Molecular Parasitology and Signaling



The ‘Unité de Parasitologie moléculaire et Signalisation (ParSig)’ investigates the parasite-specific biology of Leishmania, an important human pathogen that causes severe mortality and morbidity worldwide.



We apply systems-wide approaches and innovative genetic techniques to reveal unique regulatory mechanisms underlying parasite development and intracellular survival. Our major objective is to translate our basic research findings into pre-clinical application through pharmacological and genetic drug target validation, and the development and application of target-based and phenotypic screening assays. Our translational research program is based on the coordination of multi-disciplinary consortia, including LEISHDRUG, TRANSLEISH, TranSig or LeiSHield, which interface academic, private, and industrial partners as well as laboratories from the IP International Network (IPIN) for anti-leishmanial drug development.





Gérald Spaeth - Head of Laboratory

Unit “Molecular Parasitology and Signaling”

Institut Pasteur

25-28 rue du docteur Roux

75015 PARIS

Phone:   +


Sophie Veillault - Assistant

Phone:   +