The Pasteur Museum is housed in the apartment where Louis Pasteur spent his final seven years and offers a rare behind-the-scenes look at the living and working environment of the world-renowned scientist. Visitors can gain a unique insight into his everyday life alongside his ...
The Institut Pasteur’s scientific strategy focuses on developing original and innovative topics and promoting interdisciplinary and multidisciplinary cooperation and approaches. The Institut Pasteur teams have access to the technological resources ...
Ever since the introduction of the world’s first "Technical Microbiology" course in 1889, teaching has been a priority for the Institut Pasteur. The Institut Pasteur has an international reputation for quality teaching that attracts students from all over ...
The mission of the Industrial Partnership team is to detect, promote, assist and protect the inventive activities from research (inventions, know-how and biological materials) conducted at the Institut Pasteur (and in some Institutes of its international network), and transfer there to industrial ...
With international courses, PhD and postdoctoral traineeship, each institute of the Institut Pasteur International Network (RIIP) contributes to the transmission of knowledge with the training of young researchers all around the world. In this context, doctoral and postdoctoral programmes, study ...
The Virology Department is constituted by 21 principal investigators with their research units, covering most aspects of contemporary virology with a special emphasis on human pathogenic viruses.
The department houses different National Reference Centres and WHO Collaborating Centres for viruses. Our primary mission is to remain at the cutting edge of fundamental research and, at the same time, close to applications in global public health issues.
Most of the members of the Department are involved in teaching in the two post-graduate virology courses of Institut Pasteur.
The research teams have many collaborations within and between departments on campus, and at the national and international level, including the Institut Pasteur international network and with numerous hospitals.
Scientific background and interests
The viruses that the Virology Department study are diverse, including oncogenic viruses, that cause cancer (hepatitis viruses, papillomavirus, herpesvirus and HTLV), retroviruses (HIV, HTLV and foamy viruses - as well as their simian counterparts), respiratory viruses (influenza virus, respiratory syncytial virus), arboviruses (flaviviruses, alphaviruses, bunyaviruses).
Other viruses studied include picornaviruses, rhabdoviruses and paramyxoviruses such as measles and parainfluenza viruses. Highly pathogenic agents such as Lassa and Nipah viruses are studied in the context of the biosafety level 4 facilities in Lyon.
The Department's research aims at understanding the molecular mechanisms at play during the different steps of the viral cycle. A large effort is currently being made to decipher virus/host interactions, and physio-pathological events associated with virus infection. The Department's research includes:
The molecular and cellular mechanisms of the viral cycle – cell entry and uncoating, genome replication, particle assembly, egress.
The pathogenesis of viruses causing different diseases (cancer; immunodeficiency; neurological, respiratory, enteric and hepatic diseases).
The dissemination of the virus within the organism (crossing of anatomical barriers), between hosts and in the environment - transmission, zoonoses, animal reservoirs and vectors,entomology.
The innate and acquiredimmunity to virus infection, both at the cellular and host level, the activity of host restriction factors, and the countermeasures of virusevasion.
The molecular modelling of viral replication, virusstructure, enzymology.
The population genetics and dynamics of virus and host - molecular and clinical epidemiology and phylogeny, virus and host genomics and transcriptomics, determinants of virus and host susceptibility or resistance, adaptation and evolution.
The development of innovative antiviral approaches (antiviral compounds, vaccines, gene therapy).
The use of cutting-edge technology for virus discovery and to improve diagnostics.