The Pasteur Museum is housed in the apartment where Louis Pasteur spent his final seven years and offers a rare behind-the-scenes look at the living and working environment of the world-renowned scientist. Visitors can gain a unique insight into his everyday life alongside his ...
The Institut Pasteur’s scientific strategy focuses on developing original and innovative topics and promoting interdisciplinary and multidisciplinary cooperation and approaches. The Institut Pasteur teams have access to the technological resources ...
Ever since the introduction of the world’s first "Technical Microbiology" course in 1889, teaching has been a priority for the Institut Pasteur. The Institut Pasteur has an international reputation for quality teaching that attracts students from all over ...
The mission of the Industrial Partnership team is to detect, promote, assist and protect the inventive activities from research (inventions, know-how and biological materials) conducted at the Institut Pasteur (and in some Institutes of its international network), and transfer there to industrial ...
With international courses, PhD and postdoctoral traineeship, each institute of the Institut Pasteur International Network (RIIP) contributes to the transmission of knowledge with the training of young researchers all around the world. In this context, doctoral and postdoctoral programmes, study ...
- "Microbes and Infection", Editorial board 2000-2012
- "EMBO Reports", Editorial board 2001-
- "FEBS Letters", Editor 2002-2008
- "International Journal of Medical Microbiology", Editorial board 2004-
- Member of "Faculty of 1000"- 2001-
- "Cell": Host and Microbe" , Editorial board 2007-
- "Cell", Editorial board 2008-
- "eLife", Editorial board 2012-
- "mBio", Editorial board 2013-2015
Scientific Societies :
Member of the Société Française de Microbiologie since 1977. Member of the American Society for Microbiology since 1987. Member of the American Society for Cell Biology since 1993. Member of the Sociéte Française de Biologie Cellulaire since 2007. Member of the Société Française de Biochimie et de Biologie Moléculaire since 2007.
Main present activities :
- President of the Scientific Council of Institut Pasteur 2013-
- Member of the Scientific advisory board, Institut Curie, 2014-
- European Research Council (ERC) LS6 Panel member, vice chair, 2008-
- Member of the EMBO Council, Heidelberg, 2010-
- Co-Director of Labex “Integrative Biology of Emerging Infectious Diseases” 2011-
- Member of the Scientific Council of Institut Pasteur of Tunis, 2009-
- Member of the Teaching and Research Council of Ecole Polytechnique, Paris 2009-2013
- Member of Scientific Council of Fondation ALLIANZ-Institut de France, 2012-
- Member of the Science Assessment Panel of the Francis Crick Institute, London, UK, 2012-
- Member of the jury of Koerber European Science Prize, Hamburg, Germany, 2012-
- Member of the Board of Trustees. Fondation L’Oréal, 2012-
- Member of the Jury of the L’Oréal-UNESCO Awards for Women in Science, 1999-
Main recent activities :
- Member of the jury of the Sanofi – Institut Pasteur Awards, Paris, France, 2012-
- Member of the Council of Scientific of Human Frontier Science Program Organization (HFSPO), 2008-2011
- Member of the Scientific Advisory Board of the Biozentrum, University of Basel, Switzerland, 2002-2011
- Member of the HHMI review panel for the Early Career Initiative, 2011
- Member of the Scientific Council of the Institut Pasteur, 2002-2006, President 2003-2005, member 2011
- Member of the Scientific Council of INRA, 1998- 2006. In charge of "Mission Microbiologie in INRA" in 2001
- Member of the EMBO Course and Workshop Committee, 1999-2004. "Chair" 2001-2004
- Member of the Review Panel of the EMBL « Cell Biology and Biophysics Unit », Heidelberg, Germany, May 2005
- Member of the Jury of the 2006 INBEV-Baillet Latour Health Prize, FNRS, Brussels, 2006
- Member of the Scientific Council of the Fondation Bettencourt-Schueller, 2003-2007
- Member of the « Comité de Pilotage » of ANR, Agence Nationale pour la Recherche, « Microbiol., Immunol. et Maladies Emergentes », 2006-2009
- Member of the Scientific Council of the CNRS, 2005-2006
- Member of the Program Committee of the 2006 ASCB Annual Meeting in San Diego, US, December 2006
- Member of the Scientific Council of the « Ville de Paris », 2003-2008
- Member of the Scientific Advisory Board of the Research Center for Infectious Diseases, Würzburg University, Germany, 2000-2008
- Member of the Scientific Council of American Society Cell Biology (ASCB), 2008-2010
- Member of the FEBS Advanced Course Committee, 2008-2009
Main meetings and courses organization :
- Organization of an international INSERM/P.Laudat Conference "Microbial pathogenesis and Cell Biology", Aix-les Bains, France, October 1995
- Co-organization of a "Cellular Microbiology" EMBO-EBNIC Workshop, Sienna, Italy, January 1999
- Organization of an ESF/EMBO Conference "Frontiers of Cellular Microbiology and Cell Biology", Giens, France, October 2000
- Co-organization of the Meeting "New challenges in Biological Research : Pasteurian missions in 21st century", Académie des Sciences, Institut de
France ; Arc et Senans, France, October 2000
- Organization of EMBO/FEBS Lecture Course "Molecular basis of bacterial virulence and survival in infected hosts and in the environment", Spetsai,
Greece, September 2002
- Co-organization of the International Symposium on Threat of infection : “Microbes of high pathogenic potential –Strategies for detection, control and
eradication », joint Meeting of the Académie des Sciences, Paris, the Deutsche Akademie d er Naturforscher Leopoldina, Halle, and the Research Center
for Infectious Diseases of the University of Würzburg ;Würzburg, Germany, July 2004
- Chair of the Gordon Research Conference : “Molecular mechanisms of bacterial adhesion and signaling", Newport, USA, August 2005
- Co-organization of the Colloquium “Frontiers in Microbiology and Infectious Diseases”. Académie des Sciences, Institut de France, Paris, France,
- Co-organization of the “Gene regulation in health and disease” meeting, Institut Pasteur, Paris, France, March 2006
- Organization of EMBO/FEBS/FEMS Lecture Course "Molecular basis of bacterial virulence and survival in infected hosts and in the environment",
Spetsai, Greece, September 2006
- Co-Organization of the IUBMB/FEBS/ICGEB/UNESCO lecture course « Molecular & Cellular Basis of Infection » Hermanus, South Africa, March 08
- Co-Organisation of the EMBO/FEBS pratical course « Cell Biology of Host-Pathogen Interactions » Institut Pasteur , Paris, August 2008
- Co-organization of the 5th EIMID meeting, Arc-et Senans, France October 2008
- Organisation of the EMBO Workshop « Emerging Themes in Infection Biology », La Colle sur Loup, France, June 2010
- Organisation of the EMBO / FEBS Lecture Course « Host Microbes Interactions », Spetses, Greece, September 2010
- Co-organization of Inter-Academies Symposium on « The New microbiology ». Académie des Sciences, Institut de France, Paris, France, May 2012
- Organisation of the EMBO / FEBS Lecture Course « Host Microbes Interactions », Spetses, Greece, September 2013
- Co-organization of the EMBO / EMBL Symposium : « New approaches and concepts in microbiology », Heidelberg, Germany, October 2013
J.L. Gaillard, P. Berche, C. Frehel, E. Gouin and P. Cossart (1991). Entry of L. monocytogenes into cells is mediated by internalin, a repeat protein reminiscent of surface antigens from Gram-positive cocci. Cell, 65 : 1127-1141.
C. Kocks, E. Gouin, M. Tabouret, P. Berche, H. Ohayon and P. Cossart (1992). Listeria monocytogenes-induced actin assembly requires the actA gene product, a surface protein. Cell, 68 : 521-531.
E. Friedrich, E. Gouin, R. Hellio, C. Kocks, P. Cossart and D. Louvard (1995). Targeting of Listeria monocytogenes ActA protein to the plasma membrane as a tool to dissect both actin-based cell morphogenesis and ActA function. Embo J., 14 : 2731-2744.
S. Cudmore, P. Cossart, G. Griffiths and M. Way (1995). Actin-based motility of vaccinia virus. Nature, 378 : 636-638.
J. Mengaud, H. Ohayon, P. Gounon, R. M. Mege and P. Cossart (1996). E-cadherin is the receptor for internalin, a surface protein required for entry of Listeria monocytogenes into epithelial cells. Cell, 84 : 923-932.
P. Cossart, P. Boquet, S. Normark and R. Rappuoli (1996). Cellular Microbiology emerging. Science, 271 : 315-316.
K. Ireton, B. Payrastre, H. Chap, W. Ogawa, H. Sakaue, M. Kasuga and P. Cossart (1996). A role for Phosphoinositide 3-kinase in bacterial invasion. Science, 274 : 780-782.
I. Lasa, E. Gouin, M. Goethals, K. Vancompernolle, V. David, J. Vandekerckhove and P. Cossart (1997). Identification of two regions in the amino-terminal domain of ActA involved in the actin comet tail formation by Listeria monocytogenes. EMBO J., 16 : 1531-1540.
B.B. Finlay, and P. Cossart (1997). Exploitation of mammalian host cell functions by bacterial pathogens. Science, 276 : 718-725.
P. Mourrain, I. Lasa, A. Gautreau, A.Pugsley and P. Cossart (1997). ActA is a dimer. Proc. Natl. Acad. Sci. USA, 94 : 10034-10039.
E. Gouin, H. Gantelet, C. Egile, I. Lasa, H. Ohayon, V. Villiers, P. Gounon, P.J. Sansonetti and P. Cossart (1999). A comparative study of the actin-based motilities of the pathogenic bacteria Listeria monocytogenes, Shigella flexneri and Rickettsia conorii. J. Cell Sci., 112 : 1697-1708
M. Lecuit, S. Dramsi, C. Gottardi, M. Fedor-Chaiken, B. Gumbiner and P. Cossart (1999). A single amino-acid in E-cadherin responsible for host-specificity towards the human pathogen Listeria monocytogenes. EMBO J., 18 : 3956-3963.
M. Marino, L. Braun, P. Cossart and P. Ghosh (1999) . Structure of the InlB Leucine-rich repeats, a domain that triggers host cell invasion by the bacterial pathogen. Mol. Cell., 4 : 1063-1072.
L. Braun, B. Gebrehiwet, and P. Cossart (2000). gC1q-R/p32, a C1q-binding protein, is a receptor for the InIB invasion protein of Listeria monocytogenes. EMBO J., 19 : 1458-1466.
M. Lecuit, R. Hurme, J. Pizzaro-Cerda, H. Ohayon, B. Geiger and P. Cossart (2000). A role for a – and b-catenins in bacterial uptake. Proc. Natl. Acad. Sci., USA, 97 : 10008-10013.
H. Bierne, E. Gouin, P. Roux, P. Caroni, H. Yin and P. Cossart (2001). A role for cofilin and LIM-kinase in bacterial induced phagocytosis. J. Cell Biol., 155 : 101-112.
M. Lecuit, S. Vandormael-Pournin, Jean Lefort, M. Huerre, P. Gounon, C. Dupuy, C. Babinet and P. Cossart (2001). A transgenic model for listeriosis: role of internalin in crossing the intestinal barrirer. Science, 292 : 1722-1725.
P. Glaser, xx authors , J. Wehland, and P. Cossart (2001). Comparative genomics of Listeria species. Science, 294 : 849-853.
H.Ogata, S. Audic, P. Renesto-Audiffren, P.-E. Fournier, V. Barbe, D. Samson, V. Roux, P. Cossart, J. Weissenbach, J.-M. Claverie and D. Raoult. (2001). Mechanisms of Evolution in Rickettsia conorii and R. prowazekii. Science, 293 : 2093-2098.
J. Johansson, P. Mandin, A. Renzoni, C. Chiaruttini, M. Springer and P. Cossart (2002). An RNA Thermosensor Controls Expression of Virulence Genes in Listeria monocytogenes. Cell, 110 : 551-561.
E. Gouin, C. Egile, P. Dehoux, V. Villiers, J. Adams, F. Gertler, R. Li and P. Cossart (2004). The RickA Protein of Rickettsia conorii activates the Arp2/3 complex Nature, 427 : 457-461.
M. Lecuit, D.M. Nelson, S. D. Smith, H. Khun, M. Huerre, M.C. Vacher-Lavenu, J. I. Gordon and P. Cossart. (2004). Targeting and crossing of the human maternofetal barrier by Listeriamonocytogenes is dependent upon interactions between bacterial internalin and trophoblast
E-cadherin. Proc.Natl.Acad.Sci., USA, 101-16 : 6152-6157.
P.Cossart and P. Sansonetti. (2004). Bacterial Invasion : The paradigms of enteroinvasive pathogens. Science. 304 : 242-248.
D. Cabanes, S. Sousa, A. Cebria, M. Lecuit, F. Garcia-del Portillo and P. Cossart. (2005) Gp96 is a receptor for a novel Listeria monocytogenes virulence factor, Vip, a surface protein. EMBO J. , 24 : 2827-2838.
S. Sousa, D. Cabanes, C. Archambaud, F. Colland, E. Lemichez, M. Popoff, S. Boisson-Dupuis, E. Gouin, M. Lecuit, P. Legrain and P. Cossart. (2005). ARHGAP10 is necessary for a-catenin recruitment at adherens junctions and for Listeria invasion. Nat. Cell. Biol., 7 : 954-960
E.Veiga and P. Cossart. (2005) Listeria hijacks the clathrin-dependent endocytic machinery to invade mammalian cells. Nat. Cell. Biol., 7 : 894-900.
J.J. Martinez, S. Seveau, E. Veiga-Chacon, S. Matsuyama and P. Cossart (2005).Identification of Ku70, a component of the DNA-dependent protein kinase, as a receptor involved in Rickettsia conorii invasion of mammalian cells. Cell, 123 : 1013-1023.
J. Pizarro-Cerda and P. Cossart. (2006). Bacterial adhesion and entry into host cells. Cell, 124 : 715-727.
M. Hamon, H. Bierne and P. Cossart (2006). Listeria monocytogenes : a multifaceted model. Nat. Rev. Microbiol., 4 : 423-434.
I. Boneca,, O. Dussurget , D. Cabanes, MA Nahori, S. Sousa, M. Lecuit, E. Psylinakis, V. V. Bouriotis , JP Hugot, M. Giovannini, A. Coyle, J. Bertin, A. Namane, JC Rousselle, N. Cayet, MC Prevost, V. Balloy, M. Chignard, D. Philpott, P. Cossart* , SE Girardin (2007). A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system. Proc Natl Acad Sci USA 104 : 997-1002.
M. A. Hamon, E. Batsche, B. Regnault, T. Nam Tham, S. Seveau, C. Muchardt and P. Cossart (2007) Histone modifications induced by a family of bacterial toxins. Proc Natl Acad Sci USA, 104:13467-72
E. Veiga, J A Guttman, M Bonazzi, E. Boucrot, A. Toledo-Arana, A. E. Lin, J. Enninga, J, Pizzaro-Cerda, B. Brett Finlay, T. Kirchhausen, P. Cossart (2007). Invasive and adherent bacterial pathogens co-opt host cell clathrin forinfection. CellHost & Microbe, 15 : 340-351
O. Disson, S. Grayo, E. Huillet, G. Nikitas, F. Langa-Vives, O. Dussurget, M. Ragon, A. Le Monnier, C. Babinet, P. Cossart and M. Lecuit (2008) Conjugated action of two species-specific invasion proteins for fetoplacental listeriosis. Nature, 455 : 1114-8
A. Toledo-Arana, O. Dussurget, G. Nikitas, N. Sesto, H. Guet-Revillet, D. Balestrino, E. Loh, J. Gripenland, T. Tiensuu, K. Vaitkevicius, M. Barthelemy, M. Vergassola, M.A. Nahori, G. Soubigou, B. Régnault, J.Y. Coppée, M. Lecuit, J. Johansson, P.Cossart (2009). The Listeria transcriptional landscape from saprophytism to virulence. Nature, 459 : 950-6
H. Bierne, T. Nam Tham, E. Batsche, A. Dumay, M Leguillou, S Kerneis-Golsteyn, B. Regnault, J. Seeler, C. Muchardt, J. Feunteun, P. Cossart (2009). Human BAHD1 promotes heterochromatic gene silencing. Proc Natl Acad Sci USA, 106 : 13826-13831
E. Loh, O. Dussurget, J. Gripenland, P. Mandin, F. Repoila, C. Buchreiser, P. Cossart*, and J. Johansson* (2009). A trans-acting riboswitch controls expression of the virulence regulator PrfA in Listeria. Cell, 139: 770-9
D. Ribet, M. Hamon, E. Gouin, M.-A. Nahori, F. Impens, H. Neyret-Kahn, K. Gevaert, J. Vandekerckhove, A. Dejean and P. Cossart (2010). Listeria monocytogenes impairs SUMOylation for efficient infection. Nature, 464: 1192-1195
E. Gouin, M. Adib-Conquy, D. Balestrino, M.-A. Nahori, V. Villiers, F. Colland, S. Dramsi, O. Dussurget and P. Cossart (2010). The Listeriamonocytogenes InlC protein interferes with innate immune responses by targeting the IκB kinase α. Proc Natl Acad Sci USA, 107: 17333-8
S. Mostowy, M. Bonazzi, M.-A. Hamon, T.-N. Tham, A. Mallet, M. Lelek, E. Gouin, C. Demangel, R. Brosch, C. Zimmer, A. Sartori, M. Kinoshita, M. Lecuit and P. Cossart (2010). Entrapment of Intracytosolic Bacteria by Septin Cages. Cell Host Microbe, 8: 433-44
F. Stavru, F. Bouillaud, A. Sartori, D. Ricquier, and P. Cossart (2011). Listeria monocytogenes transiently alters mitochondrial dynamics during infection. Proc Natl Acad Sci USA, 108: 3612-7
A. Lebreton, G.Lakisic, V. Job, L. Fritsch, T.-N.Tham, A. Camejo, P.-J. Matteï, B. Regnault, M.-A. Nahori, D. Cabanes, A. Gautreau, S. Ait-Si-Al, A. Dessen, P. Cossart* and H. Bierne* (2011). A Bacterial Protein Targets the BAHD1 Chromatin Complex to Stimulate Type III Interferon Response. Science, 331: 1319-21
P. Cossart (2011). Illuminating the landscape of host-pathogen interactions with the bacterium Listeria monocytogenes. Proc Natl Acad Sci USA, 108: 19484-91
S. Mostowy, and P. Cossart (2012). Septins: the fourth component of the cytoskeleton. Nat Rev Mol Cell Biol, 3:183-94
O. Wurtzel, N. Sesto, J.-R. Mellin, I. Karunker, S. Edelheit, C. Becavin, C. Archambaud, P. Cossart* and R. Sorek* (2012). Comparative transcriptomics of pathogenic and non-pathogenic Listeria species. Mol Syst Biol., 8:583
S. Sesto, O. Wurtzel, C. Archambaud, R. Sorek and P. Cossart (2013). The excludon: a new concept in bacterial antisense RNA-mediated gene regulation. Nat Rev Microbiol, 11:75-82
H.A. Eskandarian, M.-A. Nahori, G. Soubigou, P.Y. Coppée, P. Cossart* and M. Hamon* (2013). A role for SIRT2-dependent histone H3K18 deacetylation in bacterial infection. Science, 341 : 1238858
J.-R. Mellin, T. Tiensuud, C. Bécavin, E. Gouin, J. Johansson and P. Cossart (2013). A riboswitch-regulated antisense RNA in Listeria monocytogenes. Proc Natl Acad Sci USA, 110 : 13132-7
Updated on 12/05/2014
Unité Interactions Bactéries-Cellules
INSERM U604 INRA USC2020
25, Rue du Docteur Roux
75724 Paris Cedex 15 FRANCE
Phone: + 33 (1) 45 68 88 41
Secretary: + 33 (1) 40 61 30 32
Fax: + 33 (1) 45 68 87 06
Our laboratory is located on the ground floor at the 53C entrance of the Roux Building (25, rue du Docteur Roux)
The metro stations Pasteur (line 6) and Volontaires (line 12) are within a 5 min walking distance from the Pasteur Institute.
The bus stop Pasteur (bus 95, towards Porte de Vanves) is located next to the Pasteur Institute main entrance.