Pasteur course: Tuberculosis



This two-week course is intended for medical doctors, veterinarians, pharmacists and research scientists wishing to acquire an up to date knowledge on tuberculosis and the practice of molecular methods for diagnosis, drug susceptibility testing and epidemiology.


This full-time course is composed of lectures by international scientists and a practical training workshop. The language for lectures and the practical training is English. For people who might need it, help for French or Spanish speakers will be provided during the practical training.


 Lectures will cover the global epidemiology of tuberculosis (TB); molecular epidemiology and  evolution of Mycobacterium tuberculosis strains; immune responses during tuberculosis infection and disease;  the human genetics of susceptibility; HIV co-infection; pediatric TB; mechanisms of antibiotic resistance, multidrug-resistance (MDR), and extensive drug resistance (XDR); concepts and applications of rapid diagnosis and drug susceptibility tests (DST) in different settings; evaluation of the different methods using predictive values according to TB prevalence; anti-TB treatments including MDR-TB and XDR-TB; diagnosis of TB infection; whole genome sequencing; non-tuberculosis mycobacteria and new vaccine candidates.


 The practical workshop will provide training for the different commercial tests approved for rapid diagnosis and DST using nucleic acid-based technologies: GenoType® MTBDR plus and MTBDR sl assay (HAIN Lifescience GmbH, Germany), and the GeneXpert tests (Cepheid, Sunnyvale, CA, USA). Antibiotic gene targets will be sequenced to identify antibiotic resistances (sequencing platforms and free softwares for DNA sequences analysis will be used), with an introduction to analysis of whole genome sequences. Several molecular epidemiology techniques will be compared: spoligotyping, MIRU/VNTR typing, and single nucleotide polymorphisms (SNPs) genotyping. We will work with bacterial inactivated cultures but also directly with inactivated clinical samples, without previous culturing.



L. Abel

D. Alland

A. Borderia

P. Butcher

C. Chica

R. Brosch

C. Delancourt

S. Dorman 

S. Gagneux

B. Gicquel

P. Glaziou

J-L. Herrmann

V. Joly

D. Van Soolingen

I. Soudiram

S. Stenger

P. Supply

A. Trebucq

N. Veziris

A. Witney

Y. Zhang


Flyer annoucing the 2016 course

Download the program of the Tuberculosis course  - 2015-2016 Academic year


The committee of the course will evaluate applications.


Members of the Course Committee :


E. Coeffier (Institut Pasteur),

A. Fontanet (Institut Pasteur),

B. Gicquel (Institut Pasteur),

J.-L. Herrmann (Hôpital Saint-Louis, Paris),

C. Pierre-Audigier (Institut Pasteur),

V. Ponticelli (Institut Pasteur)

M. Sala (Institut Pasteur),

H. Takiff (Institut Pasteur),

A. Trebucq (UICTMR Paris),

H. Waxin (Institut Pasteur).



Practical information


Title of the course Tuberculosis

Howard Takiff

Mycobacterial Genetics unit

Institut Pasteur

Honorary Director

Brigitte Gicquel

Mycobacterial Genetics unit

Institut Pasteur

Head of studies

Catherine Pierre-Audigier

Mycobacterial Genetics unit

Institut Pasteur

Organizing committee

Brigitte Gicquel

Catherine Pierre-Audigier

Arnaud Trébucq

Arnaud Fontanet

Howard Takiff

Language English
Participants 20
Duration 2 weeks

June 12-23, 2017

Closing date for application February 16, 2017

Institut Pasteur Diploma


ECTS for students registered in the Mastere in Public health from the Pasteur/ Cnam school of public health (Pasteur-Cnam).



On line registration


Registration fees


Registration fees

Mis à jour le 30/09/2016