color class: 
enable place filter: 
  • Early testis development - Dogma challenged: the genetic determination of testis or ovary is conserved through evolution - Institut Pasteur

    Research | 25.05.2015

    Dogma challenged: the genetic determination of testis or ovary is conserved through evolution

    In animals, sexual reproduction is almost universal but the mechanisms that determine the choice between forming a testis or ovary are highly diverse. Researchers from the Institut Pasteur and the University of Minnesota have recently proven that the genetic determination of testis or ovary has been conserved through evolution, thanks to a study of the gene DMRT1.

  • Research | 22.05.2015

    EBOV sequences from Guinea

    The Institut Pasteur and the Institut Pasteur International network are releasing EBOV sequences to support the public health response as well as the development and evaluation of EVD vaccines, therapeutics, and diagnostics. Please feel free to download, use, and analyze this data.

  • Gorille au Gabon - IRD / Nil Rahola - Des singes aux hommes : l’importance des transmissions inter-espèces dans l’émergence des rétrovirus en Afrique centrale - Institut Pasteur

    Research | 07.05.2015

    From monkeys to humans: the importance of interspecies transmission in the emergence of retroviruses in Central Africa

    Most of the viral pathogenic agents that have emerged in humans in recent decades are of animal origin. Hence, researchers from the Institut Pasteur have recently proved, for the first time scientifically at the epidemiological level, that specific contact with a monkey is a risk factor for the transmission of a pathogenic retrovirus (STLV-1/HTLV-1) to humans

  • Research | 25.03.2015

    Sanofi - Institut Pasteur Awards: call for nomination open till April 28th

    For March 9th till April 28th, Sanofi and Institut Pasteur invite scientists and researchers to submit their nominations in the 4 following fields:

    Tropical and neglected diseases,
    Drug resistances
    Neurodegenerative diseases and Ageing

    Deadline to submit nominations: April 28th, 2015

  • Super-resolution image of nuclear pores (green) and active chromatin (red). © Institut Pasteur

    Research | 06.03.2015

    Interactions between the nuclear pore and chromatin are critical for HIV-1 replication

    Little is understood about the molecular mechanisms that actually enable the HIV to integrate its genetic material into certain regions of the human genome. The scientists were able to find this link and determine the role played by the chromatin environment and nuclear pores in the replication of HIV-1.

  • Intercellular bridge between two daughter cells before cleavage. © Institut Pasteur

    Research | 05.03.2015

    The "dream" of every cell is to become two cells

    Arnaud Echard (head of the Membrane Traffic and Cell Division Lab) and his team are working to understand how a parent cell physically "cleaves" itself in two to create two distinct daughter cells. The researchers revealed that intercellular bridges split and in doing so release a structure called "midbody remnant" (MBR) into the extracellular environment. This discovery could have a significant impact on cancer research, as the presence of MBR is thought to promote the uncontrolled production of tumor cells.

  • SFB attached directly to the intestinal epithelial cells. Segmented filamentous bacteria, partners in intestinal immunity, finally cultured in vitro. © Institut Pasteur and Institut Imagine

    Research | 19.01.2015

    Segmented filamentous bacteria, partners in intestinal immunity, finally cultured in vitro

    Despite the vital role of segmented filamentous bacteria in establishing gut immune homeostasis in vivo in mice, scientists, for the past 50 years, have been unable to reproduce this symbiosis in vitro to shed light on the cellular and molecular interactions involved. Now, scientists have successfully cultured and reproduced the complex life-cycle of these bacteria outside their host for the first time.

  • Hepatic macrophage (in green) ingesting by phagocytosis pathogenic bacterium Listeria monocytogenes (in red). © Institut Pasteur

    Research | 09.01.2015

    Resident and recruited macrophages orchestrate the liver's defense against infection

    Scientists have demonstrated that liver-resident macrophages are rapidly killed by the pathogenic bacterium Listeria monocytogenes. This early death triggers the recruitment of macrophages from the bloodstream to the liver. These macrophages start by bringing the bacterial infection under control; then, in an unexpected development, they actually replace the liver-resident macrophages that have been killed by the infection.

  • A lymphocyte infected by HIV and transmission of the virus to neighboring cells © Institut Pasteur

    Research | 27.11.2014

    Defense mechanism against HIV-1 revealed

    Scientists have discovered how some of these restriction factors inhibit HIV replication in lymphocytes. These proteins belong to the IFITM (interferon-induced transmembrane proteins) family; they are broad-spectrum antiviral proteins that act on a wide range of viruses including influenza, dengue, etc. Little was previously known about their effect on HIV-1.

  • intestinal immunity, © Institut Pasteur

    Research | 07.11.2014

    A better understanding of the intestinal immunity

    The innate lymphoid cells contribute to immune defense by maintaining the integrity of the intestinal barrier. ILC are made in the bone marrow but must find their way to the gut mucosa where they perform their function. Scientists have discovered how this migration process is regulated.

  • Pages