The Pasteur Museum is housed in the apartment where Louis Pasteur spent his final seven years and offers a rare behind-the-scenes look at the living and working environment of the world-renowned scientist. Visitors can gain a unique insight into his everyday life alongside his wife and can admire his rich and diverse scientific work.
The Institut Pasteur’s scientific strategy focuses on developing original and innovative topics and promoting interdisciplinary and multidisciplinary cooperation and approaches. The Institut Pasteur teams have access to the technological resources needed to speed up and further improve the quality of their outstanding research.
Ever since the introduction of the world’s first "Technical Microbiology" course in 1889, teaching has been a priority for the Institut Pasteur. The Institut Pasteur has an international reputation for quality teaching that attracts students from all over the world who come to further their training or top up their degree programs.
The mission of the Industrial Partnership team is to detect, promote, assist and protect the inventive activities from research (inventions, know-how and biological materials) conducted at the Institut Pasteur (and in some Institutes of its international network), and transfer there to industrial and/or institutional partners, in order to serve the patient needs and for the benefit of the society, as well as to contribute to sustainability of the Institut Pasteur’s resources.
With international courses, PhD and postdoctoral traineeship, each institute of the Institut Pasteur International Network (RIIP) contributes to the transmission of knowledge with the training of young researchers all around the world. In this context, doctoral and postdoctoral programmes, study and traineeship fellowships are available to scientists. Alongside training, dynamism and attractiveness of RIIP will result in the creation of 4-year group for the young researchers.
Institut Pasteur, CNRS URA 1961
Head of Lab : Andrés Alcover, PhD
The Lymphocyte Cell Biology Unit investigates early stages of the adaptive immune response, in particular, the molecular mechanisms that lead to the generation and function of immunological synapses, and their subversion by the lymphotropic retroviruses HIV-1 and HTLV-1.
The infection of an organism by a pathogen (e.g. virus or bacteria) triggers a specific and long lasting immune response, called the adaptive immune response that allows the defense of the organism. T lymphocytes are in the center of adaptive immune responses, since they contribute to their regulation and to the destruction of infected cells.
T lymphocytes are activated when they detect on the surface of antigen presenting cells the presence of molecular fragments (antigens) derived from pathogens. When a T cell recognizes its specific antigen, it polarizes towards the antigen-presenting cell, generating an organized cell-cell contact named the immunological synapse.
Immunological synapses are multitask interfaces that allow the triggering and control of T cell activation, leading to proliferation and differentiation. They also enable T cell effector functions, like polarized secretion of cytokines and of cytotoxic granules.
Our goal is to elucidate how immunological synapses are generated and control T cell functions. We investigate the role of receptors and intracellular signaling molecules, of the actin cytoskeleton and microtubules and of intracellular vesicle traffic, in the formation of immunological synapses and in T cell activation. We also study how retroviruses that infect T lymphocytes, such as the human immunodeficiency virus (HIV-1), or the human T cell leukemia virus (HTLV-1) subvert the mechanisms of generation of immunological synapses in order to modulate T cell responses and to better spread from cell to cell.