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  • Prix Sanofi - Institut Pasteur

    Research | 29.04.2016

    5th Sanofi - Institut Pasteur Awards: call for nomination open until June 14th, 2016

    Created in 2012, the Sanofi - Institut Pasteur Awards honor international scientists whose outstanding research in life sciences contributes to progress in global public health.


    Scientists are invited to submit their nominations in the following four fields:

    Tropical and neglected diseases,
    Drug resistance,

    Deadline to submit nominations: June 14th, 2016

  • Discovery of the mechanism used to coordinate replication of the two Vibrio cholerae chromosomes. © Marie-Eve Val

    Research | 28.04.2016

    Discovery of the mechanism used to coordinate replication of the two Vibrio cholerae chromosomes

    Bacterial genomes generally contain a single chromosome and one or more extrachromosal elements such as plasmids. The initiation of bacterial chromosome replication must be carefully checked to ensure that chromosome duplication occurs only once per cell cycle. The bacterial pathogen responsible for cholera epidemics, Vibrio cholerae, is distinctive in that it has two chromosomes. The researchers have revealed an original, energy-saving mechanism known as the "replication checkpoint" that coordinates replication of the two chromosomes with the V. cholerae cell cycle.

  • Spheroid of renal cells cultivated in vitro. Division – a key moment in establishing cell polarity. Institut Pasteur

    Research | 04.04.2016

    Division – a key moment in establishing cell polarity

    One major line of research on the process of carcinogenesis lies in understanding the mechanisms underpinning the establishment of polarity. The Membrane Traffic and Cell Division Laboratory, directed at the Institut Pasteur by Arnaud Echard (Institut Pasteur/CNRS UMR 3691), is looking into apical-basal polarity acquisition mechanisms during cell division when organs are being formed. As part of this research, the team has recently discovered the crucial role of a GTPase-type enzyme known as Rab35.

  • Photomontage showing the mold Aspergillus fumigatus growing alone (left panel) and stimulated by the presence of the bacterium Pseudomonas aeruginosa (right panel). Airborne Bacterial Volatiles stimulate Fungal Growth. © Institut Pasteur

    Research | 06.04.2016

    Airborne Bacterial Volatiles stimulate Fungal Growth

    Scientists from the team led by Jean-Paul Latgé, Director of the Aspergillus Unit at the Institut Pasteur, have discovered a new communication pathway between two pathogens that colonize the same ecological niche and are both involved in acute pulmonary pathologies, particularly in patients with cystic fibrosis (the most common genetic disease in Europe).

  • Human cells infected with Chlamydia trachomatis. How Chlamydia trachomatis hijacks energy stores from its host. Institut Pasteur

    Research | 25.03.2016

    How Chlamydia trachomatis hijacks energy stores from its host

    A publication in eLife from researchers of the Institut Pasteur, CNRS, University of Lille and Indiana University (USA) explains the mechanisms by which the bacterium Chlamydia trachomatis hijacks nutrients of its host to its own benefit.

  • Vibrio cholerae. Unmasking an ancestral mechanism of integrons — key players in antibiotic resistance. © Institut Pasteur

    Research | 10.03.2016

    Unmasking an ancestral mechanism of integrons — key players in antibiotic resistance

    With the ultimate aim of combating antibiotic resistance acquired by bacteria during evolution, researchers from the Institut Pasteur and CNRS have managed to shed light on one of the mechanisms of DNA recombination in bacteria.

  • Research | 01.02.2016

    How does Legionella pneumophila, the bacterium causing legionellosis, use the host cell machinery to its own advantage?

    During analysis of its genome sequence, the team from the Biology of Intracellular Bacteria Unit (Institut Pasteur/CNRS), headed by Carmen Buchrieser, identified genes coding for proteins that were predicted to be involved in the infection of human cells. These proteins resemble proteins of higher organisms (eukaryotes), including humans, and can modify the physiology of the infected host cells. They are thus potential virulence factors. In this study, published in the journal PNAS, the researchers show that one of these proteins is secreted in the human cell and helps to block the antibacterial response of the infected cells.

  • SGB phagocytés par des polynucléaires neutrophiles. © Claire Poyart, CNR-Strep (AP-HP, Inserm)

    Research | 28.08.2015

    Following maternal transmission, group B strep mutates to siken infants

    Group B streptococcus, a mostly benign inhabitant of healthy adults, is one of the leading causes of neonatal sepsis and meningitis. Researchers from the Institut Pasteur and Inserm have now shown that these pediatric cases might occur when the bacteria mutates within the infant following transmission from the mother.

  • Research | 07.08.2015

    The ISG15 protein plays a key role in fighting bacterial infections

    Researchers from the Institut Pasteur, Inserm, INRA and the University of Freiburg have uncovered the key role played by the protein ISG15 in the fight against bacterial infections. During listeria infection, this protein promotes the release of cytokines which help the body eliminate the bacteria.

  • The molecular crossbow: a vital weapon in the bacterial arsenal. © Institut Pasteur

    Research | 23.07.2015

    The molecular crossbow: a vital weapon in the bacterial arsenal

    Scientists have made a major breakthrough in understanding the molecular structure and workings of an important part of the arsenal employed by bacteria to destroy cells or other bacteria. This study focuses on the assembly mechanism and gives a detailed description of the architecture of a key component in the bacterial type VI secretion system

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