Immunobiology of Infection

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GROUP LEADER

C. Demangel, PhD

Welcome to the DEMANGEL Lab

 

Department of Immunology

 

CNRS URA 1961

Secondary affiliation: Department of Cell Biology & Infection

 

 

 

Using pathogenic bacteria to better understand the immunological-metabolic crosstalk

 

In order to establish long-term residence in humans, pathogenic mycobacteria have evolved virulence factors that mediate bacterial persistence by modulating the host immune and metabolic responses.

 

Our Unit investigates the molecular mechanisms employed by these bioactive molecules, with the view to design innovative anti-mycobacterial strategies and explore how metabolism could be targeted as a strategy to treat inflammatory diseases. To this end, we use a trans-disciplinary approach comprising metabolomics, cell biology and human immunology.

 

Our most recent discoveries relate to the molecular mechanism underpinning Buruli ulcer pathogenesis, the disease caused by Mycobacterium ulcerans infection, and the immunometabolic profiling of Buruli ulcer patients.

 

Key words: Buruli ulcer, Leprosy, Neglected Tropical Diseases, Immune modulation, Metabolism.

Contact

logo_unitexccx81.jpgDr C. Demangel

 

Unité d’Immunobiologie de l’Infection

Département d’Immunologie

 

INSTITUT PASTEUR

25, rue du Docteur Roux

75724 PARIS Cedex 15, FRANCE
 

Office tel: +33 (0)1 40 61 30 66

Lab tel : +33 (0)1 40 61 38 92

E-mail : caroline.demangel@pasteur.fr

 

Administrative assistant:

Mme Viviane Bustanoby

Tel: +33 (0)1 40 61 33 96

viviane.bustanoby@pasteur.fr

Access

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Our laboratory is located on the 5th floor of the Bâtiment Metchnikoff (building #67 on the map below), room 5041, on the Institut Pasteur Paris campus.

The nearest subway station is “Pasteur” on the lines 6 and 12. 

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