The Pasteur Museum is housed in the apartment where Louis Pasteur spent his final seven years and offers a rare behind-the-scenes look at the living and working environment of the world-renowned scientist. Visitors can gain a unique insight into his everyday life alongside his ...
The Institut Pasteur’s scientific strategy focuses on developing original and innovative topics and promoting interdisciplinary and multidisciplinary cooperation and approaches. The Institut Pasteur teams have access to the technological resources ...
Ever since the introduction of the world’s first "Technical Microbiology" course in 1889, teaching has been a priority for the Institut Pasteur. The Institut Pasteur has an international reputation for quality teaching that attracts students from all over ...
The mission of the Industrial Partnership team is to detect, promote, assist and protect the inventive activities from research (inventions, know-how and biological materials) conducted at the Institut Pasteur (and in some Institutes of its international network), and transfer there to industrial ...
With international courses, PhD and postdoctoral traineeship, each institute of the Institut Pasteur International Network (RIIP) contributes to the transmission of knowledge with the training of young researchers all around the world. In this context, doctoral and postdoctoral programmes, study ...
Thierry has been at the Pasteur Institute since 1983 where he worked on Plasmodium falciparum and published more than 20 papers on that topic. After an experience on Yersinia, he joined our lab in January 2006 where he runs numerous projects related to flagellum formation. Also known as Shiva, Thierry uses biochemistry, immunology, molecular and cellular biology on a day-to-day basis. He recently specialised in scanning electron microscopy working at the EM platform of the Institute on virtually all the lab subjects. Trypanosomes, Plasmodium, ciliates, mammalian cilia, mouse kidney, fly tissues... nothing can hide from his hawk eyes! His recent projects are the analysis of the IFT dynein motors where he characterised four different subunits and their interactions with the IFT complexes.
Serge Bonnefoy, Institut Pasteur staff scientist (chargé de recherche)
After spending 18 months in Bolivia working on leishmaniasis, Serge joined the Institut Pasteur in Paris in 1986 where he obtained his PhD on Plasmodium falciparum in Luiz Pereira da Silva’s research group. Following a Pasteur-Roux fellowship, he obtained a permanent position in 1991. In 1995, he spent two years at Stanford University as post-doctoral fellow working on Toxoplasma gondii molecular genetics and differentiation. He then joined Odile Puijalon’s team at Institut Pasteur where he developed some reverse genetic tools to study the malaria parasite, with a special interest for P. falciparum RESA protein which he showed to be a major determinant of mechanical modifications of the infected membrane, allowing to withstand membrane destabilisation caused by febrile temperatures. On January 1st 2014, Serge joined our unit where he is going to investigate the flagellar function of Trypanosoma brucei FLAM8 protein and develop some new genetic tools to study the fate of cells inheriting either the old or the new flagellum.
Anne Cozanet, Institut Pasteur Secretary
Anne has been working at Institut Pasteur since May 2000. For eight years, she worked for the Institute's executive board, within the Scientific Assessment Department. In October 2008, she joined our lab as well as Artur Scherf's (Biology of Host Parasite Interactions). She is running multiple tasks for the lab, especially looking after all newcomers (students, post-docs) and dealing with paperwork. She is also in charge of budget preparation both on the Institut Pasteur side and the CNRS side for the URA2581, to which both labs belong. Having worked abroad for ten years before joining Institut Pasteur, Anne is fluent in English, which helps a lot since a majority of the personnel in both labs is of foreign origin.
Brice Rotureau, Institut Pasteur staff scientist (chargé de recherche)
After his PhD work on the eco-epidemiology of leishmaniases at the Faculty of Medicine of Cayenne (French Guiana), Brice spent one year as an epidemiologist at the Tropical and International Department of the French Institute for Public Health Surveillance (InVS, Saint-Maurice, France). He joined the lab as a post-doc in May 2007, to study the development and behaviour of trypanosomes during the infection of the tsetse flies. He has initiated an interaction with the CIRAD-IRD group of Gérard Cuny (Montpellier, France) who has provided the tsetse flies that were maintained and infected with T. brucei in our lab. Recently, in partnership with the CIRDES (Bobo-Dioulasso, Burkina Faso), he set up a new insectarium to maintain two tsetse colonies, in interaction with Sylvie Perrot. Brice has investigated the cell biology of trypanosomes during their multiple developmental stages in the insect, especially in the salivary glands. He recently developed the use of fluorescent parasites to monitor more precisely the role of several flagellar components in cell plasticity and motility. In July 2011, Brice obtained a permanent position as an Assistant Professor at the Institut Pasteur. In addition to the study of the roles of the trypanosome flagellum in sensing in the tseste fly, he is currently studying the development of trypanosomes during the early steps of the infection in the mammalian host by several dynamic imaging approaches in vivo.
Sylvie Perrot, Institut Pasteur Technician
Sylvie has been working at the Institut Pasteur since 1983. In the beginning she used to work on entomopathogen fungi and acquired experience in breeding different insects such as silkworm, Galleria mellonella, drosophilae and mosquitoes. She then went on to work on Plasmodium, first in the vector and then in human beings. During that period, she learned transmission and scanning electron microscopy. She joined the unit in 2011 where she is now developing the breeding of Glossina morsitans and also trying to unveil the most hidden secrets of Trypanosoma using transmission electron microscopy.
Post-doctoral fellows & students
Eloïse Bertiaux, PhD student, Paris VII University (Complexité du Vivant)
During her bachelor in Montpellier, Eloïse did an internship in Catherine Braun-Breton’s team working on host cell remodelling by Plasmodium falciparum. In the summer of 2012, she spent two months in Mathieu Picardeau’s lab at Institut Pasteur to study the role of chemotaxis in Spirochetes. In 2013, she took part in the Pasteur Microbiology Course and then joined our lab in December for a six-month internship to complete her master's degree studying the roles of IFT in trypanosome morphogenesis during the parasite cycle. Eloïse is now back in the lab to start her PhD as from October 1st, 2014.
Estefanìa Calvo-Alvarez, Post-doctoral fellow
During her PhD at the University of Leòn in Spain, Estefanìa's research was focussed on the use of fluorescent proteins and the generation of stably-transgenic Leishmania major and L. infantum strains to be used in animal models of infection at real time by using In Vivo Imaging Systems (IVIS) and in novel intraclonal genetic exchange studies within the sandfly vector Phlebotomus perniciosus.
Estefanìa joined the lab in April 2015 as a post-doctoral fellow to understand the contribution of the flagellum by examining the behaviour of fluorescent trypanosomes that are deficient in certain flagellar functions and to visualize the early steps of trypanosome infection in the mammalian host upon tsetse fly bite by intravital microscopy.
Cécile Fort, PhD student
Cecile is passionate about research and imaging techniques including both photonics and electronics. She obtained a master's degree at the University of Rouen, specializing in "Imaging for biology". Her internship was carried out in Beatrice Satiat-Jeunemaitre's lab (ISV - Gif sur Yvette) where she studied the endomembrane compartment, including the Golgi apparatus in BY2 tobacco cells. Subsequently, Cécile joined Graça Raposo's lab at Institut Curie and got interested in the formation of amyloid fibres during in vivo melanogenesis. Cecile obtained a PhD fellowship from the graduate school IVIV (ED 387) and joined Philippe's lab on October 1st, 2012. The purpose of her thesis is to understand how the IFT particle moves along flagellar microtubules.
Eugénie Grigorian, BSc student, Paris VI University
Supervised by Serge, the goal of Eugénie's four-month internship will consist in investigating the flagellar function of Trypanosoma brucei FLAM8 protein and intraflagellar transport. Molecular biology and fluorescence microscopy will be used to analyse the results.
During her PhD at the "Service de santé des Armées" (Pr. Daniel Parzy’s unit), Christelle studied the cytokines and transcriptomic responses according to the severity of malaria due to Plasmodium falciparum in hyperendemic area (DRC, Africa). She collaborated to the establishment and follow-up of a clinical trial with local medical staff (Monkole, DRC). She also contributed to the development of a high throughput screening method by coupling of proteins or peptides to magnetic beads. Christelle joined the lab in March 2014 thanks to an ANR LabEx IBEID post-doctoral fellowship. She is studying the development of trypanosomes during the early stages of the infection in the mammalian host by intravital imaging approaches in vivo and the implication of the flagellum in host-parasite interactions.
Shahaan Shafiq, Bachelor student from Keele University (UK)
Shahaan joined the lab on 1st October 2014 to work on the peculiarities of the IFT22/RABL5 protein under the supervision of Cécile. He will be staying with us until end of July 2015.
12-05-2015 Cécile is awarded a FRM fellowship to complete her thesis. This will allow to finish her two exciting projects on the role of IFT in mature flagella and on the positioning of IFT trains along axonemal microtubules.
01-04-15 Arrival of Estafania Calvo-Alvarez who will work as post-doctoral fellow under Brice's guidance to investigate interactions between trypanosomes and their environment in vivo.