The Pasteur Museum is housed in the apartment where Louis Pasteur spent his final seven years and offers a rare behind-the-scenes look at the living and working environment of the world-renowned scientist. Visitors can gain a unique insight into his everyday life alongside his wife and can admire his rich and diverse scientific work.
The Institut Pasteur’s scientific strategy focuses on developing original and innovative topics and promoting interdisciplinary and multidisciplinary cooperation and approaches. The Institut Pasteur teams have access to the technological resources needed to speed up and further improve the quality of their outstanding research.
Ever since the introduction of the world’s first "Technical Microbiology" course in 1889, teaching has been a priority for the Institut Pasteur. The Institut Pasteur has an international reputation for quality teaching that attracts students from all over the world who come to further their training or top up their degree programs.
The mission of the Industrial Partnership team is to detect, promote, assist and protect the inventive activities from research (inventions, know-how and biological materials) conducted at the Institut Pasteur (and in some Institutes of its international network), and transfer there to industrial and/or institutional partners, in order to serve the patient needs and for the benefit of the society, as well as to contribute to sustainability of the Institut Pasteur’s resources.
With international courses, PhD and postdoctoral traineeship, each institute of the Institut Pasteur International Network (RIIP) contributes to the transmission of knowledge with the training of young researchers all around the world. In this context, doctoral and postdoctoral programmes, study and traineeship fellowships are available to scientists. Alongside training, dynamism and attractiveness of RIIP will result in the creation of 4-year group for the young researchers.
Physiopathology of the Infection and Host Immune Responses to Listeria monocytogenes
[Cossart, PNAS 2011]
The infection by L. monocytogenes in vivo: bacteria, via contaminated food product, reach the intestinal barrier, cross it, and then disseminate to the brain and placenta.
[Lecuit, TRENDS in Molecular Medicine 2002]
Model for the pathophysiology of Listeria infection
[Photo: O. Dussurget, unité Interactions Bactéries-Cellules, Institut Pasteur]
Bioluminescence imaging of murine listeriosis. Luminescent Listeria monocytogenes at 5X104 CFU per BALB/c mouse were imaged 4 days post-intravenous infection with an IVIS100 imaging system (Xenogen Corp.). One mouse displayed a characteristic signal of brain growth while the four other animals controlled the infection.
[Lecuit, TRENDS in Molecular Medicine 2002]
E-cadherin expression in mice. a) Enterocyte-restricted human E-cadherin expression in iFABP-hEcad [human E-cadherin under the control of the promoter of the intestinal fatty-acid-binding protein (iFABP) gene] transgenic mice. Small intestine sections of a iFABP-hEcad transgenic mouse (left) and a non-transgenic littermate (right) immunolabeled with anti-hEcad HECD1 mouse monoclonal antibody (red). HECD1 recognizes human but not mouse E-cadherin. The background signal in the lamina propria is because of the reactivity of the secondary goat anti-mouse IgG antibody towards endogenous mouse IgG. A cross-section of a transgenic intestinal epithelial sheet allows detection of the typical honeycomb-like pattern of E-cadherin labeling. Scale BAR = 10 μm. b) Listeria monocytogenes multiplication within the lamina propria of a small-intestinal villus of an iFABP-hEcad transgenic mouse 48 h after intragastric inoculation. A small intestine section of a iFABP-hEcad transgenic mouse orally infected with L. monocytogenes and immunolabeled with rabbit anti-L. monocytogenes R11 polyclonal antibody (red). L. monocytogenes have crossed the intestinal barrier and replicate in the lamina propria, a phenomenon that is never observed in non-transgenic mice. Scale BAR = 10 μm.
Updated on 13/05/2014
Unité Interactions Bactéries-Cellules
INSERM U604 INRA USC2020
25, Rue du Docteur Roux
75724 Paris Cedex 15 FRANCE
Phone: + 33 (1) 45 68 88 41
Secretary: + 33 (1) 40 61 30 32
Fax: + 33 (1) 45 68 87 06
Our laboratory is located on the ground floor at the 53C entrance of the Roux Building (25, rue du Docteur Roux)
The metro stations Pasteur (line 6) and Volontaires (line 12) are within a 5 min walking distance from the Pasteur Institute.
The bus stop Pasteur (bus 95, towards Porte de Vanves) is located next to the Pasteur Institute main entrance.