The Pasteur Museum is housed in the apartment where Louis Pasteur spent his final seven years and offers a rare behind-the-scenes look at the living and working environment of the world-renowned scientist. Visitors can gain a unique insight into his everyday life alongside his wife and can admire his rich and diverse scientific work.
The Institut Pasteur’s scientific strategy focuses on developing original and innovative topics and promoting interdisciplinary and multidisciplinary cooperation and approaches. The Institut Pasteur teams have access to the technological resources needed to speed up and further improve the quality of their outstanding research.
Ever since the introduction of the world’s first "Technical Microbiology" course in 1889, teaching has been a priority for the Institut Pasteur. The Institut Pasteur has an international reputation for quality teaching that attracts students from all over the world who come to further their training or top up their degree programs.
With international courses, PhD and postdoctoral traineeship, each institute of the Institut Pasteur International Network (RIIP) contributes to the transmission of knowledge with the training of young researchers all around the world. In this context, doctoral and postdoctoral programmes, study and traineeship fellowships are available to scientists. Alongside training, dynamism and attractiveness of RIIP will result in the creation of 4-year group for the young researchers.
from Allergy & Autoimmunity to Cancer Immunotherapy
Antibodies are key effectors of the immune system. They are responsible for disease induction (autoimmunity, allergy) and can be protecting from or facilitating infections and tumors. Antibodies do not exert by themselves, however, biological functions: these are mainly mediated by antibody receptors (FcRs).
Our aim is to decipher the role of human antibodies, human antibody receptors (FcRs) and the cells expressing them during therapy and in the induction of pathologies. How antibodies and their receptors induce/regulate autoimmune and allergic diseases is addressed using on one hand models of rheumatoid arthritis and anaphylaxis (allergic shock) in humanized mice and, on the other hand through a clinical study (NASA). How antibodies and their receptors participate in passive antibody therapy is addressed using human tumor xenografts in the mouse. In all these projects we aim at identifying the cell population(s) responsible for antibody-mediated effects, and decipher the mechanism behind their contribution to therapy or pathology. To enhance the clinical relevance of our studies in mice, we have generated "humanized" mouse models expressing human FcRs in the presence of human antibodies. Our recent focus has been on FcR-expressing myeloid cells, in particular neutrophils and monocytes/macrophages, that we extend now to platelets and their interaction with neutrophils.
Altogether, our research, integrating fundamental, clinical and industry-driven approaches, aims at elucidating the role of antibodies, their receptors and the cells expressing them in major disease and therapy models and, hopefully, propose novel therapeutic solutions in antibody-based therapies.
- Identification of neutrophils as the cell population responsible for anti-tumor immunotherapy of solid tumors (Albanesi et al, Blood 2013).
- Demonstration that human IgG receptor (FcγRI,CD64) can trigger autoimmune and allergic diseases, and that it can mediate anti-tumor antibody therapy (Mancardi et al, Blood 2013).
- Demonstration that mouse FcγRIII (CD16) and mouse FcγRI (CD64) are responsible for anti-melanoma antibody therapy in a syngeneic mouse metastatic melanoma model (Albanesi et al., J Immunol Cutting Edge 2012)
- Demonstration that human IgG receptor (FcγRIIA,CD32A) can trigger anaphylaxis and airway inflammation (Jönsson et al, Blood 2012).
- Demonstration that neutrophils are the main inducers of active anaphylaxis in the mouse and that human neutrophils can induce anaphylaxis (Jönsson & Mancardi et al, J Clin Invest 2011).
PROJECT 1: Developing novel models of disease and vaccination in Ab- and FcR-humanized mice: establishment in these mice of clinically pertinent models of allergic and autoimmune (inflammatory) diseases.
PROJECT 2: Clinical and pathological consequences of human anti-drug antibodies (NASA study) that aims at demonstrating in the clinic that neutrophils are activated by antibody-curare complexes and involved in curare-induced anaphylaxis (allergic shock) in humans, and at establishing in parallel a mouse model of curare-induced anaphylaxis.
PROJECT 3: Role of platelets and their interactions in allergic diseases that aims at understanding how platelets induce/promote/regulate antibody-induced allergic diseases, their interaction partners (myeloid cells, endothelium) and their dynamics.
PROJECT 4: Antibody-based anti-tumor immunotherapy that aims at identifying the human FcγRs involved in melanoma and/or breast cancer immunotherapy, and at identifying the effector population(s) responsible for tumor destruction.