Welcome to the web page of Antonio A. Freitas

photoaaf.gifANTONIO A FREITAS (Antonio Angelo Bastos Alves de Freitas).

Né le  22 décembre 1947, à CUAMBA, MOZAMBIQUE

 

NATIONALITE: PORTUGAISE

 

 

Etudes:


1970 : Doctorat de Médecine, University of Lisbon, Portugal

1972 : Interne - Internal Medicine. St. Mary’s Hospital, Lisbon. Portugal.

1976 : PhD en Immunologie. University of Glasgow, U.K.

1982 : “Agregé” en Immunologie. New University of Lisbon, Portugal.

 

 

Expériences professionnelles:

1971-1973 : Interne au St. Mary’s Hospital, Lisbonne. Portugal

1973-1976 : Etudiant en thèse. Département d'Immunologie, Western Infirmary, Glasgow University.

1976-1977 : Chercheur associé. Memorial Sloan-Kettering Cancer Center, New York. USA.

1978-1978 : Basel Institute for Immunology.

1977-1980 : Professeur auxiliaire. Département d'Immunologie. Faculty of Medical Sciences. New University of Lisbon, Portugal.

1980-1984 : Associate Professor. Département d'Immunologie. Faculty of Medical Sciences. New University of Lisbon, Portugal.

1984- 2000 : Chef de Laboratoire. Institut Pasteur à Paris. France.

1995-1999 : Responsable du Laboratoire des Dynamiques Lymphocytaires. Institut Pasteur à Paris. France.

1997-2000 : Directeur du Département d'Immunologie. Institut Pasteur à Paris. France

1999- : Directeur de l'Unité de Biologie des Populations Lymphocytaires. Institut Pasteur à Paris. France

2001- : Professeur. Institut Pasteur à Paris. France.

2005- : Directeur de l'URA CNRS 1961.

2006-2010 : Sous-directeur du Département d'Immunologie. Institut Pasteur à Paris. France

 

 

Prix scientifiques:

 

1979 : Behring Prize of the Portuguese Society for Immunology.

1983 : Pfizer Prize of the Society of Medical Science, Lisbon.

1988 : Gulbenkian Prize for Science, Lisbon.

2011 : Prize “Seeds of Science”, FCT, Lisbon

 

 

Publications

 

1 - Freitas, AA (1972). Defices imunitarios. Rev. Port. Pediatria 3 : 1

 

2 - Lacerda, JMF, Mascarenhas, MJ & Freitas, AA. (1973) Leucemia de monocitos. Jornal do Medico 1562 : 77

 

3 - Freitas, AA. (1973) Relacoes hospedeiro-tumor. Aspectos imunologicos das neoplasias. Medicina Universal 16 : 323.

 

4 - Freitas, AA. & Machado Caetano, JA. (1973) Alfa-mercaptopropionilglicina e doenca de Wilson. Rev. Port. Terap. Med. 7 : 13.

 

5 - Freitas, AA. (1973) Estudo de populaçoes linfocitarias humanas. I. Distribuicao relativa de linfocitos T e B no sangue periferico de uma populaçao normal. Jornal do Medico 1584 : 317.

 

6 - Freitas, AA. (1973) Estudo de populacoes linfocitarias humanas. II. Distribuicao relativa de linfocitos T e B no sangue periferico de doencas linfoproliferativas. Jornal do Medico 1585 : 383

 

7 - Freitas, AA, Forjaz de Lacerda, JM & Ducla Soares, A. (1973) Estudo de populacoes linfocitarias humanas. Distribuicao relativa de linfocitos T e B no sangue periferico do mieloma multiplo. Jornal do Medico 1587 : 506,

 

8 - Machado Caetano, JA, Silveira Nunes, MA, Mathioli, LJ, Mateus, AM, Freitas, AA, Pereira Luis, JH, Ricardo, JA, Clemente, AF & Gentil, F. (1974) Contribuicao para o estudo imunobiologico da doença neoplasica. Medicina Universal 17 : 10,137 & 198.

 

9 - Freitas, AA. & de Sousa, M. (1975) Control mechanisms of lymphocyte traffic. Modification of the traffic of 51Cr labelled mouse lymph node cells by treatment with plant lectins in intact and splenectomized hosts. Eur. J. Immunol. 5 : 831.

 

10 - Parrot, DMV, Rose, ML, Sless, F, Freitas, AA & Bruce, RG. (1976) Factors wich determine the accumulation of immunoblasts in gut and skin. Agents & Actions 6 : 32.

 

11 - Freitas, AA & de Sousa, M. (1976) The role of cell interactions in the control of lymphocyte traffic. Cell. Immunol. 22 : 345.

 

12 - Freitas, AA & de Sousa, M. (1976). Control mechanisms of lymphocyte traffic. Altered distribution of 51Cr labelled mouse lymph node cells pre-treated in vitro with lipolysaccharide. Eur. J. Immunol. 6 : 269.

 

13 - Freitas, AA & de Sousa, M. (1976) Control mechanisms of lymphocyte traffic. Altered migration of 51Cr labelled mouse lymph node cells pre-treated in vitro with phospholipases. Eur. J. Immunol. 6 : 703.

 

14 - Freitas, AA. (1976) Control mechanisms of lymphocyte traffic in mice. Ph.D. Thesis, Glasgow University.

 

15 - Freitas, AA & de Sousa, M. (1977). Control mechanisms of lymphocyte traffic. A study of the action of two sulphated polysaccharides on the distribution of 51Cr- and 3H- labelled mouse lymph node cells. Cell. Immunol. 31 : 62.

 

16 - Freitas, AA, Rose, ML & Parrot, DMV. (1977). Mesenteric and peripheral lymph node cells in the mouse: a common pool of small recirculating T lymphocytes. Nature 270 : 731.

 

17 - Freitas, AA, Rocha, B, Chiao, JW & de Sousa, M. (1978). Divergent actions of monomeric, dimeric and tetrameric Concanavalin A on lymphocyte traffic. Cell. Immunol. 35 : 59.

 

18 - De Sousa, M, Freitas, AA, Huber, B, Cantor, H, & Boyse, EA.(1979). Migratory patterns of the Ly subsetes of T lymphocytes in the mouse. In: "Function and structure of the immune system", Muller,W, Rucholtz & Muller, HK (Eds.). Hermelink Plenum Press, p. 51.

 

19 - Freitas, AA & Bognacki, J. (1979). The role of cell locomotion in lymphocyte migration. Immunology 36 : 247.

 

20 - Rocha, B, Freitas, AA & de Sousa, M. (1979). Characterization of rat spleen cell populations. I. cell interactions in the regulation of "in vitro" responses to Concanavalin A. Immunology 36 : 619.

 

21 - Rocha, B, Cumano, A & Freitas, AA. (1979). Regulacao da resposta imunologica pelas celulas T no rato: mecanismos de interacçao celular. Acta Medica Portuguesa 1 : 671.

 

22 - Freitas, AA. (1980) Anatomia e fisiologia do sistema imune. Implicacoes e aplicacao pratica do controle da recirculacao linfocitaria. Boletim do Hosp. Geral de St. Antonio, II:121.

 

23 - Freitas, AA & Rocha, B. (1980). Ontogenia e diferenciacao dos linfocitos B. Boletim do Hosp. Geral de St. Antonio, II : 127.

 

24 - Freitas, AA, Rose, ML & Rocha, B. (1980). Ramdom recirculation of small T lymphocytes from thoracic duct lymph in the mouse. Cell. Immunology 56 : 29.

 

25 - Rocha, B, Freitas, AA & Parrot, DMV. (1980). Characterization of rat spleen cell populations. II. Activation by antigens and allogeneic cells. Immunology 41 : 825.

 

26 - Freitas, AA & Coutinho, AA. (1980). Characterization of mouse thoracic duct B-lymphocytes. I. Evidence for functional heterogeneity. Eur. J. Immunology 10 : 772

 

27 - Freitas, AA. (1981). Current concepts of lymphocyte- endothelium interactions. In: "The immune system", Lefkovits, I. & Steinberg, C. (Eds.) Vol. I, p 372.

 

28 - Freitas, AA & Coutinho, AA. (1981). Very rapid decay of mature B lymphocytes in the spleen. J. Exp. Med. 154 : 994.

 

29 - Freitas, AA, Rocha, B, Forni, L & Coutinho, AA. (1982). Population dynamics of B lymphocytes and their precursors: demonstration of high turnover in the central and peripheral lymphoid organs. J. Immunolgy 128 : 54

 

30 - Rocha, B, Ferreira, AA, Munn, G, de Sousa, M & Freitas, AA. (1982). Spleen lymphocyte populations in patients with Hodgkin's disease. Properties of cells with diferent densities. Clin. Exp. Immunol. 48 : 300.

 

31 - Freitas, AA, Rocha, B & Bognacki, J. (1983). Effects of intravenous administration of antigen on lymphocyte localization and blood flow into the mouse spleen. Acta Med. Port. 4 : 147.

 

32 - Valadas Preto, R, Rocha, B, Peixoto Menezes, A, Cruz, I. & Freitas, AA. (1983). Quadro morfologico de linfoma linfocitico associado a disfunçao T reversiveis, induzido pela difenil-hidantoina. J. do Medico 2012 : 70.

 

33 - Coutinho, AA, Bandeira, A, Bjorklund, M, Forni, L, Forsgren, S, Freitas, AA, Gullberg, M, Holmberg, D, Ivars, I, Larsson, E-L, Leandersson, T, Martinez-A, C, Petersson, S & Probor, G. (1983). From the mechanisms of lymphocyte activation to the internal activity of the immune system. Ann. Immunol. (I.P.) 134 : 93.

 

34 - Rocha, B, Freitas, AA & Coutinho, AA. (1983). Population dynamics of T lymphocytes. Renewal rate and expansion in the peripheral lymphoid organs. J. Immunolgy 131 : 2158.

 

35 - Rocha, B, Haston, W & Freitas, AA. (1984). Lymphocyte migration into collagen gels: role of lymph. Scand. J. Immunol. 19 : 297.

 

36 -Rocha, B, Larsson, E-L & Freitas, AA. (1984). Effects of hydroxyurea on Con-A induced T cell proliferation. Depletion of TCGF-reactive and TCGF producing T lymphocytes. Scand. J. Immunol. 19 : 315.

 

37 -Rocha, B & Freitas, AA. (1984). Subpopulacoes de linfocitos T no murganho: turnover maturaçao extratimica e capacidade de expansao pe-riferica. J. Ciencias Medicas 7.

 

38 - Miranda, J L, Rocha, B & Freitas, AA. (1984). Lymphocyte migration into membrane filters: the role of lymph. Ann. Immunol. (I.P.), 135D : 271.

 

39 - Coutinho, AA, Holmberg ,D, Martinez-A, C, Freitas, AA, Larsson, E-L, Pereira, P & Bandeira, A (1985). Internal activity in the immune system and its physiological significance. Modern Trends in Human Leukemia. VI. In: "Haemotology and blood transfusion", v 29. Spinger Verlag, Berlin, p. 477.

 

40 - Rocha, B & Freitas, AA. (1985). O papel da linfa na migracao linfocitaria. Recirculacao mediada por efeitos quimiotacticos? J. Ciencias Medicas 149 : 627.

 

41 - Cumano, AM, Vieira, P, Colle, J-H, Truffa-Bachi, P & Freitas, AA. (1986). Effects of Hydroxyurea "in vivo" treatment on the antibody response in the mouse. Ann. Immunol. (I.P.), 137D : 33.

 

42 - Freitas, AA, Rocha, B & Coutinho, AA. (1986). Life-span of B lymphocytes: the experimental basis for conflicting results. J. Immunol. 136 : 470.

 

43 - Freitas, AA, Rocha, B & Coutinho, AA. (1986). Two major classes of mitogen reactive B lymphocytes defined by life-span. J. Immunol. 136 : 466.

 

44 - Rocha, B & Freitas, AA. (1986). The effects of lymph on lymphocyte migration"in vivo". Ann. Immunol. (I.P.), 137D : 105

 

44 - Rocha, B & Freitas, AA. (1986). The effects of lymph on lymphocyte migration"in vivo". Ann. Immunol. (I.P.), 137D : 105

 

45 - Freitas, AA & Coutinho, AA. (1986). Population Kinetics of B lymphocytes. In: "Primary immunodeficiencies", Eibl, M & Rosen, FS, (Eds), Elsevier Publ. Co., Amsterdam, p 977.

 

46 - Portnoi, D, Freitas, AA, Holmberg, D, Bandeira, A & Coutinho, A. (1986). Immunocompetent autoreactive B lymphocytes are activated cycling cells in normal mice. J. Exp. Med. 164 : 25.

 

47 - Freitas, AA, Rocha, B & Coutinho, AA. (1986). Lymphocyte population kinetics in the mouse. Immunol. Rev. 91 : 5.

 

48 - Pereira, P, Martinez-A, C, Bandeira, A, Freitas, AA & Coutinho, AA. (1986). Polyclonal B cell activation. Bull. Inst. Pasteur 84 : 207.

 

49 - Freitas, AA, Guilbert, B, Holmberg, D, Wennerstrom, G, Coutinho, AA & Avrameas, S. (1986). Analysis of autoantibodies reactivities in hybridoma collections derived from normal adult BALB/c mice. Ann. Immunol. (I.P.) 137D : 33.

 

50 - Holmberg, D, Freitas, AA, Portnoi, D, Jaquemart, F, Avrameas, S & Coutinho, AA. (1986). Antibody repertoires of normal BALB/c mice: B lymphocyte populations defined by state of activation. Immunol. Rev. 93 : 147.

 

51 - Novo, C, Fonseca, E & Freitas, AA. (1987). Altered fatty acid membrane composition modifies lymphocyte localization "in vivo". Cell. Immunol. 106 : 387.

 

52 - Levy, M, Vieira, P, Coutinho, AA & Freitas, AA. (1987). The vast majority of natural immunoglobulin secreting cells are short-lived and the progeny of cycling lymphocytes. Eur. J. Immunol. 17 : 849.

 

53 - Rocha, B, Cumano, A, Vieira, P, Colle, J-H, Truffa-Bachi, P & Freitas, AA. (1988). Effects of surgical stress in lymphoid populations of mice In "Sirono Symposia Review", Stipa, Cavallaro and Zipano, Eds., vol. 1 : 221.

 

54 - Burlen, O, Coutinho, A & Freitas, AA. (1988). Long lasting thymus independent immune responses to anti-idiotype LPS conjugates requires continuous B cell renewal. Eur. J. Immunol. 18 : 1433.

 

55 - Freitas, AA, Burlen, O & Coutinho, A. (1988). Selection of antibody repertoires by anti-idiotype can occur at multiple steps of B cell diferentiation. J. Immunology. 140 : 4097.

 

56 - Colle, J-H, Truffa-Bachi, P & Freitas, AA. (1988). Secondary antibody responses to thymus independent antigens. Decline and life-span of memory. Eur. J. Immunol. 18 : 1307.

 

57 - Diguiero, G, Lim, A, Lembezat, M.P., Kaushik, A, Andrade, L, & Freitas, AA. (1988). Comparative study of Vh gene family usage by newborn Xid and non-Xid mice, new-born NZB and adult NZB mice and by splenic and peritoneal cavity B cellcompartments. Eur. J. Immunol. 18 : 1979.

 

58 - Freitas, AA, Pereira, P, Huetz, F, Thomas-Vaslin, V, Pena-Rossi, C, Andrade, L, Sundblad, A, Forni, L, & Coutinho, A. (1989). B cell activities in normal unmanipulated mice. In "B Lymphocytes: Function and regulation" Ed. P. del Guercio & J.M. Cruse. Contr. Microbiol. Immunol. 11 : 1.

 

59 - Abraham, E, & Freitas, AA. (1989). Hemorrhage-induced alterations in immunoglobulin-secreting B cells. Crit. Care Med. 17 : 1015.

 

60 - Rocha, B, Lembezat, M.P., Freitas, AA & Bandeira, A. (1989). IL-2 receptor expression and IL-2 production in exponentially growing T cells: Major differences between "in vivo" and "in vitro" proliferating T lymphocytes. Eur. J. Immunol. 19 : 1137.

 

61 - Thomas-Vaslin, V & Freitas, AA. (1989). Lymphocyte population kinetics during the development of the immune system. B cell persistence and life-span can be determined by the host environment. Int. Immunol. 1 : 237.

 

62 - Abraham, E & Freitas, AA. (1989). Hemorrage produces abnormalities in lymphocyte function and lymphokine generation. J. Immunol. 142 :899.

 

63 - Abraham, E, Freitas, AA, & Coutinho, A. (1989). Hemorrage in mice produces alterations in B cell repertoires. Cell. Immunol. 122 : 208.

 

64 - Freitas, AA, Lembezat, M-P, & Coutinho, A. (1989). Expression of antibody V regions is genetically and developmentally controled and modulated by the lymphocyte environment. Int. Immunol. l : 342.

 

65 - Freitas, AA, Lembezat,M-P., & Rocha, B. (1989). Selection of antibody repertoires. Transfer of mature lymphocytes modifies VH gene family usage in the actual and available B cell repertoires of athymic mice. Int. Immunol. l: 398.

 

66 - Andrade, L, Freitas, AA, Huetz, F & Coutinho, A. (1989). Immunoglobulin VH-gene expression in Ly1+ and conventional B cells. Eur. J. Immunol. 19 : 1117.

 

67 - Poncet, P, Reininger, L, Freitas, AA, Holmberg, D, Dighiero, G & Coutinho, A. (1989). Expression of VH11 genes family in hybridoma collections from peritoneum and spleen: differential correlation with BrMRBC reactivity. Res. Immunol. 140 : 255.

 

68 - Holmberg, D & Freitas, AA. (1990). Establishment of V-gene repertoires in normal mice in "Molecular aspects of autoimmunity" Eds. N. Farid & C. Bona, p. 125, Academic Press, New York.

 

69 - Freitas, AA, Andrade, L, Lembezat, M-P, & Coutinho, A. (1990). Selection of VH gene repertoires: Differentiating B cells of adult bone marrow mimic fetal development. Int. Immunol. 2 : 15.

 

70 - Coutinho, A, Bandeira, A, Pereira, P, Portnoi, D, Holmberg, D, Martinez, C. & Freitas, AA. (1990). Selection of antibody repertoires: the limits of clonal versus network organization. In "Cold Spring Harbor Symposium on Quantitative Biology" vol. 54, C.S.H.L. p. 159.

 

71 - Thomas-Vaslin, V & Freitas, AA. (1990). Population kinetics of peritoneal LPS-reactive B lymphocytes. Int. Immunol. 2 : 73.

 

72 - Mota-Santos, T, Masmoudi, H, Voegtle, D, Freitas, AA, Coutinho, A & Cazenave, P-A. (1990). Divergency in the specificity of the induction and maintenance of neonatal supression. Eur. J. Immunol 20 : 1717.

 

73 - Abraham, E, Freitas, AA & Coutinho, A. (1990). Purification and characterization of intraparenchymal lung lymphocytes. J. Immunol. 144 : 2117.

 

74 - Abraham, E, Andrade, L & Freitas, AA. (1990). Immunoglobulin VH-gene expression following hemorrage. Mol. Immunol. 27 : 921.

 

75 - Freitas, AA & Sidman, C. (1990). VH-gene families repertoires of "viable motheaten" (mev) mice. Eur. J. Immunol. 20 : 1033.

 

76 - Abraham, E, Freitas, AA, Jagels, M & Chang, Y-H. (1990). T and CD8+ cells from hemorrhaged mice produce alterations in B cell repertoires. Immunobiology 181 : 379.

 

77 - Rocha, B, Penit, C, Baron, C, Vasseur, F, Dautigny, N & Freitas, AA. (1990). Accumulation of BrdU labelled cells in central and peripheral lymphoid organs: minimal estimates of lymphocyte prodution and demonstration of high turnover rates for mature lymphocytes. Eur. J. Immunol. 20 : 1697.

 

78 - Bos, NA, Pleasants, JR, Wostman, BS, Freitas, AA & Benner, R. (1990). Renewal rate of B cells in germ-free Balb/c fed a chemically defined diet. Microecology and Therapy (Proc. Int. Symposium on Gnotobiology) 20 : 191-196.

 

79 - Nardi, N, Freitas, AA & Coutinho, A. (1990). Frequency of anti-F protein B cells in normal, immunized and tolerant mice. Res. Immunol. 141 : 711.

 

80 - Grandien, A, Coutinho, A, Andersson, J & Freitas, AA. (1991). Endogenous VH-gene family expression in immunoglobulin-transgenic mice: Evidence for selection of antibody repertoires. Int. Immunol. 3 : 67.

 

81 - Freitas, AA, Viale, A-C, Sundblad, A, Heusser, C & Coutinho, A. (1991). Normal serum immunoglobulinsparticipate in the selection of peripheral B-cell repertoires. Proc. Nat. Acad. Sci. (USA) 88 : 2640.

 

82 - Sundblad, A, Marcos, MAR, Huetz, F, Freitas, AA, Heusser, C, Portnoi, D & Coutinho, A. (1991). Normal serum immunoglobulins influence the numbers of bone marrow B and pre-B cells. Eur. J. Immunol. 21 : 1155.

 

83 - Thomas-Vaslin, V, Andrade, L, Freitas, AA & Coutinho, A. (1991). Clonal persistence of B lymphocytes in normal mice is determined by V-region dependent selection. Eur. J. Immunol. 21 : 2239.

 

84 - d'Imperio Lima, MR, Bandeira, A, Falanga, P, Freitas, AA, Kipnis, T, Pereira da Silva, L & Coutinho, A. (1991). Clonal analysis of lymphocyte responses in experimental malaria. I. Quantitation of B cell responses to P. Chabaudi infection of normal and immunoprotected animals. Int. Immunol. 3 : 1207.

 

85 - Grandien, A, Coutinho, A, Viale, A-C, Freitas, AA, Andersson, J. & Marcos, M. (1992). On the origin of natural IgM in Ig-transgenic mice. Int. Immunol. 4 : 1153.

 

86 - Coutinho, A, Freitas, AA, Holmberg, D & Grandien, A. (1992). Expression and selection of murine antibody repertoires. Int. Rev. Immunol. 8 : 173.

 

87 - Viale, A-C, Coutinho, A & Freitas, AA. (1992). Differential expression of VH-gene families in peripheral B-cell repertoires of newborn or adult IgH congenic mice. J. Exp. Med. 175 : 1449.

 

88 - Nagata,T, Freitas, AA & Coutinho, A. (1992). VH-gene family repertoires in expressed and rearrenged VDJH gene amplified from murine spleen cells by PcR. Bul. Nippon Vet. Anim. Sci. Univ. 41 : 47.

 

89 - Haury, M., Freitas, AA, Hermitte,V, Coutinho, A & Hibner, U. (1993) The physiology of bcl-2 expression in murine B lymphocytes. Oncogene 8 : 1257.

 

90 - Freitas, AA & Rocha, BB. (1993). Lymphocyte life-spans. Homeostasis, selection and competition. Immunology Today 14 : 25.

 

91 Viale, A-C, Coutinho, A, Heyman, R & Freitas, AA. (1993). V-region dependent selection of persistent resting peripheral B cells in normal mice. Int. Immunology 5 : 599.

 

92 - Leijon, K, Freitas, AA & Holmberg, D. (1993). Analysis of VH gene utilization in the non-obese diabetic mouse. Autoimmunity 15 : 11.

 

93 - Freitas, AA & Rocha, B. (1994) Lymphocyte population kinetics. A cellular competition model. In "Autoimmunity. Physiology and disease." A. Coutinho & M. Kazatchkine (Eds.). John Wiley-Liss, New York p. 143-160.

 

94 - Chies, JB., Viale, A-C, Huetz, F, Weksler, M, Freitas, AA & Coutinho, A. (1994). VH-gene family dominance in aging mice. Scand. J. Immunol. 39 : 184.

 

95 - Viale, A-C, Freitas, AA & Coutinho, A. (1994). Regulation of VH-gene expression is a lineage specific developmental marker. Eur. J. Immunol. 24 : 1353.

 

96 - Grandien, A, Modigliani, Y, Freitas, AA, Anderson, J & Coutinho, A. (1994). Positive and negative selection of antibody repertoires along B cell differentiation. Immunol. Rev. 137 : 53,.

 

97 - Sundblad, A, Marcos, M-A., Malenchere, E, Castro, A, Haury, M, Huetz, F, Nobrega, A, Freitas, A & Coutinho, A. (1994). Observations on the mode of action of normal immunglobulin at high doses. Immunol. Rev. 139 : 125.

 

98 - Chies, JB, Lembezat, M-P & Freitas, AA. (1994). Entry of B lymphocytes into the persistent cell pool in non-immunised mice is not accompanied by somatic mutation of VH-genes. Eur. J. Immunol. 24 : 1657.

 

99 - Rocha, B, Grandien, A & Freitas, AA. (1995). Anergy and exhaustion are independent mechanisms of peripheral T cell tolerance. J. Exp. Med. 181 : 993.

 

100 - Freitas, AA, Rosado, MM., Viale, A-C & Grandien, A. (1995). The role of cellular competition in B cell survival and selection of B cell repertoires. Eur. J. Immunol. 25 : 1729.

 

101 - Chies, J.A, Marodon, G, Joret, A-M, Regnault, A, Lembezat, M-P, Rocha, B & Freitas, AA. (1995). Persistence of Vb6+ T cells in Mls-1a mice: a role for the third complementary determining region (CDR3) of the TcR b chain in superantigen recognition. J. Immunol. 155 : 4171.

 

102 - Freitas, AA. (1995). Lymphocytes in a model ecosystem. Res. Immunol. 146 : 225.

 

103 - Jungman, P, Freitas, A, Bandeira, A, Minoprio, P & Coutinho, A. (1996). Murine acariasis. II. Immunological disfunction and evidence for chronic activation of Th-2 lymphocytes. Scand. J. Immunol. 43 : 604.

 

104 - Freitas, AA, Agenes, F & Coutinho, GC. (1996). Cellular competition modulates the survival and selection of CD8+ T cells. Eur. J. Immunol. 26 : 2640.

 

105 - Tanchot, C, Lemonnier, FA, Perarnau, B, Freitas, AA & Rocha, B. (1997) Differential requirements for survival and expansion of CD8 naive or memory T cells. Science. 276 : 2057, see Comment in Science, 276:2000 .

 

106 - McLean, A, Rosado, M, Agenes, F, Vasconcelos, R & Freitas, AA. (1997) Resource competition as a mechanism for B cell homeostasis. Proc. Nat. Acad. Sci. (USA) 94 : 5792, see Comment in Science, 276:1817.

 

107 - Agenes, F, Rosado, MM & Freitas, AA. (1997) Independent homeostatic regulation of B cell compartments. Eur.J.Immunol. 27 : 1801 .

 

108 - Tanchot, C, Rosado, MM, Agenes, F, Freitas, AA & Rocha, B. (1997) Lymphocyte homeostasis. Sem. Immunol. 9 : 331-337 .

 

109 - Freitas, AA & Rocha, B. (1997) Lymphocyte survival: a Red Queen Hypothesis? (perspective) Science 277 : 1950 .

 

110 - Rosado, MM & Freitas, AA. (1998) The role of B Cell Receptor V region in peripheral B cell survival. Eur. J. Immunol. 28 : 2685-2693.

 

111 - Agenes, F & Freitas, AA. (1999) Transfer of small resting B cells into immunodeficient hosts results in the selection of a self-renewing activated B cell population. J. Exp. Med. 189 : 319-329.

 

112 - Freitas, AA. (1999) Populationsbiologie der B-Lymphozyten. Aspekte 11 : 20-28.

 

113 - Freitas, AA. & Rocha, B. (1999) Peripheral T cell survival. Curr. Opin. Immunol. 11 : 152-156.

 

114 - Freitas, AA. & Rocha, B. (2000) Population biology of lymphocytes : the flight for survival. Ann. Rev. Immunol. 18 : 83-111.

 

115 - Freitas, AA. & Rocha, B. (2000) Physiologie du système immunitaire : homéostasie des populations lymphocytaires (communiqué par J.-C. Weil).In : Physiologie animale et humaines. Académie des Sciences, Tec & Doc. (eds), Paris p. 109-112.

 

116 - Agenes, F, Rosado, MM & Freitas, AA. (2000) Peripheral B cell survival. Cell. & Mol. Life Sciences 57 : 1220-1228.

 

117 - Rosado, MM & Freitas, AA. (2000) B cell positive selection by self antigens and counter-selection of dual B cell receptor cells in the peripheral B cell pool. Eur. J. Immunol. 30 : 2181-2190.

 

118 - Agenes, F, Rosado, MM & Freitas, AA. (2000) Considerations on B cell homeostasis. Curr. Top. Microbiol. Immunol. 252 : 68-75.

 

119 - Li, F, Jin, F, Freitas, AA, Szabo, P & Weksler, M. (2001) Impaired regeneration of the peripheral B cell repertoire from bone marrow following lymphopenia in old mice. Eur. J. Immunol. 31 : 500-505.

 

120 - De Boer, R, Freitas, AA & Perelson, A. (2001) Resource competition determines selection of B cell repertoires. J. Theor. Biol. 212 : 333-343.

 

121 - Almeida, ARM, Borghans, JAM & Freitas, AA. (2001) T cell homeostasis: Thymus regeneration and peripheral T cell restoration in mice with a reduced fraction of competent precursors. J. Exp. Med. 194 : 591-599.

 

122 - Legrand, N & Freitas, AA. (2001) CD8+ T lymphocytes in double ab TCR transgenic mice. I. TCR expression and thymus selection in the absence or in the presence of self-antigen. J. Immunol. 167 : 6150-6157.

 

123 - Legrand, N & Freitas, AA. (2001) CD8+ T lymphocytes in double ab TCR transgenic mice. II. Competitive fitness of dual ab TCR CD8+ T lymphocytes in the peripheral pools. J. Immunol. 167 : 6158-6164.

 

124 - De Boer, RJ, Freitas, AA & Perelson, AS. (2001) Resource competition determines selection of B cell repertoires. J. Theor. Biol. 212 : 333-343.

 

125 - Freitas, A & Chen J. (2002) Introduction: regulation of lymphocyte homeostasis. Microbes & Infec. 4 : 529-530.

 

126 - Almeida, ARM, Legrand, N, Papiernick, M & Freitas, AA. (2002) Homeostasis of peripheral CD4+ T cells: IL-2Ra and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers. J. Immunol. 169 : 4850-4860.

 

127 - Gaudin, E, Hao, Y, Rosado, MM, Chaby, R, Girard, R & Freitas, AA. (2004) Positive selection of B cells expressing low densities of self-reactive BCRs. J. Exp. Med. 199 : 843-853.

 

128  - Schlecht, G, Garcia, S, Escriou, N, Freitas, AA, Leclerc C & Dadaglio, G. (2004) Murine plasmacytoid dendritic cells Cs induce effector/memory CD8+ T cells responses in vivo after viral stimulation. Blood 104 : 1808-1815.

 

129 - Sanchez-Guajardo, V, Borghans, JAM, Marquez, M-E, Garcia, S & Freitas, AA. (2005) Different competitive capacities of Stat4- and Stat6-deficient CD4+ T cells during lymphopenia-driven proliferation. J. Immunol. 174 : 1178-1187.

 

130 -  De La Coste, A, Six, E, Fazilleau, N, Mascarell L, Legrand, N, Mailhe, M-P, Cumano, A, Laabi, Y & Freitas, AA. (2005) In vivo and in absence of a thymus the enforced expression of the Notch ligands Delta-1 or Delta-4 promotes T cell development with specific unique effects. J. Immunol. 174 : 2730-2737

 

131 - Almeida, ARM, Rocha, B, Freitas, AA & Tanchot, C. (2005) Homeostasis of T cell numbers : from thymus production to peripheral compartmentalization and the indexation of regulatory T cells. Sem. Immunol. 17 : 239-249

 

132 - Ghiringhelli, F, Ménard, C, Terme M, Flament, C, Taieb, J, Chaput, N, Puig, PE, Novault, S, Escudier, B, Vivier, E, Lecesne, A, Robert, C, Blay, J-Y, Caillat-Zucman, S, Freitas, A, Tursz, T, Wagner-Ballon, O, Capron, C, Vainchencker, W, Martin, F & Zitvogel, L. (2005) CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-b-dependent manner. J. Exp. Med. 202 : 1075-1085

 

133 - Marquez M-E, Ellmeier W, Sanchez-Guajardo V, Freitas AA, Acuto O & Di Bartolo V. (2005) T cell sensory adaptation dependent on TCR avidity for self-antigens. J. Immunol. 175 : 7388-7397.

 

134 - Wildin, RS & Freitas, A. (2005) IPEX and Foxp3 : clinical and research perspectives. J. Autoimmunity 25 : 56-62.

 

135 - De la Coste, A & Freitas, AA. (2006) Notch signaling : distinct ligands induce specific signals during lymphocyte development and maturation. Immunol letters 102 : 1-9.

 

136 - Almeida ARM, Zaragoza B & Freitas AA. (2006) Indexation as a novel mechanism of lymphocyte homeostasis: the number of CD4+CD25+ regulatory T cells is indexed to the number of IL-2 producing cells. J. Immunol. 177 : 192-200.

 

137 - Hao Y, Legrand L & Freitas AA. (2006) The clone size of peripheral CD8 T cells is regulated by TCR promiscuity. J. Exp. Med. 203 : 1643-1649.

 

138 - Almeida, ARM, Zaragoza, B & Freitas AA. (2006) Competition controls the rate of transition between the peripheral pools of CD4+CD25- and CD4+CD25+ T cells. Int. Immunol 18 : 1607-1613.

 

139 - Sanchez-Guajardo, V, Tanchot, C, O’Malley, JT, Kaplan, MH, Garcia, S & Freitas, AA. (2007) Agonist-driven development of CD4+CD25+Foxp3+ regulatory T cells requires a second signal mediated by Stat6. J. Immunol. 178 : 7550-7556

 

140 - Lampropoulou, V, Hoehlig, K, Roch, T, Neves, P, Calderon Gomez, E, Sweenie, CH, Hao, Y, Freitas, AA, Steinhoff, U, Anderton, SM & Fillatreau, S. (2008) TLR- activated B cells suppress T cell-mediated autoimmunity. J. Immunol. 180 : 4763-4773.

 

141 - Thiriot, A, Freitas, AA & Rueff-Juy D. (2008) Peritoneal B-cell subsets in the genus Mus : their role in innate immunity. Crit Rev Immunol. 28 : 341-361.

 

142 - Thiriot A, Drapier A-M, Mémet S, Fitting C, Sturny-Leclere A, Cavaillon J-M, Cazenave P-A, Freitas AA. & Rueff-Juy D. (2009) Wild-derived mouse strains, a valuable model to study B cell responses. Mol. Immunol. 46 : 601-612.

 

143 - Freitas, AA & Rocha, B. (2009) Homeostasis of naive T cells : the Foxo that fixes. Nature Immunol. 10 : 133-144.

 

144 - Leitao, C, Freitas, AA & Garcia, S. (2009) The role of TCR specificity and clonal competition during reconstruction of the peripheral T cell pool. J Immunol. 182 : 5232-5239.

 

145 - de Freitas AA. (2009) Tractus Immuno-Logicus. A brief History of the Immune System Eds Landes Bioscience

 

146 - Freitas, AA. & Garcia, S. (2010) Endogenous TCR recombination in TCR Tg single Rag-deficient mice uncovered by robust in vivo T cell activation and selection. PLoS ONE 5 : e10238.

 

147 - Lalanne, AI, Moraga, I, Hao, Y, Pereira, JP, Alves, NL, Huntington, ND, Freitas, AA, Cumano, A & Vieira, P. (2010) CpG inhibits Pro-B cell expansion through a cathepsin B-dependent mechanism. J. Immunol. 184 : 5678-5685.

 

148 - Zaragoza, B., Evaristo, C., Kissenpfennig, A., Libri, V., Malissen, B., Rocha, B., Freitas, A.A. & Almeida, A.R.M. (2011) Cell-to-cell interactions and signals involved in the reconstitution of peripheral CD8+ TCM and TEM cell pools. PLoS ONE 6 : e17423

 

149 - Almeida, A.R.M., Amado, I.F., Reynolds, J., Berges, J., Lythe, G., Molina-Paris, C. & Freitas, A.A. (2012) Quorum-sensing in CD4+ T cell homeostasis : a hypothesis and a model. Frontiers in Immunol. 3, article 125 : 1-15

 

150 - Garcia, S. &. Freitas A.A. (2012) Humanized mice : current states and perspectives. Immunol. Letters 146 : 1-7

 

151 - Montaudouin, C., Anson, M., Hao, Y., Duncker, S.V., Fernandez, T., Gaudin, E., Ehrenstein, M., Kerr, W.G., Colle, J.-H., Bruhns, P., Daëron, M. & Freitas, A.A. (2013) Quorum sensing contributes to activated IgM-secreting B cell homeostasis. J. Immunol. 190 : 106-114

 

152 - Pierson, W., Cauwe, B., Policheni, A., Schlenner, S.M., Franckaert, D., Berges, J., Humblet-Baron, S., Schönefeldt, S., Herold, M.J., Hildeman, D., Strasser, A., Bouillet, P., Lu, L.-F., Matthys, P., Freitas, A.A., Luther, R.J., Weaver, C.J., Dooley, J., Gray, D.H.D. & Liston, A. (2013) Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3+ regulatory T cells. Nature Immunol. 14 : 959-966

 

153 - Guy-Grand, D., Vassalli, P., Eberl, G., Pereira, P., Burlen-Defranoux, O., Lemaitre, F., Di Santo, J. P., Freitas, A.A., Cumano, A. & Bandeira, (2013) A. Origin, trafficking, and intraepithelial fate of gut-tropic T-cells. J. Exp. Med. 210 : 1839-1854

 

154 - Amado, I.F., Berges, J., Luther, R.J., Mailhé, M.-P., Garcia, S., Bandeira, A., Weaver, C., Liston, A. & Freitas, A.A. (2013) IL-2 coordinates IL-2-producing and regulatory T cell interplay. J. Exp. Med. 210 : 2707-2720

 

155 - Reynolds, J., Amado, I.F., Freitas, A.A., Lythe, G. & Molina-Paris, C. (2014) A mathematical perspective on CD4+ T cell quorum-sensing. J. Theor. Biol. 347 : 160-175

 

156 – Serra-Hassoun, M., Bourgine, M., Boniotto, M., Berges, J., Langa, F., Michel, M.-L., Freitas, A.A. & Garcia, S. (2014) Human hematopoietic reconstitution and HLA-restricted responses in nonpermissive alymphoid mice. J. Immunol. 193 : 1504-1511

 

157 - Marcais, A., Blevins, R., Gaumann, J., Feytout, A., Dharmalingam, G., Carroll, T., Amado, I.F., Bruno, L., Lee, K., Walzer, T., Mann, M., Freitas, A.A., Boothby, M., Fisher, A.G. & Merkenschlager, M. (2014) MicroRNA-mediated regulation of mTOR complex components facilitates discrimination between activation and anergy in CD4 T cells. J. Exp. Med. 211 : 2281-2295

 

 

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Mozambique

Mis à jour le 09/12/2014

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Actualités

Publication d'un livre  "Tractus Immuno-Logicus : a brief history of the Immune System" par Pr Antonio Freitas (eds. Landes Bioscience)

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Biologie des Populations Lymphocytaires
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