François Huetz

CURRICULUM VITAE

 

 

HUETZ François

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né le: 15-01-1961
Nationalité : Française
Marié, 2 enfants

Biologie des Populations Lymphocytaires
Institut Pasteur
25 rue du Dr Roux
75724 Paris cedex 15
francois.huetz@pasteur.fr

 
FORMATIONS :
Habilitation à Diriger des Recherches (HDR) de l'Université Paris VI - spécialité Immunologie
7/7/2004
Thèse de doctorat de l'Université Paris VI - spécialité Immunologie - Mention Très Honorable
26/9/1990
DEA d'Immunologie mention AB, Institut Pasteur et Université Pierre et Marie - Paris VI
1986
Licence de Biochimie, Université Pierre et Marie - Paris VI
1985
Maitrise de Biochimie, Université Pierre et Marie - Paris VI
1984
DEUG mention AB, Université Pierre et Marie - Paris VI
1981
Baccalauréat C, Lycée Henri IV, Paris.
1978
 
POSITIONS
Chargé de Recherche Institut Pasteur
Janvier 1995
Stage post-doctoral - Koln University - Institut für Genetik - Laboratoire du Pr K. Rajewsky - Cologne - Allemagne
1992-1994
Stage post-doctoral - Umea University - Laboratoire du Dr D. Holmberg - The unit of Applied Cell and Molecular Biology - Umea - Suède
1992-1991
Stagiaire boursier Unité d'Immunobiologie du Pr A. Coutino - Institut Pasteur - Paris
1986-1990
 
COLLABORATION

INSERM U783 "Développement du système immunitaire" - Université Paris Descartes Faculté de Médecine
Site Necker-Enfants Malades
156 rue de Vaugirard
75730 Paris cedex 15
http://www.u783.idf.inserm.fr

 
ENSEIGNEMENT
Depuis 2004 : Chef de Travaux Pratiques du cours d'Immunologie Approfondie de l'Institut Pasteur, niveau M2, master de sciences des Universités Paris V, VI et VII.
 
LANGUES
Anglais courant, notions d'Espagnol
 
SOCIETES SCIENTIFIQUES
Membre depuis 1989 de la Société Française d'Immunologie (SFI).

 

 

Liste des publications / Brevets

 

PUBLICATIONS

  1. HUETZ, F. et LUCOTTE, G. (1986) Polymorphisme de restriction des gènes d' histocompatibilité de classe I chez le chimpanzé. Bioch. Syst. Ecol., 14: 681

  2. HUETZ, F., COULONDRE, C., WILLCOX, G., MULLER, J.Y., and LUCOTTE, G. (1986) Segregation analysis of polymorphic HLA class I PVU II restriction fragments. Biosciences, 5: 197

  3. HUETZ, F., LUCOTTE, G., KAHAN, A., et AMOR, B. (1987) Polymorphisme de restriction TAQ I et allèle HLA B27 dans la Spondylarthrite Ankylosante. Rev. du Rhumatisme, 54: 175

  4. HUETZ, F., MARIOTTI, M. and LUCOTTE, G. (1987) TAQ I restriction polymorphism of HLA class I genes and hybridization with HLA-A and HLA-B specific probes. Exp. Clin. Immunogen., 4: 1

  5. HUETZ, F., SCIARD-LARSSON, E-L., PEREIRA, P., PORTNOI, D. and COUTINHO, A. (1988) T cell dependence of "natural" auto-reactive B cell activation in the spleen of normal mice. Eur. J. Immunol. , 18: 1615-1622.

  6. HUETZ, F., JACQUEMART, F., PENA ROSSI, C., VARELA, F. and COUTINHO, A. (1988) Autoimmunity: The moving boundaries between physiology and pathology. J. Autoimmunity, 1: 507-518. and in "Immunointervention in autoimmune diseases", BACH, J. F. (Ed.) Academic Press.

  7. FREITAS, A., PEREIRA, P., HUETZ, F., THOMAS-VASLIN, V., PENA-ROSSI, C., ANDRADE, L., SUNDBLAD, A., FORNI, L. and COUTINHO, A. (1989) B cell activities in normal unmanipulated mice. In " B lymphocytes : function and regulation ", Contrib Microbiol Immunol. Basel, Karger, DEL GUERCIO, P., CRUSE, J.M. (Ed.), 11: 1-26.

  8. HUETZ, F., PONCET, P., COUTINHO, A. and PORTNOI, D. (1989) Ontogenic development of auto-antibody repertoires: examples of T cell-dependent and independent reactivities.Eur. J. Immunol., 19: 1195-1201.

  9. HUETZ, F., and PONCET, P. (1989) Immunocompetence of peritoneal B cells.Res. Immunol., 140: 75-87.

  10. ANDRADE, L., FREITAS, A.A., HUETZ, F., PONCET, P., and COUTINHO, A. (1989) Immunoglobulin VH-gene expression in LY-1 and conventional B lymphocytes. Eur. J. Immunol., 19: 1117-1122.

  11. MARCOS, M.A.R., HUETZ, F., PEREIRA, P., ANDREU, J.L., MARTINEZ-A., C. and COUTINHO, A. (1989) Further evidence for coelomic-associated B lymphocytes.Eur. J. Immunol., 19: 2031-2035.

  12. WEKSLER, M., E., SCHWAB, R., HUETZ, F. and COUTINHO, A. (1989) Cellular basis of autoantibody production in old mice. Trans. Assoc. Amer. Phys., 102: 55-58.

  13. MARCOS, M.A.R., SUNDBLAD, A., GRANDIEN, A. HUETZ, F., AVRAMEAS, S. and COUTINHO, A. (1989) The physiology of autoimmune reactivities.Progress in Immunol., 7: 793-804.

  14. WEKSLER, M., E., SCHWAB, R., HUETZ, F., KIM, Y.T. and COUTINHO, A. (1990) Cellular basis for the age-associated increase in autoimmune reactions.Int. Immunol., 2: 329-335.

  15. MASMOUDI, H., MOTA-SANTOS, T, HUETZ, F., COUTINHO, A. & CAZENAVE, P.A. (1990) All T15 Id positive antibodies (but not the majority of VH T15+ antibodies) are produced by peritoneal CD5+ B lymphocytes. Int. Immunol., 2: 515-520.

  16. PONCET, P., HUETZ, F., MARCOS, M.A.R. & ANDRADE, L. (1990) All VH11 genes expressed in peritoneal lymphocytes encode anti-BrMRBC autoantibodies but other VH gene families can also contribute to this specificity. Eur. J. Immunol., 20: 1583-1590.

  17. SUNDBLAD, A., HUETZ, F., PORTNOI, D. & COUTINHO, A. (1991) Stimulation of B and T cells by in vivo high dose immunoglobulin administration in normal mice. J. Autoimmunity., 4: 325-339.

  18. MARCOS, M. A. R., GUTIERREZ, J. C., HUETZ, F., MARTINEZ-A, C. & DIETERLEN-LIEVRE, F. (1991) Waves of B-lymphopoiesis in the establishment of the mouse B-cell compartment. Scan. J. Immunol., 34: 129-135.

  19. SUNDBLAD, A., MARCOS, M.A., HUETZ, F., FREITAS, A., HEUSSER, C., PORTNOI, D. & COUTINHO, A. (1991) Normal serum immunoglobulins influence the numbers of bone marrow pre-B and B cells. Eur. J. Immunol., 21: 1155-1161.

  20. ANDRADE, L., HUETZ, F., PONCET, P., THOMAS-VASLIN, V., GOODHEART, M. & COUTINHO, A. (1991) Biased VH gene expression in murine CD5 B cells results from age-dependent cellular selection. Eur. J. Immunol., 21: 2017-2024.

  21. THOMAS-VASLIN, V., COUTINHO, A. and HUETZ, F. (1992) Origin of natural IgM secreting cells: Reconstitution potential of adult bone marrow, spleen and peritoneal cells. Eur. J. Immunol., 22: 1243-1251

  22. MARCOS, M.A.R., MALANCHERE, E., SUNDBLAD, A., HUETZ, F., GRANDIEN, A. MARTINEZ-A, C. and COUTINHO, A. (1992) Coelomic and bone marrow-derived B cells: Developmental constrainsts versus antigen-specific selection. In "CD5 B Cells in Development and Disease", HERZENBERG, L.A., HAUGHTON, G., RAJEWSKY, K. (Ed.), Annals of the New York Academy of Sciences, 651: 433-442.

  23. HUETZ, F., CARLSSON, L., TORNBERG, U-C. and HOLMBERG, D. (1993) V-region directed selection in differentiating B lymphocytes. EMBO J. ,12: 1819-1826.

  24. SUNDBLAD, A., MARCOS, M.-A.R., MALANCHERE, E., CASTRO, A., HAURY, M., HUETZ, F., NOBREGA, A., FREITAS, A. and COUTINHO, A. (1994) Observations on the mode of action of normal immunoglobulin at high doses. Immunological rev., 139: 125-158.

  25. VIALE, A.-C., CHIES, J. A. B., HUETZ, F., MALANCHERE, E., WEKSLER, M., FREITAS, A. A., and COUTINHO, A. (1994) VH-gene family dominance in ageing mice. Scand. J. Immunol., 39: 184-188.

  26. RYELANDT, M., DE WIT, D., BAZ, A., VANSANTEN, G., DENIS, O., HUETZ, F., NISOL, F., MACEDO-SOARES, F., BARCY, S., BRAIT, M., LEO, O., BAZIN, H. AND URBAIN, J. (1995) The perinatal presence of antigen (p-azophenylarsonate) or anti-µ antibodies lead to the loss of the recurrent idiotype (CRIA) in A/J mice. Int. Immunol., 7: 645-652.

  27. HUETZ, F., TORNBERG, U.-C., MALANCHERE, E., ROES, J., CARLSSON, L., COUTINHO, A., HOLMBERG, D., AND RAJEWSKY, K. (1997) Targeted disruption of the VH 81X gene: Influence on the B-cell repertoire. Eur. J. Immunol., 27: 307-314.

  28. MALANCHERE, E., HUETZ, F., AND COUTINHO, A. (1997) Maternal IgGs stimulate B-lineage cell development in the progenies. Eur. J. Immunol., 27: 788-793.

  29. HOLMBERG, D., CARLSSON, L., HUETZ, F., and TORNBERG, U-C. (1997) Immunoglobulin variable region repertoire development. In "WEIR'S Handbook of Experimental Immunology", 5TH Edition, HERZENBERG, L.A., WEIR, D.M., HERZENBERG, L.A. and BLACKWELL, C. (Ed.), CHAP 17, 17:1-17:8.

  30. GRILLOT-COURVALIN, C., GOUSSARD, S., HUETZ, F., OJCIUS, M. D., AND COURVALIN, P. (1998) Functional gene transfer from intracellular bacteria to mammalian cells Nature Biotech., 16: 862-866.

  31. BARBACCI, E., REBER, M., OTT, M-O., BREILLAT, C., HUETZ, F., and CEREGHINI, S. (1999) Variant hepatocyte nuclear factor 1 is required for visceral endoderm specification Development, 126: 4795-4805.

  32. GOUDEAU, B., HUETZ, F., SAMSON, S., DI SANTO, J.P., CUMANO, A., BEG, A., ISRAËL, A. AND MEMET, S. (2003) IΚBα/IΚBε-deficiency reveals that a critical NF-ΚB dosage is required for lymphocyte survival P.N.A.S., 100: 15800-15805.

  33. LIM, A., LEMERCIER, B, WERTZ, X., LESJEAN-POTTIER, S., HUETZ, F., AND P. KOURILSKY, P., (2008) Many human peripheral VH5-expressing IgM+ B cells display a unique heavy-chain rearrangement. Int Immunol 20:105-116.

  34. RANDRIANARISON-HUETZ, V., LAURENT, B., BARDET, V., BLOBE, G.C., HUETZ, F., AND DUMENIL, D., (2010) GFI-1B controls human erythroid and megakaryocytic differentiation by regulating TGF-ß signaling at the bipotent erythro-megakaryocytic progenitor stage. Blood, 115:2784-2795.

  35. BOUCHERMA, R., KRIDANE-MILEDI, H., LANGA VIVES, F., VAUCHY, C., BORG, C., KLEINCLAUSS, F., FIETTE, L., TIBERGHIEN, P., LEMONNIER, F. A., ROHRLICH, P.-S., AND HUETZ, F. (2012) Exploring the immunological interface of HFE, an MHC class Ib molecule that control iron metabolism, with anti-HFE TCR transgenic Eur. J. Immunol. 42 : 851-862
  36. REYNAUD, C.-A., DESCATOIRE, M., DOGAN, I., HUETZ, F., WELLER, S., AND WEILL, J.-C. (2012) IgM Memory B cells : The mouse/human paradox. Cellular and Molecular Life Sciences 69 : 1625-1634
  37. MAHEVAS, M., PATIN, P., HUETZ, F., DESCATOIRE, M., CAGNARD, N., BOLE-FEYSOT, C., LE GALLOU, S., KHELLAF, M., FAIN, O., BOUTBOUL, D., GALICIER, L., EBBO, M., LAMBOTTE, O., HAMIDOU, M., BIERLING, P., GODEAU, B., MICHEL, M., WEILL, J.-C. & REYNAUD, C.-A. (2013) B cell depletion in immune thrombocytopenia reveals splenic long-lived plasma cells. J. Clinical Invest. 123 : 432-442

 

BREVET

Brevet Européen :« Repertoire determination of a lymphocyte B population » N° de dépôt : 03293159.4 Date du dépôt : 15 Décembre 2003

 

 

 

Mis à jour le 07/02/2014

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Actualités

Publication d'un livre  "Tractus Immuno-Logicus : a brief history of the Immune System" par Pr Antonio Freitas (eds. Landes Bioscience)

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Biologie des Populations Lymphocytaires
Institut Pasteur        
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