The Pasteur Museum is housed in the apartment where Louis Pasteur spent his final seven years and offers a rare behind-the-scenes look at the living and working environment of the world-renowned scientist. Visitors can gain a unique insight into his everyday life alongside his wife and can admire his rich and diverse scientific work.
The Institut Pasteur’s scientific strategy focuses on developing original and innovative topics and promoting interdisciplinary and multidisciplinary cooperation and approaches. The Institut Pasteur teams have access to the technological resources needed to speed up and further improve the quality of their outstanding research.
Ever since the introduction of the world’s first "Technical Microbiology" course in 1889, teaching has been a priority for the Institut Pasteur. The Institut Pasteur has an international reputation for quality teaching that attracts students from all over the world who come to further their training or top up their degree programs.
During the first half of the 20th century, F. Griffith discovered natural (Griffith, 1928) while J. Lederberg and E. Tatum discovered bacterial conjugation (Lederberg & Tatum, 1946). These seminal findings opened the molecular biology erea by contributing to the identification of the molecule transferred during these processes and carrying the genetic information: DNA (Avery et al, 1944).
Nowadays, we know that natural transformation and conjugation are two highly efficient processes that promote bacterial genome plasticity and adaptive response. They are essential for bacterial survival and greatly limit the efficiency of antibiotic treatments or vaccines against some pathogenic bacteria.
Molecular devices mediating DNA translocation through the cellular envelope during conjugation and transformation have been identified. However, more than 50 years after the discovery of bacterial conjugation and transformation, the molecular details of DNA translocation during these two processes remain elusive.
The group “Biologie structurale de la sécrétion bactérienne” or “Structural biology of bacterial secretion” was created in October 2009 at institut Pasteur. We use structural biology (X-ray crystallography and high-resolution electron microscopy) and biochemistry techniques to study the structure of the membrane protein complexes involved in these events.
If you have questions about our research, or are interested in joining the lab please contact us.