Curriculum vitae - Alice Lebreton

Citizenship:  French, Swiss.

Professional address:

INSTITUT PASTEUR
Bacteria-cell interactions Unit – INSERM U604 – INRA USC2020
Department of Cell biology and Infection
25 rue du Docteur Roux -75724 PARIS Cedex 15-France
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Present position and status: INRA Research scientist (CR1).

Future position (starting 2014): Group leader, Biology Department (IBENS), École Normale Supérieure, Paris.

 

Universitary education

2002-2006  PhD thesis in Microbiology-Virology, Paris 7-Denis Diderot University.
2002  Master of Science (DEA) in Mirobiology-Virology, Paris 7-Denis Diderot University.
  Diploma of General Microbiology, Pasteur Institute, Paris, France.
2001  Agrégation in Biochemistry – Biological engineering.
1998-2002  Undergraduate studies in Molecular and Cellular Biochemistry at École Normale Supérieure de Cachan,
department of Life Sciences and Paris 7-Denis Diderot University, France.

 

Research experience

2008-Present  Research Scientist, Bacteria-Cell Interactions unit, Pasteur Institute, Paris, France.
“Chromatin subversion of host interferon response by Listeria monocytogenes”.
2006-2008  Post-doctoral fellow, laboratory of Eukaryotic mRNA splicing and decay, CGM – CNRS, Gif-sur-Yvette, France.
“Nuclear RNA quality control mechanisms and activity of the exosome”.
2002-2006  PhD student, Genetics of Macromolecular Interactions unit, Pasteur Institute.
“Dynamics of pre-ribosomal factors along ribosome biogenesis in S. cerevisiae”.
2000  Erasmus student, Microbiology Institute, ETH, Zürich, Switzerland.
“Role of the γ-glutamylamide hydrolase IpuF in the transformation of isopropylamide to L-alaninol by Pseudomonas”.
Summer 1999  Unit of Mechanisms and Consequences of Neuronal Death, Hôpital de la Pitié-Salpêtrière, Paris, France.
“Histology of astrocytes from a murine model for Parkinson Disease”.

 

Teaching

2011-Present  Occasional lecturer, Cell Biology of Host-Invasive Bacteria Interactions classes, École Normale Supérieure de Cachan (Master’s degree).
“Molecular and cellular basis of infection by Listeria and Rickettsia, two model intracellular bacteria”.
2005-2006  Occasional lecturer, General Microbiology and Genome Analysis Courses, Pasteur Institute (Master’s degree).
“Yeast interactome, from interaction networks to functional genomics”.
2002-2005  Teaching assistant in Paris VII University.
Immunology exercise sessions and practical works (Bachelor’s degree).

 

Other activities

Supervision  2012-2013, Goran Lakisic, Research Engineer.
2006-2007, Marie-Elisabeth Dufour, Assistant-Engineer.
2003 & 2009, Alice Grob, Andrew Lee, Yuwen Wu, bachelor’s degree students (summer trainings).
Animal experimentation  Licence for experimentation on mammalian organisms.
Scientific events  2012, co-organizer of the Cell Biology and Infection department retreat (Institut Pasteur).
2004 & 2005, co-organizer of the Young Researchers Congress, and thematic young researchers seminars (Institut Pasteur).

 

Oral communications

2010  “A virulence factor secreted by Listeria monocytogenes targets a human chromatin silencing complex”.
INRA Microbiology Days, Poitiers, France.
2008  “Endonucleolytic RNA Cleavage by the Yeast Exosome”.
RNA Society annual meeting, Berlin, Germany.
  “An endonuclease activity in the yeast exosome”.
Tiny European RNA Meeting, Gif-sur-Yvette, France.
2006  “End of ribosome biogenesis in yeast and recycling of shuttling pre-ribosomal factors”.
B2M annual meeting, Paris VII University, France.
2004  “Functional analysis of pre-ribosomes:
Applications of quantitative mass-spectrometry (SILAC) to the study of Nsa2”.
Club des Levuristes d’Île-de-France, Orsay, France.

 

Publication list

  • Lebreton A*, Job V*, Ragon M, Le Monnier A, Dessen A, Cossart P and Bierne H. 2014. Structural basis for the inhibition of the chromatin repressor BAHD1 by the bacterial nucleomodulin LntA. mBio< 5(1):e00775-13.
  • Archambaud C, Sismeiro O, Toedling J, Soubigou G, Bécavin C, Lechat P, Lebreton A, Ciaudo C and Cossart P. 2013. The Intestinal Microbiota Interferes with the microRNA Response upon Oral Listeria Infection. mBio 4(6):e00707-13.
  • Gudipati RK, Xu Z, Lebreton A, Séraphin B, Steinmetz LM, Jacquier A and Libri D. 2012. Extensive degradation of RNA precursors by the exosome in wild type cells. Mol. Cell 48(3):409-21.
  • Bierne H, Travier L, Mahlakõiv T, Tailleux L, Subtil A, Lebreton A, Paliwal A, Gicquel B, Staeheli P, Lecuit M and Cossart P. 2012. Activation of Type III Interferon Genes by Pathogenic Bacteria in Infected Epithelial Cells and Mouse Placenta. PLoS One 7(6):e39080.
  • Lebreton A, Cossart P et Bierne H. 2012. Bacteria tune interferon responses by playing with chromatin. Virulence 3(1):1319-21.
  • Lebreton A, Lakisic G, Job V, Fritsch L, Tham TN, Camejo A, Matteï P-J, Regnault B, Nahori M-A, Cabanes D, Gautreau A, Ait-Si-Ali S, Dessen A, Cossart P and Bierne H. 2011. A bacterial protein targets the BAHD1 chromatin complex to stimulate type III interferon response. Science 331(6022):1319-21.
  • Lebreton A*, Rafal T*, Dziembowski A and Séraphin B. 2008. Endonucleolytic RNA cleavage by a eukaryotic exosome. Nature 456(7224):993-7.
  • Lebreton A. and Séraphin B. 2008. Exosome-mediated quality control: substrate recruitment and molecular activity. BBA – Gene Regulatory Mechanisms – RNA quality control 1779(9):558-65.
  • Lebreton A, Rousselle J-C, Lenormand P, Namane A, Jacquier A, Fromont-Racine M and Saveanu C. 2008. Large ribosomal subunit assembly dynamics defined by semi-quantitative mass spectrometry of purified complexes. Nucleic Acids Res. 36(15):4988-99.
  • Pertschy B, Saveanu C, Zisser G, Lebreton A, Tengg M, Jacquier A, Liebminger E, Nobis B, Kappel L, van der Klei I, Högenauer G, Fromont-Racine M and Bergler H. 2007. Cytoplasmic recycling of 60S pre-ribosomal factors depends on the AAA-protein Drg1. Mol. Cell. Biol. 27(19):6581-92.
  • Lebreton A, Saveanu C, Decourty L, Rain J-C, Jacquier A and Fromont-Racine M. 2006. A functional network involved in the recycling of nucleo-cytoplasmic pre-60S factors. J. Cell Biol. 173(3):349-60.
  • Lebreton A, Saveanu C, Decourty L, Jacquier A and Fromont-Racine M. 2006. Nsa2, an unstable, conserved factor required for the maturation of 27SB pre-rRNAs. J. Biol. Chem. 281(37):27099-108.
  • Saveanu C, Namane A, Gleizes P-E, Lebreton A, Rousselle J-C, Noaillac-Depeyre J, Gas N, Jacquier A and Fromont-Racine M. 2003. Sequencial protein association with nascent 60S ribosomal particles. Mol. Cell. Biol. 23(13):4449-60.
  • De Azevedo Wäsch SI, van der Ploeg JR, Maire T, Lebreton A, Kiener A and Leisinger, T. 2002. Transformation of Isopropylamine to L-Alaninol by Pseudomonas sp. Strain KIE171 Involves N-Glutamylated intermediates. Appl. Environ. Microbiol. 68(5):2368-75.
Updated on 12/05/2014

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Lab address

Unité Interactions Bactéries-Cellules

INSERM U604 INRA USC2020
Institut Pasteur
25, Rue du Docteur Roux
75724 Paris Cedex 15 FRANCE

 

Phone: + 33 (1) 45 68 88 41

Secretary: + 33 (1) 40 61 30 32

Fax: + 33 (1) 45 68 87 06

 

Our laboratory is located on the ground floor at the 53C entrance of the Roux Building (25, rue du Docteur Roux)

The metro stations Pasteur (line 6) and Volontaires (line 12) are within a 5 min walking distance from the Pasteur Institute.

The bus stop Pasteur (bus 95, towards Porte de Vanves) is located next to the Pasteur Institute main entrance.

For more information: Pasteur Institute Access and Paris Metro/Bus/Tram

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