The Pasteur Museum is housed in the apartment where Louis Pasteur spent his final seven years and offers a rare behind-the-scenes look at the living and working environment of the world-renowned scientist. Visitors can gain a unique insight into his everyday life alongside his wife and can admire his rich and diverse scientific work.
The Institut Pasteur’s scientific strategy focuses on developing original and innovative topics and promoting interdisciplinary and multidisciplinary cooperation and approaches. The Institut Pasteur teams have access to the technological resources needed to speed up and further improve the quality of their outstanding research.
Ever since the introduction of the world’s first "Technical Microbiology" course in 1889, teaching has been a priority for the Institut Pasteur. The Institut Pasteur has an international reputation for quality teaching that attracts students from all over the world who come to further their training or top up their degree programs.
With international courses, PhD and postdoctoral traineeship, each institute of the Institut Pasteur International Network (RIIP) contributes to the transmission of knowledge with the training of young researchers all around the world. In this context, doctoral and postdoctoral programmes, study and traineeship fellowships are available to scientists. Alongside training, dynamism and attractiveness of RIIP will result in the creation of 4-year group for the young researchers.
Spirochetes are the causative agents of several important animal and human diseases such as syphilis, Lyme disease and Leptospirosis. The unit is composed of a research group on Leptospira and the National Reference Centers for Borrelia and Leptospira.
The main objective of the Unit is the study of virulence factors in pathogenic strains of Leptospira.
Mathieu Picardeau Lab
Our group has developed a number of tools for genetic manipulation of our model bacterium, the saprophyte L. biflexa in recent years. Since we were interested in iron homeostasis in Leptospira, we performed targeted and random mutagenesis in L. biflexa, then allowing the characterization of several genes encoding iron transporters. This project should also make it possible to evaluate the role of iron in the virulence of pathogenic Leptospira in the infected host.
We sequenced the complete genome of the saprophyte L. biflexa in collaboration with the Platform Genome Analysis of the Pasteur Institute and the Genoscope (Evry, France). The ease of genetic manipulation in L. biflexa provides us with an ideal opportunity for studies of the biology of Leptospira. A comparative genomic analysis between saprophytes and pathogens should reveal clues on the life-styles of Leptospira in the environment and in the infected host providing an opportunity for understanding the transition of an environmental bacteria into an important human and animal pathogen.
The main objective of the National Reference Centers is to transmit the epidemiological traits of Leptospirosis and Lyme disease to Health authorities. We also have the duty to improve diagnostic techniques. For example, we developed a rapid and simple typing method based on the analysis of the polymorphism of variable-number tandem repeats (VNTR) loci in the genome of the pathogenic species of Leptospira. Finally, a surveillance of the incidence of tick contamination by Borrelia is conducted concurrently in different geographical areas in France.
This Unit, covering both fundamental questions and applied sciences in collaboration with the two NRCs, should help to improve our understanding of the biology of spirochetes which remains largely unknown.