L. Deriano and D.B. Roth. Modernizing the Nonhomologous End Joining Repertoire: Alternative and Classical NHEJ Share The Stage. Annual Review of Genetics. 2013 Nov 23;47:433-55.


M. Coussens, R.L. Wendland, L. Deriano, C. Lindsay, S.M. Arnal, D.B. Roth. RAG2’s acidic hinge restricts repair-pathway choice and promotes genomic stability. Cell Reports. 2013 Sep 12; 4(5):870-8.


J. Chaumeil, M. Micsinai, P. Ntziachristos, D.B. Roth, I. Aifantis, Y. Kluger, L. Deriano, J.A. Skok. The C-terminus of RAG2 and ATM control RAG activity to limit the number of potential translocation substrates. Nature Communications. 2013 Jul 31; 4:2231.


J. Chaumeil, M. Micsinai, P. Ntziachristos, L. Deriano, J. M. Wang, Y. Ji, E.P. Nora, M.J. Rodesch, J.A. Jeddeloh, I. Aifantis, Y. Kluger, D.G. Schatz, J.A. Skok. Higher-order looping and nuclear organization of antigen receptor loci facilitate targeted RAG cleavage and regulated rearrangement in recombination centers. Cell Reports. 2013 Feb 21; 3(2):359-70.



M. Mijušković, S.M. Brown, Z. Tang, C.R. Lindsay, E. Efstathiadis, L. Deriano, D.B. Roth. A streamlined method for detecting structural variants in cancer genomes by short read paired-end sequencing. PLoS One. 2012 Oct 29; 7(10):e48314.



L. Deriano, J. Chaumeil, M. Coussens, A. Multani, Y. Chou, A.V. Alekseyenko, S. Chang, J.A. Skok, D.B. Roth. The RAG2 C-terminus suppresses genomic instability and lymphomagenesis. Nature. 2011 Mar 3; 471(7336): 119-2.



L. Deriano, T.H. Stracker, A. Baker, J.H.J. Petrini, D.B. Roth. Roles for NBS1 in alternative end joining of V(D)J recombination intermediates. Mol Cell. 2009 Apr 10; 34(1): 13-25.


T. H. Stracker, B. R. Williams, L. Deriano, J. W. Theunissen, C. A. Adelman, D. B. Roth, J.H. Petrini. Artemis and nonhomologous end joining-independent influence of DNA-dependent protein kinase catalytic subunit on chromosome stability. Mol Cell Biol. 2009 Jan; 29(2): 503-14.



B. Corneo*, R.L. Wendland*, L. Deriano*, X. Cui, I.A. Klein, S. Wong, S. Arnal, A.J. Holub, G.R. Weller, B.A. Pancake, S. Shah, V.L. Brandt, K. Meek, D.B. Roth. RAG mutations reveal robust alternative end joining. Nature, 2007 Sep; 449(7161): 483-6. (*Equal contribution)


F. Delacôte, L. Deriano, S. Lambert, P. Bertrand, Y. Saintigny, B. S. Lopez. Chronic exposure to sublethal doses of radiation mimetic Zeocintrade mark selects for clones deficient in homologous recombination. Mutat Res, 2007 Feb 3; 615(1-2): 125-33.



L. Deriano,  H. Merle-Beral, O. Guipaud, L. Sabatier, J. Delic.  Mutagenicity of non-homologous end joining DNA repair in a resistant subset of human chronic lymphocytic leukaemia B cells. Br J Haematol. 2006 Jun; 133(5): 520-5.


J. Bouley, L. Deriano, J. Delic, H. Merle-Beral.  New molecular markers in resistant B-CLL. Leuk Lymphoma. 2006 May; 47(5): 791-801.



L. Deriano, O. Guipaud, H. Merle-Béral, J. L. Binet, M. Ricoul, V. Favaudon, C. Muller, B. Salles, L. Sabatier and J. Delic.  Human chronic lymphocytic leukemia B cells can escape DNA damage-induced apoptosis through the nonhomologous end-joining DNA repair pathway. Blood. 2005 Jun 15; 105(12): 4776-83.



O. Guipaud, L. Deriano, H. Salin, L. Vallat, L. Sabatier, H. Merle-Béral and J. Delic.  B-cell chronic lymphocytic leukaemia: a polymorphic family unified by genomic features. Lancet Oncol. 2003 Aug; 4(8):505-14.



I. Pombo, S. Martin-Verdeaux, B. Iannascoli, J. Le Mao, L. Deriano, J. Rivera, U. Blank.  IgE receptor type I-dependent regulation of a Rab3D-associated kinase: a possible link in the calcium-dependent assembly of SNARE complexes. J Biol Chem. 2001 Nov 16; 276(46): 42893-900.

Updated on 14/02/2014



Our laboratory is located on the 4th floor of the Bâtiment Metchnikoff (building #67 on the map below), room 4022, on the Institut Pasteur Paris campus.

The nearest subway station is “Pasteur” on the lines 6 and 12. 



deriano.jpgGROUP LEADER

Ludovic Deriano, Ph.D.


G5 Lymphocyte Development and Oncogenesis

Immunology Department – Metchnikoff building (#67)



25, rue du Docteur Roux

75724 PARIS Cedex 15, FRANCE

Office tel: +33 (0)1 44 38 93 55

Laboratory tel : +33 (0)1 44 38 93 57

E-mail :


Administrative assistant

Cécile Nizak


Tel : +33(0)1 45 68 82 41

Fax: (0)1 40 61 31 60

Lab news

November 2013: Valentine Murigneux, bioinformatician, joins us to find novel cancer mutations!


September 2013: Nicole Clarke, grad student at Stanford University, joins our lab for a 4 months internship.


August 2013: Christophe Clouin joins the lab as a post-doctoral fellow.


All Lab News