Immunobiology of Dendritic Cells

The uniqueness of the laboratory of Immunobiology of Dendritic Cells applies a bedside-to-bench approach to scientific discovery that ensures our team stays rooted in medically relevant questions, while striving to make new fundamental discoveries about immunity to disease.

 

 

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Institut Pasteur / Inserm U818 / May 2014

 

Our laboratory is a mixed INSERM / Pasteur Unit. Our scientific objective is to characterize immune responses that are initiated by dying cells. The commitment to this field of study stems from our initial discovery that dead cells serve as a source of antigen for dendritic cell cross-presentation and cross-priming. As the group has evolved, we have tackled this from multiple perspectives: (i) defining how variable cell death programs influence inflammation and immunity; (ii) establishing a role for the cross-priming of microbial antigens as a means to boost BCG mediated tumor immunity; and more recently (iii) characterizing the intrinsic immune programs that limit inflammation and modify the trafficking of cross-primed CD8+ T cells. In addition to these scientific research goals, we are attempting to transfer some of our insights about biomarkers for treatment response and drug targets for improving treatment outcome, back into the clinic completing the circle "bench-to-bedside". Exciting new research based on our recent observations and results, are being explored in the laboratory.

Contact us

Immunobiology of Dendritic Cells
Institut Pasteur
Bâtiment Metchnikoff
25, rue du Docteur Roux
75724 Paris Cedex 15
France


Office : (33) 1 45 68 89 02
Lab : (33) 1 44 38 95 02
Fax : (33) 1 45 68 85 48

Our laboratory is always looking for motivated students and postdocs. Please send your CV and letter of motivation to sthomas@pasteur.fr

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