Innate Immunity

Head of Unit: James DI SANTO


The Innate Immunity Unit comprises 16 members (4 permanent scientists, 4 engineers/technicians, 5 postdoctoral fellows, 3 PhD students) with complementary interests and expertise in immunology, developmental biology, virology and animal models.




Together with the Lymphopoiesis Unit (Ana Cumano) and Dynamics of Immune Response Unit (Philippe Bousso), we form the Inserm Unit 668 (Pathophysiology of the Immune System) that pursues collaborative projects involving lymphocyte development, differentiation and functional dynamics.


Innate Immunity Unit
Inserm U668
Institut Pasteur
25 rue du Docteur Roux
75724 Paris Cedex 15
Tel. +33 1 45 68 82 09
Secretary +33 1 45 68 86 96
Fax + 33 1 40 61 35 10
Our lab is located on the 4th Floor of the Metchnikoff Building (building N° 67 on the map below).



Wei Xu published her work on Nfil3 in ILC precursor formation. 

Xu, W., Domingues, R.G., Fonseca-Pereira, D., Ferreira, M., Ribeiro, H., Lopez-Lastra, S., Motomura, Y., Moreira-Santos, L., Bihl, F., Braud, V.M., Kee, B., Brady, H., Coles, M.C., Vosshenrich, C.A.J., Kubo, M., Di Santo, J.P. and Veiga-Fernandes, H. (2015) NFIL3 orchestrates the emergence of common helper innate lymphoid cell precursors. Cell Reports 10:2043-2054. 


Giorgia Benigni joined our laboratory on February 16, 2015.


Naoko Satoh published her work on chemokine receptor control of ILC3 localisation and function.

Naoko Satoh-Takayama, Nicolas Serafini, Thomas Verrier, Abdessalem Rekiki, Jean-Christophe Renauld, Gad Frankel, James P. Di Santo (2014) The Chemokine Receptor CXCR6 Controls the Functional Topography of Interleukin-22 Producing Intestinal Innate Lymphoid Cells. Immunity 41: 776-788.


Cécile Pham was awarded the "Médaille d'honneur du travail".


Nicolas Serafini published his work on the role for Gata3 in ILC development in the Journal of Experimental Medicine:

Serafini, N., Klein Wolterink, R.G.J., Satoh-Takayama, N., Xu, W., Vosshenrich, C.A.J., Hendriks, R.W. and Di Santo, J.P. (2014) GATA-3 drives development of RORgt+ group 3 innate lymphoid cells. Journal of Experimental Medicine 211:199-208.


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