The Pasteur Museum is housed in the apartment where Louis Pasteur spent his final seven years and offers a rare behind-the-scenes look at the living and working environment of the world-renowned scientist. Visitors can gain a unique insight into his everyday life alongside his ...
The Institut Pasteur’s scientific strategy focuses on developing original and innovative topics and promoting interdisciplinary and multidisciplinary cooperation and approaches. The Institut Pasteur teams have access to the technological resources ...
Ever since the introduction of the world’s first "Technical Microbiology" course in 1889, teaching has been a priority for the Institut Pasteur. The Institut Pasteur has an international reputation for quality teaching that attracts students from all over ...
The mission of the Industrial Partnership team is to detect, promote, assist and protect the inventive activities from research (inventions, know-how and biological materials) conducted at the Institut Pasteur (and in some Institutes of its international network), and transfer there to industrial ...
With international courses, PhD and postdoctoral traineeship, each institute of the Institut Pasteur International Network (RIIP) contributes to the transmission of knowledge with the training of young researchers all around the world. In this context, doctoral and postdoctoral programmes, study ...
Histone modifications induced by Listeria monocytogenes
Does Listeria monocytogenes induce global histone modifications to the host cell during the course of infection? Work carried out in the last two decades has shown that L. monocytogenes is able to manipulate several host signaling pathways, and induces changes in the transcriptional profile of the host cell. The mechanism by which L. monocytogenes is able to alter host transcription is unknown, and therefore, we hypothesized that this bacterium, as viruses, might be able to control host transcription by modifying host histones during the course of infection. Using L. monocytogenes as a model organism, we have been able to show that this intracellular pathogen induces specific changes in the levels of modified histones which correlate with a specific transcriptional response. Questions asked include which cellular and bacterial factors are involved inducing histone modifications, what is the role of these modifications during infection, and can other bacteria induce similar of different histone modifications.
Updated on 12/05/2014
Unité Interactions Bactéries-Cellules
INSERM U604 INRA USC2020
25, Rue du Docteur Roux
75724 Paris Cedex 15 FRANCE
Phone: + 33 (1) 45 68 88 41
Secretary: + 33 (1) 40 61 30 32
Fax: + 33 (1) 45 68 87 06
Our laboratory is located on the ground floor at the 53C entrance of the Roux Building (25, rue du Docteur Roux)
The metro stations Pasteur (line 6) and Volontaires (line 12) are within a 5 min walking distance from the Pasteur Institute.
The bus stop Pasteur (bus 95, towards Porte de Vanves) is located next to the Pasteur Institute main entrance.