Humoral Response to Pathogens

 Welcome to the MOUQUET LAB


Laboratory of Humoral Response to Pathogens (G5 group)

Department of Immunology
Secondary affiliation with the Department of Virology


Our research group aims to study the molecular basis of antibody B-cell responses to viruses such as HIV-1, and how anti-viral antibodies may participate in controlling the infection in humans.


In addition to polyreactive “natural antibodies” that act as the first line of defense against invading pathogens, “humoral memory” is composed of high affinity antibodies that mediate long-lived immunity against infectious agents, e.g., by providing protection against re-infection. The molecular dissection of anti-pathogen B-cell responses using modern technologies to generate specific monoclonal antibodies, has allowed breakthrough discoveries in antiviral responses to Influenza virus and Human Immunodeficiency virus (HIV). These recombinant antibodies represent unique “fingerprints” for each B-cell clone and when characterized on a molecular level, provide crucial information about the antigen-specific humoral response to a given pathogen. In addition to the antibodies’ potential therapeutic interest, their characterization can lead to a better understanding of human antibody responses to pathogens, and may uncover candidate immunogens for vaccine development.


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