Dynamique structurale des macromolécules

Marc DELARUE

 

We use biophysical experimental techniques such as crystallography and SAXS to visualize at the atomic level the structure of molecules essential to life such as DNA polymerases involved in DNA Repair and Cancer and ion channels involved in the transmission of the electric nervous signal.
We complement them with molecular and normal modes dynamics, so as to go beyond the essentially static pictures given by these methods.
We also try to better understand the electrostatics of macromolecules and their interaction with the solvent, in order to be able to predict their binding properties.
Our main goal is to design structure-inspired drugs (pharmacology) and re-design active site(s) to make them accept other substrates (synthetic biology).

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Rapport d'activité

 

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Mis à jour le 26/01/2015

Contact

Structural Dynamics of Macromolecules
CNRS UMR 3528
Marc Delarue
E-mail: marc.delarue@pasteur.fr
Tel: +33 (0) 1 45 68 86 05

Secretary
Marie-Claire Rozier
 +33 (0) 1 45 68 39 45

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