Experimental evolution of arboviruses during natural transmission: identifying evolutionary trajectories and predicting emergence events

A postdoctoral position, funded by the Laboratory of Excellence  Integrative Biology of Emerging Infectious Diseases LabEx IBEID, is available in the "Viral Populations and Pathogenesis" research unit directed by Marco Vignuzzi at the Institut Pasteur in Paris.


Experimental evolution of arboviruses during natural transmission: identifying evolutionary trajectories and predicting emergence events

Arboviruses (arthropod borne) make up a large list of clinically relevant human pathogens that obligately cycle between invertebrate (e.g., mosquitoes, ticks) and vertebrate hosts (e.g., birds, mammals). 
The virus must thus overcome a variety of physical and genetic barriers that both constrain and shape its evolution. The emergence of new  adaptations that extend the virus' host range can lead to new epidemics, as was witness during the Indian Ocean islands outbreak of chikungunya virus in 2005/06. We have developed an approach coupling in vivo experimental evolution with deep sequence viral population analysis that has permitted us to identify these adaptive emergence events during a single replication cycle in vivo. The proposed work will mechanistically characterize new adaptive mutations identified in chikungunya virus, and experimentally identify similar adaptive events in other arboviruses.


Candidate requirements:

PhD in virology.

 

To apply: 

Applicants should send their CV, a motivation letter and 3 references to Marco Vignuzzi  Unité des Populations virales et Pathogenèse, Institut Pasteur, 28 rue du Dr Roux 75015 Paris

Mis à jour le 06/12/2013

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