Publications

Original reports, reviews and comments

 

2014

 

McGuire AT, Dreyer AM, Carbonetti S, Lippy A, Glenn J, Scheid JF, Mouquet H1, Stamatatos L. Antigen modification regulates competition of broad and narrow neutralizing HIV antibodies. Science. 2014;346(6215):1380-3. 

 

Mouquet H1,2. Antibody B cell responses in HIV-1 infection. Trends Immunol. 2014;35(11):549-561.

 

Bouvin-Pley M, Morgand M, Meyer L, Goujard C, Moreau A, Mouquet H1, Nussenzweig M, Pace C, Ho D, Bjorkman PJ, Baty D, Chames P, Pancera M, Kwong PD, Poignard P, Barin F, Braibant M. Drift of the HIV-1 envelope glycoprotein gp120 toward increased neutralization resistance over the course of the epidemic: a comprehensive study using the most potent and broadly neutralizing monoclonal antibodies. J Virol. 2014 ;88(23):13910-7.

 

Shingai M, Donau OK, Plishka RJ, Buckler-White A, Mascola JR, Nabel GJ, Nason MC, Montefiori D, Moldt B, Poignard P, Diskin R, Bjorkman PJ, Eckhaus MA, Klein F, Mouquet H1, Cetrulo Lorenzi JC, Gazumyan A, Burton DR, Nussenzweig MC, Martin MA, Nishimura Y. Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques. J Exp Med. 2014;211(10):2061-74.

 

Malbec M, Mouquet H1, Schwartz O. HIV-1 cell-to-cell transmission and broadly neutralizing antibodies. Med Sci (Paris). 2014;30(5):508-10.

 

 

2013

 

Malbec M, Porrot F, Rua R, Horwitz J, Klein F, Halper-Stromberg A, Scheid J.F., Eden C, Mouquet H1, Nussenzweig M.C., Schwartz O. Broadly neutralizing antibodies that inhibit HIV-1 cell-to-cell transmission.. J Exp Med. 2013 ;210(13):2813-21.

Shingai M, Nishimura Y, Klein F, Mouquet H1, Donau OK, Plishka R, Buckler-White A, Seaman M, Piatak M Jr, Lifson JD, Dimitrov DS, Nussenzweig MC, Martin MA. Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia. Nature. 2013;503(7475):277-80.

Horwitz JA, Halper-Stromberg A, Mouquet H1,Gitlin AD, Tretiakova A, Eisenreich TR, Malbec M, Gravemann S, Billerbeck E, Dorner M, Büning H, Schwartz O, Knops E, Kaiser R, Seaman MS, Wilson JM, Rice CM, Ploss A, Bjorkman PJ, Klein F, Nussenzweig MC. HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice.  Proc Natl Acad Sci U S A 2013;

 

Klein F, Mouquet H1, Dosenovic P, Scheid JF, Scharf L, Nussenzweig MC. Antibodies in HIV-1 vaccine development and therapy. Science 2013;341(6151):1199-204.

 

Mouquet H2, Nussenzweig MC. Mapping the road to an HIV vaccine. Nature 2013; 496(7446):441-2.

 

Klein F, Diskin R, Scheid JF, Gaebler C, Mouquet H, Georgiev I, Pancera M, Zhou T, Incesu RB, Zhongzheng Fu B, Gnanapragasam PNP, Oliveira TY, Seaman MS, Kwong PD, Bjorkman PJ and Nussenzweig MC. Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization. Cell 2013; 153(1):126-38

 

2012

 

Klein F, Halper-StrombergA, HorwitzJ, KruellH, ScheidJF, BournazosS, MouquetH, Spatz, LA, DiskinR, AbadirA, Zang T, Dorner M, Billerbeck E, Labitt RN, GaeblerC, MarcovecchioP, IncesuR-B, Eisenreich TR, BieniaszP, SeamanMS, BjorkmanPJ, RavetchJV, PlossA, NussenzweigMC. HIV therapy by combinations of broadly neutralizing antibodies in humanized mice. Nature 492(7427):118-22. 2012;

 

 

Mouquet H[2], Scharf L, Euler Z, Liu K , Eden C, Scheid JF, Halper-Stromberg A, Spencer DIR, Seaman MS, Schuitemaker H, Feizi T, Nussenzweig MC, Bjorkman PJ. Complex-type N-glycan recognition by potent broadly-neutralizing HIV antibodies. Proc Natl Acad Sci U S A 2012; 109(47):E3268-77. 

 

Klein F, Gaebler C, Mouquet H, Sather N, Lehmann C, Scheid J, Kraft Z, Liu Y, Pietzsch J, Hurley A, Pereyra F, Feizi T, Morris L, Montefiore D, Walker BD, Fätkenheuer G, Seaman MS, Stamatatos L, Nussenzweig MC. Broad neutralization by a combination of antibodies to the CD4 binding site and a new conformational epitope on the HIV envelope protein. J Exp Med. 2012;209(8): 1469-79.

 

Billiard F, LobryC, Darrasse-Jèze G, Waite J, LiuX, MouquetH, Danave A, Tait M, Idoyaga J, Leboeuf M, Kyratsous KA, Burton J, Katler J, Klinakis A, Zhang W, Thurston G, Merad M, Steinman RM, Murphy AJ, Yancopoulos GD, AifantisI, Skokos D. A novel function for Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice. J Exp Med. 2012;209(5):1011-28.

 

Mouquet H2, Warncke M, Scheid JF, Seaman MS, Nussenzweig MC. Enhanced HIV-1 neutralization by antibody heteroligation. Proc Natl Acad Sci U S A. 2012;109(3):875-80.

 

Mouquet H2, Nussenzweig MC. Polyreactive antibodies in adaptive immune responses to viruses. Cell Mol Life Sci. 2012;69:1435-45.

 

 

2011

 

Scheid JF, Mouquet H, Kofer J, Yurasov S, Nussenzweig MC, Wardemann H. Differential regulation of self-reactivity discriminates between IgG+ human circulating memory B cells and bone marrow plasma cells. Proc Natl Acad Sci U S A. 2011;108:18044-8.

 

 

Mouquet H, Klein F, Scheid JF, Warncke M, Pietzsch J, Oliveira TY, Velinzon K, Seaman MS, Nussenzweig MC. Memory B cell antibodies to HIV-1 gp140 cloned from individuals infected with clade A and B viruses. PLoS One. 2011;6:e24078.

 

Scheid JF, Mouquet H, Ueberheide B, Diskin R, Klein F, Oliveira TY, Pietzsch J, Fenyo D, Abadir A, Velinzon K, Hurley A, Myung S, Boulad F, Poignard P, Burton DR, Pereyra F, Ho DD, Walker BD, Seaman MS, Bjorkman PJ, Chait BT, Nussenzweig MC. Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding. Science. 2011;333:1633-7.

 

 

2010
 

Mouquet H, Scheid JF, Zoller MJ, Krogsgaard M, Ott RG, Shukair S, Artyomov MN, Pietzsch J, Connors M, Pereyra F, Walker BD, Ho DD, Wilson PC, Seaman MS, Eisen HN, Chakraborty AK, Hope TJ, Ravetch JV, Wardemann H, Nussenzweig MC. Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation. Nature. 2010;467:591-5.

 

Pietzsch J, Scheid JF, Mouquet H, Klein F, Seaman MS, Jankovic M, Corti D, Lanzavecchia A, Nussenzweig MC. Human anti-HIV-neutralizing antibodies frequently target a conserved epitope essential for viral fitness. J Exp Med. 2010;207:1995-2002.

 

Pietzsch J, Scheid JF, Mouquet H, Seaman MS, Broder CC, Nussenzweig MC. Anti-gp41 antibodies cloned from HIV-infected patients with broadly neutralizing serologic activity. J Virol. 2010;84(10):5032-42.

 

 

2009
 

Darrasse-Jèze G, Deroubaix S, Mouquet H, Victora GD, Eisenreich T, Yao KH, Masilamani RF, Dustin ML, Rudensky A, Liu K, Nussenzweig MC. Feedback control of regulatory T cell homeostasis by dendritic cells in vivo. J Exp Med. 2009;206(9):1853-62.

 

Abasq C, Mouquet H, Gilbert D, Tron F, Grassi V, Musette P, Joly P. ELISA testing of anti-desmoglein 1 and 3 antibodies in the management of pemphigus. Arch Dermatol. 2009;145(5):529-35.

 

Scheid JF, Mouquet H, Feldhahn N, Walker BD, Pereyra F, Cutrell E, Mascola JR, Wyatt RT, Wardemann H, Nussenzweig MC. A method for identification of HIV gp140 binding memory B cells in human blood. J Immunol Methods. 2009;343:65-7.

 

Scheid JF, Mouquet H, Feldhahn N, Seaman MS, Velinzon K, Pietzsch J, Ott RG, Anthony RM, Zebroski H, Hurley A, Phogat A, Chakrabarti B, Li Y, Connors M, Pereyra F, Walker BD, Wardemann H, Ho D, Wyatt RT, Mascola JR, Ravetch JV, Nussenzweig MC. Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals. Nature. 2009;458:636-40.

 

 

2008
 

Mouquet H, Musette P, Gougeon M-, Jacquot S, Lemercier B, Lim A, Gilbert D, Dutot I, Roujeau JC, D'Incan M, Bedane C, Tron F, Joly P. B-cell depletion immunotherapy in pemphigus: Effects on cellular and humoral immune responses. J Invest Dermatol. 2008;128:2859-69.

 

Mouquet H, Drenovska K, Lartigue A, Joly P, Drouot L, Thomas M, Tron F, Gilbert D. Detection and characterization of anti-envoplakin linker autoantibodies in paraneoplastic pemphigus using specific bead-based assay. Clin Immunol. 2008;129:304-12.

 

Mouquet H, Berrih-Aknin S, Bismuth J, Joly P, Gilbert D, Tron F. Expression of pemphigus-autoantigen desmoglein 1 in human thymus. Tissue Antigens. 2008;71:464-70.

 

 

2007
 

Joly P, Mouquet H, Roujeau J-, D'Incan M, Gilbert D, Jacquot S, Gougeon ML, Bedane C, Muller R, Dreno B, Doutre MS, Delaporte E, Pauwels C, Franck N, Caux F, Picard C, Tancrede-Bohin E, Bernard P, Tron F, Hertl M, Musette P. A single cycle of rituximab for the treatment of severe pemphigus. N Engl J Med. 2007;357:545-52.

 

Gilbert D, Mouquet H, Joly P. T cell involvement in pemphigus. Giornale Italiano di Dermatologia e Venereologia. 2007;142(4):353-62.

 

 

2006
 

Mouquet H, Joly P. What you should remember and understand from pemphigoid  antigens. (French). Dermatologie Pratique 2006;298: 8-10.

 

Tron F, Gilbert D, Joly P, Mouquet H, Drouot L, Ayed MB, Sellami M, Masmoudi H, Makni S. Immunogenetics of pemphigus: An update. Autoimmunity. 2006;39(7):531-9.

 

Mouquet H, Farci S, Joly P, Maillère B, Leblond J, Drouot L, Leprince J, Tonon MC, Loiseau P, Charron D, Tron F, Gilbert D. A truncated alternative spliced isoform of human desmoglein 1 contains a specific T cell epitope binding to the pemphigus foliaceus-associated HLA class II DRβ1*0102 molecule. J. Immunol. 2006;177:6517-26.

 

Mouquet H, Drouot L, Charlionnet R, Arnoult C, Bonnet-Bayeux F, Thomas M, Leprince J, Joly P, Tron F, Gilbert D. Proteomic analysis of the autoantibody response following immunization with a single autoantigen. Proteomics. 2006;6:4829-37.

 

 

2005
 

Mouquet H, Gilbert D, Musette P, Tron F, Joly P. Molecular advances in pathogenesis of autoimmune blistering skin diseases. Ann Dermatol Venereol. (French) 2005;132:231-42.

 

Tron F, Gilbert D, Mouquet H, Joly P, Drouot L, Makni S, Masmoudi H, Charron D, Zitouni M, Loiseau P, Ben Ayed M. Genetic factors in pemphigus. J Autoimmun. 2005;24:319-28.

 

 

2004
 

Kallel Sellami M, Ben Ayed M, Mouquet H, Drouot L, Zitouni M, Mokni M, Cerruti M, Turki H, Fezza B, Mokhtar I, Ben Osman A, Zahaf A, Kamoun MR, Joly P, Masmoudi H, Makni S, Tron F, Gilbert D. Anti-desmoglein 1 antibodies in tunisian healthy subjects: Arguments for the role of environmental factors in the occurrence of tunisian pemphigus foliaceus. Clin Exp Immunol. 2004;137(1):195-200.

 

Mouquet H, Gilbert D, Joly P, Tron F. Molecular aspects of autoimmune blistering skin diseases. Immuno-Analyse et Biologie Specialisée. (French) 2004;19(1):31-41.

 

 

2003
 

Martel P, Loiseau P, Joly P, Busson M, Lepage V, Mouquet H, Courville P, Flageul B, Charron D, Musette P, Gilbert D, Tron F. Paraneoplastic pemphigus is associated with the DRB1*03 allele. J Autoimmun. 2003;20(1):91-5.

 

 

Books & Chapters

 

Mouquet H. Le rôle de l’autoantigène dans les maladies autoimmunes: étude de la desmogléine 1 au cours des pemphigus. Eds universitaires européennes (Südwestdeutscher Verlag für Hochschulschriften GmbH&Co.KG) Sarrebruck, 2010. 228 pp.

 

Mouquet H, P. Musette. Les maladies bulleuses. In Immunité cutanée acquise. Immunologie cutanée. F. Bérard, J. Thivolet J.F. Nicolas, eds (John Libbey Eurotext) Paris, 2004. p43-64.
 


 

[1] As group leader of the Laboratory of Humoral Response to Pathogens.

[2] Corresponding author.

Updated on 19/12/2014

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