The Pasteur Museum is housed in the apartment where Louis Pasteur spent his final seven years and offers a rare behind-the-scenes look at the living and working environment of the world-renowned scientist. Visitors can gain a unique insight into his everyday life alongside his wife and can admire his rich and diverse scientific work.
The Institut Pasteur’s scientific strategy focuses on developing original and innovative topics and promoting interdisciplinary and multidisciplinary cooperation and approaches. The Institut Pasteur teams have access to the technological resources needed to speed up and further improve the quality of their outstanding research.
Ever since the introduction of the world’s first "Technical Microbiology" course in 1889, teaching has been a priority for the Institut Pasteur. The Institut Pasteur has an international reputation for quality teaching that attracts students from all over the world who come to further their training or top up their degree programs.
The mission of the Industrial Partnership team is to detect, promote, assist and protect the inventive activities from research (inventions, know-how and biological materials) conducted at the Institut Pasteur (and in some Institutes of its international network), and transfer there to industrial and/or institutional partners, in order to serve the patient needs and for the benefit of the society, as well as to contribute to sustainability of the Institut Pasteur’s resources.
With international courses, PhD and postdoctoral traineeship, each institute of the Institut Pasteur International Network (RIIP) contributes to the transmission of knowledge with the training of young researchers all around the world. In this context, doctoral and postdoctoral programmes, study and traineeship fellowships are available to scientists. Alongside training, dynamism and attractiveness of RIIP will result in the creation of 4-year group for the young researchers.
Genetic and epigenetic mechanisms controlling immune cell functions
Immune-mediated inflammatory diseases such as rheumatoid arthritis, spondyloarthritis (SpA), inflammatory bowel disease and psoriasis cause significant morbidity and are a substantial burden for the affected individuals and the society. Our very limited understanding of the pathogenic mechanisms currently hampers the development of better markers for early diagnosis and more specific and effective therapies.
The main goal of the Immunoregulation Unit is to unravel the fundamental mechanisms that control the differentiation and function of human T lymphocyte populations with pro-inflammatory and regulatory activities and to study their roles in the pathogenesis of inflammatory diseases.
During the past years, we have performed an integrated analysis of the signaling pathways, epigenetic modifications and genetic networks involved in T helper cell differentiation. We have studied how signals originating at the T cell receptor (TCR) and at cytokine receptors are integrated to shape a T helper subset-specific gene expression programs in primary human T lymphocytes. We have analyzed in particular the synergy of transcription factors and chromatin remodelling complexes to induce epigenetic changes and gene transcription during T helper type 1 (Th1) cell development.
More recent work focuses on the impact of genetic variation on CD4+ T cell functions in chronic inflammatory diseases and analyzes the role of subpopulations of human regulatory T cells in patients after allogeneic hematopoietic stem cell transplantation. The lab also studies epigenetic mechanisms that control the stability and plasticity of CD4+ T cell subsets.