Research

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  • Research | 04.11.2013

    Identification of a new mechanism in immunotherapy for lymphoma

    Using innovative dynamic imaging technique, scientists at the Institut Pasteur, Inserm and the VU Medical Center in Amsterdam have uncovered the mode of action of anti-CD20, an antibody therapy frequently used in the treatment of lymphomas (cancers of the immune system) as well as some auto-immune diseases. In a lymphoma model, the scientists have been able to carry out real time in vivo imaging of the cellular events activated by the treatment and resulting in the destruction of tumor cells. These discoveries should help optimize the efficacy of future therapies involving anti-CD20 antibodies. This work is the subject of an article published online November 1 on the Journal of Clinical Investigation website.

  • Research | 12.12.2013

    Carriers of a genetic mutation show increased dependence on tobacco

    Scientists at the Institut Pasteur, the French National Center for Scientific Research (CNRS) and Pierre and Marie Curie University (UPMC) have recently proven that, in mice, nicotine intake – nicotine is the main addictive substance in tobacco – is heavily regulated by a genetic mutation that is very common in humans. 

  • Research | 13.12.2013

    A prime target for the development of anti-inflammatories

    For the first time, scientists from the Institut Pasteur and Inserm have demonstrated the key role played by a particular molecule in intestinal infection.

  • Research | 19.12.2013

    Molecular marker discovered for detecting artemisinin-resistant forms of malaria

    Scientists at the Institut Pasteur in Paris and Cambodia, CNRS and NIH have identified a molecular marker for detecting malaria parasites with resistance to artemisinin derivatives

    Un marqueur moléculaire permettant de détecter les parasites du paludisme résistants aux dérivés de l’artémisinine, constituants majeurs des traitements antipaludiques actuellement recommandés par l’OMS, a été identifié par des scientifiques de l’Institut Pasteur à Paris, de l’Institut Pasteur du Cambodge, du CNRS et des National Institutes of Health (NIAID/NIH).

  • Research | 07.01.2013

    Retracing the evolutionary history and emergence of tuberculosis

    In association with CEA-Genoscope and the Sanger Institute, scientists at the Institut Pasteur in Paris, the CNRS, INSERM, the Institut Pasteur of Lille, and Université Lille 2 have recently determined the origin of the emergence of the Mycobacterium tuberculosis bacterium, the main causative agent of tuberculosis. Researchers have also provided insights into its evolutionary success. They have identified several genetic mechanisms that could have contributed to the worldwide dissemination of this pathogen, which currently infects up to 2 billion people. This research, published on the Nature Genetics website on January 6, offers possibilities for identifying new targets in the fight against tuberculosis.

  • Research | 07.02.2013

    Treatment of Cutaneous Leishmaniasis: Study of Phase III Shows Antibiotic Cream Has High Cure Rate, Few Side Effects

    An international research partnership from Tunisia, France and the United States has demonstrated a high cure rate and remarkably few side effects in treating patients with cutaneous leishmaniasis (CL) with an antibiotic cream. CL is a parasitic disease that causes disfiguring lesions and affects 1.5 million people worldwide annually, including the socio-economically disadvantaged in the developing world, especially children. The results of the study conducted by the Institut Pasteur de Tunis, the Institut Pasteur (Paris) and U.S. medical researchers were published today in the New England Journal of Medicine.

  • Research | 01.07.2013

    Retracing the evolutionary history and emergence of tuberculosis

    In association with CEA-Genoscope and the Sanger Institute, scientists at the Institut Pasteur in Paris, the CNRS, INSERM, the Institut Pasteur of Lille, and Université Lille 2 have recently determined the origin of the emergence of the Mycobacterium tuberculosis bacterium, the main causative agent of tuberculosis. Researchers have also provided insights into its evolutionary success. They have identified several genetic mechanisms that could have contributed to the worldwide dissemination of this pathogen, which currently infects up to 2 billion people. This research, published on the Nature Genetics website on January 6, offers possibilities for identifying new targets in the fight against tuberculosis.

  • Research | 14.03.2013

    Aids : 14 adult patients in long term functional remission of HIV seven years after being taken off early antiretroviral treatment

    Newly published scientific study describes 14 adult patients in long term functional remission of HIV seven years after being taken off early antiretroviral treatment. The Anrs EP 47`VISCONTI´ cohort confirms on a larger and durable scale what the Mississippi `functionally cured´ baby indicated – that early therapeutic intervention may be instrumental in HIV remission and has important implications for HIV cure research.

  • Research | 18.03.2013

    Buruli Ulcer: Mechanism Behind Tissue Erosion Revealed

    Scientists at the Pasteur Institute in Paris and the CNRS (French National Center for Scientific Research), in collaboration with the Universities of Basel (Switzerland) and Cambridge (UK) have identified the mechanism underlying the formation of Buruli ulcers caused by the bacterium Mycobacterium ulcerans. Their discovery opens avenues for the development of novel therapeutic approaches for combating this disfiguring skin disease. This study is published online by The Journal of Clinical Investigation

  • Research | 11.04.2013

    Even in low doses, antibiotics can contribute to the emergence of multi-resistant bacteria

    Scientists at the Institut Pasteur and CNRS have shown that the use of low dose antibiotics can increase the emergence of resistance among pathogenic bacteria. They have observed that a low concentration of antibiotics is enough to activate a stress response in these bacteria. This response, known as "SOS", leads to the acquisition of resistance genes via two separate pathways. This work is the subject of an article published online on the Plos Genetics website on April 11.

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