Publications

2014

 

Chany AC, Veyron-Churlet R, Tresse C, Mayau V, Casarotto V, Le Chevalier F, Guénin-Macé L, Demangel C, Blanchard N. Synthetic Variants of Mycolactone Bind and Activate Wiskott-Aldrich Syndrome ProteinsJ Med Chem. 2014

 

Geroult S, Phillips RO, Demangel C. Adhesion of the ulcerative pathogen Mycobacterium ulcerans to DACC-coated dressingsJ Wound Care. 2014 Aug;23(8):417-24.

 

Phillips RO, Sarfo FS, Landier J, Oldenburg R, Frimpong M, Wansbrough-Jones M, Abass K, Thompson W, Forson M, Fontanet A, Niang F, Demangel C. Combined inflammatory and metabolic defects reflected by reduced serum protein levels in patients with buruli ulcer disease. PLoS Negl Trop Dis. 2014 Apr 10;8(4):e2786.

 

Duffy D, Rouilly V, Libri V, Hasan M, Beitz B, David M, Urrutia A, Bisiaux A, Labrie ST, Dubois A, Boneca IG, Delval C, Thomas S, Rogge L, Schmolz M, Quintana-Murci L, Albert ML; Milieu Intérieur Consortium Functional Analysis via Standardized Whole-Blood Stimulation Systems Defines the Boundaries of a Healthy Immune Response to Complex Stimuli. Immunity. 2014 Mar 20;40(3):436-50. doi: 10.1016/j.immuni.2014.03.002.

 

Guenin-Macé L, Oldenburg R, Chrétien F, Demangel C. Pathogenesis of skin ulcers: lessons from the Mycobacterium ulcerans and Leishmania spp. pathogens. Cell Mol Life Sci. (Review) 2014 Jan 21.

 

 

2013

Guenin-Macé L, Veyron-Churlet R, Thoulouze MI, Romet-Lemonne G, Hong H, Leadlay PF, Danckaert A, Ruf MT, Mostowy S, Zurzolo C, Bousso P, Chrétien F, Carlier MF, Demangel C. Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation. J Clin Invest. 2013 Apr 1;123(4):1501-12. doi: 10.1172/JCI66576. Epub 2013 Mar 15.

 

Bounab Y, Hesse AM, Iannascoli B, Grieco L, Couté Y, Niarakis A, Roncagalli R, Lie E, Lam KP, Demangel C, Thieffry D, Garin J, Malissen B, Daëron M. Proteomic analysis of the SH2domain-containing leukocyte protein of 76 kDa (SLP76) interactome. Mol Cell Proteomics. 2013 Oct;12(10):2874-89. doi: 10.1074/mcp.M112.025908. Epub 2013 Jul 2.

 

 

2012

Biot C, Rentsch CA, Gsponer JR, Birkhäuser FD, Jusforgues-Saklani H, Lemaître F, Auriau C, Bachmann A, Bousso P, Demangel C, Peduto L, Thalmann GN, Albert ML. Preexisting BCG-specific T cells improve intravesical immunotherapy for bladder cancer. Sci Transl Med. 2012 Jun 6;4(137):137ra72. doi: 10.1126/scitranslmed.3003586.

 

Houben D, Demangel C, van Ingen J, Perez J, Baldeón L, Abdallah AM, Caleechurn L, Bottai D, van Zon M, de Punder K, van der Laan T, Kant A, Bossers-de Vries R, Willemsen P, Bitter W, van Soolingen D, Brosch R, van der Wel N, Peters PJ. ESX-1-mediated translocation to the cytosol controls virulence of mycobacteria. Cell Microbiol. 2012 Aug;14(8):1287-98. doi: 10.1111/j.1462-5822.2012.01799.x. Epub 2012 May 8.

 

 

2011

Chany AC, Casarotto V, Schmitt M, Tarnus C, Guenin-Macé L, Demangel C, Mirguet O, Eustache J, Blanchard N.A diverted total synthesis of mycolactone analogues: an insight into Buruli ulcer toxins. Chemistry. 2011 Dec 16;17(51):14413-9. doi: 10.1002/chem.201102542. Epub 2011 Nov 30.

 

Sarfo FS, Le Chevalier F, Aka N, Phillips RO, Amoako Y, Boneca IG, Lenormand P, Dosso M, Wansbrough-Jones M, Veyron-Churlet R, Guenin-Macé L, Demangel C. Mycolactone diffuses into the peripheral blood of Buruli ulcer patients--implications for diagnosis and disease monitoring.PLoS Negl Trop Dis. 2011 Jul;5(7):e1237. doi: 10.1371/journal.pntd.0001237. Epub 2011 Jul 19.

 

Guenin-Macé L, Carrette F, Asperti-Boursin F, Le Bon A, Caleechurn L, Di Bartolo V, Fontanet A, Bismuth G, Demangel C. Mycolactone impairs T cell homing by suppressing microRNA control of L-selectin expression. Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12833-8. doi: 10.1073/pnas.1016496108. Epub 2011 Jul 18.

 

 

2010

Mostowy S, Bonazzi M, Hamon MA, Tham TN, Mallet A, Lelek M, Gouin E, Demangel C, Brosch R, Zimmer C, Sartori A, Kinoshita M, Lecuit M, Cossart P. Entrapment of intracytosolic bacteria by septin cage-like structures. Cell Host Microbe. 2010 Nov 18;8(5):433-44. doi: 10.1016/j.chom.2010.10.009.

 

Tabouret G, Astarie-Dequeker C, Demangel C, Malaga W, Constant P, Ray A, Honoré N, Bello NF, Perez E, Daffé M, Guilhot C. Mycobacterium leprae phenolglycolipid-1 expressed by engineered M. bovis BCG modulates early interaction with human phagocytes. PLoS Pathog. 2010 Oct 21;6(10):e1001159. doi: 10.1371/journal.ppat.1001159.

 

Boulkroun S, Guenin-Macé L, Thoulouze MI, Monot M, Merckx A, Langsley G, Bismuth G, Di Bartolo V, Demangel C. Mycolactone suppresses T cell responsiveness by altering both early signaling and posttranslational events. J Immunol. 2010 Feb 1;184(3):1436-44. doi: 10.4049/jimmunol.0902854. Epub 2009 Dec 30.

 

 

2009

Phillips R, Sarfo FS, Guenin-Macé L, Decalf J, Wansbrough-Jones M, Albert ML, Demangel C. Immunosuppressive signature of cutaneous Mycobacterium ulcerans infection in the peripheral blood of patients with buruli ulcer disease. J Infect Dis. 2009 Dec 1;200(11):1675-84. doi: 10.1086/646615.

 

Guenin-Macé L, Siméone R, Demangel C. Lipids of pathogenic Mycobacteria: contributions to virulence and host immune suppression. Transbound Emerg Dis. 2009 Aug;56(6-7):255-68. doi: 10.1111/j.1865-1682.2009.01072.x. Epub 2009 May 26.

 

Huygen K, Adjei O, Affolabi D, Bretzel G, Demangel C, Fleischer B, Johnson RC, Pedrosa J, Phanzu DM, Phillips RO, Pluschke G, Siegmund V, Singh M, van der Werf TS, Wansbrough-Jones M, Portaels F. Buruli ulcer disease: prospects for a vaccine. Med Microbiol Immunol. 2009 May;198(2):69-77. doi: 10.1007/s00430-009-0109-6. Epub 2009 Feb 7.

 

Demangel C, Stinear TP, Cole ST. Buruli ulcer: reductive evolution enhances pathogenicity of Mycobacterium ulcerans. Nat Rev Microbiol. 2009 Jan;7(1):50-60. doi: 10.1038/nrmicro2077.

 

 

2008

Hong H, Coutanceau E, Leclerc M, Caleechurn L, Leadlay PF, Demangel C. Mycolactone diffuses from Mycobacterium ulcerans-infected tissues and targets mononuclear cells in peripheral blood and lymphoid organs. PLoS Negl Trop Dis. 2008;2(10):e325. doi: 10.1371/journal.pntd.0000325. Epub 2008 Oct 22.

 

Hong H, Demangel C, Pidot SJ, Leadlay PF, Stinear T. Mycolactones: immunosuppressive and cytotoxic polyketides produced by aquatic mycobacteria. Nat Prod Rep. 2008 Jun;25(3):447-54. doi: 10.1039/b803101k. Epub 2008 Apr 17.

 

 

2007

Hong H, Stinear T, Porter J, Demangel C, Leadlay PF. A novel mycolactone toxin obtained by biosynthetic engineering. Chembiochem. 2007 Nov 23;8(17):2043-7.

 

Coutanceau E, Decalf J, Martino A, Babon A, Winter N, Cole ST, Albert ML, Demangel C. Selective suppression of dendritic cell functions by Mycobacterium ulcerans toxin mycolactone. J Exp Med. 2007 Jun 11;204(6):1395-403. Epub 2007 May 21.

Updated on 01/09/2014

Contact

logo_unitexccx81.jpgDr C. Demangel

 

Unité d’Immunobiologie de l’Infection

Département d’Immunologie

 

INSTITUT PASTEUR

25, rue du Docteur Roux

75724 PARIS Cedex 15, FRANCE
 

Office tel: +33 (0)1 40 61 30 66

Lab tel : +33 (0)1 40 61 38 92

E-mail : caroline.demangel@pasteur.fr

 

Administrative assistant:

Mme Marie-Luce Kop

Tel: +33 (0)1 40 61 33 96

marie-luce.kop@pasteur.fr

Access

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Our laboratory is located on the 5th floor of the Bâtiment Metchnikoff (building #67 on the map below), room 5041, on the Institut Pasteur Paris campus.

The nearest subway station is “Pasteur” on the lines 6 and 12. 

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