Research

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  • Research | 19.12.2013

    Molecular marker discovered for detecting artemisinin-resistant forms of malaria

    Scientists at the Institut Pasteur in Paris and Cambodia, CNRS and NIH have identified a molecular marker for detecting malaria parasites with resistance to artemisinin derivatives

    Un marqueur moléculaire permettant de détecter les parasites du paludisme résistants aux dérivés de l’artémisinine, constituants majeurs des traitements antipaludiques actuellement recommandés par l’OMS, a été identifié par des scientifiques de l’Institut Pasteur à Paris, de l’Institut Pasteur du Cambodge, du CNRS et des National Institutes of Health (NIAID/NIH).

  • Research | 07.01.2013

    Retracing the evolutionary history and emergence of tuberculosis

    In association with CEA-Genoscope and the Sanger Institute, scientists at the Institut Pasteur in Paris, the CNRS, INSERM, the Institut Pasteur of Lille, and Université Lille 2 have recently determined the origin of the emergence of the Mycobacterium tuberculosis bacterium, the main causative agent of tuberculosis. Researchers have also provided insights into its evolutionary success. They have identified several genetic mechanisms that could have contributed to the worldwide dissemination of this pathogen, which currently infects up to 2 billion people. This research, published on the Nature Genetics website on January 6, offers possibilities for identifying new targets in the fight against tuberculosis.

  • Research | 07.02.2013

    Treatment of Cutaneous Leishmaniasis: Study of Phase III Shows Antibiotic Cream Has High Cure Rate, Few Side Effects

    An international research partnership from Tunisia, France and the United States has demonstrated a high cure rate and remarkably few side effects in treating patients with cutaneous leishmaniasis (CL) with an antibiotic cream. CL is a parasitic disease that causes disfiguring lesions and affects 1.5 million people worldwide annually, including the socio-economically disadvantaged in the developing world, especially children. The results of the study conducted by the Institut Pasteur de Tunis, the Institut Pasteur (Paris) and U.S. medical researchers were published today in the New England Journal of Medicine.

  • Research | 01.07.2013

    Retracing the evolutionary history and emergence of tuberculosis

    In association with CEA-Genoscope and the Sanger Institute, scientists at the Institut Pasteur in Paris, the CNRS, INSERM, the Institut Pasteur of Lille, and Université Lille 2 have recently determined the origin of the emergence of the Mycobacterium tuberculosis bacterium, the main causative agent of tuberculosis. Researchers have also provided insights into its evolutionary success. They have identified several genetic mechanisms that could have contributed to the worldwide dissemination of this pathogen, which currently infects up to 2 billion people. This research, published on the Nature Genetics website on January 6, offers possibilities for identifying new targets in the fight against tuberculosis.

  • Research | 14.03.2013

    Aids : 14 adult patients in long term functional remission of HIV seven years after being taken off early antiretroviral treatment

    Newly published scientific study describes 14 adult patients in long term functional remission of HIV seven years after being taken off early antiretroviral treatment. The Anrs EP 47`VISCONTI´ cohort confirms on a larger and durable scale what the Mississippi `functionally cured´ baby indicated – that early therapeutic intervention may be instrumental in HIV remission and has important implications for HIV cure research.

  • Research | 18.03.2013

    Buruli Ulcer: Mechanism Behind Tissue Erosion Revealed

    Scientists at the Pasteur Institute in Paris and the CNRS (French National Center for Scientific Research), in collaboration with the Universities of Basel (Switzerland) and Cambridge (UK) have identified the mechanism underlying the formation of Buruli ulcers caused by the bacterium Mycobacterium ulcerans. Their discovery opens avenues for the development of novel therapeutic approaches for combating this disfiguring skin disease. This study is published online by The Journal of Clinical Investigation

  • Research | 11.04.2013

    Even in low doses, antibiotics can contribute to the emergence of multi-resistant bacteria

    Scientists at the Institut Pasteur and CNRS have shown that the use of low dose antibiotics can increase the emergence of resistance among pathogenic bacteria. They have observed that a low concentration of antibiotics is enough to activate a stress response in these bacteria. This response, known as "SOS", leads to the acquisition of resistance genes via two separate pathways. This work is the subject of an article published online on the Plos Genetics website on April 11.

  • Research | 16.04.2013

    Atomic-level characterization of the effects of alcohol on a major player of the central nervous system

    Scientists at the Institut Pasteur, the CNRS and the University of Texas have been able to observe at atomic-level the effects of ethanol (the alcohol present in alcoholic beverages) on central nervous system receptors. They have identified five ethanol binding sites in a mutant of a bacterial analog of nicotinic receptors, and have determined how the binding of ethanol stimulates receptor activity. These findings can be directly extrapolated to human GABA receptors (the primary inhibitory neurotransmitters in the human brain), which are ethanol's main target in the central nervous system. This work is being published online on April 16, on the Nature Communications website. It paves the way for the synthesis of ethanol antagonist compounds that could limit the effect of alcohol on the brain.

  • Research | 17.04.2013

    Legionellosis: unique host cell reprogramming induced by the bacterial pathogen Legionella pneumophila

    Scientists at the Institut Pasteur, the CNRS, the Institut Curie and Inserm have identified a unique mechanism that enables the bacterial pathogen Legionella pneumophila (the causative agent of Legionnaires’ disease or legionellosis) to "reprogram" the gene expression of the eukaryotic cells that it infects. This mechanism, which has never been observed before, facilitates the survival and proliferation of Legionella pneumophila during infection. The work provides precious information on the regulation of the host’s gene expression, as well as important insight into the tactics used by bacteria to manipulate host cells. This research is published online on April 17, at the Cell Host & Microbe website.
     
  • Research | 18.06.2013

    Chikungunya : discovery of a human-specific factor involved in the virus replication

    Chikungunya : discovery of a human-specific factor involved in the virus replication

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