Epigenetic Regulation


Christian Muchardt


The general objective of the lab is to explore the crosstalk between the transcription machinery, the RNA it produces, and the chromatin.


Currently, we are focusing on chromatin factors best known for their role in long-term transcriptional repression (Silencing) and on the function these factors may have in regulating gene-expression and alternative splicing outside of constitutive heterochromatin.






Alternative splicing affects the activity of Silencing proteins

We have investigated how alternative splicing affects the function of two human histone methyltransferases (HMTase): G9A and SUV39H2. We show that a wide range of tissues express multiple isoforms of these proteins, each displaying activity, stability, or sub-nuclear localization.

Mauger O et al. Alternative splicing regulates the expression of G9A and SUV39H2 methyltransferases, and dramatically changes SUV39H2 functions. Nucleic Acids Res. 2015.



Bacterial effector targets HP1 and reveals their role in gut tissue regeneration

In collaboration with the team of Laurence Arbibe in the Unit of Philippe Sansonetti, we show that S. flexneri takes over transcriptional regulation of cellular defense genes by interacting with HP1. This study uncovered a role for HP1g in the dampening of the innate immune response and in increased tissue regeneration within the gut epithelium.

Harouz H et al. Shigella flexneri targets the HP1g subcode through the phosphothreonine lyase OspF. EMBO J. 2014 Nov 18;33(22):2606–22


Epigenetic Regulation (URA CNRS 2578)


Mail address :
Monod Building
Institut Pasteur
25, rue du Docteur Roux
75724 PARIS CEDEX 15

Phone : 33 1 45 68 85 25
Fax : 33 1 45 68 89 76


Location : 4th floor of the Monod building (building 66), rooms 01 and 07



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