The Pasteur Museum is housed in the apartment where Louis Pasteur spent his final seven years and offers a rare behind-the-scenes look at the living and working environment of the world-renowned scientist. Visitors can gain a unique insight into his everyday life alongside his ...
The Institut Pasteur’s scientific strategy focuses on developing original and innovative topics and promoting interdisciplinary and multidisciplinary cooperation and approaches. The Institut Pasteur teams have access to the technological resources ...
Ever since the introduction of the world’s first "Technical Microbiology" course in 1889, teaching has been a priority for the Institut Pasteur. The Institut Pasteur has an international reputation for quality teaching that attracts students from all over ...
The mission of the Industrial Partnership team is to detect, promote, assist and protect the inventive activities from research (inventions, know-how and biological materials) conducted at the Institut Pasteur (and in some Institutes of its international network), and transfer there to industrial ...
With international courses, PhD and postdoctoral traineeship, each institute of the Institut Pasteur International Network (RIIP) contributes to the transmission of knowledge with the training of young researchers all around the world. In this context, doctoral and postdoctoral programmes, study ...
G. Eberl, J.P. Di Santo and E. Vivier. 2014. The brave new world of innate lymphoid cells. Nat. Immunol., 16:1-5.
G. Fond, W. Boukouaci, G. Chevalier, A. Regnault, G. Eberl, N. Hamdani, F. Dickerson, A. Macgregor, L. Boyer, A. Dargel, J. Oliveira, R. Tamouza and M. Leboyer. 2014. The “psychomicrobiotic”: Targeting microbiota in major psychiatric disorders: A systematic review. Pathol Biol, in press.
I. Stzepourginski,G. Eberl and L. Peduto. 2014. An optimized protocol for isolating lymphoid stromal cells from the intestinal lamina propria. J. Immunol. Methods, in press.
A.N.J. McKenzie, H. Spits and G. Eberl. 2014. Innate lymphoid cells in inflammation and immunity. Immunity, 18:366-374.
B. Massot, M.-L. Michel, S. Diem, C. Ohnmacht, S. Latour, M. Dy, G. Eberl and M. C. Leite-de-Moraes. 2014. TLR-induced cytokines promote effective proinflammatory natural Th17 cell responses. J. Immunol., 192:5635-5642.
R. Wheeler, G. Chevalier, I. Gomperts-Boneca and G. Eberl. 2014. The biology of bacterial peptidoglycans and their impact on host immunity and physiology. Cellular Microb., 16:1014-1023.
E. Lécuyer, S. Rakotobe, H. Lengliné-Garnier, C. Lebreton, M. Picard, C. Juste, R. Fritzen, G. Eberl, K.D. McCoy, A.J. MacPherson, C.A. Reynaud, N. Cerf-Bensussan and V. Gaboriau-Routhiau. 2014. Segmented filamentous bacterium uses secondary and tertiary lymphoid tissues to induce gut IgA and specific T helper 17 cell responses. Immunity, 17:608-620.
S. Cording, J. Medvedovic, M. Cherrier and G. Eberl. 2014. Development and regulation of RORγt+ innate lymphoid cells. FEBS Letters, in press.
G. Eberl. 2014. A is for immunity. Nature, 508:47-48.
Z. Wang, C. Friedrich, S.C. Hagemann, W.H. Korte, N. Goharani, S. Cording, G. Eberl, T. Sparwasser and M. Lochner. 2014. Regulatory T cells promote a protective Th17-associated immune response to intestinal bacterial infection with C. Rodentium. Mucosal Immunol., 7:1290-1301.
L. Van Maele, C. Carnoy, D. Cayet, S. Ivanov, R. Porte, E. Deruy, J.A. Chabalgoity, J.C. Renauld, G. Eberl, A.G. Benecke, F. Trottein, C. Faveeuw and J.C. Sirard. 2014. Activation of type 3 innate lymphoid cells and IL-22 secretion in lung during Streptococcus pneumoniae infection. J. Infect. Dis., 210:493-503.
A.A. Kruglov, S.I. Grivennikov, D.V. Kuprash, C. Winsauer, S. Prepens, G.M. Seleznik, G. Eberl, D.R. Littman, M. Heikenwalder, A.V. Tumanov and S.A. Nedospasov. 2013. Nonredudnant function of soluble LTa3 produced by innate lymphoid cells in intestinal homeostasis. Science, 342:1243.
K. Guedj, J. Khallou-Laschet, M. Clement, M. Morvan, A.T. Gaston, G. Fornasa, J. Dai, M. Gervais-Taurel, G. Eberl, J.B. Michel, G. Cagliuri and A. Nicoletti. 2013. M1 macrophages act as LTβR-independent lymphoid tissue-inducer cells during atherosclerosis-related lymphoid neogenesis. Cardiovasc. Res., 101:434-443.
S. Viaud, F. Saccheri, G. Mignot, T. Yamazaki, R. Daillère, D. Hannani, D.P. Enot, C. Pfirschke, C. Engblom, M.J. Pittet, A. Schlitzer, F. Ginhoux, L. Apetoh, E. Chachaty, P.L. Woerther, G. Eberl, M. Bérard, C. Ecobichon, D. Clermont, C. Bizet, V. Gaboriau-Routhiau, N. Cerf-Bensussan, P. Opolon, N. Yessaad, E. Vivier, B. Ryffel, C.O. Elson, J. Doré, G. Kroemer, P. Lepage, I. Gomperts-Boneca, F. Ghiringhelli and L. Zitvogel. 2013. The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Science, 342:971-976.
D. Guy-Grand, P. Vassalli, G. Eberl, P. Peirera, O. Burlen-Defranoux, F. Lemaître, J.P. Di Santo, A.A. Freitas, A. Cumano and A. Bandeira. 2013. Origin, trafficking and intraepithelial fate of gut-tropic T cells. J. Exp. Med., 26:1839-1854.
M.L. Zarantonelli, A. Skoczynska, A. Antignac, M. El Ghachi, A.E. Deghmane, M. Szatanik, C. Mulet, C. Werts, L. Peduto, M.F. d'Andon, F. Thouron, F. Nato, L. Lebourhis, D.J. Philpott, S.E. Girardin, F.L. Vives, P. Sansonetti, G. Eberl, T. Pedron, M.K. Taha and I.G. Boneca. 2013. Penicillin Resistance Compromises Nod1-Dependent Proinflammatory Activity and Virulence Fitness of Neisseria meningitidis. Cell Host Microbe, 13:735-745.
M.R. Hepworth, L.A. Monticelli, T.C. Fung, C.G. Ziegler, S. Grunberg, R. Sinha, A.R. Mantegazza, H.L. Ma, A. Crawford, J.M. Angelosanto, E.J. Wherry, P.A. Koni, F.D. Bushman, C.O. Elson, G. Eberl, D. Artis and G.F. Sonnenberg. 2013. Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria. Nature, 498:113-117.
S. Ivanov, J. Renneson, J. Fontaine, A. Barthelemy, C. Paget, E. Macho Fernandez, F. Blanc, C. De Trez, L. Van Maele, L. Dumoutier, M.R. Huerre, G. Eberl, M. Si-Tahar, P. Gosset, J.C. Renauld, J.C. Sirard, C. Faveeuw and F. Trottein. 2013. Interleukin-22 reduces lung inflammation during influenza A virus infection and protects against secondary bacterial infection. J. Virol., 87:6911-6924.
M. McFall-Ngai, M.G. Hadfield, T.C. Bosch, H.V. Carey, T. Domazet-Loso, A.E. Douglas, N. Dubilier, G. Eberl, et al. 2013. Animals in a bacterial world, a new imperative for the life sciences. PNAS, 110:3229-3236.
H. Spits, D. Artis, M. Colonna, A. Diefenbach, J.P. Di Santo, G. Eberl, S. Koyasu, R.M. Locksley, A.N.J. McKenzie, R.E. Mebius, F. Powrie and E. Vivier. 2013. Innate lymphoid cells – a proposal for uniform nomenclature. Nat. Rev. Immunol., 13:145-149.
S. Dulauroy, S.E. Di Carlo, F. Langa, G. Eberl and L. Peduto. 2012. Lineage tracing and genetic ablation of ADAM12+ perivascular cells identify a major source of profibrotic cells during acute tissue injury. Nat. Med., 18:1262-1270.
J.P. Sherlock, B. Joyce-Shaikh, S.P. Turner, C.-C. Chao, M. Sathe, J. Grein, D.M. Gorman, E.P. Bowman, T.K. McClanahan, J.H. Yearley, G.Eberl, C.D. Buckley, R.A. Kastelein, R.H. Pierce, D.M. LaFace and D.J. Cua. 2012. IL-23 induces spondyloarthropathy by acting on RORγt+ CD3+CD4−CD8− entheseal resident T cells. Nat. Med., 18:1069-1076.
A. Müller, O. Filipe-Santos, G. Eberl, T. Aebischer, G.F. Späth and P. Bousso. 2012. CD4+ T cells rely on a cytokine gradient to control intracellular pathogens beyond sites of antigen presentation. Immunity, 37:147-157.
C. Biot, C.A. Rentsch, J.R. Gsponer, F.D. Birkhäuser, H. Jusforgues-Saklani, F. Lemaître, C. Auriau, A. Bachmann, P. Bousso, C. Demangel, L. Peduto, G.N. Thalmann and M.L. Albert. 2012. Preexisting BCG-specific T cells improve intravesical immunotherapy for bladder cancer. Sci. Transl. Med., 4:137.
P.E. Joubert, S.W. Werneke, C. de la Calle, F. Guivel-Benhassine, A. Giodini, L. Peduto, B. Levine, O. Schwartz, D.J. Lenschow and M.L. Albert. 2012. Chikungunya virus-induced autophagy delays caspase-dependent cell death. J. Exp. Med., 209:1029-1047.
M. Cherrier, C. Ohnmacht, S. Cording and G. Eberl. 2012. Development and function of intestinal innate lymphoid cells. Curr. Opin. Immunol., 24:277-283.
F. Chalmin, G. Mignot, M. Bruchard, A. Chevriaux, F. Végran, A. Hichami, S. Ladoire, V. Derangère, J. Vincent, D. Masson, S.C. Robson, G. Eberl, J.R. Pallandre, C. Borg, B. Ryffel, L. Apetoh, C. Rébé and F. Ghiringhelli. 2012. Stat3 and Gfi-1 transcription factors control Th17 cell immunosuppressive activity via the regulation of ectonucleotidase expression. Immunity, 36:362-373.
M. Cherrier and G. Eberl. 2012. The development of LTi cells. Curr. Opin. Immunol., 24:178-183.
M. Cherrier, S. Sawa and G. Eberl. 2012. Notch, Id2 and RORgt sequentially orchestrate the fetal development of lymphoid tissue inducer cells. J. Exp. Med., 209:729-740.
N. Cerf-Bensussan and G. Eberl. 2012. The dialog between microbiota and the immune system: Shaping the partners through development and evolution. Guest Editors. Sem. Immunol., 24:1-2.
G. Eberl. 2012. Development and evolution of RORgt+ cells in a microbe's world. Immunol. Rev., 245:177-188.
R. Marques and I.G. Boneca. 2011. Expression and functional importance of innate immune receptors by intestinal epithelial cells. Cell. Mol. Life Sci., 68:3661-3673.
Y. Simoni, A.S Gautron, L. Beaudoin, L.C. Bui, M.L. Michel, X. Coumoul, G. Eberl, M. Leite-de-Moraes, A. Lehuen. 2011. NOD mice contain an elevated frequency of iNKT17 cells that exacerbate diabetes. Eur. J. Immunol., 41:3574-3585.
P. Gasse, N. Riteau, R. Vacher, M.-L. Michel, A. Fautrel, F. di Padova, L. Fick, S. Charron, V. Lagente, G. Eberl, M. Le Bert, V.F.J. Quesniaux, F. Huaux, M. Leite-de-Moraes, B. Ryffel and I. Couillin. 2011. IL-1 and IL-23 mediate early IL-17A production in pulmonary inflammation leading to late fibrosis. Plos One, 6:e23185.
L. Dumoutier, M. de Heusch, C. Orabona, N. Satoh-Takayama, G. Eberl, J.C. Sirard, J.P. Di Santo and J.C. Renauld. 2011. IL-22 is produced by gc-independent CD25+ CCR6+ innate murine spleen cells upon inflammatory stimuli and contributes to LPS-induced lethality. Eur. J. Immunol., 41:1075-1085.
N. Satoh-Takayama, S. Lesjean-Pottier, S. Sawa, C.A. Vosshenrich, G. Eberl and J.P. Di Santo. 2011. Lymphotoxin-b receptor-independent development of intestinal IL-22-producing NKp46+ innate lymphoid cells. Eur. J. Immunol., 41:780-786.
S. Sawa, M. Lochner, N. Satoh-Takayama, S. Dulauroy, M. Bérard, M. Kleinschek, D. Cua, J.P. Di Santo and G. Eberl. 2011. RORgt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota. Nat. Immunol., 12:320-326.
C. Ohmnacht, R. Marques, L. Presley,S. Sawa, M. Lochner and G. Eberl. 2011. Intestinal microbiota, evolution of the immune system and the bad reputation of pro-inflammatory immunity. Cell. Microbiol., 13-653-659.
E. Letavernier, B. Dansou, M. Lochner, J. Perez, A. Bellocq, M.T. Lindenmeyer, C.D. Cohen, J.P. Haymann, G. Eberl and L. Baud. 2011. Critical role of the calpain/calpastatin balance in acute allograft rejection. Eur. J. Immunol., 41:473-484.
M. Lochner, M. Bérard, S. Sawa, V. Hauer, V. Gaboriau-Routhiau, T.D. Fernandez, J. Snel, P. Bousso, N. Cerf-Bensussan and G. Eberl. 2011. Restricted microbiota and absence of cognate TCR antigen leads to an unbalanced generation of Th17 cells. J. Immunol., 186:1531-1537.
M. Lochner, C. Ohnmacht, L. Presley, P. Bruhns, M. Si-Tahar, S. Sawa and G. Eberl. 2011. Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORgt and LTi cells. J. Exp. Med., 208:125-134.
S. Sawa, M. Cherrier, M. Lochner, N. Satoh-Takayama, H.J. Fehling, F. Langa, J.P. Di Santo and G. Eberl. 2010. Lineage relationship analysis of RORgt+ innate lymphoid cells. Science, 330:665-669.
K. Ghoreschi, A. Laurence, X. Yang, C.M. Tato, M.J. McGreachy, J. Konkel, H.L. Ramos, L. Wei, T. Davidson, N. Bouladoux, J. Grainger, Q. Chen, Y. Kanno, W.T. Watford, H. Sun, G. Eberl, E. Shevach, Y. Belkaid, D.J. Cua, W. Chen and J.J. O’Shea. 2010. Enhanced pathogenicity of Th17 cells generated in the absence of transforming growth factor-b signaling. Nature, 467:967-971.
G. Eberl and I. Gomperts-Boneca. 2010. Bacteria and MAMP-induced morphogenesis of the immune system. Curr. Opin. Immunol., 22:1-7.
O. Thaunat, N. Patey, G. Caligiuri, C. Gautreau, M. Mamani-Matsuda, Y. Mekki, M.C. Dieu-Nosjean, G. Eberl, R. Ecochard, J.B. Michel, S. Graff-Dubois and A. Nicoletti. 2010. Chronic rejection triggers the development of an aggressive intragraft immune response through recapitulation of lymphoid organogenesis. J. Immunol, 185:717-728.
G. Eberl. 2010. Close encounters of the second type. Nature, 464:1285-1286.
G. Eberl. 2010. A new vision of immunity: homeostasis of the superorganism. Mucosal Immunol., 3:450-460.
C. Schilte, T. Couderc, F. Chretien, M. Sourisseau, N. Gangneux, F. Guivel-Benhassine, A. Kraxner, J. Tschopp, S. Higgs, A. Michault, F. Arenzana-Seisdedos, M. Colonna, L. Peduto, O. Schwartz, M. Lecuit and M.L. Albert. 2010. Type I IFN controls chukungunya virus via its action on nonhematopoietic cels. J. Exp. Med., 207:429-442.
N. Satoh-Takayama, S. Lesjean-Pottier, P. vieira, S. Sawa, G. Eberl, C.A. Vosshenrich and J.P. Di Santo. 2010. IL-7 and IL-15 independently program the differentiation of intestinal CD3- NKp46+ cell subsets from Id2-dependent precursors. J. Exp. Med., 207:273-280.
G. Sellge, J.G. Magalhaes, C. Konradt, J.H. Fritz, W. Salgado-Pabon, G. Eberl, A. Bandeira, J.P. Di Santo, P.J. Sansonetti and A. Phalipon. 2010. Th17 cells are the predominant T cell subtype primed by Shigella flexneri mediating protective immunity. J. Immunol., 184:2076-2085.
G. Eberl and S. Sawa. 2010. Opening the crypt: current facts and hypotheses on the function of cryptopatches. Trends in Immunol., 31:50-55.
V. Gaboriau-Routhiau, S. Rakotobe, E. Lécuyer, I. Mulder, A. Lan, C. Bridonneau, V. Rochet, A. Pisi, M. De Paepe, G. Brandi, G. Eberl, J. Snel, D. Kelly and N. Cerf-Bensussan. 2009. The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses. Immunity, 31:677-689.
K. Lahl, C.T. Mayer, T. Bopp, J. Huehn, C. Loddenkemper, G. Eberl, G. Wirnsberger, K. Dornmair, R. Geffers, E. Schmidt, J. Buer and T. Sparwasser. 2009. Non-functional regulatory T cells and defective control of Th2 cytokine production in natural scurfy mutant mice. J. Immunol., 183:5662-5672.
L. Klotz, S. Burgdorf, I. Dani, K. Saijo, J. Flossdorf, S. Hucke, J. Alferink, N. Novak, M. Beyer, G. Meyer, B. Langhans, T. Klockgether, A. Waisman, G. Eberl, J. Schultz, M. Famulok, W. Kolanus, C. Glass, C. Kurtz and P.A. Knolle. 2009. The nuclear receptor PPARγ selectively controls Th17 differentiation in a T cell-intrinsinc fashion and suppresses CNS autoimmunity. J. Exp. Med., 206:2079-2089.
G. Eberl and M. Lochner. 2009. The development of intestinal lymphoid tissues at the interface of self and microbiota. Mucosal Immunology, 2:478-485.
J.M. Doisne, C. Becourt, L. Amniai, N. Duarte, J.B. Le Luduec, G. Eberl and K. Benlagha. 2009. Skin and peripheral lymph node invariant NKT cells are mainly retinoic acid receptor-Related orphan receptor γt and respond preferentially under inflammatory conditions. J. Immunol., 183:2142-2149.
L. Peduto. 2009. ADAM9 as a potential target molecule in cancer. Curr. Pharm. Design, 15:2282-2287.
L. Peduto, S. Dulauroy, M. Lochner, G.F. Späth, M.A. Morales, A. Cumano and G. Eberl. 2009. Inflammation recapitulates the ontogeny of lymphoid stromal cells. J. Immunol., 182:5789-5799.
N.L. Alves, O. Richard-Le Goff, N.D. Huntington, A. Patricia Sousa, F. Langa Vives, L. Peduto, P. Vieira, A. Chidgey, A. Cumano, R. Boyd, G. Eberl and J.P. Di Santo. 2009. Characterization of the thymic IL-7 niche in vivo. PNAS, 106:1512-1517.
N. Satoh-Takayama, C.A.J. Vosshenrich, S. Lesjean-Pottier, S. Sawa, M. Lochner, F. Rattis, J.J. Mention, K. Thiam, N. Cerf-Bensussan, O. Mandelboim, G. Eberl and J.P. Di Santo. 2008. Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense. Immunity, 29:958-970.
M.L. Michel, D. Mendez-da-Cruz, A. Castro Keller, M. Lochner, E. Schneider, M. Dy, G. Eberl and M.C. Leite-de-Moraes. 2008. Criticial role of RORgt in a new thymic pathway leading to IL-17-producing invariant NKT cell differentiation. PNAS, 105:19845-19850.
F. Osorio, S. Leubundgut-Landmann, M. Lochner, K. Lahl, T. Sparwasser, G. Eberl, and C. Reis e Sousa. 2008. Dendritic cells activated via dectin-1 convert regulatory T cells into IL-17 producers. Eur. J. Immunol., 38:3274-3281.
D. Bouskra, C. Brézillon, M. Bérard, C. Werts, R. Varona, I. Gomperts Boneca, and G. Eberl. 2008. Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis. Nature, 456:507-510.
M. Lochner, L. Peduto, M. Cherrier, S. Sawa, F. Langa, R. Varona, D. Riethmacher, M. Si-Tahar, J.P. Di Santo, and G. Eberl. 2008. In vivo Equilibrium of pro-inflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgt+ T cells. J. Exp. Med., 205:1381-1393.
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M.D. Boos, Y. Yokota Y, G. Eberl, and B.L. Kee. 2007. Mature natural killer cell and lymphoid tissue-inducing cell development requires Id2-mediated suppression of E protein activity. J Exp Med., 204:1119-1130.
T. Sparwasser, and G. Eberl. 2007. BAC to Immunology - Bacterial Artificial Chromosome-mediated transgenesis for targeting of immune cells. Immunology, 121:308-313.
G. Eberl. 2007. Development and function of secondary and tertiary lymphoid tissues - meeting report. Eur J Immunol., 37:300-1.
K. Lahl, C. Loddenkemper, C. Drouin, J. Freyer, J. Arnason, G. Eberl, A. Hamann, H. Wagner, J. Hühn, and T. Sparwasser. 2007. Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. J. Exp. Med., 204:57-63.
L. Peduto, V.E. Reuter, A. Sehara-Fujisawa, D.R. Shaffer, H.I. Scher and Blobel C.P. 2006. ADAM12 is highly expressed in carcinoma-associated stroma and is required for mouse prostate tumor progression. Oncogene, 25:5462-5466.
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T. Egawa, G. Eberl, I. Taniuchi, K. Benlagha, F. Geissmann, L. Hennighausen, A. Bendelac, and D.R. Littman. 2005. Genetic evidence supporting selection of Va14iNKT cell lineage from double-positive thymocyte precursors. Immunity, 22:705-716.
G. Eberl, and D.R. Littman. 2004. Thymic origin of intestinal ab T cells revealed by fate mapping of RORgt+ cells. Science, 305:248-251.
G. Eberl, S. Marmon, M.J. Sunshine, P.D. Rennert, Y. Choi, and D.R. Littman. 2004. An essential function for the nuclear receptor RORgt in the generation of fetal lymphoid tissue inducer cells. Nat. Immunol., 5:64-73.
T. Sparwasser, S. Gong, J.Y.H. Li, and G. Eberl. 2004. General method for the modification of different BAC types and the rapid generation of BAC transgenic mice. Genesis, 38:39-50.
G. Eberl, and D.R. Littman. 2003. The role of the nuclear hormone receptor RORgt in the development of lymph nodes and Peyer’s patches. Immunol. Rev., 195:81-90.
One position is to study the regulation of immune responses by stromal cells, in particular in chronic pathologies such as fibrosis and cancer.
The second position is to study the regulation of the microbiota, metabolism and adaptive immune system by innate lymphoid cells (ILCs).
The positions are open for 2015. Applicants should have a strong background in cellular immunology, cell biology or physiology, be highly motivated to do research in this competitive and exciting area, and show an innate ability to work as a team.