Intravenous immunoglobulin promotes antitumor responses by modulating macrophage polarization.


Domínguez-Soto A, de las Casas-Engel M, Bragado R, Medina-Echeverz J, Aragoneses-Fenoll L, Martín-Gayo E, van Rooijen N, Berraondo P, Toribio ML, Moro MA, Cuartero I, Castrillo A, Sancho D, Sánchez-Torres C, Bruhns P, Sánchez-Ramón S, Corbí AL.


J Immunol. 2014 Nov 15;193(10):5181-9.



Shifting FcγRIIA-ITAM from activation to inhibitory configuration ameliorates arthritis.


Ben Mkaddem S, Hayem G, Jönsson F, Rossato E, Boedec E, Boussetta T, El Benna J, Launay P, Goujon JM, Benhamou M, Bruhns P, Monteiro RC.


J Clin Invest. 2014 Sep 2;124(9):3945-59. doi: 10.1172/JCI74572. Epub 2014 Jul 25.



A FcγRIII-engaging bispecific antibody expands the range of HER2-expressing breast tumors eligible to antibody therapy.


Turini M, Chames P, Bruhns P, Baty D, Kerfelec B.


Oncotarget. 2014 Jul 30;5(14):5304-19.



Contribution of human FcγRs to disease with evidence from human polymorphisms and transgenic animal studies.


Gillis CM*, Gouel-Chéron A*, Jönsson F and Bruhns P.


Front Immunol, 2014;5:254. (*equal contributors).



The function of Fcγ receptors in dendritic cells and macrophages

Guilliams M, *Bruhns P*, Saeys Y, Hammad H and Lambrecht B.

Nat Rev Immunol, 2014; 14, 94-108.





Neutrophils mediate antibody-induced anti-tumor effects in mice.

Albanesi M, Mancardi DA, Jönsson F, Iannascoli B, Fiette L, Di Santo JP, Lowell CA, Bruhns P.

Blood. 2013 Aug 26. [Epub ahead of print].




Contribution of humoral immune responses to the antitumor effects mediated by anthracyclines.

Hannani D, Locher C, Yamazaki T, Colin-Minard V, Vetizou M, Aymeric L, Viaud S, Sanchez D, Smyth MJ, Bruhns P, Kroemer G, Zitvogel L.

Cell Death Differ. 2013 Jun 7.




Neutrophils in local and systemic antibody-dependent inflammatory and anaphylactic reactions.

Jönsson F, Mancardi DA, Albanesi M, Bruhns P.


J Leukoc Biol. 2013 May 21.




The high-affinity human IgG receptor FcγRI (CD64) promotes IgG-mediated inflammation, anaphylaxis, and antitumor immunotherapy.

Mancardi DA, Albanesi M, Jönsson F, Iannascoli B, Van Rooijen N, Kang X, England P, Daëron M, Bruhns P.

Blood. 2013 Feb 28;121(9):1563-73.




Quorum sensing contributes to activated IgM-secreting B cell homeostasis.


Montaudouin C, Anson M, Hao Y, Duncker SV, Fernandez T, Gaudin E, Ehrenstein M, Kerr WG, Colle JH, Bruhns P, Daëron M, Freitas AA.


J Immunol. 2013 Jan 1;190(1):106-14. 


PMID: 23209322






Cutting Edge: Fc RIII (CD16) and Fc RI (CD64) are responsible for anti-glycoprotein 75 monoclonal antibody TA99 therapy for experimental metastatic B16 melanoma.

Albanesi M, Mancardi DA, Macdonald LE, Iannascoli B, Zitvogel L, Murphy AJ, Leusen JH, Bruhns P.

J Immunol. 2012 Dec 15;189(12):5513-7. doi: 10.4049/jimmunol.1201511. Epub 2012 Nov 12.


PMID: 23150715

Autonomous phagosomal degradation and antigen presentation in dendritic cells.


Hoffmann E, Kotsias F, Visentin G, Bruhns P, Savina A, Amigorena S.


Proc Natl Acad Sci U S A. 2012 Aug 20. [Epub ahead of print]


PMID: 22908282




Fcγ Receptors Inhibit Mouse and Human Basophil Activation.

Cassard L, Jönsson F, Arnaud S, Daëron M.


J Immunol. 2012 Aug 20. [Epub ahead of print]






Apoptosis of mouse mast cells is reciprocally regulated by the IgG receptors FcγRIIB and FcγRIIIA.


Fang Y, Larsson L, Bruhns P, Xiang Z, Simon HU.


Allergy. 2012 Jul 30. doi: 10.1111/j.1398-9995.2012.02878.x.. [Epub ahead of print]


PMID: 22845035




A hypomorphic mutation in the Gfi1 transcriptional repressor results in a novel form of neutropenia.


Ordoñez-Rueda D, Jönsson F, Mancardi DA, Zhao W, Malzac A, Liang Y, Bertosio E, Grenot P, Blanquet V, Sabrautzki S, de Angelis MH, Méresse S, Duprez E, Bruhns P, Malissen B, Malissen M.


Eur J Immunol. 2012 Jun 11. doi: 10.1002/eji.201242589. [Epub ahead of print]


PMID: 22684987




The interactions of therapeutic antibodies with Fc receptors.


Albanesi M, Daëron M.


Immunol Lett. 2012 Mar 30;143(1):20-7. Review.


PMID: 22553779




Mast cells and company.


Jönsson F, Daëron M.


Front Immunol. 2012;3:16. Epub 2012 Feb 20.


PMID: 22566901




Properties of mouse and human IgG receptors and their contribution to disease models.


Bruhns P.


Blood. 2012 Jun 14;119(24):5640-9. Epub 2012 Apr 25. Review.


PMID: 22535666




Human FcγRIIA induces anaphylactic and allergic reactions.


Jönsson F, Mancardi DA, Zhao W, Kita Y, Iannascoli B, Khun H, van Rooijen N, Shimizu T, Schwartz LB, Daëron M, Bruhns P.


Blood. 2012 Mar 15;119(11):2533-44. Epub 2011 Dec 2.


PMID: 22138510






[An unexpected role for neutrophils in anaphylaxis].


Jönsson F, Mancardi DA, Daëron M, Bruhns P.


Med Sci (Paris). 2011 Oct;27(10):823-5. Epub 2011 Oct 21. French. No abstract available.


PMID: 22027419




A strain of Lactobacillus casei inhibits the effector phase of immune inflammation.


Schiffer C, Lalanne AI, Cassard L, Mancardi DA, Malbec O, Bruhns P, Dif F, Daëron M.


J Immunol. 2011 Sep 1;187(5):2646-55. Epub 2011 Aug 1.


PMID: 21810608




Mouse and human neutrophils induce anaphylaxis.


Jönsson F, Mancardi DA, Kita Y, Karasuyama H, Iannascoli B, Van Rooijen N, Shimizu T, Daëron M, Bruhns P.


J Clin Invest. 2011 Apr;121(4):1484-96. doi: 10.1172/JCI45232. Epub 2011 Mar 23.


PMID: 21436586




Cutting edge: intravenous Ig inhibits invariant NKT cell-mediated allergic airway inflammation through FcγRIIIA-dependent mechanisms.


Araujo LM, Chauvineau A, Zhu R, Diem S, Bourgeois EA, Levescot A, Huerre M, Gombert JM, Bayry J, Daëron M, Bruhns P, Kaveri SV, Herbelin A.


J Immunol. 2011 Mar 15;186(6):3289-93. Epub 2011 Feb 11.


PMID: 21317388




Cutting Edge: The murine high-affinity IgG receptor FcγRIV is sufficient for autoantibody-induced arthritis.


Mancardi DA, Jönsson F, Iannascoli B, Khun H, Van Rooijen N, Huerre M, Daëron M, Bruhns P.


J Immunol. 2011 Feb 15;186(4):1899-903. Epub 2011 Jan 19.


PMID: 21248252




Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORgamma t and LTi cells.


Lochner M, Ohnmacht C, Presley L, Bruhns P, Si-Tahar M, Sawa S, Eberl G.


J Exp Med. 2011 Jan 17;208(1):125-34. Epub 2010 Dec 20.


PMID: 21173107






Differential recruitment of activating and inhibitory Fc gamma RII during phagocytosis.


Syam S, Mero P, Pham T, McIntosh CA, Bruhns P, Booth JW.


J Immunol. 2010 Mar 15;184(6):2966-73. Epub 2010 Feb 12.


PMID: 20154205






Ligand binding but undetected functional response of FcR after their capture by T cells via trogocytosis.


Hudrisier D, Clemenceau B, Balor S, Daubeuf S, Magdeleine E, Daëron M, Bruhns P, Vié H.


J Immunol. 2009 Nov 15;183(10):6102-13. Epub 2009 Oct 19.


PMID: 19841164



Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses.


Bruhns P, Iannascoli B, England P, Mancardi DA, Fernandez N, Jorieux S, Daëron M.


Blood. 2009 Apr 16;113(16):3716-25. Epub 2008 Nov 18.


PMID: 19018092



Human basophils express the glycosylphosphatidylinositol-anchored low-affinity IgG receptor FcgammaRIIIB (CD16B).


Meknache N, Jönsson F, Laurent J, Guinnepain MT, Daëron M.


J Immunol. 2009 Feb 15;182(4):2542-50.


PMID: 19201911






FcgammaRIV is a mouse IgE receptor that resembles macrophage FcepsilonRI in humans and promotes IgE-induced lung inflammation.


Mancardi DA, Iannascoli B, Hoos S, England P, Daëron M, Bruhns P.


J Clin Invest. 2008 Nov;118(11):3738-50. Epub 2008 Oct 23.


PMID: 18949059






Publications prior to 2008, please search in :


Updated on 28/05/2015


Unit of Antibodies in Therapy and Pathology


Département d’Immunologie

Institut Pasteur

25, rue du Docteur Roux

75015 Paris


General enquiries: Ms Danièle SINNAYA (


Head and Principal Investigator

Dr. Pierre Bruhns, PhD



Dr. Friederike Jönsson, PhD