The Pasteur Museum is housed in the apartment where Louis Pasteur spent his final seven years and offers a rare behind-the-scenes look at the living and working environment of the world-renowned scientist. Visitors can gain a unique insight into his everyday life alongside his wife and can admire his rich and diverse scientific work.
The Institut Pasteur’s scientific strategy focuses on developing original and innovative topics and promoting interdisciplinary and multidisciplinary cooperation and approaches. The Institut Pasteur teams have access to the technological resources needed to speed up and further improve the quality of their outstanding research.
Ever since the introduction of the world’s first "Technical Microbiology" course in 1889, teaching has been a priority for the Institut Pasteur. The Institut Pasteur has an international reputation for quality teaching that attracts students from all over the world who come to further their training or top up their degree programs.
The mission of the Industrial Partnership team is to detect, promote, assist and protect the inventive activities from research (inventions, know-how and biological materials) conducted at the Institut Pasteur (and in some Institutes of its international network), and transfer there to industrial and/or institutional partners, in order to serve the patient needs and for the benefit of the society, as well as to contribute to sustainability of the Institut Pasteur’s resources.
With international courses, PhD and postdoctoral traineeship, each institute of the Institut Pasteur International Network (RIIP) contributes to the transmission of knowledge with the training of young researchers all around the world. In this context, doctoral and postdoctoral programmes, study and traineeship fellowships are available to scientists. Alongside training, dynamism and attractiveness of RIIP will result in the creation of 4-year group for the young researchers.
(A. SUBTIL, M. COSSE, L. GEHRE, M. LAVERRIERE, S. PERRINET)
One of our important discoveries was the identification of a bacterial protein translocated into the host nucleus upon infection (Pennini et al, 2010). This protein, which we called NUE (NUclear Effector), shows histone methyl transferase activity. We are currently investigating at which site and to which extent NUE’s activity modifies the chromatin during infection, and the consequences for the host gene expression. We have also undertaken the identification of other chlamydial nuclear effectors and their functional study. Along this line, the recent discovery of methods to stably transform chlamydiae opened novel strategies of research and we recently obtained our first stably transformed cell line expressing epitope-tagged NUE. We are currently developing plasmids to perform random and targeted mutagenesis in C. trachomatis. This project has received financial support from the ERC (ERC Starting grant “NUChLEAR”)
Detection of the chlamydial protein NUE in nuclear fraction (nu) over the course of infection. PARP1 is a nuclear protein and β-tubulin a cytosolic (cyt) protein. In contrast to NUE, the bacterial protein Ef-TU remains associated to the cytosolic fraction (from Pennini et al 2010)