Publications

2014

 

Serra-Hassoun, M., Bourgine, M., Boniotto, M., Berges, J., Langa, F., Michel, M.-L., Freitas, A.A. & Garcia, S. Human hematopoietic reconstitution and HLA-restricted responses in nonpermissive alymphoid mice. J. Immunol. 193 : 1504-1511 (2014)

 

Colle, J.-H., Rose, T., Rouzioux, C. & Garcia, A. Two highly variable Vpr84 and Vpr85 residues within the HIV-1-Vpr C-terminal protein transduction domain control transductionnal activity and define a clade specific polymorphism. World J. AIDS 4 : 148-155 (2014)

 

Reynolds, J., Amado, I.F., Freitas, A.A., Lythe, G. & Molina-Paris, C. A mathematical perspective on CD4+ T cell quorum-sensing. J. Theor. Biol. 347 : 160-175 (2014)

 

Duffy, D., Rouilly, V., Libri, V., Hasan, M., Beitz, B., David, M., Urrutia, A., Bisiaux, A., LaBrie, S., Dubois, A., Boneca, I.G., Delval, C., Thomas, S., Rogge, L., Schmolz, M., Quintana-Murci, L., Albert, M. & Milieu Interium Consortium. Functional analysis via standardized whole-blood stimulation systems defines the boundaries of a healthy immune response to complex stimuli. Immunity 40 : 436-450 (2014)

 

 

2013

 


Montaudouin, C., Anson, M., Hao, Y., Duncker, S.V., Fernandez, T., Gaudin, E., Ehrenstein, M., Kerr, W.G., Colle, J.-H., Bruhns, P., Daëron, M. & Freitas, A.A. Quorum sensing contributes to activated IgM-secreting B cell homeostasis. J. Immunol. 190 : 106-114 (2013)

 

Mahevas, M., Patin, P., Huetz, F., Descatoire, M., Cagnard, N., Bole-Feysot, C., Le Gallou, S., Khellaf, M., Fain, O., Boutboul, D., Galicier, L., Ebbo, M., Lambotte, O., Hamidou, M., Bierling, P., Godeau, B., Michel, M., Weill, J.-C. & Reynaud, C.-A. B cell depletion in immune thrombocytopenia reveals splenic long-lived plasma cells. J. Clinical Invest. 123 : 432-442 (2013)

 

Pierson, W., Cauwe, B., Policheni, A., Schlenner, S.M., Franckaert, D., Berges, J., Humblet-Baron, S., Schönefeldt, S., Herold, M.J., Hildeman, D., Strasser, A., Bouillet, P., Lu, L.-F., Matthys, P., Freitas, A.A., Luther, R.J., Weaver, C.J., Dooley, J., Gray, D.H.D. & Liston, A. Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3+ regulatory T cells. Nature Immunol. 14 : 959-966 (2013)

 

Guy-Grand, D., Vassalli, P., Eberl, G., Pereira, P., Burlen-Defranoux, O., Lemaitre, F., Di Santo, J. P., Freitas, A.A., Cumano, A. & Bandeira, A. Origin, trafficking, and intraepithelial fate of gut-tropic T-cells. J. Exp. Med. 210 : 1839-1854 (2013)

 

Amado, I.F., Berges, J., Luther, R.J., Mailhé, M.-P., Garcia, S., Bandeira, A., Weaver, C., Liston, A. & Freitas, A.A. IL-2 coordinates IL-2-producing and regulatory T cell interplay. J. Exp. Med. 210 : 2707-2720 (2013)

 

Carpentier, M., Chappert, P., Kuhn, C., Lalfer, M., Flament, H., Burlen-Defranoux, O., Lantz, O., Bandeira, A., Malissen, B., Davoust, J. & Gross, D.A. Extrathymic induction of Foxp3? regulatory T cells declines with age in a T-cell intrinsic manner. Eur J. Immunol. 43 : 2598-604 (2013)

 

 

2012

 


Gomes, J., Magalhaes, A., Michel, V., Amado, I.F., Aranha, P., Ovesen, R.G., Hansen, H.C.B., Gärtner, F., Reis, C.A. & Touati, E. Pteridium aquilinum and its ptaquiloside toxin induce DNA damage response in gastric epithelial cells, a link with gastric carcinogenesis. Toxicol. Sciences 126 : 60-71 (2012)

 

Almeida, A.R.M., Amado, I.F., Reynolds, J., Berges, J., Lythe, G., Molina-Paris, C. & Freitas, A.A. Quorum-sensing in CD4+ T cell homeostasis : a hypothesis and a model. Frontiers in Immunol. 3 article 125 : 1-15 (2012)

 

Garcia, S. &. Freitas A.A. Humanized mice : current states and perspectives Immunol. Letters146 : 1-7 (2012)

 

 

2011

 


Lochner, M., Bérard, M., Sawa, S., Hauer, S., Gaboriau-Routhiau, V., Fernandez, T.D., Snel, J., Bousso, P., Cerf-Bensussan, N. & Eberl, G. Restricted microbiota and absence of cognate TCR antigen leads to an unbalanced generation of Th 17 cells. J. Immunol. 186 : 1531-1537 (2011)

 

Zaragoza, B., Evaristo, C., Kissenpfennig, A., Libri, V., Malissen, B., Rocha, B., Freitas, A.A. & Almeida, A.R.M. Cell-to-cell interactions and signals involved in the reconstitution of peripheral CD8+ TCM and TEM cell pools. PLoS ONE 6 : e17423 (2011)

 

Guergnon, J., Godet, A.N., Galioot, A., Falanga, P.B., Colle, J.-H., Cayla, X. & Garcia, A. PP2A targeting by viral proteins : a widespread biological strategy from DNA/RNA tumor viruses to HIV-1. Biochim. Biophys. Acta 1812 : 1498-1507 (2011)

 

Pere, H., Montier, Y., Bayri, J., Quintin-Colonna, F., Merillon, N., Dransart, E., Badoual, C., Gey, A., Ravel, P., Marcheteau, E., Batteux, F., Sandoval, F., Adotevi, O., Chiu, C., Garcia, S., Tanchot, C., Lone, Y.C., Ferreira, L.C., Nelson, B.H., Hanahan , D., Fridman, W.H., Johannes, L. & Tartour, E. A CCR4 antagonist combined with vaccines induces antigen-specific CD8+ T cells and tumor immunity against self antigens. Blood 118 : 4853-4862 (2011)

 

Bouvier I., Jusforgues-Saklani H., Lim A., Lemaître F., Lemercier B., Auriau C., Nicola M.-A., Leroy S. Law H. K., Bandeira A., Moon J. J., Bousso P. & Albert M.L. Immunization route dictates cross-priming efficiency and impacts the optimal timing of adjuvant delivery. Front. Immunol. 2 : 1-18 (2011)

 

 

2010

 


Montaudouin, C., Boucontet, L., Mailhe-Lembezat, M.-P., Mariotti-Ferrandiz, M.-E., Louise, A., Six, A., Freitas, A.A. & Garcia, S. Endogenous TCR recombination in TCR Tg single Rag-deficient mice uncovered by robust in vivo T cell activation and selection. PLoS ONE : e10238 (2010)

 

Lalanne A.I., Moraga I., Hao Y., Pereira J.P., Alves N.L., Huntington N.D., Freitas A.A., Cumano A. & Vieira P. CpG inhibits Pro-B cell expansion through a cathepsin B-dependent mechanism. J. Immunol. 184 : 5678-5685 (2010)

 

 

2009


Thiriot Aude, Drapier Anne-Marie, Mémet Sylvie, Fitting Catherine, Sturny-Leclere Aude, Cavaillon Jean-Marc, Cazenave Pierre-André, Freitas Antonio A. & Rueff-Juy Dominique. Wild-derived mouse strains, a valuable model to study B cell responses. Mol. Immunol.46 : 601-612 (2009)


Freitas, A.A. & Rocha B. Homeostasis of naive T cells : the Foxo that fixes. Nature Immunol. 10 : 133-144 (2009)

 

Leitao, C., Freitas, A.A. & Garcia, S. The role of TCR specificity and clonal competition during reconstruction of the peripheral T cell pool. J Immunol. 182 : 5232-5239 (2009)

 

Rose T, Lambotte O, Pallier C, Delfraissy JF & Colle JH. Identification and Biochemical Characterization of Human Plasma Soluble Interleukin-7 Receptor: Lower Concentrations in HIV-1-infected patients. J. Immunol. 182: 7389-7397 (2009)

 

de Freitas A.A.
Tractus Immuno-Logicus. A brief History of the Immune System
Eds Landes Bioscience (2009)

 

 

 

2008


Lampropoulou, V., Hoehlig, K., Roch, T., Neves, P., Calderon Gomez, E., Sweenie, C.H., Hao, Y., Freitas, A.A., Steinhoff, U., Anderton, S.M. & Fillatreau, S. TLR- activated B cells suppress T cell-mediated autoimmunity. J. Immunol. 180 : 4763-4773 (2008)

 

Thiriot, A., Freitas, A.A. & Rueff-Juy D. Peritoneal B-cell subsets in the genus Mus : their role in innate immunity. Crit Rev Immunol. 28 : 341-361 (2008)

 

 

2007

 


Sanchez-Guajardo, V., Tanchot, C., O’Malley, J.T., Kaplan, M.H., Garcia, S. & Freitas, A.A. Agonist-driven development of CD4+CD25+Foxp3+ regulatory T cells requires a second signal mediated by Stat6. J. Immunol. 178 : 7550-7556 (2007)

 

Thiriot, A., Drapier, A.-M., Vieira, P., Fitting, C., Cavaillon, J.-M., Cazenave, P.-A. & Rueff-Juy, D. The Bw cells, a novel B cell population conserved in the whole genus Mus. J. Immunol. 179 : 6568-6578 (2007)

 

 

2006

 


De la Coste, A. & Freitas, A.A. Notch signaling : distinct ligands induce specific signals during lymphocyte development and maturation. Immunol letters 102 : 1-9 (2006)

 

Mascarell, L., Auger, R., Kanellopoulos, J.M. & Truffa-Bachi, P. The usage of alternative splice sites in mus musculus synaptotagmin-like 2 gene is modulated by cyclosporin A and FK506 in T-lymphocytes. Mol Immunol. 43 : 1846 – 1854 (2006)

 

Almeida ARM, Zaragoza B. & Freitas AA. Indexation as a novel mechanism of lymphocyte homeostasis: the number of CD4+CD25+ regulatory T cells is indexed to the number of IL-2 producing cells. J. Immunol. 177 : 192-200 (2006)

 

Hao Y., Legrand L. & Freitas AA. The clone size of peripheral CD8 T cells is regulated by TCR promiscuity. J. Exp. Med. 203 : 1643-1649 (2006)

 

Almeida, ARM., Zaragoza, B. & Freitas A.A. Competition controls the rate of transition between the peripheral pools of CD4+CD25- and CD4+CD25+ T cells. Int. Immunol. 18 : 1607-1613 (2006)

 

 

2005

 


Wildin, R.S. & Freitas, A. IPEX and Foxp3 : clinical and research perspectives. J. Autoimmunity 25 : 56-62 (2005)

 

Sanchez-Guajardo, V., Borghans, J.A.M., Marquez, M.-E., Garcia, S. & Freitas, A.A. Different competitive capacities of Stat4- and Stat6-deficient CD4+ T cells during lymphopenia-driven proliferation. J. Immunol. 174 : 1178-1187 (2005)

 

De La Coste, A., Six, E., Fazilleau, N., Mascarell L., Legrand, N., Mailhe, M.-P., Cumano, A., Laabi, Y. & Freitas, A.A. In vivo and in absence of a thymus the enforced expression of the Notch ligands Delta-1 or Delta-4 promotes T cell development with specific unique effects. J. Immunol. 174 : 2730-2737 (2005)

 

Almeida, A.R.M., Rocha, B., Freitas, A..A & Tanchot, C. Homeostasis of T cell numbers : from thymus production to peripheral compartmentalization and the indexation of regulatory T cells. Sem. Immunol. 17 : 239-249 (2005)

 

Agenes, F., Bosco, N., Mascarell, L., Fritah, S. & Ceredig, R. Differential expression of regulator of G-protein signalling transcripts and in vivo migration of CD4+ naïve and regulatory T cells. Immunology 115 : 179-188 (2005)

 

Ghiringhelli, F., Ménard, C., Terme M., Flament, C., Taieb, J., Chaput, N., Puig, P.E., Novault, S., Escudier, B., Vivier, E., Lecesne, A., Robert, C., Blay, J.-Y., Caillat-Zucman, S., Freitas, A., Tursz, T., Wagner-Ballon, O., Capron, C., Vainchencker, W., Martin, F. & Zitvogel, L. CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-b-dependent manner. J. Exp. Med. 202 : 1075-1085 (2005)

 

Marquez M.-E., Ellmeier W., Sanchez-Guajardo V., Freitas A.A., Acuto O. & Di Bartolo V. T cell sensory adaptation dependent on TCR avidity for self-antigens. J. Immunol. 175 : 7388-7397 (2005).

 

 

2004


Gaudin, E., Rosado, M., Agenes, F., McLean, A. & Freitas, A.A. B-cell homeostasis, competition, resources, and positive selection by self-antigens. Immunol. Rev. 197 : 102-115 (2004)

 

De Boer R.J., Borghans, J.A.M., van Boven, M., Kesmir, C. & Weissing, F.J. Heterozygote advantage fails to explain the high degree of polymorphism of the MHC. Immunogenetics 55 : 725-731 (2004)



Borghans, J.A.M., Beltman, J.B. & De Boer, R.J. MHC polymorphism under host-pathogen coevolution. Immunogenetics 55 : 732- 739 (2004)



Gaudin, E., Hao, Y., Rosado, M.M., Chaby, R., Girard, R. & Freitas, A.A. Positive selection of B cells expressing low densities of self-reactive BCRs. J. Exp. Med. 199 : 843-853 (2004)



Mascarell, L., Auger, R., Alcover, A., Ojcius, D.M., Jungas, T., Cadet-Daniel, V., Kanellopoulos, J.M. & Truffa-Bachi, P. Characterization of a gene encoding two isoforms of a mitochondrial protein up-regulated by cyclosporin A in activated T cells. J. Biol. Chem. 279 : 10556-10563 (2004)



Mascarell, L. & Truffa-Bachi, P. T lymphocyte activation initiates the degradation of the CD62L encoding mRNA and increases the transcription of the corresponding gene. Immunol. Letters 94 : 115-122 (2004)

 

Schlecht, G., Garcia, S., Escriou, N., Freitas, A.A., Leclerc C. & Dadaglio, G. Murine plasmacytoid dendritic cells Cs induce effector/memory CD8+ T cells responses in vivo after viral stimulation. Blood 104 : 1808-1815 (2004)

 

 

2003

 


Borghans, J.A.M., Noest, A.J. & De Boer R.J. Thymic selection does not limit the individual MHC diversity. Eur. J. Immunol. 33 : 3353-3358 (2003)



Mascarell, L. & Truffa-Bachi P. New aspects of cyclosporin A mode of action: from gene silencing to gene up-regulation. Mini Rev. Med. Chem. 3 : 207-216 (2003)

 


2002

 


Borghans, J.A.M. & De Boer, R.J. Memorizing innate instructions requires a sufficiently specific adaptive immune system. Int. Immunol. 14 : 525-532 (2002)

 

Freitas, A. & Chen J. Introduction : regulation of lymphocyte homeostasis. Microbes & Infec. 4 : 529-530 (2002)

 

Almeida, A.R.M., Legrand, N., Papiernick, M. & Freitas, A.A. Homeostasis of peripheral CD4+ T cells : IL-2Ra and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers. J. Immunol. 169 : 4850-4860 (2002)

 

Haller, C., Fillatreau, S., Hoffmann, R. & Agenes, F. Structure, chromosomal localization and expression of the mouse regulator of G-protein signaling10 gene (mRGS10) Gene 297 : 39-49 (2002)

 

Mascarell, L. & Truffa-Bachi, P. Cyclosporin A therapy differently affects immunological-relevant gene expression following immunization. Immunol. Letters 84 : 137-143 (2002)

 


2001


Li, F., Jin, F., Freitas, A.A., Szabo, P. & Weksler, M.E. Impaired regeneration of the peripheral B cell repertoire from bone marrow following lymphopenia in old mice. Eur. J. Immunol. 31 : 500-505 (2001)

 

Almeida, A.R.M., Borghans, J.A.M. & Freitas, A.A. T cell homeostasis : thymus regeneration and peripheral T cell restoration in mice with a reduced fraction of competent precursors. J. Exp. Med. 194 : 591-599 (2001)

 

Legrand, N. & Freitas A.A. CD8+ T lymphocytes in double ab TCR transgenic mice. I. TCR expression and thymus selection in the absence or in the presence of self-antigen. J. Immunol. 167 : 6150-6157 (2001)

 

Legrand, N. & Freitas A.A. CD8+ T lymphocytes in double ab TCR transgenic mice. II. Competitive fitness of dual ab TCR CD8+ T lymphocytes in the peripheral pools. J. Immunol. 167 : 6158-6164 (2001)

 

De Boer, R.J., Freitas, A.A & Perelson, A.S. Resource competition determines selection of B cell repertoires. J. Theor. Biol. 212 : 333-343 (2001)

 

Kourilsky, P. & Truffa-Bachi P. Cytokines fields and the polarization of the immune response. Trends in Immunol., formely Immunol. Today 22 : 502-509 (2001)

 

 

2000

 


Freitas, A.A. & Rocha, B. (communiqué par Weill, J.-C.) Physiologie du système immunitaire: homéostasie des populations lymphocytaires. In : « La physiologie animale et humaine - vers une physiologie intégrative » Eds. Académie des Sciences 109-112 (2000)

 

Freitas, A.A. & Rocha, B. Population biology of lymphocytes: the flight for survival. Ann. Rev. Immunol. 18 : 83-111 (2000)

 

Agenes, F., Rosado, M.M. & Freitas, A.A. Peripheral B cell survival. Cell. Mol. Life Science 57 : 1220-1228 (2000)

 

Rosado, M.M. & Freitas, A.A. B cell positive selection by self antigens and counter-selection of dual B cell receptor in the peripheral B cell pools. Eur. J. Immunol. 30 : 2181-2190 (2000)

 

Agenes, F., Rosado, M.M. & Freitas, A.A. Considerations on B cell homeostasis Curr. Top. Microbio. & Immuno. 252 : 67-75 (2000)

 

 

1999

 


Agenes, F. & Freitas, A.A. Transfer of small resting B cells into immunodeficient hosts results in the selection of a self-renewing activated B cell population. J. Exp. Med. 189 : 319-329 (1999)

 

Freitas, A.A. & Rocha, B. Peripheral T cell survival. Curr. Opin. Immunol. 11 : 152-156 (1999

 

Freitas, A.A. Populationsbiologie der B-lymphozyten. Aspekte 11 : 20 (1999)

 

 

1998

 


Rosado, M.M. & Freitas, A.A. The role of the B cell receptor V region in peripheral B cell survival. Eur. J. Immunol. 28 : 2685-2693 (1998)

 

McLean A.R. Mathematical modelling of effectiveness. In: Preclinical and clinical development of new vaccines. Plotkin S., Brown F. & Horaud F. (eds). Dev. Biol. Stand. Basel, Karger. 95 : 225-233 (1998)

 

McLean A.R. Development and use of vaccines against evolving pathogens: vaccine design. In: Evolution in health and disease. S. Stearns (eds). Oxford University Press 138-151 (1998)

 

Bangham, C., Anderson, R., Baquero, F., Bax, R., Hastings, I., Koella, J., Lipsitch, M., McLean, A., Smith, T., Taddei, F. & Levin, B. Evolution of infectious diseases: the impact of vaccines, drugs, and social factors. In: Evolution in health and disease. S. Stearns (eds). Oxford University Press 152-160 (1998)

 

 


1997

 


McLean, A.R., Rosado, M.M., Agenes, F., Vasconcellos, R. & Freitas, A.A. Resource competition as a mechanism for B cell homeostasis. Proc. Natl. Acad. Sci. USA 94 : 5792-5797 (1997)



Tanchot, C., Lemonnier, F.A., Pérarnau, B., Freitas, A.A. & Rocha, B. Differential requirements for survival and proliferation of CD8 naïve or memory T cells. Science 276 : 2057-2062 (1997)



Freitas, A.A. & Rocha, B. Lymphocyte survival: a red queen hypothesis. Science 277 : 1950 (1997)

 

Feinberg, M.B. & McLean A.R. AIDS: decline and fall of immune surveillance? Curr. Biol. 7 : R136-R140 (1997)

 

Tanchot, C., Rosado, M.M., Agenes, F., Freitas, A.A. & Rocha, B. Lymphocyte homeostasis. Sem. in Immunol. 9 : 331-337 (1997)

 

Agenes, F., Rosado, M.M. & Freitas, A.A. Independent homeostatic regulation of B cell compartments. Eur. J. Immunol. 27 : 1801-1807 (1997)

 

 

1996

 


Jungmann, P., Freitas, A., Bandeira, A., Nobrega, A., Coutinho, A., Marcos, M.-A. & Minoprio, P. Murine acariasis. II. Immunological dysfunction and evidence for chronic activation of Th-2 lymphocytes. Scand. J. Immunol. 43 : 604-612 (1996)



Freitas, A.A., Agenes, F. & Coutinho, G.C. Cellular competition modulates survival and selection of CD8+ T cells. Eur. J. Immunol. 26 : 2640-2649 (1996)

 

 

1995


Chies, J.A.B., Marodon, G., Joret, A.-M., Regnault, A., Lembezat, M.-P, Rocha, B. & Freitas, A.A. Persistence of Vb6+ T cells in Mls-1amice. A role for the third complementarity-determining region (CDR3) of the T cell receptor b chain in superantigen recognition. J. Immunol. 155 : 4171-4178 (1995)



Rocha, B., Grandien, A. & Freitas, A.A. Anergy and exhaustion are independent mechanisms of peripheral T cell tolerance. J. Exp. Med. 181 : 993-1003 (1995)



Freitas, A.A., Rosado, M.M., Viale, A.-C. & Grandien, A. The role of cellular competition in B cell survival and selection of B cell repertoires. Eur. J. Immunol. 25 : 1729-1738 (1995)



Freitas, A.A. Lymphocytes in a model ecosystem. Res. Immunol.146 : 225-233 (1995)



McLean, A.R. Vaccination, evolution and changes in the efficacy of vaccines: a theoretical framework. Proc. R. Soc. Lond. B. 261 : 389-393 (1995)



McLean, A.R. & Blower, S.M. Modelling HIV vaccination. Trends in Microbiol. 3 : 458-463 (1995)

Mis à jour le 28/07/2014

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Publication d'un livre  "Tractus Immuno-Logicus : a brief history of the Immune System" par Pr Antonio Freitas (eds. Landes Bioscience)

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