Comparative genomic and phylogeographic analysis of two epidemic and multidrug resistant bacterial populations: Shigella dysenteriae type 1 (Shiga's bacillus) and Salmonella Kentucky ST198

A postdoctoral position, funded by the Laboratory of Excellence Integrative Biology of Emerging Infectious Diseases (LabEx IBEID:  http://www.pasteur.fr/labex/ibeid), is available in the "Enteric Bacterial Pathogens" research unit directed by François-Xavier Weill at the Institut Pasteur in Paris.

 

Comparative genomic and phylogeographic analysis of two epidemic and multidrug resistant bacterial populations: Shigella dysenteriae type 1 (Shiga's bacillus) and Salmonella Kentucky ST198


The Laboratory of Excellence Integrative Biology of Emerging Infectious Diseases (LabEx IBEID) at Institut Pasteur seeks a Postdoctoral Scholar to perform comparative genomics on two epidemic and multidrug resistant bacterial populations: Shigella dysenteriae type 1 (Shiga's bacillus) and Salmonella Kentucky ST198 from global collections (1915 to 2013).

The successful candidate will work under the supervision of Dr. François-Xavier Weill (http://www.pasteur.fr/ip/easysite/pasteur/en/research/labex/integrative-biology-of-emerginginfectious- diseases--ibeid-/principal-investigators/weill) and in collaboration with S. Le Hello, Institut Pasteur, S. Brisse, Institut Pasteur, K. Holt, University of Melbourne and N. Thomson, Wellcome Trust Sanger Institute.

The "Unité des Bactéries Pathogènes Entériques » (BPE Unit) is a Unit with both Research and Public Health activities. The research of the BPE Unit focuses on the biodiversity of enteric bacterial pathogens (population structures of Salmonella, Shiga toxin-producing E. coli, Shigella, and Vibrio, dynamics of particular populations, including those resistant to antibiotics) and on development of new molecular typing or subtyping methods for Public Health purposes.


Work on this project would include genetic and genomic analyses from a large number of strains (130-150 Shigella dysenteriae type 1 and 50-70 Salmonella Kentucky ST198) and 10-12 large multidrug resistant plasmids with a focus on bioinformatics using Illumina (strains) and 454  (plasmids) sequences, phylogenetic analyses, and microbiological lab work (omnilog phenotype microarray analyses, biofilm assays, development of strain-specific PCR or genotyping assays). The successful candidate will also be responsible for presenting and publishing the study results.

 

Candidate requirements: Qualified applicant must have a Ph.D. in bioinformatics, microbiology, computer science, or a related field with background and strong interest in microbial evolution. The ideal candidate will already have some experience working with large genomic data sets, experience with basic molecular biology techniques and oral and written communication skills as demonstrated by publications as first author in English language peer-reviewed journals and oral presentations at international meetings. Prior programming or scripting expertise is a plus.

 

To apply: Applicants should send their CV, a motivation letter and 3 references to François-Xavier Weill (fxweill@pasteur.fr) Unité des Bactéries Pathogènes Entériques, Institut Pasteur, 28 rue du Dr Roux 75015 Paris

Mis à jour le 08/11/2013