The Pasteur Museum is housed in the apartment where Louis Pasteur spent his final seven years and offers a rare behind-the-scenes look at the living and working environment of the world-renowned scientist. Visitors can gain a unique insight into his everyday life alongside his wife and can admire his rich and diverse scientific work.
The Institut Pasteur’s scientific strategy focuses on developing original and innovative topics and promoting interdisciplinary and multidisciplinary cooperation and approaches. The Institut Pasteur teams have access to the technological resources needed to speed up and further improve the quality of their outstanding research.
Ever since the introduction of the world’s first "Technical Microbiology" course in 1889, teaching has been a priority for the Institut Pasteur. The Institut Pasteur has an international reputation for quality teaching that attracts students from all over the world who come to further their training or top up their degree programs.
The mission of the Industrial Partnership team is to detect, promote, assist and protect the inventive activities from research (inventions, know-how and biological materials) conducted at the Institut Pasteur (and in some Institutes of its international network), and transfer there to industrial and/or institutional partners, in order to serve the patient needs and for the benefit of the society, as well as to contribute to sustainability of the Institut Pasteur’s resources.
With international courses, PhD and postdoctoral traineeship, each institute of the Institut Pasteur International Network (RIIP) contributes to the transmission of knowledge with the training of young researchers all around the world. In this context, doctoral and postdoctoral programmes, study and traineeship fellowships are available to scientists. Alongside training, dynamism and attractiveness of RIIP will result in the creation of 4-year group for the young researchers.
The living world is presently divided into three cellular lineages: the Bacteria, the Archaea and the Eucarya. We are interested in the events and mechanisms that lead to the establishment of these three lineages and in the role that viruses have played in that history.
The main research axis of our unit focuses on studying viruses of hyperthermophilic Archaea. These viruses are much more diverse than those infecting bacteriaand their virions display unique morphotypes, opening new questions on the origin of viruses and their relationships with cellular organisms. We are studying at the molecular level DNA replication and transcription for several viruses as well as their interactions with their hosts. We are also exploring these highly stable viruses for their potential application in nanotechnologies.
Beside these experimental studies, we are studying several fundamental questions related to microbial evolution using /in silico/ methods through approaches ofmicrobial phylogenomics. We are particularly interested in the phylogeny of microorganisms, and in the emergence and evolution of various key cellular structures and processes, with a focus on the evolutionary links among the three domains of life.
Our interest for viruses infecting microbes leaded us to develop a new project focusing on the study of interactions between bacteriophages and bacteria in animals. Several new viruses infecting bacterial pathogens have been isolated. Their in vivo characterization using two animal models revealed the therapeutic potential of these bacteriophages.
Keywords: Archaea, Viruses, Evolution, Microbial Phylogeny, Bacteriophages and Therapy.