Benoit Arcangioli Lab
Genomic imprinting (Helen V. Crouse, 1960) is necessary for proper growth and development in many species, and as been implicated in cancer, aging and development in humans.
The programmed strand-specific imprinting (SSB) at the mating-type locus constitutes a novel type of imprint actively studied in the laboratory. Because the homologous recombination process can be viewed as an integral part of DNA replication, we address how DNA is repaired in the G0/quiescent state. Recently, we have shown that S. pombe is a good cellular model for degenerative diseases.