The Pasteur Museum is housed in the apartment where Louis Pasteur spent his final seven years and offers a rare behind-the-scenes look at the living and working environment of the world-renowned scientist. Visitors can gain a unique insight into his everyday life alongside his wife and can admire his rich and diverse scientific work.
The Institut Pasteur’s scientific strategy focuses on developing original and innovative topics and promoting interdisciplinary and multidisciplinary cooperation and approaches. The Institut Pasteur teams have access to the technological resources needed to speed up and further improve the quality of their outstanding research.
Ever since the introduction of the world’s first "Technical Microbiology" course in 1889, teaching has been a priority for the Institut Pasteur. The Institut Pasteur has an international reputation for quality teaching that attracts students from all over the world who come to further their training or top up their degree programs.
With international courses, PhD and postdoctoral traineeship, each institute of the Institut Pasteur International Network (RIIP) contributes to the transmission of knowledge with the training of young researchers all around the world. In this context, doctoral and postdoctoral programmes, study and traineeship fellowships are available to scientists. Alongside training, dynamism and attractiveness of RIIP will result in the creation of 4-year group for the young researchers.
Thierry has been at the Pasteur Institute since 1983 where he worked on Plasmodium falciparum and published more than 20 papers on that topic. After an experience on Yersinia, he joined our lab in January 2006 where he runs numerous projects related to flagellum formation. Also known as Shiva, Thierry uses biochemistry, immunology, molecular and cellular biology on a day-to-day basis. He recently specialised in scanning electron microscopy working at the EM platform of the Institute on virtually all the lab subjects. Trypanosomes, Plasmodium, ciliates, mammalian cilia, mouse kidney, fly tissues... nothing can hide from his hawk eyes! His recent projects are the analysis of the IFT dynein motors where he characterised four different subunits and their interactions with the IFT complexes.
Serge Bonnefoy, Institut Pasteur staff scientist (chargé de recherche)
After spending 18 months in Bolivia working on leishmaniasis, Serge joined the Institut Pasteur in Paris in 1986 where he obtained his PhD on Plasmodium falciparum in Luiz Pereira da Silva’s research group. Following a Pasteur-Roux fellowship, he obtained a permanent position in 1991. In 1995, he spent two years at Stanford University as post-doctoral fellow working on Toxoplasma gondii molecular genetics and differentiation. He then joined Odile Puijalon’s team at Institut Pasteur where he developed some reverse genetic tools to study the malaria parasite, with a special interest for P. falciparum RESA protein which he showed to be a major determinant of mechanical modifications of the infected membrane, allowing to withstand membrane destabilisation caused by febrile temperatures. On January 1st 2014, Serge joined our unit where he is going to investigate the flagellar function of Trypanosoma brucei FLAM8 protein and develop some new genetic tools to study the fate of cells inheriting either the old or the new flagellum.
Anne Cozanet, Institut Pasteur Secretary
Anne has been working at Institut Pasteur since May 2000. For eight years, she worked for the Institute's executive board, within the Scientific Assessment Department. In October 2008, she joined our lab as well as Artur Scherf's (Biology of Host Parasite Interactions). She is running multiple tasks for the lab, especially looking after all newcomers (students, post-docs) and dealing with paperwork. She is also in charge of budget preparation both on the Institut Pasteur side and the CNRS side for the URA2581, to which both labs belong. Having worked abroad for ten years before joining Institut Pasteur, Anne is fluent in English, which helps a lot since a majority of the personnel in both labs is of foreign origin.
Brice Rotureau, Institut Pasteur staff scientist (chargé de recherche)
After his PhD work on the eco-epidemiology of leishmaniases at the Faculty of Medicine of Cayenne (French Guiana), Brice spent one year as an epidemiologist at the Tropical and International Department of the French Institute for Public Health Surveillance (InVS, Saint-Maurice, France). He joined the lab as a post-doc in May 2007, to study the development and behaviour of trypanosomes during the infection of the tsetse flies. He has initiated an interaction with the CIRAD-IRD group of Gérard Cuny (Montpellier, France) who has provided the tsetse flies that were maintained and infected with T. brucei in our lab. Recently, in partnership with the CIRDES (Bobo-Dioulasso, Burkina Faso), he set up a new insectarium to maintain two tsetse colonies, in interaction with Sylvie Perrot. Brice has investigated the cell biology of trypanosomes during their multiple developmental stages in the insect, especially in the salivary glands. He recently developed the use of fluorescent parasites to monitor more precisely the role of several flagellar components in cell plasticity and motility. In July 2011, Brice obtained a permanent position as an Assistant Professor at the Institut Pasteur. In addition to the study of the roles of the trypanosome flagellum in sensing in the tseste fly, he is currently studying the development of trypanosomes during the early steps of the infection in the mammalian host by several dynamic imaging approaches in vivo.
Sylvie Perrot, Institut Pasteur Technician
Sylvie has been working at the Institut Pasteur since 1983. In the beginning she used to work on entomopathogen fungi and acquired experience in breeding different insects such as silkworm, Galleria mellonella, drosophilae and mosquitoes. She then went on to work on Plasmodium, first in the vector and then in human beings. During that period, she learned transmission and scanning electron microscopy. She joined the unit in 2011 where she is now developing the breeding of Glossina morsitans and also trying to unveil the most hidden secrets of Trypanosoma using transmission electron microscopy.
Post-doctoral fellows & students
Norus Ahmed, master student, Keele University (Royaume Uni)
During his bachelor degree at Keele University Norus carried out an internship at the Institut Pasteur in Catherine Bourgouin’lab working on gametocyte maturation and sex ratios in P. falciparum NF54. He has joined our lab in February 2014 for a seven-month internship working on T.brucei transition zone.
Eloïse Bertiaux, master student, Paris VII University
Eloïse is a Master 2 IMVI student from the Paris Diderot University. During her bachelor in Montpellier, she did an internship in Catherine Braun-Breton’s team working on host cell remodelling by Plasmodium falciparum. In 2013, she took part in the Pasteur Microbiology Course. Last summer, she spent two months in Mathieu Picardeau’s lab at Institut Pasteur to study the role of chemotaxis in Spirochetes. She joined our lab in December 2013 for a six-month internship. She is studying the roles of IFT in trypanosome morphogenesis during the parasite cycle.
Cécile Fort, PhD student
Cecile is passionate about research and imaging techniques including both photonics and electronics. She obtained a master's degree at the University of Rouen, specializing in "Imaging for biology". Her internship was carried out in Beatrice Satiat-Jeunemaitre's lab (ISV - Gif sur Yvette) where she studied the endomembrane compartment, including the Golgi apparatus in BY2 tobacco cells. Subsequently, Cécile joined Graça Raposo's lab at Institut Curie and got interested in the formation of amyloid fibres during in vivo melanogenesis. Cecile obtained a PhD fellowship from the graduate school IVIV (ED 387) and joined Philippe's lab on October 1st, 2012. The purpose of her thesis is to understand how the IFT particle moves along flagellar microtubules.
Julien Santi-Rocca, Post-doctoral fellow
During his PhD at the Institut Pasteur (Dr. Nancy Guillén’s lab), Julien studied the molecular biology of Entamoeba histolytica, the agent of amoebiasis. He developed RNAi methods to knockdown gene expression in this protozoan parasite as well as a diagnosis tool for the detection of intestinal amoebiasis. His thesis won a special award from the Société Française de Parasitologie. After defending his PhD in 2008, Julien chose to go on with the study of host-parasite interactions, focusing on the immunology of Chagas disease. He joined Pr. Fresno’s lab at the CBMSO (Madrid, Spain) for a first post-doc, where he used Trypanosoma cruzi as a model to investigate about the bittersweet dialogue between the parasite and the host. The modulation of the immune system impacting both parasite and host survival was studied both in vivo and in vitro. Julien joined the lab in September 2012 thanks to an FRM post-doctoral fellowship. He is studying the mechanisms controlling variations of flagellum length during the life cycle of Trypanosoma brucei.
During her PhD at the "Service de santé des Armées" (Pr. Daniel Parzy’s unit), Christelle studied the cytokines and transcriptomic responses according to the severity of malaria due to Plasmodium falciparum in hyperendemic area (DRC, Africa). She collaborated to the establishment and follow-up of a clinical trial with local medical staff (Monkole, DRC). She also contributed to the development of a high throughput screening method by coupling of proteins or peptides to magnetic beads. Christelle joined the lab in March 2014 thanks to an ANR LabEx IBEID post-doctoral fellowship. She is studying the development of trypanosomes during the early stages of the infection in the mammalian host by intravital imaging approaches in vivo and the implication of the flagellum in host-parasite interactions.
After his PhD in Bordeaux on the structure of membrane proteins using cryo-electron tomography, Sylvain did his first post-doc in Frankfurt, Germany where he continued working with electron microscopes on whole bacteria cells. With his strong background in electron microscopy, he is now a post-doc member of the U759 Inserm unit at the Institut Curie in Orsay where he is working on the structure and ultrastructure of Trypanosoma brucei brucei axoneme components in collaboration with Philippe Bastin and his group.