Fungal Biology and Pathogenicity

                                                 

The Fungal Biology and Pathogenicity Unit at Institut Pasteur studies the yeasts that are responsible for infections in Humans. In the recent years, fungal infections have become a prominent problem. This in part reflects the increase in immunocompromized individuals (HIV infected individuals, transplant recipients, patients in intensive care units) as well as increased life expectancy. In developed countries, fungal infections are considered as one of the primary causes of nosocomial infections.

Hemiascomycetous yeasts of the genus Candida, and most notably Candida albicans, are responsible for most of the life-threatening systemic fungal infections, especially among intensive-care unit (ICU) patients, cancer patients receiving chemotherapy and patients awaiting transplantation. Life-threatening infections due to Candida species are estimated at > 400,000 cases and ~200,000 deaths per year.

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Christophe d’Enfert’s lab

Cryptococcus neoformans, a basidiomycetous yeast, is responsible for deadly infections in immunocompromized patients, especially those with AIDS. It is globally distributed and causes pneumonia and meningoencephalitis in an estimated 1 million people annually, leading to ~620,000 deaths per year. Fungal infections represent a real concern because of their high mortality rate, despite the availability of antifungal treatments and other therapeutic approaches.

  

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The main aims of the Fungal Biology and Pathogenicity Unit are to study the biology of C. albicans and C. neoformans, the pathophysiology of infections due to these opportunistic pathogens and their epidemiology, with a view to providing solutions for the management of fungal infections. Research within our Unit is therefore focused on four main themes:

 

 

Research on these themes relies on functional genomics tools, some of which are developed within our Unit. We, together with the Munro group at the University of Aberdeen, have developed the C. albicans ORFeome, a plasmid collection for >5200 C. albicans ORFs and are proceeding towards the establishment of collections of barcoded overexpression plasmids and strains.

 

Our Unit forms part of the Mycology Department at Institut Pasteur. We are also affiliated with the department of Genomes and Genetics at Institut Pasteur, and with the Microbiology and the Food Chain Department at the National Institute for Agronomic Research (USC 2019).

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We are organizing the 6th FEBS Advanced Lecture Course on Human Fungal Pathogens in La Colle-sur-Loup, France, May 16-22, 2015.

 

Registration will open December 1st at http://www.pasteur.fr/hfp2015

 

Contact: hfp2015[at]pasteur.fr

Contact

Christophe d’Enfert

Fungal Biology and Pathogenicity Unit

Mycology Department

 

Tel +33 1 40 61 32 57

Fax +33 1 40 61 34 56

Email bpf[at]Pasteur.fr

 

The lab is located on the fourth floor of the Fernbach building, n°68 on the Institut Pasteur’s campus map

 

How to get to Institut Pasteur

News

05-11-2014 Axel Brakhage, HKI Jena Germany, to talk about “Interaction of Aspergillus fumigatus with the immune system”, salle Lwoff 014-015, Institut Pasteur, November 13th at 12 am

 

05-11-2014 Greg Jedd, the National University of Singapore, to talk about “Cell biology of the microfluidic hypha”, salle Jules Bordet, Institut Pasteur, November 7th at 10 am

 

01-11-2014 The Fungal Biology and Pathogenicity Unit joins the newly created Mycology Department at Institut Pasteur. Visit the web site

 

30-10-14 The paper “One Small Step for a Yeast - Microevolution within Macrophages Renders Candida glabrata Hypervirulent Due to a Single Point Mutation » by Brunke et al. And to which we contributed was just published in PLoS Pathogens

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