Publications

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The GTPase IFT27 is involved in both anterograde and retrograde intraflagellar transport.

Huet D, Blisnick T, Perrot S, Bastin P.

Elife. 2014 Apr 24;3:e02419. doi: 10.7554/eLife.02419.

PMID: 24843028 [PubMed]

 

The Leishmania donovani chaperone cyclophilin 40 is essential for intracellular infection independent of its stage-specific phosphorylation status.

Yau WL, Pescher P, Macdonald A, Hem S, Zander D, Retzlaff S, Blisnick T, Rotureau B, Rosenqvist H, Wiese M, Bastin P, Clos J, Späth GF.

Mol Microbiol. 2014 May 8. doi: 10.1111/mmi.12639. [Epub ahead of print]

 

Proteomic analysis of intact flagella of procyclic Trypanosoma brucei cells identifies novel flagellar proteins with unique sub-localisation and dynamics.

Subota I, Julkowska D, Vincensini L, Reeg N, Buisson J, Blisnick T, Huet D, Perrot S, Santi-Rocca J, Duchateau M, Hourdel V, Rousselle JC, Cayet N, Namane A, Chamot-Rooke J, Bastin P.

Mol Cell Proteomics. 2014 Apr 16. [Epub ahead of print]

 

Boarder control on the IFT train.

Fort C, Bastin P.

Elife. 2014 Mar 18;3:e02531. doi: 10.7554/eLife.02531.

 

Morga B, Bastin P.

Cilia. 2013 Nov 29;2(1):16. doi: 10.1186/2046-2530-2-16.

 


More than meets the eye: understanding Trypanosoma brucei morphology in the tsetse.

Ooi CP, Bastin P.

Front Cell Infect Microbiol. 2013 Nov 13;3:71. doi: 10.3389/fcimb.2013.00071. Review.

 


Forward motility is essential for trypanosome infection in the tsetse fly.

Rotureau B, Ooi CP, Huet D, Perrot S, Bastin P.

Cell Microbiol. 2013 Oct 18. doi: 10.1111/cmi.12230. [Epub ahead of print]

Van Den Abbeele J, Rotureau B.

Front Cell Infect Microbiol. 2013 Oct 16;3:63. doi: 10.3389/fcimb.2013.00063.

 


Through the dark continent: African trypanosome development in the tsetse fly.

Rotureau B, Van Den Abbeele J.

Front Cell Infect Microbiol. 2013 Sep 18;3:53. doi: 10.3389/fcimb.2013.00053. Review.

 


Molecular basis of tubulin transport within the cilium by IFT74 and IFT81.

Bhogaraju S, Cajanek L, Fort C, Blisnick T, Weber K, Taschner M, Mizuno N, Lamla S, Bastin P, Nigg EA, Lorentzen E.

Science. 2013 Aug 30;341(6149):1009-12. doi: 10.1126/science.1240985.

 


Apoptotic marker expression in the absence of cell death in staurosporine-treated Leishmania donovani.

Foucher AL, Rachidi N, Gharbi S, Blisnick T, Bastin P, Pemberton IK, Späth GF.

Antimicrob Agents Chemother. 2013 Mar;57(3):1252-61. doi: 10.1128/AAC.01983-12. Epub 2012 Dec 21.

 


Trypanosoma brucei FKBP12 differentially controls motility and cytokinesis in procyclic and bloodstream forms.

Brasseur A, Rotureau B, Vermeersch M, Blisnick T, Salmon D, Bastin P, Pays E, Vanhamme L, Pérez-Morga D.

Eukaryot Cell. 2013 Feb;12(2):168-81. doi: 10.1128/EC.00077-12. Epub 2012 Oct 26.

 


Intraflagellar transport proteins cycle between the flagellum and its base.

Buisson J, Chenouard N, Lagache T, Blisnick T, Olivo-Marin JC, Bastin P.

J Cell Sci. 2013 Jan 1;126(Pt 1):327-38. doi: 10.1242/jcs.117069. Epub 2012 Sep 19.


 

NUP-1 Is a large coiled-coil nucleoskeletal protein in trypanosomes with lamin-like functions.

DuBois KN, Alsford S, Holden JM, Buisson J, Swiderski M, Bart JM, Ratushny AV, Wan Y, Bastin P, Barry JD, Navarro M, Horn D, Aitchison JD, Rout MP, Field MC.

PLoS Biol. 2012 Mar 27.

PMID: 22479148 [PubMed - indexed for MEDLINE]



Apoptotic marker expression in the absence of cell death in staurosporine treated Leishmania donovani.

Foucher AL, Rachidi N, Gharbi S, Blisnick T, Bastin P, Pemberton IK, Späth GF.

Antimicrob Agents Chemother. 2012 Dec 21.

 

 

Trypanosoma brucei FKBP12 differentially controls motility and cytokinesis in procyclic and bloodstream forms.

Brasseur A, Rotureau B, Vermeersch M, Blisnick T, Salmon D, Bastin P, Pays E, Vanhamme L, Pérez-Morga D.

Eukaryot Cell. 2012 Oct 26.

 

 

Intraflagellar transport proteins cycle between the flagellum and its base.

Buisson J, Chenouard N, Lagache T, Blisnick T, Olivo-Marin JC, Bastin P.

J Cell Sci. 2012 Sep 19.

PMID:22992454 [PubMed - as supplied by publisher]

 

A new asymmetric division contributes to the continuous production of infective trypanosomes in the tsetse fly.

Rotureau B, Subota I, Buisson J, Bastin P.

Development. 2012 May;139(10):1842-50. Epub 2012 Apr 4.

PMID: 22491946 [PubMed - indexed for MEDLINE]


 

Genetic engineering of Trypanosoma (Dutonella) vivax and in vitro differentiation under axenic conditions.

D'Archivio S, Medina M, Cosson A, Chamond N, Rotureau B, Minoprio P, Goyard S.

PLoS Negl Trop Dis. 2011 Dec;5(12):e1461. doi: 10.1371/journal.pntd.0001461. Epub 2011 Dec 27.

PMID: 22216367 [PubMed - indexed for MEDLINE]

 

 

ALBA proteins are stage regulated during trypanosome development in the tsetse fly and participate in differentiation.

Subota I, Rotureau B, Blisnick T, Ngwabyt S, Durand-Dubief M, Engstler M, Bastin P.

Mol Biol Cell. 2011 Nov;22(22):4205-19. Epub 2011 Sep 30.

PMID: 21965287 [PubMed - in process] Related citations

 

 

[The importance of model organisms to study cilia and flagella biology].

Vincensini L, Blisnick T, Bastin P.

Biol Aujourdhui. 2011;205(1):5-28. Epub 2011 Apr 19. Review. French.

PMID: 21501571 [PubMed - indexed for MEDLINE] Related citations

 

Quantitative proteome profiling informs on phenotypic traits that adapt Leishmania donovani for axenic and intracellular proliferation.

Pescher P, Blisnick T, Bastin P, Späth GF.

Cell Microbiol. 2011 Jul;13(7):978-91. doi: 10.1111/j.1462-5822.2011.01593.x. Epub 2011 Apr 26.

PMID: 21501362 [PubMed - indexed for MEDLINE] Related citations

 

The ciliary pocket: a once-forgotten membrane domain at the base of cilia.

Ghossoub R, Molla-Herman A, Bastin P, Benmerah A.

Biol Cell. 2011 Mar;103(3):131-44. Review.

PMID: 21275905 [PubMed - indexed for MEDLINE] Related citations

 

 

Vincensini L, Blisnick T, Bastin P.

Biol Cell. 2011 Mar;103(3):109-30. Review.

PMID: 21275904 [PubMed - indexed for MEDLINE] Related citations

 

 

Molecular bases of cytoskeleton plasticity during the Trypanosoma brucei parasite cycle.

Rotureau B, Subota I, Bastin P.

Cell Microbiol. 2011 May;13(5):705-16. doi: 10.1111/j.1462-5822.2010.01566.x. Epub 2011 Jan 18.

PMID: 21159115 [PubMed - indexed for MEDLINE] Related citations

 

 

Cyclosporin A treatment of Leishmania donovani reveals stage-specific functions of cyclophilins in parasite proliferation and viability.

Yau WL, Blisnick T, Taly JF, Helmer-Citterich M, Schiene-Fischer C, Leclercq O, Li J, Schmidt-Arras D, Morales MA, Notredame C, Romo D, Bastin P, Späth GF.

PLoS Negl Trop Dis. 2010 Jun 29;4(6):e729.

PMID: 20614016 [PubMed - indexed for MEDLINE] Related citations

 

 

Bastin P.

Curr Opin Microbiol. 2010 Aug;13(4):450-2. Epub 2010 Jun 25. No abstract available.

PMID: 20579933 [PubMed - indexed for MEDLINE] Related citations

 

The ciliary pocket: an endocytic membrane domain at the base of primary and motile cilia.

Molla-Herman A, Ghossoub R, Blisnick T, Meunier A, Serres C, Silbermann F, Emmerson C, Romeo K, Bourdoncle P, Schmitt A, Saunier S, Spassky N, Bastin P, Benmerah A.

J Cell Sci. 2010 May 15;123(Pt 10):1785-95. Epub 2010 Apr 27.

PMID: 20427320 [PubMed - indexed for MEDLINE] Related citations

 

 

Kinesin 9 family members perform separate functions in the trypanosome flagellum.

Demonchy R, Blisnick T, Deprez C, Toutirais G, Loussert C, Marande W, Grellier P, Bastin P, Kohl L.

J Cell Biol. 2009 Nov 30;187(5):615-22. Epub 2009 Nov 23.

PMID: 19948486 [PubMed - indexed for MEDLINE] Related citations



 

Loss-of-function mutations in the human ortholog of Chlamydomonas reinhardtii ODA7 disrupt dynein arm assembly and cause primary ciliary dyskinesia.

Duquesnoy P, Escudier E, Vincensini L, Freshour J, Bridoux AM, Coste A, Deschildre A, de Blic J, Legendre M, Montantin G, Tenreiro H, Vojtek AM, Loussert C, Clément A, Escalier D, Bastin P, Mitchell DR, Amselem S.

Am J Hum Genet. 2009 Dec;85(6):890-6. Epub .

PMID: 19944405 [PubMed - indexed for MEDLINE] Related citations

 

 

A novel function for the atypical small G protein Rab-like 5 in the assembly of the trypanosome flagellum.

Adhiambo C, Blisnick T, Toutirais G, Delannoy E, Bastin P.

J Cell Sci. 2009 Mar 15;122(Pt 6):834-41. Epub 2009 Feb 24.

PMID: 19240117 [PubMed - indexed for MEDLINE] Related citations

 

The flagellum-mitogen-activated protein kinase connection in Trypanosomatids: a key sensory role in parasite signalling and development?

Rotureau B, Morales MA, Bastin P, Späth GF.

Cell Microbiol. 2009 May;11(5):710-8. doi: 10.1111/j.1462-5822.2009.01295.x. Epub 2009 Feb 4. Review.

PMID: 19207727 [PubMed - indexed for MEDLINE] Related citations

 

Tools for analyzing intraflagellar transport in trypanosomes.

Julkowska D, Bastin P.

Methods Cell Biol. 2009;93:59-80. Epub 2009 Dec 4.

PMID: 20409811 [PubMed - indexed for MEDLINE] Related citations

 

Flagellum elongation is required for correct structure, orientation and function of the flagellar pocket in Trypanosoma brucei.

Absalon S, Blisnick T, Bonhivers M, Kohl L, Cayet N, Toutirais G, Buisson J, Robinson D, Bastin P.

J Cell Sci. 2008 Nov 15;121(Pt 22):3704-16. Epub 2008 Oct 21.

PMID: 18940910 [PubMed - indexed for MEDLINE] Related citations

 

Intraflagellar transport and functional analysis of genes required for flagellum formation in trypanosomes.

Absalon S, Blisnick T, Kohl L, Toutirais G, Doré G, Julkowska D, Tavenet A, Bastin P.

Mol Biol Cell. 2008 Mar;19(3):929-44. Epub 2007 Dec 19.

PMID: 18094047 [PubMed - indexed for MEDLINE] Related citations

 

The Argonaute protein TbAGO1 contributes to large and mini-chromosome segregation and is required for control of RIME retroposons and RHS pseudogene-associated transcripts.

Durand-Dubief M, Absalon S, Menzer L, Ngwabyt S, Ersfeld K, Bastin P.

Mol Biochem Parasitol. 2007 Dec;156(2):144-53. Epub 2007 Aug 1.

PMID: 17822785 [PubMed - indexed for MEDLINE] Related citations

 

Basal body positioning is controlled by flagellum formation in Trypanosoma brucei.

Absalon S, Kohl L, Branche C, Blisnick T, Toutirais G, Rusconi F, Cosson J, Bonhivers M, Robinson D, Bastin P.

PLoS One. 2007 May 9;2(5):e437.

PMID: 17487282 [PubMed - indexed for MEDLINE] Related citations

 

 

Conserved and specific functions of axoneme components in trypanosome motility.

Branche C, Kohl L, Toutirais G, Buisson J, Cosson J, Bastin P.

J Cell Sci. 2006 Aug 15;119(Pt 16):3443-55. Epub 2006 Aug 1.

PMID: 16882690 [PubMed - indexed for MEDLINE] Related citation

Updated on 06/06/2014

News

02-07-14 Thierry's paper describing the functioning of the IFT dynein motor is now published in Molecular Biology of the Cell

 

05-06-2014 Sabrina Absalon visits the department and will give a talk on 3rd  July at 12:00. Sabrina got her PhD in our lab in 2007 and now works in Harvard on Plasmodium egress from red blood cells.

 

 

All news

We and 3 other European groups are organising the 2nd European Cilia meeting in Paris.

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We are coordinators of the French network GDR CILS that groups 30 teams throughout France working on cilia and flagella in diverse species.

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The third Trypanosomatid meeting will be held at the Muséum d'Histoire Naturelle.

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Job opportunities

There are currently no positions available in the lab but spontaneous applications are always welcome.

How to find us

campus1.jpgInstitut Pasteur
25 rue du Docteur Roux
75724 Paris cedex 15
France

tel. +33 1 45 68 86 27
fax. +33 1 40 61 38 25

The lab is located on the first floor of the Nicolle building, n°65 on the Map of Institut Pasteur


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