Molecular parasitology and Signaling - G. Spaeth


Foucher AL, Rachidi N, Gharbi S, Blisnick T, Bastin P, Pemberton IK, Späth GF, "Apoptotic marker expression in the absence of cell death in staurosporine treated Leishmania donovani", Antimicrob Agents Chemother. 2012 Dec 21. [Epub ahead of print].


Horjales S, Schmidt-Arras D, Limardo RR, Leclercq O, Obal G, Prina E, Turjanski AG, Späth GF, Buschiazzo A. Structure, “The crystal structure of the MAP kinase LmaMPK10 from Leishmania major reveals parasite-specific features and regulatory mechanisms”, 2012 Oct 10;20(10):1649-60. doi: 10.1016/j.str.2012.07.005. Epub 2012 Aug 9.


Müller AJ, Filipe-Santos O, Eberl G, Aebischer T, Späth GF, Bousso P. Immunity, “CD4+ T cells rely on a cytokine gradient to control intracellular pathogens beyond sites of antigen presentation”, 2012 Jul 27;37(1):147-57. doi: 10.1016/j.immuni.2012.05.015. Epub 2012 Jun 21.


Forestier C.L., Machu C., Loussert C., Pescher P., and Späth G.F., “Imaging host cell-Leishmania interaction dynamics implicates parasite motility, lysosome recruitment and host cell wounding in the infection process”, Cell Host Microbe. 2011 Apr 21;9(4):319-30.


Morales M.A., Watanabe R., Dacher M., Chafey P., Osorio y Fortéa J., Scott D.A., Beverley S.M.,  Ommen G., Clos J., Hem S., Lenormand P., Rousselle J., Namane A., and Späth G.F.,  "Phosphoproteome dynamics reveal heat shock protein complexes specific to the Leishmania donovani infectious stage", PNAS 2010,107(18):8381-6.


Aspergillus - JP LATGE


Fontaine T, Delangle A, Simenel C, Coddeville B, Van Vliet S, Van Kooyk Y, Bozza S, Moretti S, Schwarz F, Trichot C, Aebi M, Delepierre M, Elbim C, Romani L, Latgé JP. (2011) Galactosaminogalactan, a new immunosuppressive polysaccharide of Aspergillus fumigatus. Plos Pathogens e1002372


Gastebois A, Fontaine T, Latgé JP, Mouyna I. (2010) The {beta}(1-3)glucanosyltransférase Gel4p is essential for Aspergillus fumigatus. Eukaryot Cell. 9:1294-1298.


Aimanianda V, Bayry J, Biozza S, Kniemeyer O, Perruccio K, Elluru R, Clavaud C, Paris S, Brakhage AA, Kaveri SV, Romani L, Latgé JP. (2009) Surface hydrophobin prevents immune recognition of airborne fungal conidia. Nature. 460:1117-1123


Beauvais A, Schmidt C, Guadagnini S, Roux P, Perret E, Henry C, Paris S, Mallet A, Prévost MC, & Latgé JP. (2007) An extracellular matrix glues together the aerial-grown hyphae of Aspergillus fumigatus. Cell Microbiol. 9(6):1588-1600.


Fontaine T, Simenel C, Dubreucq G, Adam O, Delepierre M, Lemoine J, Vorgias CE, Diaquin M, Latgé JP (2000) Molecular organization of the alkali-insoluble fraction of Aspergillus fumigatus cell wall. J. Biol. Chem. 275: :27594-607.


Biology of Host-Parasite Interactions - A. SCHERF


Mancio-Silva, L., Lopez-Rubio J.J. and Scherf A.  Sir2a regulates rRNA transcription and multiplication rate in the human malaria parasite Plasmodium falciparum. Nature Communication (in press)


Malmquist N., Moss M., Mecheri S, Scherf A.1, Fuchter M1. Small molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in P. falciparumPNAS 2012 Oct 9;109(41):16708-13(1 corresponding authors)


Zhang Q, Huang Y, Zhang Y, Fang X, Claes A, Duchateau M, Namane A, Lopez-Rubio JJ, Pan W, Scherf A. A critical role of perinuclear filamentous actin in spatial repositioning and mutually exclusive expression of virulence genes in malaria parasites. Cell Host Microbe. 2011 Nov 17;10(5):451-63.


Porcherie A, Mathieu C, Peronet R, Schneider E, Claver J, Commere PH, Kiefer-Biasizzo H, Karasuyama H, Milon G, Dy M, Kinet JP, Louis J, Blank U, Mécheri S. Critical role of the neutrophil-associated high-affinity receptor for IgE in the pathogenesis of experimental cerebral malaria. J Exp Med. 2011 Oct 24;208(11):2225-36. Epub 2011 Oct 3.


Lopez-Rubio, JJ., Mancio-Silva, L., Scherf, A. (2009) Perinuclear epigenetic factories control phenotypic plasticity and virulence in malaria parasites. Cell Host&Microbe 19;5(2):179-90.




Crawford JE, Bischoff E, Garnier T, Gneme A, Eiglmeier K, Holm I, Riehle MM, Guelbeogo WM, Sagnon N, Lazzaro BP, Vernick KD. Evidence for Population-Specific Positive Selection on Immune Genes of Anopheles gambiae. G3 (Bethesda). 2012; 2(12):1505-19. PMCID: 3516473.


Holm I, Lavazec C, Garnier T, Mitri C, Riehle MM, Bischoff E, Brito-Fravallo E, Takashima E, Thiery I, Zettor A, Petres S, Bourgouin C, Vernick KD, Eiglmeier K. Diverged Alleles of the Anopheles gambiae Leucine-Rich Repeat Gene APL1A Display Distinct Protective Profiles against Plasmodium falciparum. PLoS ONE. 2012;7(12):e52684.


Isaacs AT, Jasinskiene N, Tretiakov M, Thiery I, Zettor A, Bourgouin C, James AA. Transgenic Anopheles stephensi coexpressing single-chain antibodies resist Plasmodium falciparum development. Proceedings of the National Academy of Sciences of the United States of America. 2012;109(28):E1922-30. PMCID: 3396534.


Mitri C, Vernick KD. Anopheles gambiae pathogen susceptibility: the intersection of genetics, immunity and ecology. Curr Opin Microbiol. 2012;15(3):285-91. PMCID: 3404259.


Riehle MM, Guelbeogo WM, Gneme A, Eiglmeier K, Holm I, Bischoff E, Garnier T, Snyder GM, Li X, Markianos K, Sagnon N, Vernick KD. A cryptic subgroup of Anopheles gambiae is highly susceptible to human malaria parasites. Science. 2011;331(6017):596-8. PMCID: 3065189.


Parasite Molecular Immunology - O. PUIJALON


Safeukui I, Correas JM, Brousse V, Hirt D, Deplaine G, Mulé S, Lesurtel M, Goasguen N, Sauvanet A, Couvelard A, Kerneis S, Khun H, Vigan-Womas I, Ottone C, Molina TJ, Tréluyer JM, Mercereau-Puijalon O, Milon G, David PH, Buffet PA. Retention of Plasmodium falciparum ring-infected erythrocytes in the slow, open microcirculation of the human spleen. Blood. 2008 Sep 15;112(6):2520-8. PMID: 18579796.


Ménard D, Barnadas C, Bouchier C, Henry-Halldin C, Gray R, Ratsimbasoa A, Thonier V, Carod J-F, Domarle O, Colin Y, Bertrand O, Picot J, King CL, Grimberg BT, Mercereau-Puijalon O, Zimmerman PA. Plasmodium vivax Clinical Malaria is Commonly Observed in Duffy-negative Malagasy People. Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5967-71. PMID: 20231434.


Deplaine G, Safeukui I, Jeddi F, Lacoste F, Brousse V, Perrot S, Biligui S, Guillotte M, Guitton C, Dokmak S, Aussilhou B, Sauvanet A, Cazals Hatem D, Paye F, Thellier M, Mazier D, Milon G, Mohandas N, Mercereau-Puijalon O, David PH, Buffet PA. The sensing of poorly deformable red blood cells by the human spleen can be mimicked in vitro. Blood. 2011 Feb 24;117(8):e88-95. Epub 2010 Dec 16. PMID: 21163923


Vigan-Womas I, Guillotte M, Juillerat A, Hessel A, Raynal B, England P, Cohen JJ, Bertrand O, Peyrard T, Bentley GA, Lewit-Bentley A, Mercereau-Puijalon O. Structural basis for the ABO blood-group dependence of Plasmodium falciparum rosetting. PloS Pathogens 2012 Jul;8(7):e1002781. Epub 2012 Jul 12. PMID:22807674


Witkowski B, Khim N, Chim P, Kim S, Ke S, Kloeung N, Chy S, Duong S, Leang R, Ringwald P, Dondorp AM, Tripura R, Benoit-Vical F, Berry A, Gorgette O, Ariey F, Barale JC, Mercereau-Puijalon O, Menard D. Reduced artemisinin susceptibility of Plasmodium falciparum ring stages in western Cambodia. Antimicrob Agents Chemother. 2013 Feb;57(2):914-23. doi: 10.1128/AAC.01868-12. Epub 2012 Dec 3. PMID:  23208708


Trypanosome Cell Biology - Ph. BASTIN


Buisson, J., Chenouard, N., Lagache, T., Blisnick, T., Olivo-Marin, J.C., and Bastin, P. (2013). Intraflagellar transport proteins cycle between the flagellum and its base. J Cell Sci 126, 327-338. Highlighted in the Journal. 2nd Highest Download.


Rotureau, B., Subota, I., Buisson, J., and Bastin, P. (2012). A new asymmetric division contributes to the continuous production of infective trypanosomes in the tsetse fly. Development 139, 1842-1850. Cited on F1000.


Subota, I., Rotureau, B., Blisnick, T., Ngwabyt, S., Durand-Dubief, M., Engstler, M., and Bastin, P. (2011). ALBA proteins are stage regulated during trypanosome development in the tsetse fly and participate in differentiation. Mol Biol Cell 22, 4205-4219.


Absalon, S., Blisnick, T., Kohl, L., Toutirais, G., Dore, G., Julkowska, D., Tavenet, A., and Bastin, P. (2008). Intraflagellar transport and functional analysis of genes required for flagellum formation in trypanosomes. Mol Biol Cell 19, 929-944. Cited on F1000.


Kohl, L., Robinson, D., and Bastin, P. (2003). Novel roles for the flagellum in cell morphogenesis and cytokinesis of trypanosomes. EMBO J 22, 5336-5346. Front cover. Highlighted in Science and Nature Microbiology.


Malaria Biology and Genetics - R. MENARD


Bargieri, D., Lagal, V., Tardieux, I., Ménard, R. (2012). Host cell invasion by apicomplexans: what do we know? Trends in Parasitology 28, 131-135.


Giovannini, D., Spaeth, S., Lacroix, C., Perazzi, A., Bargieri, D., Lagal, V., Lebugle, C. Combe, A., Thiberge, S., Baldacci, P., Tardieux, I., Ménard, R. (2011). Independent roles of AMA1 and RON4 in distinct steps of host cell invasion by Apicomplexa. Cell Host Microbe 10, 591-602.


Lacroix, C., Giovannini, D., Combe, A. Bargieri, D.Y., Späth, S., Panchal, D., Tawk, L., Thiberge, S., Carvalho, T.G., Barale, J.C., Bhanot, P., Ménard, R. (2011). FLP/FRT-mediated conditional mutagenesis in pre-erythrocytic stages of Plasmodium berghei. Nature Protocols 6, 1412-1428.


Combe, A., Giovannini, D., Carvalho, T.G., Spath, S., Boisson, B., Loussert, C., Thiberge, S., Lacroix, C., Gueirard, P., Ménard, R. (2009). Clonal conditional mutagenesis in malaria parasites. Cell Host Microbe 5, 386-396.


Gonzalez, V., Combe, A., David, V., Malmquist, NA., Delorme, V., Leroy, C., Blazquez, S., Ménard, R., Tardieux, I. (2009). Host cell entry by apicomplexa parasites requires actin polymerization in the host cell. Cell Host Microbe 19, 259-272.


Updated on 07/10/2014

Departement seminars

Seminars 2015-2016



Next external seminars


9th september 2015


Oregon Health & Science University

Department of Molecular Microbiology & Immunology, Portland - USA

KHARON: How flagellar membrane proteins get across the river styx in Leishmania and African Trypanosomes


17th september 2015

Dr Ruslan Afasizhev

Boston University School of Dental Medicine

Department of Molecular and Cell Biology, Boston - USA

RNA editing enzyme machines


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Next internal seminars


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