Research

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  • Research | 29.05.2013

    Worldwide Outbreak of Highly Antibiotic-Resistant Salmonella Risks Spreading to European Poultry Farms

    In a study published online May 28th for the Lancet Infectious Diseases medical journal, scientists at the Institut Pasteur in Paris and the Institut Pasteur in Morocco once again bring attention to the rapid worldwide spread of Salmonella Kentucky (S. Kentucky), a bacterium showing resistance to several classes of antibiotics. S. Kentucky is responsible for foodborne infections and has spread at an astonishing rate throughout Africa and the Middle East in the space of only a few years. In this study, the authors note that the bacterium has recently spread to India and South-East Asia and has acquired new resistance, particularly resistance to antibiotics of “last resort”. The scientists also point out the considerable risk of this multi-resistant strain spreading to farmed poultry in industrialized countries. This bacterium has already been detected in farmed turkeys in Europe.

  • Research | 02.08.2013

    Dengue: identifying mosquito genetic factors that control virus transmission

    Dengue is currently the most common insect-borne viral disease of humans worldwide. Scientists from the Institut Pasteur, the French National Center for Scientific Research (CNRS), and the Armed Forces Research Institute of Medical Sciences (AFRIMS) have discovered several genetic factors controlling the transmission of various dengue virus strains in a natural population of mosquitoes in Thailand. Their results indicate that the transmission of these viruses in nature depends not only on mosquito genetic factors but also on their specific interaction with viral genetic factors. This discovery significantly advances our understanding of dengue biology in nature. From a more general standpoint, this study also refines our view of the genetic basis of host-pathogen interactions. This work was published August 1st, 2013 on the PLoS Genetics website.

  • Research | 01.10.2013

    Potential therapeutic targets for blocking AIDS virus replication

    Scientists from the Institut Pasteur and Inserm have identified several proteins in humans as potential new therapeutic targets for treating the AIDS virus. These proteins are part of a complex cellular mechanism that blocks the virus replication in cells called macrophages. The discovery of this mechanism and the proteins involved gives scientists a solid theoretical basis for developing new therapeutic strategies to be used alongside anti-retroviral treatments currently in use. This research was published online September 30, 2013 by the scientific journal Proceedings of the National Academy of Sciences.

  • Research | 10.10.2013

    Fine-tuning the approach to malaria and toxoplasmosis research

    A study carried out by teams from the Institut Pasteur, the Institut Cochin (Inserm, CNRS, Paris Descartes University), and the Wellcome Trust Centre for Molecular Parasitology at the University of Glasgow, may very well redefine current approaches to malaria and toxoplasmosis research in terms of treatment development. Their research which focuses on the role played by the protein AMA1 (present in both parasites) was published october 9, on the Nature Communications website. For many years AMA1 has been the focus of studies aiming to develop malaria treatments and vaccines. However, the authors of this study express their reservations about strategies that focus strictly on blocking AMA1 and show that malaria and toxoplasmosis parasites without AMA1 are still capable of developing normally.

  • Research | 05.11.2013

    Two European programs reinforce the fight against emerging diseases

    The 31 partners involved in the two major European research programs PREDEMICS and ANTIGONE are to meet for a joint seminar at the Institut Pasteur on November 6th. These two programs will respectively receive €11.7 million and €12 million funding of the European Union over five years to study the emergence mechanisms of infectious diseases in order to strengthen existing treatment and prevention. Since their launch, PREDEMICS and ANTIGONE have been active in various areas, in particular for modeling the spread and evolution of emerging pathogens and for studying host-pathogen interactions.

  • Research | 04.11.2013

    Identification of a new mechanism in immunotherapy for lymphoma

    Using innovative dynamic imaging technique, scientists at the Institut Pasteur, Inserm and the VU Medical Center in Amsterdam have uncovered the mode of action of anti-CD20, an antibody therapy frequently used in the treatment of lymphomas (cancers of the immune system) as well as some auto-immune diseases. In a lymphoma model, the scientists have been able to carry out real time in vivo imaging of the cellular events activated by the treatment and resulting in the destruction of tumor cells. These discoveries should help optimize the efficacy of future therapies involving anti-CD20 antibodies. This work is the subject of an article published online November 1 on the Journal of Clinical Investigation website.

  • Research | 12.12.2013

    Carriers of a genetic mutation show increased dependence on tobacco

    Scientists at the Institut Pasteur, the French National Center for Scientific Research (CNRS) and Pierre and Marie Curie University (UPMC) have recently proven that, in mice, nicotine intake – nicotine is the main addictive substance in tobacco – is heavily regulated by a genetic mutation that is very common in humans. 

  • Research | 13.12.2013

    A prime target for the development of anti-inflammatories

    For the first time, scientists from the Institut Pasteur and Inserm have demonstrated the key role played by a particular molecule in intestinal infection.

  • Research | 19.12.2013

    Molecular marker discovered for detecting artemisinin-resistant forms of malaria

    Scientists at the Institut Pasteur in Paris and Cambodia, CNRS and NIH have identified a molecular marker for detecting malaria parasites with resistance to artemisinin derivatives

    Un marqueur moléculaire permettant de détecter les parasites du paludisme résistants aux dérivés de l’artémisinine, constituants majeurs des traitements antipaludiques actuellement recommandés par l’OMS, a été identifié par des scientifiques de l’Institut Pasteur à Paris, de l’Institut Pasteur du Cambodge, du CNRS et des National Institutes of Health (NIAID/NIH).

  • Research | 07.01.2013

    Retracing the evolutionary history and emergence of tuberculosis

    In association with CEA-Genoscope and the Sanger Institute, scientists at the Institut Pasteur in Paris, the CNRS, INSERM, the Institut Pasteur of Lille, and Université Lille 2 have recently determined the origin of the emergence of the Mycobacterium tuberculosis bacterium, the main causative agent of tuberculosis. Researchers have also provided insights into its evolutionary success. They have identified several genetic mechanisms that could have contributed to the worldwide dissemination of this pathogen, which currently infects up to 2 billion people. This research, published on the Nature Genetics website on January 6, offers possibilities for identifying new targets in the fight against tuberculosis.

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