The Pasteur Museum is housed in the apartment where Louis Pasteur spent his final seven years and offers a rare behind-the-scenes look at the living and working environment of the world-renowned scientist. Visitors can gain a unique insight into his everyday life alongside his wife and can admire his rich and diverse scientific work.
The Institut Pasteur’s scientific strategy focuses on developing original and innovative topics and promoting interdisciplinary and multidisciplinary cooperation and approaches. The Institut Pasteur teams have access to the technological resources needed to speed up and further improve the quality of their outstanding research.
Ever since the introduction of the world’s first "Technical Microbiology" course in 1889, teaching has been a priority for the Institut Pasteur. The Institut Pasteur has an international reputation for quality teaching that attracts students from all over the world who come to further their training or top up their degree programs.
With international courses, PhD and postdoctoral traineeship, each institute of the Institut Pasteur International Network (RIIP) contributes to the transmission of knowledge with the training of young researchers all around the world. In this context, doctoral and postdoctoral programmes, study and traineeship fellowships are available to scientists. Alongside training, dynamism and attractiveness of RIIP will result in the creation of 4-year group for the young researchers.
Adaptive constraints at the genomic and genic level in E. coli
Abstract: To uncover the molecular determinants of bacterial adaptation, we have used two alternatives approaches: one at the genome level and one at the gene level. At the genome level, whole genome sequencing of more than 100 lineages independently evolved to high temperature revealed that adaptation proceed through a large diversity of mutation events that affected a few functional targets. Moreover, statistical analysis of the distribution of mutations among lineages uncovered the presence of pervasive epistasis that constrained and shaped the adaptive path of the different populations. At the gene level, we produced, sequenced and phenotypes 10,000 random mutants in betalactamase TEM and studied the determinants of mutation effects on that enzyme. We showed that a biophysical model of protein stability could capture both mutation effects and epistatic interactions among mutations.