Research

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  • Bacteriophages eliminating Staphylococcus aureus bacteria on a petri dish. Identification of a new bacterial defense system against phages. © Institut Pasteur.

    Research | 23.09.2016

    Identification of a new bacterial defense system against phages

    Bacteria are under constant attack from viruses known as bacteriophages or phages, recognized as the most abundant organisms on the planet. In response, bacteria have developed an entire arsenal of defense mechanisms against phages, including CRISPR systems, the recent discovery of which is currently giving rise to a surge of new applications, especially in the field of gene editing (gene therapy). Scientists have recently identified a new system used by staphylococci to defend themselves against phages.

  • Institut Pasteur

    Research | 26.08.2016

    A new approach for deciphering complex immune responses

    The response to infection is highly variable from one individual to another. The Milieu Intérieur consortium seeks to establish the parameters that characterize the immune system of healthy individuals and its natural variability. The researchers describe a new approach for analyzing the inflammatory response at the gene expression level in blood samples from healthy individuals, which reproduces the conditions of in vivo stimulation.

  • Tunneling nanotubes between neurons enable the spread of Parkinson's disease via lysosomes. © Institut Pasteur

    Research | 22.08.2016

    Tunneling nanotubes between neurons enable the spread of Parkinson's disease via lysosomes

    Scientists from the Institut Pasteur have demonstrated the role of lysosomal vesicles in transporting α-synuclein aggregates, responsible for Parkinson's and other neurodegenerative diseases, between neurons. These proteins move from one neuron to the next in lysosomal vesicles which travel along the "tunneling nanotubes" between cells.

  • Macrophages infected by group B Streptococcus. A new mechanism used by group B Streptococcus to evade the host immune system. © Institut Pasteur / E. Davenas et P. Trieu-Cuot.

    Research | 13.07.2016

    A new mechanism used by group B Streptococcus to evade the host immune system

    Pathogenic bacteria produce a number of molecules that can be recognized by the innate immune system. These molecules associated with pathogens trigger an inflammatory response by stimulating specific signaling pathways in infected immune cells. Scientists have demonstrated that group B Streptococcus degrades one of these molecules so that it can control the inflammatory response of the infected host.

  • A gorilla in Gabon. Discovery of new strains of the HTLV-4 virus in hunters bitten by gorillas in Gabon. © IRD / Nil Rahola

    Research | 07.07.2016

    Discovery of new strains of the HTLV-4 virus in hunters bitten by gorillas in Gabon

    Scientists from the Institut Pasteur and the CNRS have identified two new strains of the HTLV-4 virus in two hunters who were bitten by gorillas in Gabon. These findings support the notion that gorillas represent a major source of infectious agents that can be passed on to humans.

  • Observation by fluorescence microscopy of a cell infected by Listeria. When Listeria attacks the intestinal microbiota. © Institut Pasteur/Edith GOUIN, Olivier DUSSURGET

    Research | 19.05.2016

    When Listeria attacks the intestinal microbiota

    Although several Listeria strains can cause listeriosis, some are particularly virulent. This is because they secrete a toxin that damages the intestinal microbiota, preventing it from serving as a barrier and promoting infection.

  • Key cellular factors for chikungunya virus replication identified

    Research | 12.05.2016

    Key cellular factors for chikungunya virus replication identified

    Scientists from the Institut Pasteur, Inserm and the Max Planck Institute have used high-throughput screening to identify the cellular factors involved in the replication of chikungunya virus in human cells. These findings have revealed potential therapeutic targets that could help tackle this virus.

  • Prix Sanofi - Institut Pasteur

    Research | 29.04.2016

    5th Sanofi - Institut Pasteur Awards: call for nomination open until June 14th, 2016

    Created in 2012, the Sanofi - Institut Pasteur Awards honor international scientists whose outstanding research in life sciences contributes to progress in global public health.

     

    Scientists are invited to submit their nominations in the following four fields:

    Tropical and neglected diseases,
    Immunology,
    Drug resistance,
    Neuroscience.

    Deadline to submit nominations: June 14th, 2016

  • Discovery of the mechanism used to coordinate replication of the two Vibrio cholerae chromosomes. © Marie-Eve Val

    Research | 28.04.2016

    Discovery of the mechanism used to coordinate replication of the two Vibrio cholerae chromosomes

    Bacterial genomes generally contain a single chromosome and one or more extrachromosal elements such as plasmids. The initiation of bacterial chromosome replication must be carefully checked to ensure that chromosome duplication occurs only once per cell cycle. The bacterial pathogen responsible for cholera epidemics, Vibrio cholerae, is distinctive in that it has two chromosomes. The researchers have revealed an original, energy-saving mechanism known as the "replication checkpoint" that coordinates replication of the two chromosomes with the V. cholerae cell cycle.

  • Spheroid of renal cells cultivated in vitro. Division – a key moment in establishing cell polarity. Institut Pasteur

    Research | 04.04.2016

    Division – a key moment in establishing cell polarity

    One major line of research on the process of carcinogenesis lies in understanding the mechanisms underpinning the establishment of polarity. The Membrane Traffic and Cell Division Laboratory, directed at the Institut Pasteur by Arnaud Echard (Institut Pasteur/CNRS UMR 3691), is looking into apical-basal polarity acquisition mechanisms during cell division when organs are being formed. As part of this research, the team has recently discovered the crucial role of a GTPase-type enzyme known as Rab35.

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