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Andrew Griffiths, membre externe, laboratoire de biochimie, École supérieure de physique et de chimie industrielles de la Ville de Paris.
Andrew Griffiths, born in 1964 in Hathersage, U.K., is Professor of Biochemistry at the ESPCI ParisTech, Paris since September 2012. In 2013, he co-founded HiFiBiO, a start-up company developing high-throughput solutions based on single cell technologies for drug discovery.
Andrew Griffiths received a B.Sc. in Biochemistry (First Class) from the University of Sheffield in 1985 and a Ph.D. from the University of Leicester in 1988. He then joined Greg Winter at the MRC Laboratory of Molecular Biology (LMB), Cambridge. There he started developing phage-display
for the selection of human antibodies for therapy, first as a Post Doc. (1989-1990) and later as a Cancer Research Campaign Fellow (1991-1995). This led to the creation of the Cambridge Antibody Technology and Domantis and to the drugs Humira® and Benlysta®.
From 1995 to 2005, while working as a Senior Scientist at the LMB, with Dr. Dan Tawfik, Andrew Griffiths developed a novel system for high-throughput screening and directed evolution based on in vitro compartmentalisation (IVC) of reactions in aqueous microdroplets in water-in-oil emulsions.
In 2004, based on the intellectual property (IP) associated with this work, he co-founded RainDance Technologies, who market droplet-based microfluidic systems for targeted resequencing and digital PCR. He holds an ERC Advanced Grant and is also coordinator and deputy coordinator, respectively, of two Investissement d’Avenir projects: DigiDiag and Medalis.
HONORS AND AWARDS
In October 2005, he received a Chaire d’Excellence from the French Research Ministry, which enabled him to move his team to the Institut de Science et d’Ingénierie Supramoléculaires (ISIS) in Strasbourg. There he developed droplet-based microfluidic systems for directed evolution of enzymes,
high-throughput screening for drug discovery and diagnostic applications.
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