The Pasteur Museum is housed in the apartment where Louis Pasteur spent his final seven years and offers a rare behind-the-scenes look at the living and working environment of the world-renowned scientist. Visitors can gain a unique insight into his everyday life alongside his wife and can admire his rich and diverse scientific work.
The Institut Pasteur’s scientific strategy focuses on developing original and innovative topics and promoting interdisciplinary and multidisciplinary cooperation and approaches. The Institut Pasteur teams have access to the technological resources needed to speed up and further improve the quality of their outstanding research.
Ever since the introduction of the world’s first "Technical Microbiology" course in 1889, teaching has been a priority for the Institut Pasteur. The Institut Pasteur has an international reputation for quality teaching that attracts students from all over the world who come to further their training or top up their degree programs.
With international courses, PhD and postdoctoral traineeship, each institute of the Institut Pasteur International Network (RIIP) contributes to the transmission of knowledge with the training of young researchers all around the world. In this context, doctoral and postdoctoral programmes, study and traineeship fellowships are available to scientists. Alongside training, dynamism and attractiveness of RIIP will result in the creation of 4-year group for the young researchers.
Our Unit investigates and characterises the molecular, genetic and cellular basis of the infection by Legionella.
Legionella are environmental bacteria but some species like Legionella pneumophila or Legionella longbeachae are also opportunistic pathogens that can cause Legionnaires' disease, a severe pneumonia, in particular in people whose immune defences are weakened. The bacterium's survival and spread depends on the ability to replicate inside eukaryotic phagocytic cells. It is known for its dual host system allowing the intracellular growth in protozoa like Acanthamoeba castellanii, Hartmanella sp. or Naeglaria sp., and in human alveolar macrophages. It can be speculated that the interaction of L. pneumophila with aquatic protozoa has generated a pool of virulence traits during evolution, which allow it to infect also human cells. Upon internalization into the eukaryotic cell, Legionella guarantee their survival by manipulating host cell functions such as disturbing vesicle trafficking, therewith reprogramming the endosomal-lysosomal degradation pathway of the phagocytic cell.
We aim to understand 1) the relationship between virulence and genetic diversity among different isolates of Legionella pneumophila and different species of Legionella, to decipher 2) the mechanisms leading to this diversity and to understand 3) the role diversity plays in infection and environmental adaptation. In line with this, we aim to gain knowledge on 4) how Legionella adapts/regulates its cycle between a eukaryotic host and the environment and to understand 5) the function newly identified putative virulence factors of Legionella pneumophila and Legionella longbeachae have in the intracellular infection cycle.
Updated on 22/01/2014
Biology of Intracellular Bacteria
CNRS UMR 3525
28, Rue du Docteur Roux
75724 Paris Cedex 15