The Pasteur Museum is housed in the apartment where Louis Pasteur spent his final seven years and offers a rare behind-the-scenes look at the living and working environment of the world-renowned scientist. Visitors can gain a unique insight into his everyday life alongside his wife and can admire his rich and diverse scientific work.
The Institut Pasteur’s scientific strategy focuses on developing original and innovative topics and promoting interdisciplinary and multidisciplinary cooperation and approaches. The Institut Pasteur teams have access to the technological resources needed to speed up and further improve the quality of their outstanding research.
Ever since the introduction of the world’s first "Technical Microbiology" course in 1889, teaching has been a priority for the Institut Pasteur. The Institut Pasteur has an international reputation for quality teaching that attracts students from all over the world who come to further their training or top up their degree programs.
The mission of the Industrial Partnership team is to detect, promote, assist and protect the inventive activities from research (inventions, know-how and biological materials) conducted at the Institut Pasteur (and in some Institutes of its international network), and transfer there to industrial and/or institutional partners, in order to serve the patient needs and for the benefit of the society, as well as to contribute to sustainability of the Institut Pasteur’s resources.
With international courses, PhD and postdoctoral traineeship, each institute of the Institut Pasteur International Network (RIIP) contributes to the transmission of knowledge with the training of young researchers all around the world. In this context, doctoral and postdoctoral programmes, study and traineeship fellowships are available to scientists. Alongside training, dynamism and attractiveness of RIIP will result in the creation of 4-year group for the young researchers.
Bacteria-cell interactions Unit – INSERM U604 – INRA USC2020
Department of Cell biology and Infection
25 rue du Docteur Roux -75724 PARIS Cedex 15-France
Present position and status: INRA Research scientist (CR1).
Future position (starting 2014): Group leader, Biology Department (IBENS), École Normale Supérieure, Paris.
PhD thesis in Microbiology-Virology, Paris 7-Denis Diderot University.
Master of Science (DEA) in Mirobiology-Virology, Paris 7-Denis Diderot University.
Diploma of General Microbiology, Pasteur Institute, Paris, France.
Agrégation in Biochemistry – Biological engineering.
Undergraduate studies in Molecular and Cellular Biochemistry at École Normale Supérieure de Cachan,
department of Life Sciences and Paris 7-Denis Diderot University, France.
Research Scientist, Bacteria-Cell Interactions unit, Pasteur Institute, Paris, France.
“Chromatin subversion of host interferon response by Listeria monocytogenes”.
Post-doctoral fellow, laboratory of Eukaryotic mRNA splicing and decay, CGM – CNRS, Gif-sur-Yvette, France.
“Nuclear RNA quality control mechanisms and activity of the exosome”.
PhD student, Genetics of Macromolecular Interactions unit, Pasteur Institute.
“Dynamics of pre-ribosomal factors along ribosome biogenesis in S. cerevisiae”.
Erasmus student, Microbiology Institute, ETH, Zürich, Switzerland.
“Role of the γ-glutamylamide hydrolase IpuF in the transformation of isopropylamide to L-alaninol by Pseudomonas”.
Unit of Mechanisms and Consequences of Neuronal Death, Hôpital de la Pitié-Salpêtrière, Paris, France.
“Histology of astrocytes from a murine model for Parkinson Disease”.
Occasional lecturer, Cell Biology of Host-Invasive Bacteria Interactions classes, École Normale Supérieure de Cachan (Master’s degree).
“Molecular and cellular basis of infection by Listeria and Rickettsia, two model intracellular bacteria”.
Occasional lecturer, General Microbiology and Genome Analysis Courses, Pasteur Institute (Master’s degree).
“Yeast interactome, from interaction networks to functional genomics”.
Teaching assistant in Paris VII University.
Immunology exercise sessions and practical works (Bachelor’s degree).
2012-2013, Goran Lakisic, Research Engineer. 2006-2007, Marie-Elisabeth Dufour, Assistant-Engineer. 2003 & 2009, Alice Grob, Andrew Lee, Yuwen Wu, bachelor’s degree students (summer trainings).
Licence for experimentation on mammalian organisms.
2012, co-organizer of the Cell Biology and Infection department retreat (Institut Pasteur). 2004 & 2005, co-organizer of the Young Researchers Congress, and thematic young researchers seminars (Institut Pasteur).
“A virulence factor secreted by Listeria monocytogenes targets a human chromatin silencing complex”.
INRA Microbiology Days, Poitiers, France.
“Endonucleolytic RNA Cleavage by the Yeast Exosome”.
RNA Society annual meeting, Berlin, Germany.
“An endonuclease activity in the yeast exosome”.
Tiny European RNA Meeting, Gif-sur-Yvette, France.
“End of ribosome biogenesis in yeast and recycling of shuttling pre-ribosomal factors”.
B2M annual meeting, Paris VII University, France.
“Functional analysis of pre-ribosomes:
Applications of quantitative mass-spectrometry (SILAC) to the study of Nsa2”.
Club des Levuristes d’Île-de-France, Orsay, France.
Lebreton A*, Job V*, Ragon M, Le Monnier A, Dessen A, Cossart P and Bierne H. 2014. Structural basis for the inhibition of the chromatin repressor BAHD1 by the bacterial nucleomodulin LntA. mBio< 5(1):e00775-13.
Archambaud C, Sismeiro O, Toedling J, Soubigou G, Bécavin C, Lechat P, Lebreton A, Ciaudo C and Cossart P. 2013. The Intestinal Microbiota Interferes with the microRNA Response upon Oral Listeria Infection. mBio 4(6):e00707-13.
Gudipati RK, Xu Z, Lebreton A, Séraphin B, Steinmetz LM, Jacquier A and Libri D. 2012. Extensive degradation of RNA precursors by the exosome in wild type cells. Mol. Cell 48(3):409-21.
Bierne H, Travier L, Mahlakõiv T, Tailleux L, Subtil A, Lebreton A, Paliwal A, Gicquel B, Staeheli P, Lecuit M and Cossart P. 2012. Activation of Type III Interferon Genes by Pathogenic Bacteria in Infected Epithelial Cells and Mouse Placenta. PLoS One 7(6):e39080.
Lebreton A, Cossart P et Bierne H. 2012. Bacteria tune interferon responses by playing with chromatin. Virulence 3(1):1319-21.
Lebreton A, Lakisic G, Job V, Fritsch L, Tham TN, Camejo A, Matteï P-J, Regnault B, Nahori M-A, Cabanes D, Gautreau A, Ait-Si-Ali S, Dessen A, Cossart P and Bierne H. 2011. A bacterial protein targets the BAHD1 chromatin complex to stimulate type III interferon response. Science 331(6022):1319-21.
Lebreton A*, Rafal T*, Dziembowski A and Séraphin B. 2008. Endonucleolytic RNA cleavage by a eukaryotic exosome. Nature 456(7224):993-7.
Lebreton A. and Séraphin B. 2008. Exosome-mediated quality control: substrate recruitment and molecular activity. BBA – Gene Regulatory Mechanisms – RNA quality control 1779(9):558-65.
Lebreton A, Rousselle J-C, Lenormand P, Namane A, Jacquier A, Fromont-Racine M and Saveanu C. 2008. Large ribosomal subunit assembly dynamics defined by semi-quantitative mass spectrometry of purified complexes. Nucleic Acids Res. 36(15):4988-99.
Pertschy B, Saveanu C, Zisser G, Lebreton A, Tengg M, Jacquier A, Liebminger E, Nobis B, Kappel L, van der Klei I, Högenauer G, Fromont-Racine M and Bergler H. 2007. Cytoplasmic recycling of 60S pre-ribosomal factors depends on the AAA-protein Drg1. Mol. Cell. Biol. 27(19):6581-92.
Lebreton A, Saveanu C, Decourty L, Rain J-C, Jacquier A and Fromont-Racine M. 2006. A functional network involved in the recycling of nucleo-cytoplasmic pre-60S factors. J. Cell Biol. 173(3):349-60.
Lebreton A, Saveanu C, Decourty L, Jacquier A and Fromont-Racine M. 2006. Nsa2, an unstable, conserved factor required for the maturation of 27SB pre-rRNAs. J. Biol. Chem. 281(37):27099-108.
Saveanu C, Namane A, Gleizes P-E, Lebreton A, Rousselle J-C, Noaillac-Depeyre J, Gas N, Jacquier A and Fromont-Racine M. 2003. Sequencial protein association with nascent 60S ribosomal particles. Mol. Cell. Biol. 23(13):4449-60.
De Azevedo Wäsch SI, van der Ploeg JR, Maire T, Lebreton A, Kiener A and Leisinger, T. 2002. Transformation of Isopropylamine to L-Alaninol by Pseudomonas sp. Strain KIE171 Involves N-Glutamylated intermediates. Appl. Environ. Microbiol. 68(5):2368-75.
Updated on 12/05/2014
Unité Interactions Bactéries-Cellules
INSERM U604 INRA USC2020
25, Rue du Docteur Roux
75724 Paris Cedex 15 FRANCE
Phone: + 33 (1) 45 68 88 41
Secretary: + 33 (1) 40 61 30 32
Fax: + 33 (1) 45 68 87 06
Our laboratory is located on the ground floor at the 53C entrance of the Roux Building (25, rue du Docteur Roux)
The metro stations Pasteur (line 6) and Volontaires (line 12) are within a 5 min walking distance from the Pasteur Institute.
The bus stop Pasteur (bus 95, towards Porte de Vanves) is located next to the Pasteur Institute main entrance.