The Pasteur Museum is housed in the apartment where Louis Pasteur spent his final seven years and offers a rare behind-the-scenes look at the living and working environment of the world-renowned scientist. Visitors can gain a unique insight into his everyday life alongside his wife and can admire his rich and diverse scientific work.
The Institut Pasteur’s scientific strategy focuses on developing original and innovative topics and promoting interdisciplinary and multidisciplinary cooperation and approaches. The Institut Pasteur teams have access to the technological resources needed to speed up and further improve the quality of their outstanding research.
Ever since the introduction of the world’s first "Technical Microbiology" course in 1889, teaching has been a priority for the Institut Pasteur. The Institut Pasteur has an international reputation for quality teaching that attracts students from all over the world who come to further their training or top up their degree programs.
With international courses, PhD and postdoctoral traineeship, each institute of the Institut Pasteur International Network (RIIP) contributes to the transmission of knowledge with the training of young researchers all around the world. In this context, doctoral and postdoctoral programmes, study and traineeship fellowships are available to scientists. Alongside training, dynamism and attractiveness of RIIP will result in the creation of 4-year group for the young researchers.
Genetic diversity of influenza viruses is jointly determined by the ecology of transmission and host demography
Abstract: Avian Influenza Viruses (AIVs) have been pivotal to the origination of human pandemic strains. Despite their scientific and public health significance, however, there remains much to be understood about the ecology and evolution of AIVs in wild birds, where major pools of genetic diversity are generated and maintained. Here, we present comparative phylodynamic analyses of human and avian influenza viruses in North America, demonstrating significantly higher standing genetic diversity and phylogenetic topology with a weaker signature of immune escape in AIVs compared with human viruses. To explain these differences, we performed statistical analyses that eliminated several potential explanations, including host diversity, differences in nucleotide substitution, and geographic structuring. In contrast, a new model shows the interaction of host demography and ecology of transmission, specifically differential persistence of subtypes in aquatic environments, to be a parsimonious explanatory mechanism. Environmental transmission---a manifestation of the ``storage effect''---highlights the potentially unpredictable impact of AIV reservoir for future human pandemics.