14(1):124.

 

Guilmatre A, Huguet G, Delorme R, Bourgeron T. The emerging role of SHANK genes in neuropsychiatric disorders. Dev Neurobiol. 2013 74(2): 113-22.

 

Ey E, Torquet N, Le Sourd AM, Leblond CS, Boeckers TM, Faure P and Bourgeron T. (2013) The Autism ProSAP1/Shank2 Mouse Model Displays Quantitative and Structural Abnormalities in Ultrasonic Vocalisations. Behav Brain Res. doi:pii: S0166-4328

 

Boissart C, Poulet A, Georges P, Darville H, Julita E, Delorme R, Bourgeron T, Peschanski M, Benchoua A. (2013) Differentiation from human pluripotent stem cells of cortical neurons of the superficial layers amenable to psychiatric disease modeling and high-throughput drug screening. Transl Psychiatry. 3:e294.

 

Huguet G, Ey E and Bourgeron T. (2013) The genetic landscapes of autism spectrum disorders. Annu Rev Genomics Hum Genet. 14:191-213.

 

Delorme R, Ey E, Toro R, Leboyer M, Gillberg C, and Bourgeron T. (2013) Progress towards treatments for synaptic defects in autism. Nature Medicine 19(6):685-94

 

Mercati O, Danckaert A, André-Leroux G, Bellinzoni M, Gouder L, Watanabe K, Shimoda Y, Grailhe R, de Chaumont F, Bourgeron T and Cloëz-Tayarani I (2013) Contactin 4, -5 and -6 differentially regulate neuritogenesis while they display identical PTPRG binding sites. Biology Open 2:324-34

 

Wang L, Li J, Ruan Y, Lu T, Liu C, Jia M, Yue W, Liu J, Bourgeron T, Zhang D. (2013) Sequencing ASMT Identifies Rare Mutations in Chinese Han Patients with Autism. PLoS One. 8(1):e53727.

 

2012

 

     El-Kordi A, Winkler D, Hammerschmidt K, Kästner A, Krueger D, Ronnenberg A, Ritter C, Jatho J, Radyushkin K, Bourgeron T, Fischer J, Brose N, Ehrenreich H. Development of an autism severity score for mice using Nlgn4 null mutants as a construct-valid model of heritable monogenic autism. Behav Brain Res. 2012 Nov 23.

 

     Nava C, Lamari F, Héron D, Mignot C, Rastetter A, Keren B, Cohen D, Faudet A, Bouteiller D, Gilleron M, Jacquette A, Whalen S, Afenjar A, Périsse D, Laurent C, Dupuits C, Gautier C, Gérard M, Huguet G, Caillet S, Leheup B, Leboyer M, Gillberg C, Delorme R, Bourgeron T, Brice A, Depienne C. Analysis of the chromosome X exome in patients with autism spectrum disorders identified novel candidate genes, including TMLHE. Transl Psychiatry. 2012 Oct 23;2:e179.

 

     Ey E, Yang M, Katz AM, Woldeyohannes L, Silverman JL, Leblond CS, Faure P, Torquet N, Le Sourd AM, Bourgeron T, Crawley JN. Absence of deficits in social behaviors and ultrasonic vocalizations in later generations of mice lacking neuroligin4. Genes Brain Behav. 2012 Sep 18.

 

     Anney R, Klei L, Pinto D, Almeida J, Bacchelli E, Baird G, Bolshakova N, Bölte S, Bolton PF, Bourgeron T et al. Individual common variants exert weak effects on the risk for autism spectrum disorders. Hum Mol Genet. 2012 Aug 8. [Epub ahead of print]

 

     Le Floch E, Guillemot V, Frouin V, Pinel P, Lalanne C, Trinchera L, Tenenhaus A, Moreno A, Zilbovicius M, Bourgeron T, Dehaene S, Thirion B, Poline JB, Duchesnay E. Significant correlation between a set of genetic polymorphisms and a functional brain network revealed by feature selection and sparse Partial Least Squares. Neuroimage 2012 Jul 8;63(1):11-24.

 

Chaste P, Betancur C, Gérard-Blanluet M, Bargiacchi A, Kuzbari S, Drunat S, Leboyer M, Bourgeron T, Delorme R. High-Functioning Autism Spectrum Disorder and Fragile X Syndrome: Report of Two Affected Sisters Mol Autism. 2012 3(1):5

 

Goubran Botros H, Legrand P, Pagan C, Bondet V, Weber P, Ben Abdallah M, Lemière N, Huguet G, Bellalou J, Maronde E, Beguin P, Haouz A, Shepard W and Bourgeron T. Crystal structure and functional mapping of ASMT, the last enzyme of the melatonin synthesis pathway. J. Pineal Res. 54:46–57.

 

Etain B, Bellivier F, Dumaine A, Deshommes J, Pagan C, Goubran-Botros H, Moreno S, Moustafa K, Mathieu F, Henry C, Kahn JP, Launay JM, Bourgeron T, Leboyer M, Jamain S. Functional alterations of ASMT, the last enzyme of the melatonin pathway, in patients with bipolar disorders. Hum. Mol. Genet. (2012) 21:4030-7.

 

     Sato D, Lionel AC, Leblond CS, Prasad A, Pinto D, Walker S, O’Connor I, Russell C, Drmic IE, Hamdan FF, MichaudJL, Endris V, Roeth R, Delorme R, Huguet G, Leboyer M, Rastam M, Gillberg C, Lathrop M, Stavropoulos DJ, Anagnostou E, Weksberg R, Fombonne E, Zwaigenbaum L, Fernandez BA, Roberts W, Rappold GA, Marshall CR, Bourgeron T, Szatmari P and Scherer SW. SHANK1 Deletions in Males with Autism Spectrum Disorder. Am. J. Hum. Genet. (2012) 90:879-87

 

     Schmeisser MJ, Ey E, Kuebler A, Bockmann J, Wegener S, Stempel AV, Kuebler A, Janssen AL, Udvardi PT, Shiban E, Spilker C, Balschun D, Skryabin BV, tom Dieck S, Smalla KH, Montag D, Leblond CS, Faure P, Torquet N, Le Sourd AM, Toro R, Grabrucker AM, Shoichet SA, Schmitz D, Kreutz MR, Bourgeron T, Gundelfinger ED and Boeckers TM. Hyperactivity and autistic-like behaviours in mice lacking ProSAP1/Shank2. Nature (2012) 486 : 256-60

 

Leblond CS, Heinrich J, Delorme R, Proepper C, Betancur C, Huguet G, Konyukh M, Chaste P, Ey E, Rastam M, Anckarsäter H, Nygren G, Gillberg IC, Melke J, Toro R, Regnault B, Fauchereau F, Mercati O, Lemière N, Skuse D, Poot M, Holt R, Monaco AP, Järvelä I, Kantojärvi K, Vanhala R, Curran S, Collier DA, Bolton P, Chiocchetti A, Klauck SM, Poustka F, Freitag CM, Waltes R, Kopp M, Duketis E, Bacchelli E, Minopoli F, Ruta L, Battaglia A, Mazzone L, Maestrini E, Sequeira AF, Oliveira B, Vicente A, Oliveira G, Pinto D, Scherer SW, Zelenika D, Delepine M, Lathrop M, Bonneau D, Guinchat V, Devillard F, Assouline B, Mouren MC, Leboyer M, Gillberg C, Boeckers TM, Bourgeron T. Genetic and functional analyses of SHANK2 mutations provide evidence for a multiple hit model of autism spectrum disorders. PLoS Genetics 2012 8:e1002521.

 

Pinel P, Fauchereau F, Moreno A, Barbot A, Lathrop M, Zelenika D, Le Bihan D, Poline JB, Bourgeron T, Dehaene S. Genetic Variants of FOXP2 and KIAA0319/TTRAP/THEM2 Locus Are Associated with Altered Brain Activation in Distinct Language-Related Regions. J Neurosci. (2012) 32:817-825.

 

Chabout J, Serreau P, Ey E, Bellier L, Aubin T, Bourgeron T, Granon S. Adult male mice emit context-specific ultrasonic vocalizations that are modulated by prior isolation or group rearing environment. PLoS One. 2012;7(1):e29401.

 

Casey JP, Magalhaes T, Conroy JM, Regan R, Shah N, Anney R, Shields DC, Abrahams BS, Almeida J, Bacchelli E, Bailey AJ, Baird G, Battaglia A, Berney T, Bolshakova N, Bolton PF, Bourgeron T, et al. A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder. Hum Genet. (2012) 131(4):565-79.

 

2011

 

Poot M, van der Smagt JJ, Brilstra EH, Bourgeron T. Disentangling the Myriad Genomics of Complex Disorders, Specifically Focusing on Autism, Epilepsy, and Schizophrenia. Cytogenet Genome Res. (2011) 135(3-4):228-40.

 

Chaste P, Clement N, Botros HG, Guillaume JL, Konyukh M, Pagan C, Scheid I, Nygren G, Anckarsäter H, Rastam M, Ståhlberg O, Gillberg IC, Melke J, Delorme R, Leblond C, Toro R, Huguet G, Fauchereau F, Boudarene L, Serrano E, Lemière N, Launay JM, Heath S, Lathrop M, Boland A, Zelenica D, Leboyer M, Jockers R, Gillberg C and Bourgeron T Genetic variations of the melatonin pathway in patients with Attention Deficit and Hyperactivity Disorders J. Pineal Research 51(4):394-9.

 

Durand CM, Perroy J, Loll F, Fagni L, Bourgeron T, Montcouquiol M, Sans N. SHANK3 mutations identified in autism lead to modification of dendritic spine morphology via an actin-dependent mechanism. (2011) Molecular Psychiatry 17(1):71-84.

 

Maronde E, Saade A, Ackermann K, Goubran-Botros H, Rami A, Bourgeron T, Dehghani F, Stehle JH. Dynamics in enzymatic protein complexes offer a novel principle for the regulation of melatonin synthesis in the human pineal gland. (2011) J. Pineal Research 51(1):145-55.

 

     Amaral D, Rogers SJ, Baron-Cohen S, Bourgeron T, Caffo E, Fombonne E, Fuentes J, Howlin P, Rutter M, Klin A, Volkmar F, Lord C, Minshew N, Nardocci F, Rizzolatti G, Russo S, Scifo R, van der Gaag RJ. Against le packing: a consensus statement. J Am Acad Child Adolesc Psychiatry. 2011 Feb;50(2):191-2.

 

Pagan C, Goubran-Botros H, Poirier K, Dumaine A, Jamain S, Moreno S, de Brouwer A, Van Esch H, Delorme R, Launay JM, Tzschach A, Kalscheuer VM, Lacombe D, Briault S, Laumonnier F, Raynaud M, van Bon BW, Willemsen MH, Leboyer M, Chelly J and Bourgeron T. Mutation screening of ASMT, the last enzyme of the melatonin pathway, in a large sample of patients with Intellectual Disability. (2011) BMC Medical Genetics 2(1):17.

 

Konyukh M, Delorme R, Chaste P, Leblond C, Lemière N, Nygren G, Anckarsäter H, Rastam M, Ståhlberg O, Gillberg IC, Mouren-Simeoni MC, Gillberg C, Leboyer M and Bourgeron T. Mutations of the candidate gene SEZ6L2 on chromosome 16p11.2 in patients with autism spectrum disorders and in human populations. (2011) PLoS ONE 6, e17289

 

Ey E., Leblond C, Bourgeron T. Behavioral profiles of mouse models for autism spectrum disorders. Autism Research. (2011) 4(1):5-16.

 

Ben-Abdallah M, Bondet V, Fauchereau F, Béguin P, Goubran-Boutros H, Pagan C, Bourgeron T and Bellalou J. Production of soluble, active acetyl serotonin methyl transferase in Leishmania tarentolae. Protein Expression and Purification (2011) 75:114-118.

 

2010

 

Anney R, Klei L, Pinto D, Pagnamenta A, Merico D, Regan R, Conroy J, Magalhaes T, Correia C, Abrahams BS, Almeida J, Bacchelli E, Bader GD, Bailey AJ, Baird G, Battaglia A, Berney T, Bolshakova N, Bölte S, Bolton PF, Bourgeron T et al. A genomewide scan for common risk variants nominates phospholipase D and polysialyltransferase proteins for a role in autism. Hum. Mol. Genet. (2010) 19:4072-82.

 

Chaste P, Clement N, Mercati O, Guillaume JL, Delorme R, Botros HG, Pagan C, Périvier S, Scheid I, Nygren G, Anckarsäter H, Rastam M, Ståhlberg O, Gillberg IC, Serrano E, Lemière N, Launay JM, Mouren-Simeoni MC, Leboyer M, Gillberg C, Jockers R and Bourgeron T. Identification of pathway-biased and deleterious melatonin receptor mutants in autism spectrum disorders and in the general population PLoS One (2010) 5:e11495.

 

Toro R,  Konyukh M, Delorme R, Leblond C, Chaste P, Fauchereau F, Coleman M, Leboyer M, Gillberg C and Bourgeron T. Key role for gene dosage and synaptic homeostasis in autism spectrum disorders. Trends in Genetics (2010) 26:363-372.

 

Pinto D, Pagnamenta A, Klei L Merico D, Anney R , Merico D, Regan R, Conroy J, Magalhaes T, Correia C, Abrahams BS, Almeida J, Bacchelli E, Bader GD, Bailey AJ, Baird G, Battaglia A, Berney T, Bolshakova N, Bölte S, Bolton PF, Bourgeron T et al. Functional impact of global rare copy number variation in autism Nature (2010) 466 : 368-72.

 



Corringer Laboratory

 

2014

 

Sauguet L, Shahsavar A, Poitevin F, Huon C, Menny A, Nemecz A, Haouz A, Changeux JP, Corringer PJ, Delarue M. Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation. Proc Natl Acad Sci U S A. 2014 111(3):966-71.

 

 

2013

Sauguet L, Poitevin F, Murail S, Van Renterghem C, Moraga-Cid G, Malherbe L, Thompson AW, Koehl P, Corringer PJ, Baaden M, Delarue M. Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels. EMBO J. 2013 32(5):728-41.

 

Sauguet L, Howard R., Malherbe L. Lee U, Corringer P.J., R. Harris A., Delarue M. Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel. Nat. Communication 16;4:1697 (2013)


Labriola JM, Pandhare A, Jansen M, Blanton MP, Corringer PJ, Baenziger JE.


Structural sensitivity of a prokaryotic pentameric ligand-gated ion channel to its membrane environment. J Biol Chem. 2013 288(16):11294-303

 

Prevost MS, Delarue-Cochin S, Marteaux J, Colas C, Van Renterghem C, Blondel A, Malliavin T, Corringer PJ, Joseph D. Identification of Cinnamic Acid Derivatives As Novel Antagonists of the Prokaryotic Proton-Gated Ion Channel GLIC. J Med Chem. 2013 56(11):4619-30

       

Prevost MS, Moraga-Cid, G, Van Renterghem, C, Edelstein, J, Changeux JP, Corringer PJ. An intermediate closed state for glycine receptor function revealed by cysteine cross-linking. Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):17113-8

 

2012

Prevost, MS., Sauguet, L., Nury H., Van Renterghem, C., Huon, C., Poitevin, F., Baaden, M., Delarue, M.*, Corringer, P.J.* a novel locally-closed conformation of a bacterial pentameric proton-gated ion channel, Nat Struct Mol Biol. 2012 19:642-9 (Ranked 8 by Faculty of 1000)

 

Spurny R, Ramerstorfer J, Price K, Brams M, Ernst M, Nury H, Verheij M, Legrand P, Bertrand D, Bertrand S, Dougherty DA, de Esch IJ, Corringer PJ, Sieghart W, Lummis SC, Ulens C. Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines. Proc Natl Acad Sci U S A. 2012 109(44):E3028-34.

Corringer PJ, Poitevin F, Prevost MS, Sauguet L, Delarue M, Changeux JP. Structure and pharmacology of pentameric receptor channels: from bacteria to brain Structure. 2012 ;20(6):941-56.

 

2011

Nury, H, Van Renterghem, C, Weng, Y, Tran, A, Baaden, M, Dufresne, V, Changeux, J.P., Sonner, J.M., Delarue, M*, Corringer, P.J.* X-ray structures of general anesthetics bound to a pentameric ligand-gated ion channel Nature, 469:428-31 (2011) (Ranked 17 by Faculty of 1000)

 

Duret, C., Van Renterghem, C, Weng, Y, Prevost, M., Moraga, G., Huon, C., Sonner, J.M., Corringer P.J.* A functional prokaryotic-eukaryotic chimera from the pentameric ligand-gated ion channel family, Proc Natl Acad Sci U S A. 108:12143-8 (Ranked 10 by Faculty of 1000)

 

Howard RJ, Murail S, Ondricek KE, Corringer PJ, Lindahl E, Trudell JR, Harris RA. Structural basis for alcohol modulation of a pentameric ligand-gated ion channel.

Proc Natl Acad Sci U S A. 2011 108(29):12149-54.

 

Taly A, Colas C, Malliavin T, Blondel A, Nilges M, Corringer PJ, Joseph D. Discrimination of agonists versus antagonists of nicotinic ligands based on docking onto AChBP structures. J Mol Graph Model. 30 : 100-109 (2011)

 

Marti F, Arib O, Morel C, Dufresne V, Maskos U, Corringer PJ, de Beaurepaire R, Faure P. Smoke Extracts and Nicotine, but not Tobacco Extracts, Potentiate Firing and Burst Activity of Ventral Tegmental Area Dopaminergic Neurons in Mice. Neuropsychopharmacology. 2011 36(11):2244-57. (Ranked 8 by Faculty of 1000).

 

Baenziger J.E. and Corringer, P.J. 3D structure and allosteric modulation of the transmembrane domain of pentameric ligand-gated ion channels, Neuropharmacology, 60 : 116-125 (2011)

Nury H, Delarue M, Corringer PJ. X-ray structures of general anesthetics bound to their molecular targets Med Sci (Paris). 2011 27(12):1056-7.

 

Chasapis CT, Argyriou AI, Corringer PJ, Bentrop D, Spyroulias GA. Unravelling the Conformational Plasticity of the Extracellular Domain of a Prokaryotic nAChR Homologue in Solution by NMR. Biochemistry. 2011 50:9681-3

 

 

2010

Nury H, Bocquet N, Le Poupon C, Raynal B, Haouz A, Corringer PJ, Delarue M.* Crystal Structure of the Extracellular Domain of a Bacterial Ligand-Gated Ion Channel. J Mol Biol. 395, 1114–1127 (2010)

 

Weng Y, Yang L, Corringer PJ, Sonner JM.* Anesthetic Sensitivity of the Gloeobacter violaceus Proton-Gated Ion Channel. Anesth Analg. 110(1):59-63 (2010) (Ranked 6 by Faculty of 1000).

 

Corringer, P.J., Baaden, M., Bocquet, N., Delarue, M., Dufresne, V., Nury, H., Prevost, M., Van Renterghem, C., Atomic structure and dynamics of pentameric ligand-gated ion channels: new insight from bacterial homologues, J. Physiol, 588(Pt 4):565-72 (2010)

 

Nury, H, Poitevin, P, Van Renterghem, C, Changeux, J.P., Corringer P.J., Delarue, M.*, and Baaden M.* One-microsecond molecular dynamics simulation of channel gating in a nicotinic receptor homologue Proc Natl Acad Sci U S A. 107(14):6275-80 (2010) (Ranked 8 by Faculty of 1000)

 

2009

 

Bocquet, N., Nury, H., Baaden, M., Le Poupon, C., Changeux, J.P., Delarue, M.*, Corringer, P.J.* X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation, Nature, 457(7225) :111-4 (2009) (Ranked 14 by Faculty of 1000)

 

Taly A, Corringer PJ, Guedin D, Lestage P, Changeux JP., Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system. Nat Rev Drug Discov. 8:733-50 (2009)

 

 

 

Digregorio Laboratory

2014

Lourenco, J., Pacioni, S., Rebola, N., van Woerden, G.M., Marinelli, S., DiGregorio, D.A., and Bacci, A.. Non-associative Potentiation of Perisomatic Inhibition Alters the Temporal Coding of Neocortical Layer 5 Pyramidal Neurons. PLoS Biology 12, e1001903 (2014).

2012

Fink AE., Bender, KJ., Trussell, LO., Otis, TS. and DiGregorio, DA. Two-photon compatibility and single-voxel, single-trial detection of subthreshold neuronal activity by a two-component optical voltage sensor. PLoS One, 7(8):e41434 (2012).

 

Abrahamsson, T., Cathala, L., Matsui, K., Shigemoto, R., and DiGregorio, DA. Thin dendrites of cerebellar interneurons confer sublinear synaptic integration and a gradient of short-term plasticity. Neuron, 73: 1159-1172 (2012).

 

2011

DiGregorio DA. 2011. Confocal spot detection of presynaptic Ca2+ domains. In: Imaging in neuroscience: A laboratory manual (ed. Helmchen F, Konnerth A, Yuste R), pp. 141-150. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.

 

2009

Bradley, J., Luo, R., Otis, T.S. and DiGregorio, D.A., Submillisecond optical reporting of membrane potential in situ using a neuronal tracer dye. Journal of Neuroscience, 29(29):9197–9209 (2009).

 

 

LLEDO Laboratory

 

2014

 

Cuccioli V, Belvindrah R, Lledo P-M & Martinez S. (2014). Attractive function of FGF-signaling contributes to the postnatal developing hippocampus. Hippocampus (in press).

 

Lepousez G, Nissant A & Lledo P-M. (2014). The future of the rejuvenating brain. Neuron (in press).

 

Sailor KA & Lledo P-M. (2014). Top-down modulation of interneuron survival in the olfactory bulb (Commentary on Komano-Inoue et al. Eur J Neurosci. 40, 2014). Eur. J. Neurosci. 40, 2723.

 

Lazarini F, Gabellec M-M, Moigneu C, de Chaumont F, Olivo-Marin JC & Lledo P-M. (2014). Adult neurogenesis restores dopaminergic neuronal loss in the olfactory bulb. J. Neurosci., 34, 14430-14442.

 

Lepousez G, Nissant A, Bryant AK, Gheusi G, Greer C & Lledo P-M. (2014). Olfactory learning promotes input-specific synaptic plasticity in adult-born neurons. Proc. Natl. Acad. Sci. (in press).

 

Lepousez G, Nissant A & Lledo P-M. (2014). The future of the rejuvenating adult brain. Neuron (in press).

 

Gheusi G & Lledo P-M (2014). Adult neurogenesis in the olfactory system shapes odor memory and perception. Prog. Brain Res. 208, 157-175.

 

Soria-Gómez E, et coll. (2014). The endocannabinoid system controls food intake via olfactory processes. Nat. Neurosci. 17, 407-415 (selected for Faculty of 1000 Biology).

 

2013

 

Khodosevich K, Lazarini F, Kaneko H, Lledo P-M & Monyer H (2013). Connective tissue growth factor regulates interneuron survival and information processing in the olfactory bulb. Neuron 79, 1136-1151.

 

Valley MT, Henderson LG, Inverso SA & Lledo P-M. (2013). Adult neurogenesis produces neurons with unique GABAergic synapses in the olfactory bulb. J. Neurosci. 33, 14660-14665.

 

Lepousez G & Lledo P-M. (2013). Dissecting the microcircuit that drives gamma oscillations and long-range synchronisation in the awake mouse olfactory bulb. Neuron 80, 1010-1024.

 

Lepousez G, Valley M & Lledo P-M. (2013). Adult neurogenesis in olfactory processing. Annual Review of Physiology 75, 339-363.

 

Gheusi G, Lepousez G & Lledo P-M. (2013). Adult-Born Neurons in the Olfactory Bulb: Integration and Functional Consequences. Curr Top Behav Neurosci. 15, 49-72.

 

Brus M, Meurisse M, Gheusi G, Keller M, Lledo P-M & Levy F. (2013). Dynamics of olfactory and hippocampal neurogenesis in adult sheep. J Comp. Neurol. 521, 169-1688.

 

2012

 

Gallarda BW & Lledo P-M. (2012). Adult neurogenesis in the olfactory system and neurodegenerative disease. Current Molecular Medicine Review, 12, 1253-1260.

 

Pallotto M, Nissant A, Fritschy J-M, Rudolph U, Sassoè-Pognetto M, Panzanelli P & Lledo P-M. (2012). Early formation of GABAergic synapses governs the development of adult-born neurons in the olfactory bulb. J. Neurosci. 32, 9103-9115.

 

Díaz D, Lepousez G, Gheusi G, Alonso JR, Lledo P-M* & Weruaga E*. (2012). Bone marrow cell transplantation restores olfaction in the degenerated olfactory bulb. J. Neurosci. 32, 9053-9058 (*Co-auteurs Seniors).

 

Jaillard C, Mouret A, Niepon ML, Lee-Rivera I, Clérin E, Aït-Ali N, Millet-Puel G, Sedmak T, Yang Y, Raffelsberger W, Kinzel B, Trembleau A, Poch O, Bennett J, Wolfrum U, Lledo P-M, Sahel JA & Léveillard T. (2012). Nxnl2 splicing results in dual functions in neuronal cell survival and maintenance of cell integrity. Human Molecular Genetics, 21, 2298-2311.

 

Alonso M, Wagner S, Lepousez G, Gabellec MM, Torquet N & Lledo P-M. (2012). Activation of adult-born neurons facilitates learning and memory. Nat. Neurosci. 15, 897-904 (selected for Faculty of 1000 Biology).

 

Lazarini F, Gabellec MM, Torquet N & Lledo P-M. (2012). Early activation of microglia triggers long-lasting impairment of adult neurogenesis in the olfactory bulb. J. Neurosci. 32, 3652-64.

 

Mejia-Gervacio S, Murray K, Sapir T, Belnindrah R, Reiner O & Lledo P-M. (2012). Mark2/Par-1 guides the directionality of neuroblasts migrating to the olfactory bulb. Molecular and Cellular Neuroscience 49, 97-103.

 

2011

 

Lepousez G, Alonso M, Wagner S, Gallarda BW & Lledo P-M (2011). Selective viral transduction of adult-born olfactory neurons for chronic in vivo optogenetic stimulation. J Vis Exp. Dec 28 ; (58). pii: 3380.

 

Tepavcevic V, Lazarini F, Alfaro-Cervello C, Kerninon C, Yoshikawa K, Garcia Verdugo J-M, Lledo P-M, Nait-Oumesmar B & Baron-Van Evercooren A. (2011). Inflammation-induced subventricular zone dysfunction leads to olfactory deficits in a targeted mouse model of multiple sclerosis. Journal of Clinical Investigation, 121, 4722-4734.

 

Valley M, Wagner S, Gallarda BW & Lledo P-M. (2011). Using Affordable LED Arrays for Photo-Stimulation of Neurons. J Vis Exp. 57, pii: 3379.

 

Lepousez G et Lledo P-M. (2011). Life and death decision in adult neurogenesis: In praise of napping. Neuron 71, 768-771.

 

Belvindrah R, Nissant A et Lledo P-M. (2011). Abnormal neuronal migration changes the fate of developing neurons of the postnatal forebrain. J. Neurosci. 31, 7551-7562.

 

Scotto-Lomassese S, Nissant A, Mota T, Neant-Fery M, Oostra BA, Greer CA, Lledo P-M, Trembleau A & Caille I. (2011). Fragile X mental retardation protein regulates new neuron differentiation  in the adult olfactory bulb. J. Neurosci. 31, 2205-2215.

 

Mejia-Gervacio S, Murray K & Lledo P-M. (2011). NKCC1 controls GABAergic signaling and neuroblast migration in the postnatal forebrain. Neural Development 6, 4.

 

Lazarini F & Lledo P-M. (2011). Is adult neurogenesis essential for olfaction? Trends in Neurosciences 34, 20-30.

 

Katagiri H, Pallotto M, Nissant A, Murray K, Sassoè-Pognetto M & Lledo P-M. (2011). Dynamic development of the first synapse impinging on adult-born neurons in the olfactory bulb circuit. Neural Systems & Circuits 1, 6.

 

2010

 

Feierstein C#, Lazarini F, Wagner S, Gabellec MM, de Chaumont F, Olivo-Marin JC, Boussin FD, Lledo PM# & Gheusi G. (2010). Disruption of adult neurogenesis in the olfactory bulb affects social interaction but not maternal behavior. Frontiers in Behavioral Neuroscience, 4, Article 176. # Corresponding authors.

 

Bardy C, Alonso M, Bouthour W & Lledo P-M. (2010). How, when and where new inhibitory neurons release neurotransmitters in the adult olfactory bulb. J. Neurosci. 30, 17023-17034.

 

Belvindrah R, Lazarini F & Lledo P-M. (2010). Postnatal neurogenesis: From neuroblast migration to integration into mature circuits. Reviews in the Neurosciences, 20, 331-346.

 

Alén F, Mouret A, Viveros MP, Llorente R, Lepousez G, Lledo P-M & López-Moreno JA. (2010). Converging action of alcohol consumption and cannabinoid receptor activation on adult hippocampal neurogenesis. Int. J. Neuropsychopharmacol. 13, 191-205.

 

2009

 

Panzanelli P, Bardy C, Nissant A, Pallotto M, Sassoè-Pognetto M, Lledo P-M & Fritschy J-M. (2009). Early synapse formation in developing interneurons of the adult olfactory bulb. J. Neurosci. 29, 15039-15052.

 

Sassoè-Pognetto M, Panzanelli P, Lagier S, Fritschy JM & Lledo P-M. (2009). GABA receptor heterogeneity modulates dendrodendritic inhibition. Ann N Y Acad Sci. 1170, 259-263.

 

Mouret A, Gras J, Lepousez G, Gabellec MM & Lledo P-M. (2009). Constitutive death of new olfactory bulb interneurons optimizes olfaction. J. Neurosci. 29, 12302-12314.

 

Lazarini F, Mouthon MA, Gheusi G, de Chaumont F, Olivo-Marin JC, Lamarque S, Nora Abrous D, Boussin FD & Lledo P-M. (2009). Cellular and behavioral effects of cranial irradiation of the adult subventricular zone. PlosOne 4, e7017.

 

Mouret A, Murray K & Lledo P-M. (2009). Centrifugal drive onto local inhibitory interneurons of the olfactory bulb. Ann N Y Acad Sci. 1170, 239-254.

 

Lledo P-M. (2009). Dissecting the pathophysiology of depression with a Swiss army knife. Neuron 62, 453-455.

 

Gheusi G, Ortega-Perez I, Murray K & Lledo P-M. (2009). A niche for neurogenesis in social behavior. Behavioural Brain Research 200, 315-322.

 

Nissant A, Bardy C, Katagiri H, Murray K & Lledo P-M. (2009). Neurogenesis promotes synaptic plasticity in the adult olfactory bulb. Nat. Neurosci. 12, 728-730 (selected for Faculty of 1000 Biology).

 

 

MASKOS Laboratory

 

2014

 

Sanjakdar SS, Maldoon PP, Marks MJ, Brunzell DH, Maskos U, McIntosh JM, Bowers MS, Damaj MI. Differential Roles of α6β2* and α4β2* Neuronal Nicotinic Receptors in Nicotine- and Cocaine-Conditioned Reward in Mice. Neuropsychopharmacology. 2014 Jul 18. doi: 10.1038/npp.2014.177. [Epub ahead of print]

 

Moretti M, Zoli M, George AA, Lukas RJ, Pistillo F, Maskos U, Whiteaker P, Gotti C. The novel α7β2-nicotinic acetylcholine receptor subtype is expressed in mouse and human basal forebrain: biochemical and pharmacological characterization. Mol Pharmacol. 2014 Sep;86(3):306-17. doi: 10.1124/mol.114.093377. Epub 2014 Jul 7.

 

Muldoon PP, Jackson KJ, Perez E, Harenza JL, Molas S, Rais B, Anwar H, Zaveri NT, Maldonado R,Maskos U, McIntosh JM, Dierssen M, Miles MF, Chen X, De Biasi M, Damaj MI. The α3β4* nicotinic ACh receptor subtype mediates physical dependence to morphine: mouse and human studies. Br J Pharmacol. 2014 Aug;171(16):3845-57. doi: 10.1111/bph.12741.

 

Somm E, Guérardel A, Maouche K, Toulotte A, Veyrat-Durebex C, Rohner-Jeanrenaud F, Maskos U, Hüppi PS, Schwitzgebel VM. Concomitant alpha7 and beta2 nicotinic AChR subunit deficiency leads to impaired energy homeostasis and increased physical activity in mice. Mol Genet Metab. 2014 May;112(1):64-72. doi: 10.1016/j.ymgme.2014.03.003. Epub 2014 Mar 19.

 

Morel C, Fattore L, Pons S, Hay YA, Marti F, Lambolez B, De Biasi M, Lathrop M, Fratta W, *Maskos U, *Faure P. Nicotine consumption is regulated by a human polymorphism in dopamine neurons. Mol Psychiatry. 2014 Aug;19(8):930-6. doi: 10.1038/mp.2013.158. Epub 2013 Dec 3.

 

H Himburg, JR Harris, P. Daher, J L Russell, M Quarmyne, P L Doan, K Helms, G Herradon, N J. Chao, S Harroch, JP Chute. Pleiotrophin is produced by the vascular niche and regulates hematopoietic stem cell self renewal and regeneration in vivo. Cell report in press.

 

2013

 

Collo G, Bono F, Cavalleri L, Plebani L, Mitola S, Merlo Pich E, Millan MJ, Zoli M, Maskos U, Spano P, Missale C. Nicotine-induced structural plasticity in mesencephalic dopaminergic neurons is mediated by dopamine D3 receptors and Akt-mTORC1 signaling. Mol Pharmacol. 2013 Jun;83(6):1176-89. doi: 10.1124/mol.113.084863. Epub 2013 Mar 29.

 

Maouche K, Medjber K, Zahm JM, Delavoie F, Terryn C, Coraux C, Pons S, Cloëz-Tayarani I, Maskos U, Birembaut P, Tournier JM. Contribution of α7 nicotinic receptor to airway epithelium dysfunction under nicotine exposure. Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4099-104. doi: 10.1073/pnas.1216939110. Epub 2013 Feb 19.

 

Marti F, Maskos U, Faure P. Disinhibition goes up in smoke. Mol Psychiatry. 2013 Mar;18(3):267. doi: 10.1038/mp.2013.14.

 

Valley MT, Henderson LG, Inverso SA, Lledo PM. Adult neurogenesis produces neurons with unique GABAergic synapses in the olfactory bulb. J Neurosci. 2013 Sep 11;33(37):14660-5. doi: 10.1523/JNEUROSCI.2845-13.2013.

 

Tolu S, Eddine R, Marti F, David V, Graupner M, Pons S, Baudonnat M, Husson M, Besson M, Reperant C, Zemdegs J, Pagès C, Hay YA, Lambolez B, Caboche J, Gutkin B, Gardier AM, Changeux JP, Faure P, Maskos U. Co-activation of VTA DA and GABA neurons mediates nicotine reinforcement. Mol Psychiatry. 2013 Mar;18(3):382-93. doi: 10.1038/mp.2012.83. Epub 2012 Jul 3.

 

2012

 

Cohen S, Shoshana OY, Zelman-Toister E, Maharshak N, Binsky-Ehrenreich I, Gordin M, Hazan-Halevy I, Herishanu Y, Shvidel L, Haran M, Leng L, Bucala R, Harroch S, Shachar I. The cytokine midkine and its receptor RPTPζ regulate B cell survival in a pathway induced by CD74. J Immunol. 188, 259-69.

 

Receptor-type tyrosine phosphatase ligands: looking for the needle in the haystack. Mohebiany AN, Nikolaienko RM, Bouyain S, Harroch S. FEBS J.

 

JP Bourgeois, V Meas-Yeadid, AM Lesourd, P Faure, S Pons, U Maskos, JP Changeux, JC Olivo-Marin & S Granon (2012) Prefrontal nicotinic receptors mediate flexible choices during novelty exploration. Cerebral Cortex 22, 1007-1015.

 

M Besson, V David, P Cazala, J-P Guilloux, C Reperant, I Cloez-Tayarani, J-P Changeux, AM Gardier & S Granon (2012) Alpha7-nicotinic receptors modulate nicotine-induced reinforcement and extracellular dopamine outflow in the mesolimbic system in mice. Psychopharmacology 220, 1-14.

J Chabout*, P Serreau*, E Ey, L Bellier, T Aubin, T Bourgeron & S Granon (2012) Adult male mice emit context-specific ultrasonic vocalizations that are modulated by prior isolation or group rearing environment. PLoS ONE 7:e29401

R Exley, JM McIntosh, M J Marks, U Maskos & SJ Cragg (2012) Striatal α5 nicotinic receptor subunit regulates dopamine release probability in dorsal striatum. J Neurosci 32, 2352-2356.
 

F de Chaumont, R Dos-Santos Coura, P Serreau, A Cressant, J Chabout, S Granon & J-C Olivo-Marin (2012) Computerized video analysis of social interactions in mice. Nature Methods 9, 410-417.

 

MJ Orejarena, A Herrera-Solís, S Pons, U Maskos, R Maldonado &P Robledo (2012) Selective Re-expression of β2 Nicotinic Acetylcholine Receptor Subunit in the Ventral Tegmental Area Restores intravenous Nicotine Self-Administration. Neuropharmacology EPub 28 March

 

S Tolu, R Eddine, F Marti, V David, M Graupner, S Pons, M Baudonnat, M Husson, M Besson, C Reperant, J Zemdegs, C Pagès, YAH Hay, B Lambolez, J Caboche, B Gutkin, AM Gardier, J-P Changeux, P Faure & U Maskos (2012) Co-activation of VTA DA and GABA neurons mediates nicotine reinforcement. Mol Psychiatry EPub 3 July 


 

2011

 

Lamprianou S, Chatzopoulou E, Thomas JL, Bouyain S, Harroch S. A complex between contactin-1 and the protein tyrosine phosphatase PTPRZ controls the development of oligodendrocyte precursor cells. Proc Natl Acad Sci U S A. 108(42): 17498-503.

 

R Exley*, N Maubourguet*, V David*, R Eddine, A Evrard, S Pons, F Marti, S Threlfell, P Cazala, JM McIntosh, J-P Changeux, U Maskos, SJ Cragg & P Faure (2011) Distinct contributions of nicotinic acetylcholine receptor subunit α4 and subunit α6 to the reinforcing effects of nicotine. Proc Natl Acad Sci U S A 108, 7577-7582.


ME Avale, J Chabout, S Pons, P Serreau, F de Chaumont, JC Olivo-Marin, JP Bourgeois, U Maskos, JP Changeux& S Granon(2011) Prefrontal nicotinic receptors control novel social interaction between mice. FASEB J. 25, 2145-2155.

 

D Toulorge, S Guerreiro, A Hild, U Maskos, EC Hirsch&PP Michel(2011) Neuroprotection of midbrain dopamine neurons by nicotine is gated by cytoplasmic Ca2+. FASEB J. 25, 2563-2573.

 

P Serreau, J Chabout, SV Suarez, J Naudé & S Granon (2011) Beta2-containing neuronal nicotinic receptors as major actors in the flexible choice between conflicting motivations. Behav Brain Res 225, 151-159.

 

S Frahm, MA Slimak, L Ferrarese, J Santos-Torres, B Antolin-Fontes, S Auer, S Filkin, S Pons, J-F Fontaine, V Tsetlin, U Maskos & I Ibanez-Tallon (2011) Aversion to nicotine is regulated by the balanced activity of b4 and α5 nicotinic receptor subunits in the medial habenula. Neuron 70, 522-535.

 

F Marti, O Arib, V Dufresne, U Maskos, P-J Corringer, R de Beaurepaire & P Faure (2011)Smoke extracts and nicotine, but not tobacco extracts, potentiate firing and burst activity of Ventral Tegmental Area dopaminergic neurons in mice. Neuropsycho-pharmacology 36, 2244-2257.

 

K Guillem, RB Poorthuis, B Bloem, M Loos, AB Smit, U Maskos, S Spijker & H Mansvelder (2011) Nicotinic acetylcholine receptor b2 subunits in the medial prefrontal cortex control attention. Science 333, 888-891.

 

2010
 

S Tolu, ME Avale, H Nakatani, S Pons, F Tronche, H Monyer, J-P Changeux & U Maskos (2010) A versatile system for the neuronal subtype specific expression of lentiviral vectors. FASEB J. 24, 723-730.
 

U Maskos (2010) Role of endogenous acetylcholine in the regulation of nicotinic receptors in the dopaminergic system. J. Neurochem. 114, 641-646.

M Melis, S Carta, L Fattore, S Tolu, S Yasar, SR Goldberg, W Fratta, U Maskos & M Pistis (2010) PPARα modulates dopamine neuron activity specifically through nicotinic receptors. Biol. Psychiatry 68, 256-264.
O Arib, P Rat, R Molimard, A Chait, P Faure & R de Beaurepaire (2010) Electrophysiological characterization of harmane-induced activation of mesolimbic dopamine neurons. Eur. J. Pharmacol. 629, 47-52.

C Reperant, S Pons, E Dufour, H Rollema, AM Gardier & U Maskos (2010) Effect of the α4β2* nicotinic acetylcholine receptor (nAChR) partial agonist varenicline on dopamine release: a study in β2-/- mice with selective re-expression of the β2 nAChR subunit in the ventral tegmental area. Neuropharmacology 58, 346-350.

M Besson, S Suarez, J-P Changeux & S Granon (2010) A low dose of nicotine is sufficient to produce nicotine withdrawal in mice. Health 2, 1-7.

W Saba, H Valette, S Granon, Y Xiao, KJ Kellar, F Dollé & M Bottlaender (2010) [18F]ZW-104, a new radioligand for imaging a2- a3- a4 / b2 central nicotinic acetylcholine receptors: evaluation in mutant mice. Synapse 64, 570-572.

L Azam, U Maskos, J-P Changeux, C Dowell, S Christensen, M De Biasi & JM McIntosh (2010) a-Conotoxin BuIA[T5A;P6O] discriminates between α6β4* and α6β2* nAChRs and blocks nicotine-stimulated norepinephrine release in mouse hippocampus. FASEB J.


K Cambon, R Dos-Santos Coura, L Groc, A Carbon, D Weissmann, J-P Changeux, JF Pujol & S Granon (2010) Aggressive behavior during social interaction in mice is controlled by the modulation of tyrosine hydroxylase expression in the prefrontal cortex. Neuroscience Oct 19.

AS Villégier, L Salomon, S Granon, N Champtiaux, J-P Changeux & J-P Tassin (2010) α7 and β2* nicotinic receptors control monoamine-mediated locomotor response. Neuroreport 21, 1085-1089.

S Suarez, A Amadon, E Giacomini, A Wiklund, J-P Changeux, D Le Bihan & S Granon (2008) Brain activation by short-term nicotine exposure in anesthetized wild-type and beta2-nicotinic receptors knockout mice: a BOLD fMRI study. Psychopharmacology 202, 599-610.

 

2009

A Wiklund, S Granon, P Faure, E Sundman, JP Changeux & LI Eriksson (2009) Object memory in young and aged mice after sevoflurane anaesthesia. Neuroreport 20, 1419-1423.

K Maouche, M Polette, T Jolly, K Medjber, I Cloëz-Tayarani, J-P Changeux, H Burlet, C Terryn, C Coraux, J-M Zahm, P Birembaut & J-M Tournier (2009) α7 Nicotinic Acetylcholine Receptor Regulates Airway Epithelium Differentiation by Controlling Basal Cell Proliferation. Am. J. Pathology 175, 1868-1882.
 

 

 

PETIT Laboratory

 

2014

 

Behlouli A, Bonnet C, Abdi S, Bouaita A, Lelli A, Hardelin JP, Schietroma C, Rous Y, Louha M, Cheknane A, Lebdi H, Boudjelida K, Makrelouf M, Zenati A, Petit C (2014) EPS8, encoding an actin-binding protein of cochlear hair cell stereocilia, is a new causal gene for autosomal recessive profound deafness. Orphanet J Rare Dis 9, 55.

 

El-Amraoui A, Petit C (2014) The retinal phenotype of Usher syndrome: pathophysiological insights from animal models. C R Biologies 337, 167-77.

 

Kamiya K, Michel V, Giraudet F, Riederer B, Foucher I, Papal S, Perfettini I, Le Gal S, Verpy E, Xia W, Seidler U, Georgescu M-M, Avan P, El-Amraoui A, Petit C (2014) An unusually powerful mode of low-frequeny sound interference due to defective hair bundles of the auditory outer hair cells. Proc Natl Acad Sci USA 111, 9307-12.

 

Michalski N, Petit C (2014) Genetics of auditory mechano-electrical transduction. Pflügers Arch Jun 25 [Epub ahead of print] PMID: 24957570.

 

Pepermans E, Michel V, Goodyear R, Bonnet C, Abdi S, Dupont T, Gherbi S, Holder M, Makrelouf M, Hardelin J-P, Marlin S, Zenati A, Richardson G, Avan P, Bahloul A, Petit C (2014) The CD2 isoform of protocadherin-15 is an essential component of the tip-link complex in mature auditory hair cells. EMBO Mol Med 6, 984-92.

 

Riahi Z, Bonnet C, Zainine R, Louha M, Bouyacoub Y, Laroussi N, Chargui M, Kefi R, Jonard L, Dorboz I, Hardelin JP, Salah SB, Levilliers J, Weil D, McElreavey K, Boespflug OT, Besbes G, Abdelhak S, Petit C (2014) Whole exome sequencing identifies new causative mutations in Tunisian families with nonsyndromic deafness. PLoS One 9(6):e99797. doi: 10.1371.

 

Romdhane L, Ben Halim N, Rejeb I, Kefi R, Bouyacoub Y, Ben Rekaya M, Messai H, Messaoud O, Riahi Z, Bonnet C, Ben Rhouma F, Nagara M, Petit C, McElreavey K, Romeo G, Abdelhak S (2014) Specific aspects of consanguinity: some examples from the Tunisian population. Hum Hered 77, 167-74.

 

Vincent PF, Bouleau Y, Safieddine S, Petit C, Dulon D (2014) Exocytotic machineries of vestibular type i and cochlear ribbon synapses display similar intrinsic otoferlin-dependent Ca2+ sensitivity but a different coupling to Ca2+ channels. J Neurosci 34, 10853-69.

 

Wang H, Zhao Y, Yi Y, Gao Y, Liu Q, Wang D, Li Q, Lan L, Li N, Guan J, Yin Z, Han B, Zhao F, Zong L, Xiong W, Yu L, Song L, Yi X, Yang L, Petit C, Wang Q (2014) Targeted high-throughput sequencing identifies pathogenic mutations in KCNQ4 in two large Chinese families with autosomal dominant hearing loss. PLoS One 9, e103133.

 

2013

 

Avan P, Büki B, Petit C (2013) Auditory distortions: origins and functions. Physiol Rev 93, 1563–1619.

 

Bonnet C, Louha M, Loundon N, Michalski N, Verpy E, Smagghe L, Hardelin J-P, Rouillon I, Jonard L, Couderc R, Gherbi S, Garabedian EN, Denoyelle F, Petit C, Marlin S (2013) Biallelic nonsense mutations in the otogelin-like gene (OTOGL) in a child affected by mild to moderate hearing impairment. Gene 527, 537-40.

 

Boulay A-C, del Castillo FJ, Giraudet F, Hamard G, Giaume C, Petit C, Avan P, Cohen-Salmon M (2013) Hearing is normal without connexin30. J Neurosci 33, 430-34.

 

El-Amraoui A, Petit C (2013) Cadherin defects in inherited human diseases. Progr Mol Biol Transl Sci, Conn PM (ed.), Elsevier 116, 361-84.

 

Greenspan R, Petit C (2013) Neurogenetics. Curr Opin Neurobiol. 23, 1-2.

 

Lepelletier L, Boutet de Monvel J, Buisson J, Desdouets C, Petit C (2013) Auditory hair cell centrioles undergo confined brownian motion throughout the developmental migration of the kinocilium. Biophys J 105, 48-58.

 

Meyer A, Petit C, Safieddine S (2013) [Gene therapy for human hearing loss: challenges and promises]. Med Sci (Paris) 29, 883-9.

 

Papal S, Cortese M, Legendre K, Sorusch N, Dragavon J, Sahly I, Shorte S, Wolfrum U, Petit C, El-Amraoui A (2013) The giant spectrin βV couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route. Hum Mol Genet 22, 3773-88.

 

Zhao Y, Zhao F, Zong L, Zhang P, Guan L, Zhang J, Wang D, Wang J, Chai W, Lan L, Li Q, Han B, Yang L, Jin X, Yang W, Hu X, Wang X, Li N, Li Y, Petit C, Wang J, Wang HY, Wang Q (2013) Exome sequencing and linkage analysis identified tenascin-C (TNC) as a novel causative gene in nonsyndromic hearing loss. PLoS One 8, e69549.

 

2012

 

Bonnet C, El-Amraoui A (2012) Usher syndrome (sensorineural deafness and retinitis pigmentosa): pathogenesis, molecular diagnosis and therapeutic approaches. Curr Opin Neurol 25, 42-49.

 

Delmaghani S, Aghaïe A, Michalski N, Bonnet C, Weil D, Petit C (2012) Defect in the gene encoding the EAR/EPTP domain-containing protein TSPEAR causes DFNB98 profound deafness. Hum Mol Genet 21, 3835-44.

 

Fakin A, Glavac D, Bonnet C, Petit C, Hawlina M (2012) Fundus autofluorescence and optical coherence tomography in relation to visual function in Usher syndrome type 1 and 2. Vision Res 75, 60-70.

 

Lukashkin AN, Legan PK, Weddell TD, Lukashkina VA, Goodyear RJ, Welstead LJ, Petit C, Russell IJ, Richardson GP (2012) A mouse model for human deafness DFNB22 reveals that hearing impairment is due to a loss of inner hair cell stimulation. Proc Natl Acad Sci USA. 109, 19351-6.

 

Petit C, El-Amraoui A, Avan P (2012) Audition: Hearing and Deafness. In Neuroscience in the 21st Century: From Basic to Clinical. Pfaff DW (ed.), Heidelberg: Springer Verlag, pp. 675-741.

 

Safieddine S, El-Amraoui A, Petit C (2012) The auditory hair cell ribbon synapse: From assembly to function. Annu Rev Neurosci 35, 509-28.

 

Sahly I, Dufour E, Schietroma C, Michel V, Bahloul A, Perfettini I, Pepermans E, Estivalet A, Carette D, Aghaie A, Ebermann I, Lelli A, Iribarne M, Hardelin J-P, Weil D, Sahel J-A, El-Amraoui A, Petit C (2012) Localization of Usher 1 proteins to the photoreceptor calyceal processes, which are absent from mice. J Cell Biol 199, 381-99.

 

2011

 

Bonnet C, Grati Mh, Marlin S, Levilliers J, Hardelin J-P, Parodi M, Niasme-Grare M, Zelenika D, Délépine M, Feldmann D, Jonard L, El-Amraoui A, Weil D, Delobel B, Vincent C, Dollfus H, Eliot M-M, David A, Calais C, Vigneron J, Montaut B, Bonneau D, Dubin J, Thauvin C, Duvillard A, Francannet C, Mom T, Lacombe D, Duriez F, Drouin-Garraud V, Thuillier-Obstoy M-F, Sigaudy S, Frances A-M, Collignon P, Challe G, Couderc R, Lathrop M, Sahel J-A, Weissenbach J, Petit C, Denoyelle F (2011) Complete exon sequencing of all known Usher syndrome genes greatly improves molecular diagnosis. Orphanet J Rare Dis 6, 21-39.

 

Caberlotto E, Michel V, Foucher I, Bahloul A, Goodyear RJ, Pepermans E, Michalski N, Perfettini I, Alegria-Prevot O, Chardenoux S, Do Cruzeiro M, Hardelin J-P, Richardson GP, Avan P, Weil D, Petit C (2011) Usher type 1G protein sans is a critical component of the tip-link complex, a structure controlling actin polymerization in stereocilia. Proc Natl Acad Sci USA 108, 5825-30

 

Caberlotto E, Michel V, Boutet de Monvel J, Petit C (2011) Coupling of the mechanotransduction machinery and F-actin polymerization in the cochlear hair bundles. BioArchitecture 1, 169-74.

 

Reisinger E, Bresee C, Neef J, Nair R, Reuter K, Bulankina A, Nouvian R, Koch M, Buckers J, Kastrup L, Roux I, Petit C, Hell SW, Brose N, Rhee JS, Kugler S, Brigande JV, Moser T (2011) Probing the functional equivalence of otoferlin and synaptotagmin 1 in exocytosis. J Neurosci 31, 4886-95.

 

Richardson GP, Boutet de Monvel J, Petit C (2011) How the genetics of deafness illuminates auditory physiology. Annu Rev Physiol 73, 311–34.

 

Verpy E, Leibovici M, Michalski N, Goodyear R, Houdon C, Weil D, Richardson G, Petit C (2011) Stereocilin connects outer-hair-cell stereocilia to one another and to the tectorial membrane. J Comp Neurol 519, 194-210.

 

2010

 

Ashmore J, Avan P, Brownell WE, Dallos P, Dierkes K, Fettiplace R, Grosh K, Hackney CM, Hudspeth AJ, Julicher F, Lindner B, Martin P, Meaud J, Petit C, Sacchi JR, Canlon B (2010) The remarkable cochlear amplifier. Hear Res 266, 1-17.

 

Avan P, Petit C (2010) Top connectors of the hair bundle are required for waveform distortion and suppression masking but not cochlear amplification. Hear Res 266, 3-4.

 

Bahloul A, Michel V, Hardelin J-P, Nouaille S, Hoos S, Houdusse A, England P, Petit C (2010) Cadherin-23, myosin VIIa and harmonin, encoded by Usher syndrome type I genes, form a ternary complex and interact with membrane phospholipids. Hum Mol Genet 19, 3557–3565.

 

Beurg M, Michalski N, Safieddine S, Bouleau Y, Schneggenburger R, Chapman ER, Petit C, Dulon D (2010) Control of exocytosis by synaptotagmins and otoferlin in auditory hair cells. J Neurosci 30, 13281–13290.

Boutet de Monvel J, Petit C (2010) Wrapping up stereocilia rootlets. Cell 141, 748-50.

 

del Castillo FJ, Cohen-Salmon M, Charollais A, Caille D, Lampe P, Chavrier P, Meda P, Petit C (2010) Consortin, a trans-Golgi network cargo receptor for the plasma membrane targeting and recycling of connexins. Hum Mol Genet 19, 262-75.

 

El-Amraoui A, Petit C (2010) Cadherins as targets for genetic diseases. Cold Spring Harb Perspect Biol 2, a003095 / 387-406.

 

El-Amraoui A, Petit C (2010) Thérapie cellulaire dans l’oreille interne - Nouveaux développements et perspectives. Med Sci (Paris), 26, 981-85.

 

Etournay R, Lepelletier L, Boutet de Monvel J, Michel V, Cayet N, Leibovici M, Weil D, Foucher I, Hardelin J-P, Petit C (2010) Cochlear outer hair cells undergo an apical circumference remodeling constrained by the hair bundle shape. Development 137, 1373-83.

 

Marlin S, Feldmann D, Nguyen Y, Rouillon I, Loundon N, Jonard L, Bonnet C, Couderc R, Garabedian EN, Petit C, Denoyelle F (2010) Temperature-sensitive auditory neuropathy associated with an otoferlin mutation: Deafening fever! Biochem Biophys Res Commun 394, 737-742.

 

Wang DY, Wang YC, Weil D, Zhao YL, Rao SQ, Zong L, Ji YB, Liu Q, Li JQ, Yang HM, Shen Y, Benedict-Alderfer C, Zheng QY, Petit C, Wang QJ (2010) Screening mutations of OTOF gene in Chinese patients with auditory neuropathy, including a familial case of temperature-sensitive auditory neuropathy. BMC Med Genet 11, 79-85.

 

2009

 

Bahloul A, Simmler M-C, Michel V, Leibovici M, Perfettini I, Roux I, Weil D, Nouaille S, Zuo J, Zadro C, Licastro D, Gasparini P, Avan P, Hardelin J-P, Petit C. (2009) Vezatin, an integral membrane protein of adherens junctions, is required for the sound-resilience of cochlear hair cells. EMBO Mol Med 1, 125-138.

 

Belguith H, Masmoudi S, Medlej-Hashim M, Chouery E, Weil D, Ayadi H, Petit C, Megarbane A. (2009) Re-assigning the DFNB33 locus to chromosome 10p11.23-q21.1. Eur J Hum Genet 17, 122-4.

 

Dulon D, Safieddine S, Jones SM, Petit C (2009) Otoferlin is critical for a highly sensitive and linear calcium dependent exocytosis at vestibular hair cell ribbon synapses. J Neurosci 29, 10474-87.

 

Lagresle-Peyrou C, Six EM, Picard C, Rieux-Laucat F, Michel V, Ditadi A, Demerens-de Chappedelaine C, Morillon E, Valensi F, Simon-Stoos KL, Mullikin JC, Noroski LM, Besse C, Wulffraat NM, Ferster A, Abecasis MM, Calvo F, Petit C, Candotti F, Abel L, Fischer A, Cavazzana-Calvo M. (2009) Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness. Nat Genet 41, 106-11.

 

Legendre K, Petit C, El-Amraoui A (2009) La cellule ciliée externe de la cochlée des mammifères: un amplificateur aux propriétés exceptionnelles - (The outer hair cell of the mammalian cochlea: an outstanding amplifier). Med Sci (Paris) 25, 117-20.

 

Michalski N, Michel V, Caberlotto E, Lefèvre GM, van Aken AFJ, Tinevez J-Y, Bizard E, Houbron C, Weil D, Hardelin J-P, Richardson GP, Kros C, Martin P, Petit C (2009) Harmonin-b, an actin-binding scaffold protein, is involved in the adaptation of mechanoelectrical transduction by sensory hair cells. Pflügers Arch-Eur J Physiol 459, 115-130.

 

Petit C (2009) Entendre: bases physiologiques de l’audition In Aux origines du dialogue humain : Parole et musique Dehaene S,  Petit C (eds.). Paris: Odile Jacob.

 

Petit C, Richardson GP (2009) Linking genes underlying deafness to hair-bundle development and function. Nat Neurosci 12, 703-10.

 

Roux I, Hosie S, Johnson SL, Bahloul A, Cayet N, Nouaille S, Kros CJ, Petit C, Safieddine S (2009) Myosin VI is required for the proper maturation and function of inner hair cell ribbon synapses. Hum Mol Genet 18, 4615-28.

 

 

Mis à jour le 23/10/2014

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