Pharmacoepidemiology and Infectious Diseases

Director: Pr Didier Guillemot

Department of Infection and Epidemiology


The Pharmacoepidemiology and Infectious Diseases (Pharmacoépidémiologie et Maladies Infectieuses–PhEMI) research group was launched at the Institut Pasteur in 2007 as one of the teams of INSERM U657, subsequently becoming a separate Institut Pasteur unit in January 2008. Following an AERES evaluation (February 2009), a research team was also established at the University of Versailles Saint Quentin (UVSQ) in January 2010. The group became affiliated to INSERM again in January 2011. It is located on two different sites: the Institut Pasteur campus in Paris, and the UVSQ Medical School, Raymond Poincare University Hospital, Garches.



Our research activities focus on the effects of population exposure to anti-infectious agents, in terms of the risks of infection, bacterial resistance to antibiotics and escape from vaccination, in particular. We investigate the interactions between human populations, antimicrobial drugs, and antimicrobial treatment escape by microbes at the population level, in both hospital and community settings. Our studies aim to evaluate the respective and combined impacts of cross-transmission, host-bacterium interaction (natural or induced by vaccination) and changes in the exposure of the population to antibiotics and vaccines.


We are currently exploring the interaction between exposure of the population to anti-infectious agents and the risk of infectious diseases, taking into account the environmental context of infectious risk dynamics. We use a combination of ad hoc epidemiological investigations and population-wide databases and our work involves the refinement of statistical methods, applications of mathematical modeling (population dynamics), computer simulation and social-science methods.


The specific objectives of our research programs are:

- To improve our understanding and to quantify the influence of selection due to exposure to anti-infectious agents on the spread and escape mechanisms of human pathogens.

- To investigate the factors underlying the dynamics of pathogenic microorganisms, including clone epidemicity, exposure to anti-infectious agents and contact between individuals.

- To assess the public-health impact of changes in exposure to antimicrobial drugs.



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