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  • Photomontage showing the mold Aspergillus fumigatus growing alone (left panel) and stimulated by the presence of the bacterium Pseudomonas aeruginosa (right panel). Airborne Bacterial Volatiles stimulate Fungal Growth. © Institut Pasteur

    Research | 06.04.2016

    Airborne Bacterial Volatiles stimulate Fungal Growth

    Scientists from the team led by Jean-Paul Latgé, Director of the Aspergillus Unit at the Institut Pasteur, have discovered a new communication pathway between two pathogens that colonize the same ecological niche and are both involved in acute pulmonary pathologies, particularly in patients with cystic fibrosis (the most common genetic disease in Europe).

  • Human cells infected with Chlamydia trachomatis. How Chlamydia trachomatis hijacks energy stores from its host. Institut Pasteur

    Research | 25.03.2016

    How Chlamydia trachomatis hijacks energy stores from its host

    A publication in eLife from researchers of the Institut Pasteur, CNRS, University of Lille and Indiana University (USA) explains the mechanisms by which the bacterium Chlamydia trachomatis hijacks nutrients of its host to its own benefit.

  • Vibrio cholerae. Unmasking an ancestral mechanism of integrons — key players in antibiotic resistance. © Institut Pasteur

    Research | 10.03.2016

    Unmasking an ancestral mechanism of integrons — key players in antibiotic resistance

    With the ultimate aim of combating antibiotic resistance acquired by bacteria during evolution, researchers from the Institut Pasteur and CNRS have managed to shed light on one of the mechanisms of DNA recombination in bacteria.

  • Research | 01.02.2016

    How does Legionella pneumophila, the bacterium causing legionellosis, use the host cell machinery to its own advantage?

    During analysis of its genome sequence, the team from the Biology of Intracellular Bacteria Unit (Institut Pasteur/CNRS), headed by Carmen Buchrieser, identified genes coding for proteins that were predicted to be involved in the infection of human cells. These proteins resemble proteins of higher organisms (eukaryotes), including humans, and can modify the physiology of the infected host cells. They are thus potential virulence factors. In this study, published in the journal PNAS, the researchers show that one of these proteins is secreted in the human cell and helps to block the antibacterial response of the infected cells.

  • SGB phagocytés par des polynucléaires neutrophiles. © Claire Poyart, CNR-Strep (AP-HP, Inserm)

    Research | 28.08.2015

    Following maternal transmission, group B strep mutates to siken infants

    Group B streptococcus, a mostly benign inhabitant of healthy adults, is one of the leading causes of neonatal sepsis and meningitis. Researchers from the Institut Pasteur and Inserm have now shown that these pediatric cases might occur when the bacteria mutates within the infant following transmission from the mother.

  • Research | 07.08.2015

    The ISG15 protein plays a key role in fighting bacterial infections

    Researchers from the Institut Pasteur, Inserm, INRA and the University of Freiburg have uncovered the key role played by the protein ISG15 in the fight against bacterial infections. During listeria infection, this protein promotes the release of cytokines which help the body eliminate the bacteria.

  • The molecular crossbow: a vital weapon in the bacterial arsenal. © Institut Pasteur

    Research | 23.07.2015

    The molecular crossbow: a vital weapon in the bacterial arsenal

    Scientists have made a major breakthrough in understanding the molecular structure and workings of an important part of the arsenal employed by bacteria to destroy cells or other bacteria. This study focuses on the assembly mechanism and gives a detailed description of the architecture of a key component in the bacterial type VI secretion system

  • Dr Asier Saez-Cirion, Unité HIV, inflammation et persistance, Institut Pasteur

    Research | 21.07.2015

    The first case of prolonged remission in an HIV-infected child – an interview with Asier Saez-Cirion

    At the 8th International AIDS Society (IAS) Conference on HIV Pathogenesis, Treatment and Prevention, Dr Asier Saez-Cirion (HIV, Inflammation and Persistence Unit, Institut Pasteur) presented the world’s first case of prolonged remission, in a child being monitored in the French ANRS pediatric cohort.

  • Micrographie électronique à contraste négatif du virus SIRV2 - Un virus issu d’un environnement extrême ouvre la voie à de nouvelles stratégies thérapeutiques - Institut Pasteur.

    Research | 15.06.2015

    A microbial virus from extreme environment opens doors to new therapeutical strategies

    Following their research on virus SIRV2, a virus found to survive in extreme environments (very hot and acidic), researchers from the University of Washington, the University of Virginia and the Institut Pasteur have discovered what appears to be a basic mechanism of resistance to heat, dehydratation and ultraviolet radiation. This finding could potentially lead to many applications, including the development of new ways to package DNA for gene therapy.

  • Institut Pasteur loboratory

    Research | 28.05.2015

    Institut Pasteur's involvement in the fight against Ebola

    The Institut Pasteur and the Institut Pasteur International Network are assisting the international aid effort by offering diagnostic support and epidemiological surveillance in collaboration with the Guinean Ministry of Health. On the occasion of the international congress " Targeting Ebola 2015 ", held at the Institut Pasteur in Paris on May 28 and 29, 2015, find all the information about research projects involving the Institute in the fight against Ebola.

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