Human population genomics and genetic epidemiology

This two-week course presents theoretical lectures, research examples and hands-on computer training on concepts and tools used in the study of human population genomics and genetic epidemiology.

 

The first week consists in three days of both theoretical lectures and research examples, and two days of hands-on-computer training and discussions presenting the concepts and the technical tools used in both human population genomics and genetic epidemiology.

 

Topics include :

 

  • Introductory concepts in human genomics and populations genetics.
  • Basic concepts in statistical genetics and genomics.
  • Introduction to genetic epidemiology.
  • Population genetics: mutation, recombination and linkage disequilibrium.
  • Public databases in human genomics (HapMap, 1,000 Genomes).
  • Genetic epidemiology (linkage analyses and association studies).
  • Methods to detect natural selection in the human genome.
  • Research examples.
  • Lectures from keynote speakers in genetic epidemiology and population genetics.

 

The second week consists in two days of detailed theoretical bases in population genomics and genetic epidemiology analyses and three days of practical computer-based training in the most recent concepts and analyses used in both disciplines. The practical training (computer laboratory work and discussion of the results) is based on real-data examples, using as a paradigm infectious diseases.

 

Topics include :

 

  • Quantitative genetics and expression quantitative trait loci (eQTL) analysis.
  • Analysis of rare variants and population structure.
  • Next Generation Data – design and analysis.
  • Genome-wide association analyses (GWAS) – exomes – whole genome sequencing – transcriptomics - RNA seq.
  • Computer laboratory work in genetic epidemiology.
  • Computer laboratory work in population genetics.
  • Lectures from keynote speakers.

 

 

Program of the course Human population genomics and genetic epidemiology 2013-2014 (PDF)

 

 

Candidates must have basic knowledge in molecular genetics, statistics and informatics.

The committee of the course will evaluate applications.

 

Members of the course committee :

 

E. Coeffier (Institut Pasteur),

S. Garnier (Université Pierre et Marie Curie),

L. Quintana-Murci (Institut Pasteur),

C. Alcaide (Université Paris-Diderot),

C. Parsot (Institut Pasteur),

S. Lyonnet (Université Paris-Descartes),

A. Alcais (INSERM-Necker).

 

Informations pratiques

 

Title of the course Human population genomics and genetics epidemiology
Directors

Lluis Quintana-Murci

Human Evolutionary Genetics Unit

Institut Pasteur

 

Alexandre Alcais

Human Genetics of Infectious Diseases

INSERM U. 980

Necker Medical School

Language    English
Participants  30
Duration two weeks
Dates     September 29 to October 10, 2014
Applications up to  June 15, 2014
Diplomas

Diplôme de l'Institut Pasteur

 

ECTS Master 2 students registered in partner universities

 

The course can be validated as a " module d'école,doctorale " for students registered at partner universities

Contact 

enseignement@pasteur.fr

Application

On line registration

 

Registration fees

 

Mis à jour le 03/11/2014

Chiffres clés

5_1_chiffres_courspasteur.png