Articles and reviews


Laurenceau R, Péhau-Arnaudet G, Baconnais S, Gault J, Malosse C, Dujeancourt A, Campo N, Chamot-Rooke J, Le Cam E, Claverys JP, Fronzes R.
PLoS Pathog. 2013 Jun;9(6):e1003473.

Rivera-Calzada A, Fronzes R, Savva CG, Chandran V, Lian PW, Laeremans T, Pardon E, Steyaert J, Remaut H, Waksman G, Orlova EV.


EMBO J. 2013 Apr 17;32(8):1195-204. 

Baranova E, Fronzes R, Garcia-Pino A, Van Gerven N, Papapostolou D, Péhau-Arnaudet G, Pardon E, Steyaert J, Howorka S, Remaut H.

Nature. 2012 Jul 5;487(7405):119-22.

Waksman G. and Fronzes R.
Molecular architecture of bacterial type IV secretion systems
Trends in Biochemical Sciences, 2010 Dec;35(12):691-8

Rego AT, Fronzes R, Waksman G.
SnapShot: Bacterial Appendages II.
Cell. 2010 Jan 22;140(2):294-294.e1.

Rego AT, Fronzes R, Waksman G.
SnapShot: Bacterial Appendages I.
Cell. 2010 Jan 8;140(1):162

Chandran V*., Fronzes R.* , Duquerroy S., Cronin N., Navaza J., Waksman G.
*share equal contribution
Crystal structure of the outer membrane complex of a type IV secretion system

Nature. 2009 Dec 24;462(7276):1011-5. Epub 2009 Nov 29.

Fronzes R., Christie P.J. and Waksman G.
The structural biology of type IV secretion systems.
Nat Rev Microbiol. 2009 Oct;7(10):703-14.

Durand E, Verger D, Rêgo AT, Chandran V, Meng G, Fronzes R., Waksman G.
Structural Biology of Bacterial Secretion Systems in Gram-negative Pathogens- Potential for New Drug Targets.
Infect Disord Drug Targets. 2009 Oct 1.

Meng G., Fronzes R., Chandran V., Remaut H. and Waksman G.
Protein oligomerization in the bacterial outer membrane.
Mol Membr Biol. 2009 Apr;26(3):136-45.

Fronzes R., Schäfer E., Wang L., Saibil H., Orlova E. and Waksman G.
Structure of a type IV secretion system core complex.
Science. 2009 Jan 9;323(5911):266-8.

Backert S., Fronzes R. and Waksman G.
VirB2 and VirB5 proteins: specialized adhesins in bacterial type-IV secretion systems?
Trends Microbiol. 2008 Sep;16(9):409-13.

Fronzes R., Remaut H. and Waksman G.
Architectures and biogenesis of non-flagellar protein appendages in Gram-negative bacteria.
EMBO J. 2008 Sep 3;27(17):2271-80.

Goyon V. *, Fronzes R.*, Salin B, di-Rago J.P., Velours J. and Brèthes D.
*share equal contribution
Yeast cells depleted in Atp14p fail to assemble Atp6p within the ATP synthase and exhibit altered mitochondrial cristae morphology.
J Biol Chem. 2008 Apr 11;283(15):9749-58.

Bayliss, R., Harris R., Coutte L., Monier A., Fronzes R., Christie, P.J, Driscoll P. and Waksman G.
NMR structure of a complex between the VirB9/VirB7 interaction domains of the pKM101 type IV secretion system.
Proc Natl Acad Sci U S A, 2007 Jan 30;104(5):1673-8.

Fronzes R., Weimann T., Vaillier J., Velours J. and Brèthes D.
The peripheral stalk participates in the yeast ATP synthase dimerization independently of e and g subunits.
Biochemistry. 2006 May 30;45(21):6715-23.

Fronzes R., Chaignepain S., Bathany K., Giraud M.F., Arselin G., Schmitter J.M., Dautant A., Velours J. and Brèthes D.
Topological and functional study of subunit h of the F1Fo ATP synthase complex in yeast Saccharomyces cerevisiae.
Biochemistry. 2003 Oct 21;42(41):12038-49.


Book chapters



Envelope spanning secretion systems in Gram-negative bacteria

Matthias J Brunner, Rémi Fronzes, Thomas C Marlovits

Bacterial membranes: Structural and molecular biology, Horizon press, In press

Daviter T, Fronzes R.

Methods Mol Biol. 2013;1008:35-62. doi: 10.1007/978-1-62703-398-5_2.


Books edited

Bacterial membranes: Structural and molecular biology, Horizon press, In press
Edited by Han Remaut and Rémi Fronzes


Updated on 11/03/2014


t4ss.jpgMarch 2014

The architecture of an assembled type IV sercretion system revealed.


amy.jpgAugust 2013

Amy Diallo joins the lab as a PhD Student.


cover-book.pngJuly 2013

Book "Bacterial membranes: Structural and Molecular Biology" edited by Han Remaut and Rémi Fronzes to be published by Horizon Press.

pilus.jpgJune 2013

Discovery of a type IV pilus involved in natural transformation of Streptococcus pneumoniae, a major human pathogen.


Read more


Dr Rémi Fronzes
Unité G5 Biologie structurale de la sécrétion bactérienne,
Institut Pasteur, 25-28 rue du Docteur Roux
75724 Paris Cedex 15, France
Tel: +33(0)145688864

To find us