This two-week course is intended for medical doctors, veterinarians, pharmacists and research scientists wishing to acquire an up to date knowledge on tuberculosis and in the practice of molecular methods for diagnosis, drug susceptibility testing and epidemiology.
This full-time course is composed of lectures given by international scientists and a practical training workshop. The language for lectures and the practical training is English. For people who might need it, help in French will be provided during the practical training.
Lectures will cover the global epidemiology of tuberculosis (TB); molecular epidemiology and evolution of Mycobacterium tuberculosis strains; host-pathogen interactions; immune responses during tuberculosis infection and disease; HIV co-infection; mechanisms of antibiotic resistance, multidrug-resistance (MDR), and extensive drug resistance (XDR); concepts and applications of rapid diagnosis and drug susceptibility tests (DST) in different settings; evaluation of the different methods using predictive values according to TB prevalence; anti-TB treatments including MDR-TB and XDR-TB; diagnosis of TB infection; BCG vaccination, and new vaccine candidates.
The practical workshop will provide training for the different commercial tests for rapid diagnosis and DST using nucleic acid-based technologies: GenoType® MTBDR plus and MTBDR sl assay (HAIN Lifescience GmbH, Germany), and the GeneXpert tests (Cepheid, Sunnyvale, CA, USA). Antibiotic gene targets will be sequenced to identify antibiotic resistances (sequencing platforms and free softwares for DNA sequences analysis will be used). Several molecular epidemiology techniques will be compared: spoligotyping, MIRU/VNTR typing, and single nucleotide polymorphisms (SNPs) genotyping. We will work with bacterial inactivated cultures but also directly with inactivated clinical samples, without previous culturing.
The preliminary program of the course can be downloaded to get detailed information on the general frame of the course.
The committee of the course will evaluate applications.
Members of the Teaching Committee :
R.Brosch (Institut Pasteur),
E. Coeffier (Institut Pasteur),
S. Eyangoh (Yaounde Cameroon),
A. Fontanet (Institut Pasteur),
B. Gicquel (Institut Pasteur),
J.-L. Herrmann (Hôpital Saint-Louis, Paris),
C. Pierre-Audigier (Institut Pasteur),
A. Trebucq (UICTMR Paris),
C. Parsot (Institut Pasteur).
|Title of the course||Tuberculosis|
Mycobacterial genetics unit & National reference centre for mycoses and antifungal agents
|Head of studies||Sara Eyangoh
|Dates||June16th to June 27th, 2014|
|Closing date for application||February 15th, 2014|
Institut Pasteur Diploma
ECTS for students registered in the Mastere in Public health from the Pasteur/ Cnam school of public health (Pasteur-Cnam).